Helicobacter pylori infection is associated with worse severity of Parkinson's disease.
Identifieur interne : 000505 ( PubMed/Checkpoint ); précédent : 000504; suivant : 000506Helicobacter pylori infection is associated with worse severity of Parkinson's disease.
Auteurs : Ai Huey Tan [Malaisie] ; Sanjiv Mahadeva [Malaisie] ; Connie Marras [Canada] ; Abdul Malik Thalha [Malaisie] ; Chiun Khang Kiew [Malaisie] ; Chia Ming Yeat [Malaisie] ; Sheang Wen Ng [Malaisie] ; Sheau Phing Ang [Malaisie] ; Siew Kian Chow [Malaisie] ; Mun Fai Loke [Malaisie] ; Jamunarani S. Vadivelu [Malaisie] ; Norlinah Ibrahim [Malaisie] ; Hoi Sen Yong [Malaisie] ; Chong Tin Tan [Malaisie] ; Susan H. Fox [Canada] ; Anthony E. Lang [Canada] ; Shen-Yang Lim [Malaisie]Source :
- Parkinsonism & related disorders [ 1873-5126 ] ; 2015.
English descriptors
- KwdEn :
- Age Factors, Aged, Aged, 80 and over, Breath Tests, Female, Helicobacter Infections (physiopathology), Helicobacter pylori (pathogenicity), Humans, Male, Middle Aged, Parkinson Disease (microbiology), Parkinson Disease (physiopathology), Predictive Value of Tests, Quality of Life, Severity of Illness Index, Spectrophotometry, Infrared, Statistics, Nonparametric, Surveys and Questionnaires.
- MESH :
- microbiology : Parkinson Disease.
- pathogenicity : Helicobacter pylori.
- physiopathology : Helicobacter Infections, Parkinson Disease.
- Age Factors, Aged, Aged, 80 and over, Breath Tests, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Quality of Life, Severity of Illness Index, Spectrophotometry, Infrared, Statistics, Nonparametric, Surveys and Questionnaires.
Abstract
Some studies have suggested that chronic Helicobacter pylori (HP) infection can aggravate the neurodegenerative process in Parkinson's disease (PD), and targeted intervention could potentially modify the course of this disabling disease. We aimed to study the impact of HP infection on motor function, gastrointestinal symptoms, and quality of life in a large cohort of PD patients.
DOI: 10.1016/j.parkreldis.2014.12.009
PubMed: 25560322
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Helicobacter pylori infection is associated with worse severity of Parkinson's disease.</title><author><name sortKey="Tan, Ai Huey" sort="Tan, Ai Huey" uniqKey="Tan A" first="Ai Huey" last="Tan">Ai Huey Tan</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Mahadeva, Sanjiv" sort="Mahadeva, Sanjiv" uniqKey="Mahadeva S" first="Sanjiv" last="Mahadeva">Sanjiv Mahadeva</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine (Division of Gastroenterology), University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Medicine (Division of Gastroenterology), University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name><affiliation wicri:level="1"><nlm:affiliation>Morton and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Morton and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital</wicri:regionArea><wicri:noRegion>Toronto Western Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Thalha, Abdul Malik" sort="Thalha, Abdul Malik" uniqKey="Thalha A" first="Abdul Malik" last="Thalha">Abdul Malik Thalha</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine (Division of Gastroenterology), University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Medicine (Division of Gastroenterology), University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Kiew, Chiun Khang" sort="Kiew, Chiun Khang" uniqKey="Kiew C" first="Chiun Khang" last="Kiew">Chiun Khang Kiew</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Yeat, Chia Ming" sort="Yeat, Chia Ming" uniqKey="Yeat C" first="Chia Ming" last="Yeat">Chia Ming Yeat</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Ng, Sheang Wen" sort="Ng, Sheang Wen" uniqKey="Ng S" first="Sheang Wen" last="Ng">Sheang Wen Ng</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Ang, Sheau Phing" sort="Ang, Sheau Phing" uniqKey="Ang S" first="Sheau Phing" last="Ang">Sheau Phing Ang</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Chow, Siew Kian" sort="Chow, Siew Kian" uniqKey="Chow S" first="Siew Kian" last="Chow">Siew Kian Chow</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Loke, Mun Fai" sort="Loke, Mun Fai" uniqKey="Loke M" first="Mun Fai" last="Loke">Mun Fai Loke</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Microbiology, University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Medical Microbiology, University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Vadivelu, Jamunarani S" sort="Vadivelu, Jamunarani