Effect of 24-h continuous rotigotine treatment on stationary and non-stationary locomotion in de novo patients with Parkinson disease in an open-label uncontrolled study.
Identifieur interne : 000532 ( PubMed/Checkpoint ); précédent : 000531; suivant : 000533Effect of 24-h continuous rotigotine treatment on stationary and non-stationary locomotion in de novo patients with Parkinson disease in an open-label uncontrolled study.
Auteurs : Mariano Serrao [Italie] ; Alberto Ranavolo [Italie] ; Carmela Conte [Italie] ; Chiara Davassi [Italie] ; Silvia Mari [Italie] ; Alfonso Fasano [Canada] ; Giorgia Chini [Italie] ; Gianluca Coppola [Italie] ; Francesco Draicchio [Italie] ; Francesco Pierelli [Italie]Source :
- Journal of neurology [ 1432-1459 ] ; 2015.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Biomechanical Phenomena, Dopamine Agonists (administration & dosage), Dopamine Agonists (pharmacology), Female, Gait Disorders, Neurologic (diagnosis), Gait Disorders, Neurologic (drug therapy), Gait Disorders, Neurologic (etiology), Humans, Locomotion (drug effects), Male, Middle Aged, Outcome Assessment (Health Care), Parkinson Disease (complications), Parkinson Disease (drug therapy), Tetrahydronaphthalenes (administration & dosage), Tetrahydronaphthalenes (pharmacology), Thiophenes (administration & dosage), Thiophenes (pharmacology).
- MESH :
- chemical , administration & dosage : Dopamine Agonists, Tetrahydronaphthalenes, Thiophenes.
- chemical , pharmacology : Dopamine Agonists, Tetrahydronaphthalenes, Thiophenes.
- complications : Parkinson Disease.
- diagnosis : Gait Disorders, Neurologic.
- drug effects : Locomotion.
- drug therapy : Gait Disorders, Neurologic, Parkinson Disease.
- etiology : Gait Disorders, Neurologic.
- Aged, Aged, 80 and over, Biomechanical Phenomena, Female, Humans, Male, Middle Aged, Outcome Assessment (Health Care).
Abstract
The aim of this study was to investigate the effect of a rotigotine transdermal patch on stationary and non-stationary locomotion in de novo Parkinson disease (PD) patients in an open-label uncontrolled study. A 3-D gait analysis system was used to investigate four different locomotor tasks: steady-state linear walking, gait initiation, gait termination and 180°-turning. A series of gait variables were measured for each locomotor task. PD patients who received rotigotine treatment (4-8 mg) displayed: (1) increased step length, gait speed, cadence and arm oscillations, and reduced double support duration and step asymmetry during steady-state linear gait; (2) increased initial step length during gait initiation; (3) increased final step length and gait speed, and decreased stability index during gait termination; (4) decreased duration of turning and head-pelvis delays during 180°-turning. The main finding that emerges from the present study is that the dopamine agonist rotigotine can improve various aspects of gait in de novo PD patients.
DOI: 10.1007/s00415-015-7883-4
PubMed: 26303834
Affiliations:
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pubmed:26303834Le document en format XML
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<front><div type="abstract" xml:lang="en">The aim of this study was to investigate the effect of a rotigotine transdermal patch on stationary and non-stationary locomotion in de novo Parkinson disease (PD) patients in an open-label uncontrolled study. A 3-D gait analysis system was used to investigate four different locomotor tasks: steady-state linear walking, gait initiation, gait termination and 180°-turning. A series of gait variables were measured for each locomotor task. PD patients who received rotigotine treatment (4-8 mg) displayed: (1) increased step length, gait speed, cadence and arm oscillations, and reduced double support duration and step asymmetry during steady-state linear gait; (2) increased initial step length during gait initiation; (3) increased final step length and gait speed, and decreased stability index during gait termination; (4) decreased duration of turning and head-pelvis delays during 180°-turning. The main finding that emerges from the present study is that the dopamine agonist rotigotine can improve various aspects of gait in de novo PD patients.</div>
</front>
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<DateCreated><Year>2015</Year>
<Month>11</Month>
<Day>10</Day>
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<DateCompleted><Year>2016</Year>
<Month>09</Month>
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<Title>Journal of neurology</Title>
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<ArticleTitle>Effect of 24-h continuous rotigotine treatment on stationary and non-stationary locomotion in de novo patients with Parkinson disease in an open-label uncontrolled study.</ArticleTitle>
