A heme oxygenase-1 transducer model of degenerative and developmental brain disorders.
Identifieur interne : 000601 ( PubMed/Checkpoint ); précédent : 000600; suivant : 000602A heme oxygenase-1 transducer model of degenerative and developmental brain disorders.
Auteurs : Hyman M. Schipper [Canada] ; Wei Song [Canada]Source :
- International journal of molecular sciences [ 1422-0067 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Heme Oxygenase-1.
- genetics : Alzheimer Disease, Parkinson Disease.
- metabolism : Alzheimer Disease, Heme Oxygenase-1, Iron, Parkinson Disease.
- therapy : Alzheimer Disease, Parkinson Disease.
- Animals, Humans, Signal Transduction.
Abstract
Heme oxygenase-1 (HO-1) is a 32 kDa protein which catalyzes the breakdown of heme to free iron, carbon monoxide and biliverdin. The Hmox1 promoter contains numerous consensus sequences that render the gene exquisitely sensitive to induction by diverse pro-oxidant and inflammatory stimuli. In "stressed" astroglia, HO-1 hyperactivity promotes mitochondrial iron sequestration and macroautophagy and may thereby contribute to the pathological iron deposition and bioenergetic failure documented in Alzheimer disease, Parkinson disease and certain neurodevelopmental conditions. Glial HO-1 expression may also impact neuroplasticity and cell survival by modulating brain sterol metabolism and the proteasomal degradation of neurotoxic proteins. The glial HO-1 response may represent a pivotal transducer of noxious environmental and endogenous stressors into patterns of neural damage and repair characteristic of many human degenerative and developmental CNS disorders.
DOI: 10.3390/ijms16035400
PubMed: 25761244
Affiliations:
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pubmed:25761244Le document en format XML
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<term>Heme Oxygenase-1 (genetics)</term>
<term>Heme Oxygenase-1 (metabolism)</term>
<term>Humans</term>
<term>Iron (metabolism)</term>
<term>Parkinson Disease (genetics)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Parkinson Disease (therapy)</term>
<term>Signal Transduction</term>
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<term>Heme Oxygenase-1</term>
<term>Iron</term>
<term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Alzheimer Disease</term>
<term>Parkinson Disease</term>
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<front><div type="abstract" xml:lang="en">Heme oxygenase-1 (HO-1) is a 32 kDa protein which catalyzes the breakdown of heme to free iron, carbon monoxide and biliverdin. The Hmox1 promoter contains numerous consensus sequences that render the gene exquisitely sensitive to induction by diverse pro-oxidant and inflammatory stimuli. In "stressed" astroglia, HO-1 hyperactivity promotes mitochondrial iron sequestration and macroautophagy and may thereby contribute to the pathological iron deposition and bioenergetic failure documented in Alzheimer disease, Parkinson disease and certain neurodevelopmental conditions. Glial HO-1 expression may also impact neuroplasticity and cell survival by modulating brain sterol metabolism and the proteasomal degradation of neurotoxic proteins. The glial HO-1 response may represent a pivotal transducer of noxious environmental and endogenous stressors into patterns of neural damage and repair characteristic of many human degenerative and developmental CNS disorders.</div>
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<Abstract><AbstractText>Heme oxygenase-1 (HO-1) is a 32 kDa protein which catalyzes the breakdown of heme to free iron, carbon monoxide and biliverdin. The Hmox1 promoter contains numerous consensus sequences that render the gene exquisitely sensitive to induction by diverse pro-oxidant and inflammatory stimuli. In "stressed" astroglia, HO-1 hyperactivity promotes mitochondrial iron sequestration and macroautophagy and may thereby contribute to the pathological iron deposition and bioenergetic failure documented in Alzheimer disease, Parkinson disease and certain neurodevelopmental conditions. Glial HO-1 expression may also impact neuroplasticity and cell survival by modulating brain sterol metabolism and the proteasomal degradation of neurotoxic proteins. The glial HO-1 response may represent a pivotal transducer of noxious environmental and endogenous stressors into patterns of neural damage and repair characteristic of many human degenerative and developmental CNS disorders.</AbstractText>
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