Increased motor cortical facilitation and decreased inhibition in Parkinson disease.
Identifieur interne : 000908 ( PubMed/Checkpoint ); précédent : 000907; suivant : 000909Increased motor cortical facilitation and decreased inhibition in Parkinson disease.
Auteurs : Zhen Ni [Canada] ; Nina Bahl ; Carolyn A. Gunraj ; Filomena Mazzella ; Robert ChenSource :
- Neurology [ 1526-632X ] ; 2013.
English descriptors
- KwdEn :
- Aged, Electromyography (methods), Evoked Potentials, Motor (physiology), Female, Humans, Male, Middle Aged, Motor Cortex (pathology), Motor Cortex (physiology), Neural Inhibition (physiology), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Transcranial Magnetic Stimulation (methods).
- MESH :
- methods : Electromyography, Transcranial Magnetic Stimulation.
- pathology : Motor Cortex.
- physiology : Evoked Potentials, Motor, Motor Cortex, Neural Inhibition.
- physiopathology : Parkinson Disease.
- therapy : Parkinson Disease.
- Aged, Female, Humans, Male, Middle Aged.
Abstract
To identify the changes in motor cortical facilitatory and inhibitory circuits in Parkinson disease (PD) by detailed studies of their time courses and interactions.
DOI: 10.1212/WNL.0b013e3182919029
PubMed: 23576626
Affiliations:
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pubmed:23576626Le document en format XML
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Safra Program in Parkinson's Disease, Toronto Western Research Institute, Krembil Neuroscience Centre, University Health Network, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Bahl, Nina" sort="Bahl, Nina" uniqKey="Bahl N" first="Nina" last="Bahl">Nina Bahl</name></author><author><name sortKey="Gunraj, Carolyn A" sort="Gunraj, Carolyn A" uniqKey="Gunraj C" first="Carolyn A" last="Gunraj">Carolyn A. Gunraj</name></author><author><name sortKey="Mazzella, Filomena" sort="Mazzella, Filomena" uniqKey="Mazzella F" first="Filomena" last="Mazzella">Filomena Mazzella</name></author><author><name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23576626</idno><idno type="pmid">23576626</idno><idno type="doi">10.1212/WNL.0b013e3182919029</idno><idno type="wicri:Area/PubMed/Corpus">000919</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000919</idno><idno type="wicri:Area/PubMed/Curation">000919</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000919</idno><idno type="wicri:Area/PubMed/Checkpoint">000919</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000919</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Increased motor cortical facilitation and decreased inhibition in Parkinson disease.</title><author><name sortKey="Ni, Zhen" sort="Ni, Zhen" uniqKey="Ni Z" first="Zhen" last="Ni">Zhen Ni</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurology, Department of Medicine, University of Toronto and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Research Institute, Krembil Neuroscience Centre, University Health Network, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurology, Department of Medicine, University of Toronto and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Research Institute, Krembil Neuroscience Centre, University Health Network, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Bahl, Nina" sort="Bahl, Nina" uniqKey="Bahl N" first="Nina" last="Bahl">Nina Bahl</name></author><author><name sortKey="Gunraj, Carolyn A" sort="Gunraj, Carolyn A" uniqKey="Gunraj C" first="Carolyn A" last="Gunraj">Carolyn A. Gunraj</name></author><author><name sortKey="Mazzella, Filomena" sort="Mazzella, Filomena" uniqKey="Mazzella F" first="Filomena" last="Mazzella">Filomena Mazzella</name></author><author><name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name></author></analytic><series><title level="j">Neurology</title><idno type="eISSN">1526-632X</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Electromyography (methods)</term><term>Evoked Potentials, Motor (physiology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motor Cortex (pathology)</term><term>Motor Cortex (physiology)</term><term>Neural Inhibition (physiology)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Transcranial Magnetic Stimulation (methods)</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electromyography</term><term>Transcranial Magnetic Stimulation</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Motor Cortex</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Evoked Potentials, Motor</term><term>Motor Cortex</term><term>Neural Inhibition</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To identify the changes in motor cortical facilitatory and inhibitory circuits in Parkinson disease (PD) by detailed studies of their time courses and interactions.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23576626</PMID><DateCreated><Year>2013</Year><Month>05</Month><Day>07</Day></DateCreated><DateCompleted><Year>2013</Year><Month>07</Month><Day>02</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1526-632X</ISSN><JournalIssue CitedMedium="Internet"><Volume>80</Volume><Issue>19</Issue><PubDate><Year>2013</Year><Month>May</Month><Day>07</Day></PubDate></JournalIssue><Title>Neurology</Title><ISOAbbreviation>Neurology</ISOAbbreviation></Journal><ArticleTitle>Increased motor cortical facilitation and decreased inhibition in Parkinson disease.