Transient improvement of acquired hepatocerebral degeneration with parkinsonian symptoms after failed liver transplant: case report and literature review.
Identifieur interne : 000B28 ( PubMed/Checkpoint ); précédent : 000B27; suivant : 000B29Transient improvement of acquired hepatocerebral degeneration with parkinsonian symptoms after failed liver transplant: case report and literature review.
Auteurs : Yuanyuan Chen [Canada] ; Mazhar Haque ; Eric M. YoshidaSource :
- Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation [ 2146-8427 ] ; 2011.
English descriptors
- KwdEn :
- Antiparkinson Agents (therapeutic use), Antiviral Agents (therapeutic use), End Stage Liver Disease (etiology), End Stage Liver Disease (surgery), Fatal Outcome, Graft Rejection (etiology), Hepatitis C (complications), Hepatitis C (diagnosis), Hepatitis C (drug therapy), Hepatolenticular Degeneration (diagnosis), Hepatolenticular Degeneration (etiology), Hepatolenticular Degeneration (surgery), Humans, Liver Cirrhosis (etiology), Liver Cirrhosis (surgery), Liver Transplantation (adverse effects), Magnetic Resonance Imaging, Male, Middle Aged, Parkinsonian Disorders (diagnosis), Parkinsonian Disorders (drug therapy), Parkinsonian Disorders (etiology), Parkinsonian Disorders (surgery), Recurrence, Treatment Failure.
- MESH :
- chemical , therapeutic use : Antiparkinson Agents, Antiviral Agents.
- adverse effects : Liver Transplantation.
- complications : Hepatitis C.
- diagnosis : Hepatitis C, Hepatolenticular Degeneration, Parkinsonian Disorders.
- drug therapy : Hepatitis C, Parkinsonian Disorders.
- etiology : End Stage Liver Disease, Graft Rejection, Hepatolenticular Degeneration, Liver Cirrhosis, Parkinsonian Disorders.
- surgery : End Stage Liver Disease, Hepatolenticular Degeneration, Liver Cirrhosis, Parkinsonian Disorders.
- Fatal Outcome, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Recurrence, Treatment Failure.
Abstract
Acquired (non-Wilsonian) hepato-cerebral degeneration is an infrequent neurologic disorder in patients with liver dysfunction and longstanding portal-systemic shunting. The clinical manifestations include dysarthria, ataxia, tremor, and cognitive dysfunction. Typically, patients with acquired hepatocerebral degeneration respond poorly to medical therapy as the underlying end-stage liver disease remains. Information regarding the effect of orthotopic liver transplant on acquired hepatocerebral degeneration, however, is limited and conflicting.
PubMed: 22142042
Affiliations:
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Yoshida</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:22142042</idno><idno type="pmid">22142042</idno><idno type="wicri:Area/PubMed/Corpus">000B50</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000B50</idno><idno type="wicri:Area/PubMed/Curation">000B50</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000B50</idno><idno type="wicri:Area/PubMed/Checkpoint">000B50</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000B50</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Transient improvement of acquired hepatocerebral degeneration with parkinsonian symptoms after failed liver transplant: case report and literature review.</title><author><name sortKey="Chen, Yuanyuan" sort="Chen, Yuanyuan" uniqKey="Chen Y" first="Yuanyuan" last="Chen">Yuanyuan Chen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, University of British Columbia, Vancouver, BC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, University of British Columbia, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Haque, Mazhar" sort="Haque, Mazhar" uniqKey="Haque M" first="Mazhar" last="Haque">Mazhar Haque</name></author><author><name sortKey="Yoshida, Eric M" sort="Yoshida, Eric M" uniqKey="Yoshida E" first="Eric M" last="Yoshida">Eric M. Yoshida</name></author></analytic><series><title level="j">Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation</title><idno type="eISSN">2146-8427</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiparkinson Agents (therapeutic use)</term><term>Antiviral Agents (therapeutic use)</term><term>End Stage Liver Disease (etiology)</term><term>End Stage Liver Disease (surgery)</term><term>Fatal Outcome</term><term>Graft Rejection (etiology)</term><term>Hepatitis C (complications)</term><term>Hepatitis C (diagnosis)</term><term>Hepatitis C (drug therapy)</term><term>Hepatolenticular Degeneration (diagnosis)</term><term>Hepatolenticular Degeneration (etiology)</term><term>Hepatolenticular Degeneration (surgery)</term><term>Humans</term><term>Liver Cirrhosis (etiology)</term><term>Liver Cirrhosis (surgery)</term><term>Liver Transplantation (adverse effects)</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Parkinsonian Disorders (diagnosis)</term><term>Parkinsonian Disorders (drug therapy)</term><term>Parkinsonian Disorders (etiology)</term><term>Parkinsonian Disorders (surgery)</term><term>Recurrence</term><term>Treatment Failure</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Antiviral Agents</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Liver Transplantation</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Hepatitis C</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hepatitis C</term><term>Hepatolenticular Degeneration</term><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Hepatitis C</term><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>End Stage Liver Disease</term><term>Graft Rejection</term><term>Hepatolenticular Degeneration</term><term>Liver Cirrhosis</term><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>End Stage Liver Disease</term><term>Hepatolenticular Degeneration</term><term>Liver Cirrhosis</term><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Fatal Outcome</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Recurrence</term><term>Treatment Failure</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Acquired (non-Wilsonian) hepato-cerebral degeneration is an infrequent neurologic disorder in patients with liver dysfunction and longstanding portal-systemic shunting. The clinical manifestations include dysarthria, ataxia, tremor, and cognitive dysfunction. Typically, patients with acquired hepatocerebral degeneration respond poorly to medical therapy as the underlying end-stage liver disease remains. Information regarding the effect of orthotopic liver transplant on acquired hepatocerebral degeneration, however, is limited and conflicting.