NTS-Polyplex: a potential nanocarrier for neurotrophic therapy of Parkinson's disease.
Identifieur interne : 000A28 ( PubMed/Checkpoint ); précédent : 000A27; suivant : 000A29NTS-Polyplex: a potential nanocarrier for neurotrophic therapy of Parkinson's disease.
Auteurs : Daniel Martinez-Fong [Mexique] ; Michael J. Bannon ; Louis-Eric Trudeau ; Juan A. Gonzalez-Barrios ; Martha L. Arango-Rodriguez ; Nancy G. Hernandez-Chan ; David Reyes-Corona ; Juan Armendáriz-Borunda ; Ivan Navarro-QuirogaSource :
- Nanomedicine : nanotechnology, biology, and medicine [ 1549-9642 ] ; 2012.
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : DNA.
- chemistry : Nanostructures, Neurotensin.
- genetics : Parkinson Disease.
- chemical , metabolism : Neurotensin.
- methods : Genetic Therapy.
- therapy : Parkinson Disease.
- Amino Acid Sequence, Animals, Gene Transfer Techniques, Humans, Molecular Sequence Data.
Abstract
Nanomedicine has focused on targeted neurotrophic gene delivery to the brain as a strategy to stop and reverse neurodegeneration in Parkinson's disease. Because of improved transfection ability, synthetic nanocarriers have become candidates for neurotrophic therapy. Neurotensin (NTS)-polyplex is a "Trojan horse" synthetic nanocarrier system that enters dopaminergic neurons through NTS receptor internalization to deliver a genetic cargo. The success of preclinical studies with different neurotrophic genes supports the possibility of using NTS-polyplex in nanomedicine. In this review, we describe the mechanism of NTS-polyplex transfection. We discuss the concept that an effective neurotrophic therapy requires a simultaneous effect on the axon terminals and soma of the remaining dopaminergic neurons. We also discuss the future of this strategy for the treatment of Parkinson's disease.
DOI: 10.1016/j.nano.2012.02.009
PubMed: 22406187
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:22406187Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">NTS-Polyplex: a potential nanocarrier for neurotrophic therapy of Parkinson's disease.</title><author><name sortKey="Martinez Fong, Daniel" sort="Martinez Fong, Daniel" uniqKey="Martinez Fong D" first="Daniel" last="Martinez-Fong">Daniel Martinez-Fong</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Fisiología, Biofísica y Neurociencias, México D.F., México. dmartine@fisio.cinvestav.mx</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Fisiología, Biofísica y Neurociencias, México D.F.</wicri:regionArea><wicri:noRegion>México D.F.</wicri:noRegion></affiliation></author><author><name sortKey="Bannon, Michael J" sort="Bannon, Michael J" uniqKey="Bannon M" first="Michael J" last="Bannon">Michael J. Bannon</name></author><author><name sortKey="Trudeau, Louis Eric" sort="Trudeau, Louis Eric" uniqKey="Trudeau L" first="Louis-Eric" last="Trudeau">Louis-Eric Trudeau</name></author><author><name sortKey="Gonzalez Barrios, Juan A" sort="Gonzalez Barrios, Juan A" uniqKey="Gonzalez Barrios J" first="Juan A" last="Gonzalez-Barrios">Juan A. Gonzalez-Barrios</name></author><author><name sortKey="Arango Rodriguez, Martha L" sort="Arango Rodriguez, Martha L" uniqKey="Arango Rodriguez M" first="Martha L" last="Arango-Rodriguez">Martha L. Arango-Rodriguez</name></author><author><name sortKey="Hernandez Chan, Nancy G" sort="Hernandez Chan, Nancy G" uniqKey="Hernandez Chan N" first="Nancy G" last="Hernandez-Chan">Nancy G. Hernandez-Chan</name></author><author><name sortKey="Reyes Corona, David" sort="Reyes Corona, David" uniqKey="Reyes Corona D" first="David" last="Reyes-Corona">David Reyes-Corona</name></author><author><name sortKey="Armendariz Borunda, Juan" sort="Armendariz Borunda, Juan" uniqKey="Armendariz Borunda J" first="Juan" last="Armendáriz-Borunda">Juan Armendáriz-Borunda</name></author><author><name sortKey="Navarro Quiroga, Ivan" sort="Navarro Quiroga, Ivan" uniqKey="Navarro Quiroga I" first="Ivan" last="Navarro-Quiroga">Ivan Navarro-Quiroga</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:22406187</idno><idno type="pmid">22406187</idno><idno type="doi">10.1016/j.nano.2012.02.009</idno><idno type="wicri:Area/PubMed/Corpus">000A20</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A20</idno><idno type="wicri:Area/PubMed/Curation">000A20</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000A20</idno><idno type="wicri:Area/PubMed/Checkpoint">000A20</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000A20</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">NTS-Polyplex: a potential nanocarrier for neurotrophic therapy of Parkinson's disease.</title><author><name sortKey="Martinez Fong, Daniel" sort="Martinez Fong, Daniel" uniqKey="Martinez Fong D" first="Daniel" last="Martinez-Fong">Daniel Martinez-Fong</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Fisiología, Biofísica y Neurociencias, México D.F., México. dmartine@fisio.cinvestav.mx</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Fisiología, Biofísica y Neurociencias, México D.F.</wicri:regionArea><wicri:noRegion>México D.F.