</ArticleTitle><Pagination><MedlinePgn>1746-53</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1212/WNL.0b013e3182919029</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To identify the changes in motor cortical facilitatory and inhibitory circuits in Parkinson disease (PD) by detailed studies of their time courses and interactions.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Short-interval intracortical facilitation (SICF) and short-interval intracortical inhibition (SICI) were measured with a paired-pulse paradigm using transcranial magnetic stimulation. Twelve patients with PD in both ON and OFF medication states and 12 age-matched healthy controls were tested. The first experiment tested the time course of SICF in PD and controls. The second experiment tested SICI at different times corresponding to SICF peaks and troughs to investigate whether SICI was affected by SICF.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">SICF was increased in PD OFF state and was reduced by dopaminergic medications. The reduction in SICF from the OFF to ON state correlated with the improvement in PD motor signs. SICI was reduced in PD OFF state and was only partially normalized by dopaminergic medications. At SICF peaks, improvement in SICI with medication correlated with improvement in PD motor sign. Principal component analysis showed that variations of SICF and SICI were explained by the same principal component only in the PD OFF group, suggesting that decreased SICI in the OFF state is related to increased SICF.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Motor cortical facilitation is increased and inhibition is decreased in PD. Increased cortical facilitation partly accounts for the decreased inhibition, but there is also impairment in synaptic inhibition in PD. Increased cortical facilitation may be a compensatory mechanism in PD.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ni</LastName><ForeName>Zhen</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Division of Neurology, Department of Medicine, University of Toronto and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Research Institute, Krembil Neuroscience Centre, University Health Network, Toronto, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bahl</LastName><ForeName>Nina</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Gunraj</LastName><ForeName>Carolyn A</ForeName><Initials>CA</Initials></Author><Author ValidYN="Y"><LastName>Mazzella</LastName><ForeName>Filomena</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Robert</ForeName><Initials>R</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>MOP 62917</GrantID><Agency>Canadian Institutes of Health Research</Agency><Country>Canada</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>04</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Neurology</MedlineTA><NlmUniqueID>0401060</NlmUniqueID><ISSNLinking>0028-3878</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Exp Brain Res. 1990;80(1):177-88</RefSource><PMID Version="1">1972680</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Exp Brain Res. 2003 Aug;151(3):330-7</RefSource><PMID Version="1">12802553</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 1995 Feb;37(2):181-8</RefSource><PMID Version="1">7847860</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain. 1996 Feb;119 ( Pt 1):71-7</RefSource><PMID 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UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009044" MajorTopicYN="N">Motor Cortex</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009433" MajorTopicYN="N">Neural Inhibition</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D050781" MajorTopicYN="N">Transcranial Magnetic Stimulation</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC3719423</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>4</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>4</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>7</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23576626</ArticleId><ArticleId IdType="pii">WNL.0b013e3182919029</ArticleId><ArticleId IdType="doi">10.1212/WNL.0b013e3182919029</ArticleId><ArticleId IdType="pmc">PMC3719423</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Bahl, Nina" sort="Bahl, Nina" uniqKey="Bahl N" first="Nina" last="Bahl">Nina Bahl</name><name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name><name sortKey="Gunraj, Carolyn A" sort="Gunraj, Carolyn A" uniqKey="Gunraj C" first="Carolyn A" last="Gunraj">Carolyn A. Gunraj</name><name sortKey="Mazzella, Filomena" sort="Mazzella, Filomena" uniqKey="Mazzella F" first="Filomena" last="Mazzella">Filomena Mazzella</name></noCountry><country name="Canada"><noRegion><name sortKey="Ni, Zhen" sort="Ni, Zhen" uniqKey="Ni Z" first="Zhen" last="Ni">Zhen Ni</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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