Severity of depression and anxiety are predictors of response to antidepressant treatment in Parkinson's disease.
Identifieur interne : 000650 ( PubMed/Checkpoint ); précédent : 000649; suivant : 000651Severity of depression and anxiety are predictors of response to antidepressant treatment in Parkinson's disease.
Auteurs : A J H. Moonen [Pays-Bas] ; A. Wijers [Pays-Bas] ; A F G. Leentjens [Pays-Bas] ; C W Christine [États-Unis] ; S A Factor [États-Unis] ; J. Juncos [États-Unis] ; J M Lyness [États-Unis] ; L. Marsh [États-Unis] ; M. Panisset [Canada] ; R. Pfeiffer [États-Unis] ; D. Rottenberg [États-Unis] ; C. Serrano Ramos [Porto Rico] ; L. Shulman [États-Unis] ; C. Singer [États-Unis] ; J. Slevin [États-Unis] ; W. Mcdonald [États-Unis] ; P. Auinger [États-Unis] ; I H Richard [États-Unis]Source :
- Parkinsonism & related disorders [ 1873-5126 ] ; 2014.
English descriptors
- KwdEn :
- Aged, Antidepressive Agents (therapeutic use), Anxiety (drug therapy), Cyclohexanols (therapeutic use), Datasets as Topic, Depression (drug therapy), Double-Blind Method, Female, Follow-Up Studies, Humans, Male, Middle Aged, Parkinson Disease (complications), Paroxetine (therapeutic use), Predictive Value of Tests, Psychiatric Status Rating Scales, Randomized Controlled Trials as Topic, Severity of Illness Index, Venlafaxine Hydrochloride.
- MESH :
- chemical , therapeutic use : Antidepressive Agents, Cyclohexanols, Paroxetine.
- complications : Parkinson Disease.
- drug therapy : Anxiety, Depression.
- Aged, Datasets as Topic, Double-Blind Method, Female, Follow-Up Studies, Humans, Male, Middle Aged, Predictive Value of Tests, Psychiatric Status Rating Scales, Randomized Controlled Trials as Topic, Severity of Illness Index, Venlafaxine Hydrochloride.
Abstract
Antidepressants have appeared to be more effective than placebo treatment in treating depressive syndromes in patients with Parkinson's disease (PD).
DOI: 10.1016/j.parkreldis.2014.02.025
PubMed: 24679737
Affiliations:
- Canada, Pays-Bas, Porto Rico, États-Unis
- Californie, Floride, Géorgie (États-Unis), Kentucky, Maryland, Minnesota, Québec, Tennessee, État de New York
- Baltimore, Montréal
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pubmed:24679737Le document en format XML
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Wijers</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Maastricht University, Maastricht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Maastricht University, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Leentjens, A F G" sort="Leentjens, A F G" uniqKey="Leentjens A" first="A F G" last="Leentjens">A F G. Leentjens</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Maastricht University, Maastricht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Maastricht University, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Christine, C W" sort="Christine, C W" uniqKey="Christine C" first="C W" last="Christine">C W Christine</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of California, San Francisco, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Factor, S A" sort="Factor, S A" uniqKey="Factor S" first="S A" last="Factor">S A Factor</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Emory University, Atlanta, GA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Emory University, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Juncos, J" sort="Juncos, J" uniqKey="Juncos J" first="J" last="Juncos">J. Juncos</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Emory University, Atlanta, GA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Emory University, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Lyness, J M" sort="Lyness, J M" uniqKey="Lyness J" first="J M" last="Lyness">J M Lyness</name><affiliation wicri:level="2"><nlm:affiliation>University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Rochester School of Medicine and Dentistry, Rochester, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Marsh, L" sort="Marsh, L" uniqKey="Marsh L" first="L" last="Marsh">L. Marsh</name><affiliation wicri:level="1"><nlm:affiliation>Mental Health Care Line, Michael E. DeBakey Veterans Administration Medical Center, Houston, USA; Department of Psychiatry, Baylor College of Medicine, Houston, USA; Department of Neurology, Baylor College of Medicine, Houston, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mental Health Care Line, Michael E. DeBakey Veterans Administration Medical Center, Houston, USA; Department of Psychiatry, Baylor College of Medicine, Houston, USA; Department of Neurology, Baylor College of Medicine, Houston</wicri:regionArea><wicri:noRegion>Houston</wicri:noRegion></affiliation></author><author><name sortKey="Panisset, M" sort="Panisset, M" uniqKey="Panisset M" first="M" last="Panisset">M. Panisset</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, University of Montreal, Montreal, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurology, University of Montreal, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Pfeiffer, R" sort="Pfeiffer, R" uniqKey="Pfeiffer R" first="R" last="Pfeiffer">R. 