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22142042</PMID><DateCreated><Year>2011</Year><Month>12</Month><Day>06</Day></DateCreated><DateCompleted><Year>2012</Year><Month>04</Month><Day>03</Day></DateCompleted><DateRevised><Year>2011</Year><Month>12</Month><Day>06</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2146-8427</ISSN><JournalIssue CitedMedium="Internet"><Volume>9</Volume><Issue>6</Issue><PubDate><Year>2011</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation</Title><ISOAbbreviation>Exp Clin Transplant</ISOAbbreviation></Journal><ArticleTitle>Transient improvement of acquired hepatocerebral degeneration with parkinsonian symptoms after failed liver transplant: case report and literature review.</ArticleTitle><Pagination><MedlinePgn>363-9</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">Acquired (non-Wilsonian) hepato-cerebral degeneration is an infrequent neurologic disorder in patients with liver dysfunction and longstanding portal-systemic shunting. The clinical manifestations include dysarthria, ataxia, tremor, and cognitive dysfunction. Typically, patients with acquired hepatocerebral degeneration respond poorly to medical therapy as the underlying end-stage liver disease remains. Information regarding the effect of orthotopic liver transplant on acquired hepatocerebral degeneration, however, is limited and conflicting.</AbstractText><AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">We conducted a review of literature via a PubMed search to summarize the effect of orthotopic liver transplant on acquired hepatocerebral degeneration.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">We present a 56-year-old man with compensated hepatitis C cirrhosis who developed acquired hepatocerebral degeneration with Parkinsonian symptoms refractory to conventional Parkinson medical therapy. Orthotopic liver transplant led to marked clinical improvement of the acquired hepatocerebral degeneration. However, the patient developed recurrence of acquired hepatocerebral degeneration 6-week postorthotopic liver transplant as he developed graft failure from aggressive progressive hepatitis C recurrence. Our review found a heterogeneous group of case series, suggesting that the experience with orthotopic liver transplant is variable.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our experience demonstrates that orthotopic liver transplant may lead to resolution of acquired hepatocerebral degeneration; however, acquired hepatocerebral degeneration may return with recurrent liver disease. Future studies with long-term follow-up are needed.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Yuanyuan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Medicine, University of British Columbia, Vancouver, BC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haque</LastName><ForeName>Mazhar</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Yoshida</LastName><ForeName>Eric M</ForeName><Initials>EM</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Turkey</Country><MedlineTA>Exp Clin Transplant</MedlineTA><NlmUniqueID>101207333</NlmUniqueID><ISSNLinking>1304-0855</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000978">Antiparkinson Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000978" MajorTopicYN="N">Antiparkinson Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058625" MajorTopicYN="N">End Stage Liver Disease</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017809" MajorTopicYN="N">Fatal Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006084" MajorTopicYN="N">Graft Rejection</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006526" MajorTopicYN="N">Hepatitis C</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006527" MajorTopicYN="N">Hepatolenticular Degeneration</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008103" MajorTopicYN="N">Liver Cirrhosis</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016031" MajorTopicYN="N">Liver Transplantation</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008279" MajorTopicYN="N">Magnetic Resonance Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020734" MajorTopicYN="N">Parkinsonian Disorders</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012008" MajorTopicYN="N">Recurrence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017211" MajorTopicYN="N">Treatment Failure</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>12</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>12</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>4</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">22142042</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Haque, Mazhar" sort="Haque, Mazhar" uniqKey="Haque M" first="Mazhar" last="Haque">Mazhar Haque</name><name sortKey="Yoshida, Eric M" sort="Yoshida, Eric M" uniqKey="Yoshida E" first="Eric M" last="Yoshida">Eric M. Yoshida</name></noCountry><country name="Canada"><noRegion><name sortKey="Chen, Yuanyuan" sort="Chen, Yuanyuan" uniqKey="Chen Y" first="Yuanyuan" last="Chen">Yuanyuan Chen</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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