S" uniqKey="Vadivelu J" first="Jamunarani S" last="Vadivelu">Jamunarani S. Vadivelu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Microbiology, University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Medical Microbiology, University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Ibrahim, Norlinah" sort="Ibrahim, Norlinah" uniqKey="Ibrahim N" first="Norlinah" last="Ibrahim">Norlinah Ibrahim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine (Division of Neurology), Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Medicine (Division of Neurology), Universiti Kebangsaan Malaysia, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Yong, Hoi Sen" sort="Yong, Hoi Sen" uniqKey="Yong H" first="Hoi Sen" last="Yong">Hoi Sen Yong</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Biological Sciences, University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Institute of Biological Sciences, University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Tan, Chong Tin" sort="Tan, Chong Tin" uniqKey="Tan C" first="Chong Tin" last="Tan">Chong Tin Tan</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Fox, Susan H" sort="Fox, Susan H" uniqKey="Fox S" first="Susan H" last="Fox">Susan H. Fox</name><affiliation wicri:level="1"><nlm:affiliation>Morton and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Morton and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital</wicri:regionArea><wicri:noRegion>Toronto Western Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name><affiliation wicri:level="1"><nlm:affiliation>Morton and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Morton and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital</wicri:regionArea><wicri:noRegion>Toronto Western Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Lim, Shen Yang" sort="Lim, Shen Yang" uniqKey="Lim S" first="Shen-Yang" last="Lim">Shen-Yang Lim</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur, Malaysia. Electronic address: limshenyang@ymail.com.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25560322</idno><idno type="pmid">25560322</idno><idno type="doi">10.1016/j.parkreldis.2014.12.009</idno><idno type="wicri:Area/PubMed/Corpus">000560</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000560</idno><idno type="wicri:Area/PubMed/Curation">000560</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000560</idno><idno type="wicri:Area/PubMed/Checkpoint">000560</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000560</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Helicobacter pylori infection is associated with worse severity of Parkinson's disease.</title><author><name sortKey="Tan, Ai Huey" sort="Tan, Ai Huey" uniqKey="Tan A" first="Ai Huey" last="Tan">Ai Huey Tan</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Mahadeva, Sanjiv" sort="Mahadeva, Sanjiv" uniqKey="Mahadeva S" first="Sanjiv" last="Mahadeva">Sanjiv Mahadeva</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine (Division of Gastroenterology), University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Medicine (Division of Gastroenterology), University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name><affiliation wicri:level="1"><nlm:affiliation>Morton and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Morton and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital</wicri:regionArea><wicri:noRegion>Toronto Western Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Thalha, Abdul Malik" sort="Thalha, Abdul Malik" uniqKey="Thalha A" first="Abdul Malik" last="Thalha">Abdul Malik Thalha</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine (Division of Gastroenterology), University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Medicine (Division of Gastroenterology), University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Kiew, Chiun Khang" sort="Kiew, Chiun Khang" uniqKey="Kiew C" first="Chiun Khang" last="Kiew">Chiun Khang Kiew</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Yeat, Chia Ming" sort="Yeat, Chia Ming" uniqKey="Yeat C" first="Chia Ming" last="Yeat">Chia Ming Yeat</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Ng, Sheang Wen" sort="Ng, Sheang Wen" uniqKey="Ng S" first="Sheang Wen" last="Ng">Sheang Wen Ng</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Ang, Sheau Phing" sort="Ang, Sheau Phing" uniqKey="Ang S" first="Sheau Phing" last="Ang">Sheau Phing Ang</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Chow, Siew Kian" sort="Chow, Siew Kian" uniqKey="Chow S" first="Siew