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Rottenberg</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, University of Minnesota, Minneapolis, MN, USA; Department of Radiology, University of Minnesota, Minneapolis, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Minnesota, Minneapolis, MN, USA; Department of Radiology, University of Minnesota, Minneapolis, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Serrano Ramos, C" sort="Serrano Ramos, C" uniqKey="Serrano Ramos C" first="C" last="Serrano Ramos">C. Serrano Ramos</name><affiliation wicri:level="1"><nlm:affiliation>University of Puerto Rico School of Medicine, Puerto Rico.</nlm:affiliation><country xml:lang="fr">Porto Rico</country><wicri:regionArea>University of Puerto Rico School of Medicine</wicri:regionArea></affiliation></author><author><name sortKey="Shulman, L" sort="Shulman, L" uniqKey="Shulman L" first="L" last="Shulman">L. Shulman</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, University of Maryland School of Medicine, Baltimore, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Maryland School of Medicine, Baltimore</wicri:regionArea><placeName><settlement type="city">Baltimore</settlement><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Singer, C" sort="Singer, C" uniqKey="Singer C" first="C" last="Singer">C. Singer</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Slevin, J" sort="Slevin, J" uniqKey="Slevin J" first="J" last="Slevin">J. 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Auinger</name><affiliation wicri:level="2"><nlm:affiliation>University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Rochester School of Medicine and Dentistry, Rochester, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Richard, I H" sort="Richard, I H" uniqKey="Richard I" first="I H" last="Richard">I H Richard</name><affiliation wicri:level="2"><nlm:affiliation>University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Rochester School of Medicine and Dentistry, Rochester, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24679737</idno><idno type="pmid">24679737</idno><idno type="doi">10.1016/j.parkreldis.2014.02.025</idno><idno type="wicri:Area/PubMed/Corpus">000743</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000743</idno><idno type="wicri:Area/PubMed/Curation">000743</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000743</idno><idno type="wicri:Area/PubMed/Checkpoint">000743</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000743</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Severity of depression and anxiety are predictors of response to antidepressant treatment in Parkinson's disease.</title><author><name sortKey="Moonen, A J H" sort="Moonen, A J H" uniqKey="Moonen A" first="A J H" last="Moonen">A J H. Moonen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Maastricht University, Maastricht, The Netherlands. Electronic address: anja.moonen@maastrichtuniversity.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Maastricht University, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Wijers, A" sort="Wijers, A" uniqKey="Wijers A" first="A" last="Wijers">A. Wijers</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Maastricht University, Maastricht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Maastricht University, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Leentjens, A F G" sort="Leentjens, A F G" uniqKey="Leentjens A" first="A F G" last="Leentjens">A F G. Leentjens</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Maastricht University, Maastricht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Maastricht University, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Christine, C W" sort="Christine, C W" uniqKey="Christine C" first="C W" last="Christine">C W Christine</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of California, San Francisco, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Factor, S A" sort="Factor, S A" uniqKey="Factor S" first="S A" last="Factor">S A Factor</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Emory University, Atlanta, GA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Emory University, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Juncos, J" sort="Juncos, J" uniqKey="Juncos J" first="J" last="Juncos">J. Juncos</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Emory University, Atlanta, GA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Emory University, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Lyness, J M" sort="Lyness, J M" uniqKey="Lyness J" first="J M" last="Lyness">J M Lyness</name><affiliation wicri:level="2"><nlm:affiliation>University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Rochester School of Medicine and Dentistry, Rochester, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Marsh, L" sort="Marsh, L" uniqKey="Marsh L" first="L" last="Marsh">L. Marsh</name><affiliation wicri:level="1"><nlm:affiliation>Mental Health Care Line, Michael E. DeBakey Veterans Administration Medical Center, Houston, USA; Department of Psychiatry, Baylor College of Medicine, Houston, USA; Department of Neurology, Baylor College of Medicine, Houston, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mental Health Care Line, Michael E. DeBakey