</wicri:noRegion></affiliation></author><author><name sortKey="Bannon, Michael J" sort="Bannon, Michael J" uniqKey="Bannon M" first="Michael J" last="Bannon">Michael J. Bannon</name></author><author><name sortKey="Trudeau, Louis Eric" sort="Trudeau, Louis Eric" uniqKey="Trudeau L" first="Louis-Eric" last="Trudeau">Louis-Eric Trudeau</name></author><author><name sortKey="Gonzalez Barrios, Juan A" sort="Gonzalez Barrios, Juan A" uniqKey="Gonzalez Barrios J" first="Juan A" last="Gonzalez-Barrios">Juan A. Gonzalez-Barrios</name></author><author><name sortKey="Arango Rodriguez, Martha L" sort="Arango Rodriguez, Martha L" uniqKey="Arango Rodriguez M" first="Martha L" last="Arango-Rodriguez">Martha L. Arango-Rodriguez</name></author><author><name sortKey="Hernandez Chan, Nancy G" sort="Hernandez Chan, Nancy G" uniqKey="Hernandez Chan N" first="Nancy G" last="Hernandez-Chan">Nancy G. Hernandez-Chan</name></author><author><name sortKey="Reyes Corona, David" sort="Reyes Corona, David" uniqKey="Reyes Corona D" first="David" last="Reyes-Corona">David Reyes-Corona</name></author><author><name sortKey="Armendariz Borunda, Juan" sort="Armendariz Borunda, Juan" uniqKey="Armendariz Borunda J" first="Juan" last="Armendáriz-Borunda">Juan Armendáriz-Borunda</name></author><author><name sortKey="Navarro Quiroga, Ivan" sort="Navarro Quiroga, Ivan" uniqKey="Navarro Quiroga I" first="Ivan" last="Navarro-Quiroga">Ivan Navarro-Quiroga</name></author></analytic><series><title level="j">Nanomedicine : nanotechnology, biology, and medicine</title><idno type="eISSN">1549-9642</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>DNA (administration & dosage)</term><term>Gene Transfer Techniques</term><term>Genetic Therapy (methods)</term><term>Humans</term><term>Molecular Sequence Data</term><term>Nanostructures (chemistry)</term><term>Neurotensin (chemistry)</term><term>Neurotensin (metabolism)</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (therapy)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>DNA</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Nanostructures</term><term>Neurotensin</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Neurotensin</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Genetic Therapy</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Gene Transfer Techniques</term><term>Humans</term><term>Molecular Sequence Data</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Nanomedicine has focused on targeted neurotrophic gene delivery to the brain as a strategy to stop and reverse neurodegeneration in Parkinson's disease. Because of improved transfection ability, synthetic nanocarriers have become candidates for neurotrophic therapy. Neurotensin (NTS)-polyplex is a "Trojan horse" synthetic nanocarrier system that enters dopaminergic neurons through NTS receptor internalization to deliver a genetic cargo. The success of preclinical studies with different neurotrophic genes supports the possibility of using NTS-polyplex in nanomedicine. In this review, we describe the mechanism of NTS-polyplex transfection. We discuss the concept that an effective neurotrophic therapy requires a simultaneous effect on the axon terminals and soma of the remaining dopaminergic neurons. We also discuss the future of this strategy for the treatment of Parkinson's disease.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22406187</PMID><DateCreated><Year>2012</Year><Month>09</Month><Day>24</Day></DateCreated><DateCompleted><Year>2013</Year><Month>02</Month><Day>11</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1549-9642</ISSN><JournalIssue CitedMedium="Internet"><Volume>8</Volume><Issue>7</Issue><PubDate><Year>2012</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Nanomedicine : nanotechnology, biology, and medicine</Title><ISOAbbreviation>Nanomedicine</ISOAbbreviation></Journal><ArticleTitle>NTS-Polyplex: a potential nanocarrier for neurotrophic therapy of Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>1052-69</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.nano.2012.02.009</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1549-9634(12)00085-8</ELocationID><Abstract><AbstractText Label="UNLABELLED">Nanomedicine has focused on targeted neurotrophic gene delivery to the brain as a strategy to stop and reverse neurodegeneration in Parkinson's disease. Because of improved transfection ability, synthetic nanocarriers have become candidates for neurotrophic therapy. Neurotensin (NTS)-polyplex is a "Trojan horse" synthetic nanocarrier system that enters dopaminergic neurons through NTS receptor internalization to deliver a genetic cargo. The success of preclinical studies with different neurotrophic genes supports the possibility of using NTS-polyplex in nanomedicine. In this review, we describe the mechanism of NTS-polyplex transfection. We discuss the concept that an effective neurotrophic therapy requires a simultaneous effect on the axon terminals and soma of the remaining dopaminergic neurons. We also discuss the future of this strategy for the treatment of Parkinson's disease.