Kian" last="Chow">Siew Kian Chow</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Loke, Mun Fai" sort="Loke, Mun Fai" uniqKey="Loke M" first="Mun Fai" last="Loke">Mun Fai Loke</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Microbiology, University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Medical Microbiology, University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Vadivelu, Jamunarani S" sort="Vadivelu, Jamunarani S" uniqKey="Vadivelu J" first="Jamunarani S" last="Vadivelu">Jamunarani S. Vadivelu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Microbiology, University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Medical Microbiology, University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Ibrahim, Norlinah" sort="Ibrahim, Norlinah" uniqKey="Ibrahim N" first="Norlinah" last="Ibrahim">Norlinah Ibrahim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine (Division of Neurology), Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Medicine (Division of Neurology), Universiti Kebangsaan Malaysia, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Yong, Hoi Sen" sort="Yong, Hoi Sen" uniqKey="Yong H" first="Hoi Sen" last="Yong">Hoi Sen Yong</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Biological Sciences, University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Institute of Biological Sciences, University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Tan, Chong Tin" sort="Tan, Chong Tin" uniqKey="Tan C" first="Chong Tin" last="Tan">Chong Tin Tan</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Fox, Susan H" sort="Fox, Susan H" uniqKey="Fox S" first="Susan H" last="Fox">Susan H. Fox</name><affiliation wicri:level="1"><nlm:affiliation>Morton and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Morton and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital</wicri:regionArea><wicri:noRegion>Toronto Western Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name><affiliation wicri:level="1"><nlm:affiliation>Morton and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Morton and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital</wicri:regionArea><wicri:noRegion>Toronto Western Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Lim, Shen Yang" sort="Lim, Shen Yang" uniqKey="Lim S" first="Shen-Yang" last="Lim">Shen-Yang Lim</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur, Malaysia. Electronic address: limshenyang@ymail.com.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author></analytic><series><title level="j">Parkinsonism & related disorders</title><idno type="eISSN">1873-5126</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Breath Tests</term><term>Female</term><term>Helicobacter Infections (physiopathology)</term><term>Helicobacter pylori (pathogenicity)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (microbiology)</term><term>Parkinson Disease (physiopathology)</term><term>Predictive Value of Tests</term><term>Quality of Life</term><term>Severity of Illness Index</term><term>Spectrophotometry, Infrared</term><term>Statistics, Nonparametric</term><term>Surveys and Questionnaires</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Helicobacter pylori</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Helicobacter Infections</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Breath Tests</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Predictive Value of Tests</term><term>Quality of Life</term><term>Severity of Illness Index</term><term>Spectrophotometry, Infrared</term><term>Statistics, Nonparametric</term><term>Surveys and Questionnaires</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Some studies have suggested that chronic Helicobacter pylori (HP) infection can aggravate the neurodegenerative process in Parkinson's disease (PD), and targeted intervention could potentially modify the course of this disabling disease. We aimed to study the impact of HP infection on motor function, gastrointestinal symptoms, and quality of life in a large cohort of PD patients.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25560322</PMID><DateCreated><Year>2015</Year><Month>02</Month><Day>24</Day></DateCreated><DateCompleted><Year>2015</Year><Month>11</Month><Day>17</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-5126</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>3</Issue><PubDate><Year>2015</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Parkinsonism & related disorders</Title><ISOAbbreviation>Parkinsonism Relat. Disord.