Veterans Administration Medical Center, Houston, USA; Department of Psychiatry, Baylor College of Medicine, Houston, USA; Department of Neurology, Baylor College of Medicine, Houston</wicri:regionArea><wicri:noRegion>Houston</wicri:noRegion></affiliation></author><author><name sortKey="Panisset, M" sort="Panisset, M" uniqKey="Panisset M" first="M" last="Panisset">M. Panisset</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, University of Montreal, Montreal, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurology, University of Montreal, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Pfeiffer, R" sort="Pfeiffer, R" uniqKey="Pfeiffer R" first="R" last="Pfeiffer">R. Pfeiffer</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Tennessee Health Science Center, Memphis, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Rottenberg, D" sort="Rottenberg, D" uniqKey="Rottenberg D" first="D" last="Rottenberg">D. Rottenberg</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, University of Minnesota, Minneapolis, MN, USA; Department of Radiology, University of Minnesota, Minneapolis, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Minnesota, Minneapolis, MN, USA; Department of Radiology, University of Minnesota, Minneapolis, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Serrano Ramos, C" sort="Serrano Ramos, C" uniqKey="Serrano Ramos C" first="C" last="Serrano Ramos">C. Serrano Ramos</name><affiliation wicri:level="1"><nlm:affiliation>University of Puerto Rico School of Medicine, Puerto Rico.</nlm:affiliation><country xml:lang="fr">Porto Rico</country><wicri:regionArea>University of Puerto Rico School of Medicine</wicri:regionArea></affiliation></author><author><name sortKey="Shulman, L" sort="Shulman, L" uniqKey="Shulman L" first="L" last="Shulman">L. Shulman</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, University of Maryland School of Medicine, Baltimore, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Maryland School of Medicine, Baltimore</wicri:regionArea><placeName><settlement type="city">Baltimore</settlement><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Singer, C" sort="Singer, C" uniqKey="Singer C" first="C" last="Singer">C. Singer</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Slevin, J" sort="Slevin, J" uniqKey="Slevin J" first="J" last="Slevin">J. Slevin</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, University of Kentucky College of Medicine, Lexington, KY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Kentucky College of Medicine, Lexington, KY</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation></author><author><name sortKey="Mcdonald, W" sort="Mcdonald, W" uniqKey="Mcdonald W" first="W" last="Mcdonald">W. Mcdonald</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Auinger, P" sort="Auinger, P" uniqKey="Auinger P" first="P" last="Auinger">P. Auinger</name><affiliation wicri:level="2"><nlm:affiliation>University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Rochester School of Medicine and Dentistry, Rochester, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Richard, I H" sort="Richard, I H" uniqKey="Richard I" first="I H" last="Richard">I H Richard</name><affiliation wicri:level="2"><nlm:affiliation>University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Rochester School of Medicine and Dentistry, Rochester, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j">Parkinsonism & related disorders</title><idno type="eISSN">1873-5126</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Antidepressive Agents (therapeutic use)</term><term>Anxiety (drug therapy)</term><term>Cyclohexanols (therapeutic use)</term><term>Datasets as Topic</term><term>Depression (drug therapy)</term><term>Double-Blind Method</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (complications)</term><term>Paroxetine (therapeutic use)</term><term>Predictive Value of Tests</term><term>Psychiatric Status Rating Scales</term><term>Randomized Controlled Trials as Topic</term><term>Severity of Illness Index</term><term>Venlafaxine Hydrochloride</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antidepressive Agents</term><term>Cyclohexanols</term><term>Paroxetine</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Anxiety</term><term>Depression</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Datasets as Topic</term><term>Double-Blind Method</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Predictive Value of Tests</term><term>Psychiatric Status Rating Scales</term><term>Randomized Controlled Trials as Topic</term><term>Severity of Illness Index</term><term>Venlafaxine Hydrochloride</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Antidepressants have appeared to be more effective than placebo treatment in treating depressive syndromes in patients with Parkinson's disease (PD).</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24679737</PMID><DateCreated><Year>2014</Year><Month>05</Month><Day>19</Day></DateCreated><DateCompleted><Year>2015</Year><Month>01</Month><Day>14</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-5126</ISSN><JournalIssue CitedMedium="Internet"><Volume>20</Volume><Issue>6</Issue><PubDate><Year>2014</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Parkinsonism & related disorders</Title><ISOAbbreviation>Parkinsonism Relat. Disord.