Air pollution and detrimental effects on children's brain. The need for a multidisciplinary approach to the issue complexity and challenges.
Identifieur interne : 000796 ( PubMed/Checkpoint ); précédent : 000795; suivant : 000797Air pollution and detrimental effects on children's brain. The need for a multidisciplinary approach to the issue complexity and challenges.
Auteurs : Lilian Calder N-Garcidue As [États-Unis] ; Ricardo Torres-Jard N [Mexique] ; Randy J. Kulesza [États-Unis] ; Su-Bin Park [Canada] ; Amedeo D'Angiulli [Canada]Source :
- Frontiers in human neuroscience ; 2014.
Abstract
Millions of children in polluted cities are showing brain detrimental effects. Urban children exhibit brain structural and volumetric abnormalities, systemic inflammation, olfactory, auditory, vestibular and cognitive deficits v low-pollution controls. Neuroinflammation and blood-brain-barrier (BBB) breakdown target the olfactory bulb, prefrontal cortex and brainstem, but are diffusely present throughout the brain. Urban adolescent Apolipoprotein E4 carriers significantly accelerate Alzheimer pathology. Neurocognitive effects of air pollution are substantial, apparent across all populations, and potentially clinically relevant as early evidence of evolving neurodegenerative changes. The diffuse nature of the neuroinflammation and neurodegeneration forces to employ a weight of evidence approach incorporating current clinical, cognitive, neurophysiological, radiological and epidemiological research. Pediatric air pollution research requires extensive multidisciplinary collaborations to accomplish a critical goal: to protect exposed children through multidimensional interventions having both broad impact and reach. Protecting children and teens from neural effects of air pollution should be of pressing importance for public health.
DOI: 10.3389/fnhum.2014.00613
PubMed: 25161617
Affiliations:
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Urban children exhibit brain structural and volumetric abnormalities, systemic inflammation, olfactory, auditory, vestibular and cognitive deficits v low-pollution controls. Neuroinflammation and blood-brain-barrier (BBB) breakdown target the olfactory bulb, prefrontal cortex and brainstem, but are diffusely present throughout the brain. Urban adolescent Apolipoprotein E4 carriers significantly accelerate Alzheimer pathology. Neurocognitive effects of air pollution are substantial, apparent across all populations, and potentially clinically relevant as early evidence of evolving neurodegenerative changes. The diffuse nature of the neuroinflammation and neurodegeneration forces to employ a weight of evidence approach incorporating current clinical, cognitive, neurophysiological, radiological and epidemiological research. Pediatric air pollution research requires extensive multidisciplinary collaborations to accomplish a critical goal: to protect exposed children through multidimensional interventions having both broad impact and reach. 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The need for a multidisciplinary approach to the issue complexity and challenges.</ArticleTitle><Pagination><MedlinePgn>613</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3389/fnhum.2014.00613</ELocationID><Abstract><AbstractText>Millions of children in polluted cities are showing brain detrimental effects. Urban children exhibit brain structural and volumetric abnormalities, systemic inflammation, olfactory, auditory, vestibular and cognitive deficits v low-pollution controls. Neuroinflammation and blood-brain-barrier (BBB) breakdown target the olfactory bulb, prefrontal cortex and brainstem, but are diffusely present throughout the brain. Urban adolescent Apolipoprotein E4 carriers significantly accelerate Alzheimer pathology. Neurocognitive effects of air pollution are substantial, apparent across all populations, and potentially clinically relevant as early evidence of evolving neurodegenerative changes. The diffuse nature of the neuroinflammation and neurodegeneration forces to employ a weight of evidence approach incorporating current clinical, cognitive, neurophysiological, radiological and epidemiological research. Pediatric air pollution research requires extensive multidisciplinary collaborations to accomplish a critical goal: to protect exposed children through multidimensional interventions having both broad impact and reach. Protecting children and teens from neural effects of air pollution should be of pressing importance for public health.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Calderón-Garcidueñas</LastName><ForeName>Lilian</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Biomedical Sciences, The Center for Structural and Functional Neurosciences, University of Montana Missoula, MT, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Torres-Jardón</LastName><ForeName>Ricardo</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Centro de Ciencias de la Atmósfera, Universidad Nacional Autonoma de Mexico Mexico City, Mexico.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kulesza</LastName><ForeName>Randy J</ForeName><Initials>RJ</Initials><AffiliationInfo><Affiliation>Auditory Research Center, Lake Erie College of Osteopathic Medicine Erie, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Park</LastName><ForeName>Su-Bin</ForeName><Initials>SB</Initials><AffiliationInfo><Affiliation>Neuroscience, NICER Lab (Neuroscience of Imagery Cognition and Emotion Research Lab), Carleton University Ottawa, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>D'Angiulli</LastName><ForeName>Amedeo</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Neuroscience, NICER Lab (Neuroscience of Imagery Cognition and Emotion Research Lab), Carleton University Ottawa, ON, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>08</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Front Hum 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Owner="NOTNLM"><Keyword MajorTopicYN="N">Alzheimer</Keyword><Keyword MajorTopicYN="N">Parkinson</Keyword><Keyword MajorTopicYN="N">air pollution</Keyword><Keyword MajorTopicYN="N">brain volumetric changes</Keyword><Keyword MajorTopicYN="N">cognition</Keyword><Keyword MajorTopicYN="N">cytokines</Keyword><Keyword MajorTopicYN="N">urban children</Keyword><Keyword MajorTopicYN="N">white matter hyperintensities</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>01</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>07</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>8</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>8</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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Kulesza</name></country><country name="Mexique"><noRegion><name sortKey="Torres Jard N, Ricardo" sort="Torres Jard N, Ricardo" uniqKey="Torres Jard N R" first="Ricardo" last="Torres-Jard N">Ricardo Torres-Jard N</name></noRegion></country><country name="Canada"><noRegion><name sortKey="Park, Su Bin" sort="Park, Su Bin" uniqKey="Park S" first="Su-Bin" last="Park">Su-Bin Park</name></noRegion><name sortKey="D Angiulli, Amedeo" sort="D Angiulli, Amedeo" uniqKey="D Angiulli A" first="Amedeo" last="D'Angiulli">Amedeo D'Angiulli</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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