</ISOAbbreviation></Journal><ArticleTitle>Helicobacter pylori infection is associated with worse severity of Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>221-5</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.parkreldis.2014.12.009</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1353-8020(14)00483-0</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Some studies have suggested that chronic Helicobacter pylori (HP) infection can aggravate the neurodegenerative process in Parkinson's disease (PD), and targeted intervention could potentially modify the course of this disabling disease. We aimed to study the impact of HP infection on motor function, gastrointestinal symptoms, and quality of life in a large cohort of PD patients.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">102 consecutive PD patients underwent (13)C urea breath testing and blinded evaluations consisting of the Unified Parkinson's Disease Rating Scale (UPDRS) including "On"-medication motor examination (Part III), objective and quantitative measures of bradykinesia (Purdue Pegboard and timed gait), Leeds Dyspepsia Questionnaire, and PDQ-39 (a health-related quality of life questionnaire).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">32.4% of PD patients were HP-positive. HP-positive patients were older (68.4 ± 7.3 vs. 63.8 ± 8.6 years, P = 0.009) and had worse motor function (UPDRS Part III 34.0 ± 13.0 vs. 27.3 ± 10.0, P = 0.04; Pegboard 6.4 ± 3.3 vs. 8.0 ± 2.7 pins, P = 0.04; and timed gait 25.1 ± 25.4 vs. 15.5 ± 7.6 s, P = 0.08). In the multivariate analysis, HP status demonstrated significant main effects on UPDRS Part III and timed gait. The association between HP status and these motor outcomes varied according to age. Gastrointestinal symptoms and PDQ-39 Summary Index scores did not differ between the two groups.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">This is the largest cross-sectional study to demonstrate an association between HP positivity and worse PD motor severity.</AbstractText><CopyrightInformation>Copyright © 2014 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tan</LastName><ForeName>Ai Huey</ForeName><Initials>AH</Initials><AffiliationInfo><Affiliation>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mahadeva</LastName><ForeName>Sanjiv</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Medicine (Division of Gastroenterology), University of Malaya, Kuala Lumpur, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marras</LastName><ForeName>Connie</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Morton and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thalha</LastName><ForeName>Abdul Malik</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Department of Medicine (Division of Gastroenterology), University of Malaya, Kuala Lumpur, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kiew</LastName><ForeName>Chiun Khang</ForeName><Initials>CK</Initials><AffiliationInfo><Affiliation>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yeat</LastName><ForeName>Chia Ming</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ng</LastName><ForeName>Sheang Wen</ForeName><Initials>SW</Initials><AffiliationInfo><Affiliation>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ang</LastName><ForeName>Sheau Phing</ForeName><Initials>SP</Initials><AffiliationInfo><Affiliation>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chow</LastName><ForeName>Siew Kian</ForeName><Initials>SK</Initials><AffiliationInfo><Affiliation>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Loke</LastName><ForeName>Mun Fai</ForeName><Initials>MF</Initials><AffiliationInfo><Affiliation>Department of Medical Microbiology, University of Malaya, Kuala Lumpur, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vadivelu</LastName><ForeName>Jamunarani S</ForeName><Initials>JS</Initials><AffiliationInfo><Affiliation>Department of Medical Microbiology, University of Malaya, Kuala Lumpur, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ibrahim</LastName><ForeName>Norlinah</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Medicine (Division of Neurology), Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yong</LastName><ForeName>Hoi Sen</ForeName><Initials>HS</Initials><AffiliationInfo><Affiliation>Institute of Biological Sciences, University of Malaya, Kuala Lumpur, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tan</LastName><ForeName>Chong Tin</ForeName><Initials>CT</Initials><AffiliationInfo><Affiliation>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fox</LastName><ForeName>Susan H</ForeName><Initials>SH</Initials><AffiliationInfo><Affiliation>Morton and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lang</LastName><ForeName>Anthony E</ForeName><Initials>AE</Initials><AffiliationInfo><Affiliation>Morton and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lim</LastName><ForeName>Shen-Yang</ForeName><Initials>SY</Initials><AffiliationInfo><Affiliation>Division of Neurology and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur, Malaysia. Electronic address: limshenyang@ymail.