</ISOAbbreviation></Journal><ArticleTitle>Severity of depression and anxiety are predictors of response to antidepressant treatment in Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>644-6</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.parkreldis.2014.02.025</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1353-8020(14)00078-9</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Antidepressants have appeared to be more effective than placebo treatment in treating depressive syndromes in patients with Parkinson's disease (PD).</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To identify factors that predict improvement in depressive symptoms during antidepressant treatment in depressed PD patients.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A secondary analysis was performed on the dataset of the Randomized Placebo-controlled Study of Antidepressants in PD (SAD-PD), in which 76 patients received active treatment with either paroxetine or venlafaxine extended release (XR), and 39 patients received placebo treatment. Backward stepwise regression analyses were conducted with change in 24-item Hamilton Depression Rating Scale (HAMD-24) score between assessments at baseline and week 12 as the main outcome measure, and sex, age, baseline HAMD-24 score, Unified Parkinson's Disease Rating Scale section III (UPDRS-III) score, Mini-Mental State Examination (MMSE), and the Clinical Anxiety Scale (CAS) as independent variables.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In both the active treatment and placebo groups, higher baseline HAMD-24 score and lower UPDRS-III score were associated with greater reduction in HAMD-24 score. Higher anxiety scores predicted less response in the active treatment group. Higher MMSE scores predicted greater response only in the placebo-treated group. Sex and age were no predictors of response.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Higher pre-treatment depression scores and lower pre-treatment anxiety scores are the two most important predictors for improvement during antidepressant treatment in depressed PD patients, which is in line with those found in treatment studies of depressed non-PD patients. Furthermore, our results indicate the requirement for different or more intensive treatment for depressed PD patients with more severe anxiety symptoms.</AbstractText><CopyrightInformation>Copyright © 2014 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Moonen</LastName><ForeName>A J H</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Maastricht University, Maastricht, The Netherlands. Electronic address: anja.moonen@maastrichtuniversity.nl.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wijers</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Maastricht University, Maastricht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leentjens</LastName><ForeName>A F G</ForeName><Initials>AF</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Maastricht University, Maastricht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Christine</LastName><ForeName>C W</ForeName><Initials>CW</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Factor</LastName><ForeName>S A</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>Department of Neurology, Emory University, Atlanta, GA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Juncos</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Neurology, Emory University, Atlanta, GA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lyness</LastName><ForeName>J M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marsh</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Mental Health Care Line, Michael E. DeBakey Veterans Administration Medical Center, Houston, USA; Department of Psychiatry, Baylor College of Medicine, Houston, USA; Department of Neurology, Baylor College of Medicine, Houston, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Panisset</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Montreal, Montreal, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pfeiffer</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rottenberg</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Minnesota, Minneapolis, MN, USA; Department of Radiology, University of Minnesota, Minneapolis, MN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Serrano Ramos</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>University of Puerto Rico School of Medicine, Puerto Rico.