</AbstractText><AbstractText Label="FROM THE CLINICAL EDITOR" NlmCategory="UNASSIGNED">This review paper focuses on nanomedicine-based treatment of Parkinson's disease, a neurodegenerative condition with existing symptomatic but no curative treatment. Neurotensin-polyplex is a synthetic nanocarrier system that enables delivery of genetic cargo to dopaminergic neurons via NTS receptor internalization.</AbstractText><CopyrightInformation>Copyright © 2012 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Martinez-Fong</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Departamento de Fisiología, Biofísica y Neurociencias, México D.F., México. dmartine@fisio.cinvestav.mx</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bannon</LastName><ForeName>Michael J</ForeName><Initials>MJ</Initials></Author><Author ValidYN="Y"><LastName>Trudeau</LastName><ForeName>Louis-Eric</ForeName><Initials>LE</Initials></Author><Author ValidYN="Y"><LastName>Gonzalez-Barrios</LastName><ForeName>Juan A</ForeName><Initials>JA</Initials></Author><Author ValidYN="Y"><LastName>Arango-Rodriguez</LastName><ForeName>Martha L</ForeName><Initials>ML</Initials></Author><Author ValidYN="Y"><LastName>Hernandez-Chan</LastName><ForeName>Nancy G</ForeName><Initials>NG</Initials></Author><Author ValidYN="Y"><LastName>Reyes-Corona</LastName><ForeName>David</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Armendáriz-Borunda</LastName><ForeName>Juan</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Navarro-Quiroga</LastName><ForeName>Ivan</ForeName><Initials>I</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>DA006470</GrantID><Acronym>DA</Acronym><Agency>NIDA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>OPD-79574</GrantID><Agency>Canadian Institutes of Health Research</Agency><Country>Canada</Country></Grant><Grant><GrantID>R01 DA006470</GrantID><Acronym>DA</Acronym><Agency>NIDA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>MOP-49591</GrantID><Agency>Canadian Institutes of Health Research</Agency><Country>Canada</Country></Grant><Grant><GrantID>R01 DA006470-04</GrantID><Acronym>DA</Acronym><Agency>NIDA NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>03</Month><Day>07</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Nanomedicine</MedlineTA><NlmUniqueID>101233142</NlmUniqueID><ISSNLinking>1549-9634</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>39379-15-2</RegistryNumber><NameOfSubstance UI="D009496">Neurotensin</NameOfSubstance></Chemical><Chemical><RegistryNumber>9007-49-2</RegistryNumber><NameOfSubstance UI="D004247">DNA</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections 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MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D049329" MajorTopicYN="N">Nanostructures</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009496" MajorTopicYN="N">Neurotensin</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">NIHMS362679</OtherID><OtherID Source="NLM">PMC3394898</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2011</Year><Month>10</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2012</Year><Month>02</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2012</Year><Month>02</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>3</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>3</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>2</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">22406187</ArticleId><ArticleId IdType="pii">S1549-9634(12)00085-8</ArticleId><ArticleId IdType="doi">10.1016/j.nano.2012.02.009</ArticleId><ArticleId IdType="pmc">PMC3394898</ArticleId><ArticleId IdType="mid">NIHMS362679</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Mexique</li></country></list><tree><noCountry><name sortKey="Arango Rodriguez, Martha L" sort="Arango Rodriguez, Martha L" uniqKey="Arango Rodriguez M" first="Martha L" last="Arango-Rodriguez">Martha L. Arango-Rodriguez</name><name sortKey="Armendariz Borunda, Juan" sort="Armendariz Borunda, Juan" uniqKey="Armendariz Borunda J" first="Juan" last="Armendáriz-Borunda">Juan Armendáriz-Borunda</name><name sortKey="Bannon, Michael J" sort="Bannon, Michael J" uniqKey="Bannon M" first="Michael J" last="Bannon">Michael J. Bannon</name><name sortKey="Gonzalez Barrios, Juan A" sort="Gonzalez Barrios, Juan A" uniqKey="Gonzalez Barrios J" first="Juan A" last="Gonzalez-Barrios">Juan A. Gonzalez-Barrios</name><name sortKey="Hernandez Chan, Nancy G" sort="Hernandez Chan, Nancy G" uniqKey="Hernandez Chan N" first="Nancy G" last="Hernandez-Chan">Nancy G. Hernandez-Chan</name><name sortKey="Navarro Quiroga, Ivan" sort="Navarro Quiroga, Ivan" uniqKey="Navarro Quiroga I" first="Ivan" last="Navarro-Quiroga">Ivan Navarro-Quiroga</name><name sortKey="Reyes Corona, David" sort="Reyes Corona, David" uniqKey="Reyes Corona D" first="David" last="Reyes-Corona">David Reyes-Corona</name><name sortKey="Trudeau, Louis Eric" sort="Trudeau, Louis Eric" uniqKey="Trudeau L" first="Louis-Eric" last="Trudeau">Louis-Eric Trudeau</name></noCountry><country name="Mexique"><noRegion><name sortKey="Martinez Fong, Daniel" sort="Martinez Fong, Daniel" uniqKey="Martinez Fong D" first="Daniel" last="Martinez-Fong">Daniel Martinez-Fong</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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