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>12</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Parkinsonism Relat Disord</MedlineTA><NlmUniqueID>9513583</NlmUniqueID><ISSNLinking>1353-8020</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001944" MajorTopicYN="N">Breath Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016481" MajorTopicYN="N">Helicobacter Infections</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016480" MajorTopicYN="N">Helicobacter pylori</DescriptorName><QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011237" MajorTopicYN="N">Predictive Value of Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011788" MajorTopicYN="N">Quality of Life</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013055" MajorTopicYN="N">Spectrophotometry, Infrared</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018709" MajorTopicYN="N">Statistics, Nonparametric</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011795" MajorTopicYN="N">Surveys and Questionnaires</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Gastrointestinal dysfunction</Keyword><Keyword MajorTopicYN="N">Helicobacter pylori</Keyword><Keyword MajorTopicYN="N">Parkinson's disease</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>09</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>12</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>12</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>1</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>1</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>11</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25560322</ArticleId><ArticleId IdType="pii">S1353-8020(14)00483-0</ArticleId><ArticleId IdType="doi">10.1016/j.parkreldis.2014.12.009</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li><li>Malaisie</li></country></list><tree><country name="Malaisie"><noRegion><name sortKey="Tan, Ai Huey" sort="Tan, Ai Huey" uniqKey="Tan A" first="Ai Huey" last="Tan">Ai Huey Tan</name></noRegion><name sortKey="Ang, Sheau Phing" sort="Ang, Sheau Phing" uniqKey="Ang S" first="Sheau Phing" last="Ang">Sheau Phing Ang</name><name sortKey="Chow, Siew Kian" sort="Chow, Siew Kian" uniqKey="Chow S" first="Siew Kian" last="Chow">Siew Kian Chow</name><name sortKey="Ibrahim, Norlinah" sort="Ibrahim, Norlinah" uniqKey="Ibrahim N" first="Norlinah" last="Ibrahim">Norlinah Ibrahim</name><name sortKey="Kiew, Chiun Khang" sort="Kiew, Chiun Khang" uniqKey="Kiew C" first="Chiun Khang" last="Kiew">Chiun Khang Kiew</name><name sortKey="Lim, Shen Yang" sort="Lim, Shen Yang" uniqKey="Lim S" first="Shen-Yang" last="Lim">Shen-Yang Lim</name><name sortKey="Loke, Mun Fai" sort="Loke, Mun Fai" uniqKey="Loke M" first="Mun Fai" last="Loke">Mun Fai Loke</name><name sortKey="Mahadeva, Sanjiv" sort="Mahadeva, Sanjiv" uniqKey="Mahadeva S" first="Sanjiv" last="Mahadeva">Sanjiv Mahadeva</name><name sortKey="Ng, Sheang Wen" sort="Ng, Sheang Wen" uniqKey="Ng S" first="Sheang Wen" last="Ng">Sheang Wen Ng</name><name sortKey="Tan, Chong Tin" sort="Tan, Chong Tin" uniqKey="Tan C" first="Chong Tin" last="Tan">Chong Tin Tan</name><name sortKey="Thalha, Abdul Malik" sort="Thalha, Abdul Malik" uniqKey="Thalha A" first="Abdul Malik" last="Thalha">Abdul Malik Thalha</name><name sortKey="Vadivelu, Jamunarani S" sort="Vadivelu, Jamunarani S" uniqKey="Vadivelu J" first="Jamunarani S" last="Vadivelu">Jamunarani S. Vadivelu</name><name sortKey="Yeat, Chia Ming" sort="Yeat, Chia Ming" uniqKey="Yeat C" first="Chia Ming" last="Yeat">Chia Ming Yeat</name><name sortKey="Yong, Hoi Sen" sort="Yong, Hoi Sen" uniqKey="Yong H" first="Hoi Sen" last="Yong">Hoi Sen Yong</name></country><country name="Canada"><noRegion><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name></noRegion><name sortKey="Fox, Susan H" sort="Fox, Susan H" uniqKey="Fox S" first="Susan H" last="Fox">Susan H. Fox</name><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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