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<Abstract><AbstractText>The aim of this study was to investigate the effect of a rotigotine transdermal patch on stationary and non-stationary locomotion in de novo Parkinson disease (PD) patients in an open-label uncontrolled study. A 3-D gait analysis system was used to investigate four different locomotor tasks: steady-state linear walking, gait initiation, gait termination and 180°-turning. A series of gait variables were measured for each locomotor task. PD patients who received rotigotine treatment (4-8 mg) displayed: (1) increased step length, gait speed, cadence and arm oscillations, and reduced double support duration and step asymmetry during steady-state linear gait; (2) increased initial step length during gait initiation; (3) increased final step length and gait speed, and decreased stability index during gait termination; (4) decreased duration of turning and head-pelvis delays during 180°-turning. The main finding that emerges from the present study is that the dopamine agonist rotigotine can improve various aspects of gait in de novo PD patients.</AbstractText>
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<Initials>A</Initials>
<AffiliationInfo><Affiliation>Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, ON, Canada.</Affiliation>
</AffiliationInfo>
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<Initials>G</Initials>
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<AffiliationInfo><Affiliation>IRCCS Neuromed, Pozzilli, Isernia, Italy.</Affiliation>
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<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2015</Year>
<Month>08</Month>
<Day>25</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Germany</Country>
<MedlineTA>J Neurol</MedlineTA>
<NlmUniqueID>0423161</NlmUniqueID>
<ISSNLinking>0340-5354</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D018491">Dopamine Agonists</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D013764">Tetrahydronaphthalenes</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D013876">Thiophenes</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>5QTR54Z0E1</RegistryNumber>
<NameOfSubstance UI="C047508">rotigotine</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001696" MajorTopicYN="N">Biomechanical Phenomena</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018491" MajorTopicYN="N">Dopamine Agonists</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020233" MajorTopicYN="N">Gait Disorders, Neurologic</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008124" MajorTopicYN="N">Locomotion</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017063" MajorTopicYN="Y">Outcome Assessment (Health Care)</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013764" MajorTopicYN="N">Tetrahydronaphthalenes</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013876" MajorTopicYN="N">Thiophenes</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">3-D gait analysis</Keyword>
<Keyword MajorTopicYN="N">De novo Parkinson</Keyword>
<Keyword MajorTopicYN="N">Kinematics</Keyword>
<Keyword MajorTopicYN="N">Non-stationary locomotion</Keyword>
<Keyword MajorTopicYN="N">Rotigotine</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year>
<Month>06</Month>
<Day>29</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2015</Year>
<Month>08</Month>
<Day>12</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2015</Year>
<Month>07</Month>
<Day>31</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2015</Year>
<Month>8</Month>
<Day>26</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2015</Year>
<Month>8</Month>
<Day>26</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2016</Year>
<Month>9</Month>
<Day>7</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">26303834</ArticleId>
<ArticleId IdType="doi">10.1007/s00415-015-7883-4</ArticleId>
<ArticleId IdType="pii">10.1007/s00415-015-7883-4</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Canada</li>
<li>Italie</li>
</country>
<region><li>Latium</li>
<li>Lombardie</li>
<li>Ontario</li>
</region>
<settlement><li>Milan</li>
<li>Rome</li>
<li>Toronto</li>
</settlement>
<orgName><li>Université de Toronto</li>
</orgName>
</list>
<tree><country name="Italie"><noRegion><name sortKey="Serrao, Mariano" sort="Serrao, Mariano" uniqKey="Serrao M" first="Mariano" last="Serrao">Mariano Serrao</name>
</noRegion>
<name sortKey="Chini, Giorgia" sort="Chini, Giorgia" uniqKey="Chini G" first="Giorgia" last="Chini">Giorgia Chini</name>
<name sortKey="Conte, Carmela" sort="Conte, Carmela" uniqKey="Conte C" first="Carmela" last="Conte">Carmela Conte</name>
<name sortKey="Coppola, Gianluca" sort="Coppola, Gianluca" uniqKey="Coppola G" first="Gianluca" last="Coppola">Gianluca Coppola</name>
<name sortKey="Davassi, Chiara" sort="Davassi, Chiara" uniqKey="Davassi C" first="Chiara" last="Davassi">Chiara Davassi</name>
<name sortKey="Draicchio, Francesco" sort="Draicchio, Francesco" uniqKey="Draicchio F" first="Francesco" last="Draicchio">Francesco Draicchio</name>
<name sortKey="Mari, Silvia" sort="Mari, Silvia" uniqKey="Mari S" first="Silvia" last="Mari">Silvia Mari</name>
<name sortKey="Pierelli, Francesco" sort="Pierelli, Francesco" uniqKey="Pierelli F" first="Francesco" last="Pierelli">Francesco Pierelli</name>
<name sortKey="Ranavolo, Alberto" sort="Ranavolo, Alberto" uniqKey="Ranavolo A" first="Alberto" last="Ranavolo">Alberto Ranavolo</name>
</country>
<country name="Canada"><region name="Ontario"><name sortKey="Fasano, Alfonso" sort="Fasano, Alfonso" uniqKey="Fasano A" first="Alfonso" last="Fasano">Alfonso Fasano</name>
</region>
</country>
</tree>
</affiliations>
</record>
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