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shulman</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Maryland School of Medicine, Baltimore, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Singer</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Neurology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Slevin</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Kentucky College of Medicine, Lexington, KY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McDonald</LastName><ForeName>W</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Auinger</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Richard</LastName><ForeName>I H</ForeName><Initials>IH</Initials><AffiliationInfo><Affiliation>University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>M01-RR00052</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 NS046487</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>03</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Parkinsonism Relat Disord</MedlineTA><NlmUniqueID>9513583</NlmUniqueID><ISSNLinking>1353-8020</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000928">Antidepressive Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003511">Cyclohexanols</NameOfSubstance></Chemical><Chemical><RegistryNumber>41VRH5220H</RegistryNumber><NameOfSubstance UI="D017374">Paroxetine</NameOfSubstance></Chemical><Chemical><RegistryNumber>7D7RX5A8MO</RegistryNumber><NameOfSubstance UI="D000069470">Venlafaxine Hydrochloride</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000928" MajorTopicYN="N">Antidepressive Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001007" MajorTopicYN="N">Anxiety</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003511" MajorTopicYN="N">Cyclohexanols</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D066264" MajorTopicYN="N">Datasets as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003863" MajorTopicYN="N">Depression</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004311" MajorTopicYN="N">Double-Blind Method</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017374" MajorTopicYN="N">Paroxetine</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011237" MajorTopicYN="N">Predictive Value of Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011569" MajorTopicYN="N">Psychiatric Status Rating Scales</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016032" MajorTopicYN="N">Randomized Controlled Trials as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000069470" MajorTopicYN="N">Venlafaxine Hydrochloride</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Clinical trials randomized controlled</Keyword><Keyword MajorTopicYN="N">Depression</Keyword><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">Paroxetine</Keyword><Keyword MajorTopicYN="N">Venlafaxine</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>01</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>02</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>02</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>4</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>4</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>1</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24679737</ArticleId><ArticleId IdType="pii">S1353-8020(14)00078-9</ArticleId><ArticleId IdType="doi">10.1016/j.parkreldis.2014.02.025</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li><li>Pays-Bas</li><li>Porto Rico</li><li>États-Unis</li></country><region><li>Californie</li><li>Floride</li><li>Géorgie (États-Unis)</li><li>Kentucky</li><li>Maryland</li><li>Minnesota</li><li>Québec</li><li>Tennessee</li><li>État de New York</li></region><settlement><li>Baltimore</li><li>Montréal</li></settlement></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Moonen, A J H" sort="Moonen, A J H" uniqKey="Moonen A" first="A J H" last="Moonen">A J H. Moonen</name></noRegion><name sortKey="Leentjens, A F G" sort="Leentjens, A F G" uniqKey="Leentjens A" first="A F G" last="Leentjens">A F G. Leentjens</name><name sortKey="Wijers, A" sort="Wijers, A" uniqKey="Wijers A" first="A" last="Wijers">A. Wijers</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Christine, C W" sort="Christine, C W" uniqKey="Christine C" first="C W" last="Christine">C W Christine</name></region><name sortKey="Auinger, P" sort="Auinger, P" uniqKey="Auinger P" first="P" last="Auinger">P. Auinger</name><name sortKey="Factor, S A" sort="Factor, S A" uniqKey="Factor S" first="S A" last="Factor">S A Factor</name><name sortKey="Juncos, J" sort="Juncos, J" uniqKey="Juncos J" first="J" last="Juncos">J. Juncos</name><name sortKey="Lyness, J M" sort="Lyness, J M" uniqKey="Lyness J" first="J M" last="Lyness">J M Lyness</name><name sortKey="Marsh, L" sort="Marsh, L" uniqKey="Marsh L" first="L" last="Marsh">L. Marsh</name><name sortKey="Mcdonald, W" sort="Mcdonald, W" uniqKey="Mcdonald W" first="W" last="Mcdonald">W. Mcdonald</name><name sortKey="Pfeiffer, R" sort="Pfeiffer, R" uniqKey="Pfeiffer R" first="R" last="Pfeiffer">R. Pfeiffer</name><name sortKey="Richard, I H" sort="Richard, I H" uniqKey="Richard I" first="I H" last="Richard">I H Richard</name><name sortKey="Rottenberg, D" sort="Rottenberg, D" uniqKey="Rottenberg D" first="D" last="Rottenberg">D. Rottenberg</name><name sortKey="Shulman, L" sort="Shulman, L" uniqKey="Shulman L" first="L" last="Shulman">L. Shulman</name><name sortKey="Singer, C" sort="Singer, C" uniqKey="Singer C" first="C" last="Singer">C. Singer</name><name sortKey="Slevin, J" sort="Slevin, J" uniqKey="Slevin J" first="J" last="Slevin">J. Slevin</name></country><country name="Canada"><region name="Québec"><name sortKey="Panisset, M" sort="Panisset, M" uniqKey="Panisset M" first="M" last="Panisset">M. 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