Impact of Parkinson's disease on proprioceptively based on-line movement control.
Identifieur interne : 000495 ( PubMed/Checkpoint ); précédent : 000494; suivant : 000496Impact of Parkinson's disease on proprioceptively based on-line movement control.
Auteurs : David Mongeon [Canada] ; Pierre Blanchet ; Stéphanie Bergeron ; Julie MessierSource :
- Experimental brain research [ 1432-1106 ] ; 2015.
English descriptors
- KwdEn :
- Aged, Analysis of Variance, Biomechanical Phenomena, Dopamine Agents (pharmacology), Dopamine Agents (therapeutic use), Female, Hand (physiopathology), Humans, Male, Middle Aged, Movement (physiology), Parkinson Disease (complications), Parkinson Disease (drug therapy), Photic Stimulation, Proprioception (drug effects), Proprioception (physiology), Psychomotor Performance (drug effects), Range of Motion, Articular (drug effects), Range of Motion, Articular (physiology), Sensation Disorders (drug therapy), Sensation Disorders (etiology), Visual Perception (drug effects), Visual Perception (physiology).
- MESH :
- chemical , pharmacology : Dopamine Agents.
- chemical , therapeutic use : Dopamine Agents.
- complications : Parkinson Disease.
- drug effects : Proprioception, Psychomotor Performance, Range of Motion, Articular, Visual Perception.
- drug therapy : Parkinson Disease, Sensation Disorders.
- etiology : Sensation Disorders.
- physiology : Movement, Proprioception, Range of Motion, Articular, Visual Perception.
- physiopathology : Hand.
- Aged, Analysis of Variance, Biomechanical Phenomena, Female, Humans, Male, Middle Aged, Photic Stimulation.
Abstract
Evidence suggests that Parkinson's disease (PD) patients produce large spatial errors when reaching to proprioceptively defined targets. Here, we examined whether these movement inaccuracies result mainly from impaired use of proprioceptive inputs for movement planning mechanisms or from on-line movement guidance. Medicated and non-medicated PD patients and healthy controls performed three-dimensional reaching movements in four sensorimotor conditions that increase proprioceptive processing requirements. We assessed the influence of these sensorimotor conditions on the final accuracy and initial kinematics of the movements. If the patterns of final errors are primarily determined by planning processes before the initiation of the movement, the initial kinematics of reaching movements should show similar trends and predict the pattern of final errors. Medicated and non-medicated PD patients showed a greater mean level of final 3D errors than healthy controls when proprioception was the sole source of information guiding the movement, but this difference reached significance only for medicated PD patients. However, the pattern of initial kinematics and final spatial errors were markedly different both between sensorimotor conditions and between groups. Furthermore, medicated and non-medicated PD patients were less efficient than healthy controls in compensating for their initial spatial errors (hand distance from target location at peak velocity) when aiming at proprioceptively defined compared to visually defined targets. Considered together, the results are consistent with a selective deficit in proprioceptively based movement guidance in PD. Furthermore, dopaminergic medication did not improve proprioceptively guided movements in PD patients, indicating that dopaminergic dysfunction within the basal ganglia is not solely responsible for these deficits.
DOI: 10.1007/s00221-015-4343-4
PubMed: 26055990
Affiliations:
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Édouard-Montpetit, Montreal, QC, H3T 1J4, Canada</wicri:regionArea><wicri:noRegion>Canada</wicri:noRegion></affiliation></author><author><name sortKey="Blanchet, Pierre" sort="Blanchet, Pierre" uniqKey="Blanchet P" first="Pierre" last="Blanchet">Pierre Blanchet</name></author><author><name sortKey="Bergeron, Stephanie" sort="Bergeron, Stephanie" uniqKey="Bergeron S" first="Stéphanie" last="Bergeron">Stéphanie Bergeron</name></author><author><name sortKey="Messier, Julie" sort="Messier, Julie" uniqKey="Messier J" first="Julie" last="Messier">Julie Messier</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26055990</idno><idno type="pmid">26055990</idno><idno type="doi">10.1007/s00221-015-4343-4</idno><idno type="wicri:Area/PubMed/Corpus">000426</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000426</idno><idno type="wicri:Area/PubMed/Curation">000426</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000426</idno><idno type="wicri:Area/PubMed/Checkpoint">000426</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000426</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Impact of Parkinson's disease on proprioceptively based on-line movement control.</title><author><name sortKey="Mongeon, David" sort="Mongeon, David" uniqKey="Mongeon D" first="David" last="Mongeon">David Mongeon</name><affiliation wicri:level="1"><nlm:affiliation>Département de Kinésiologie, Université de Montréal, 2100, boul. Édouard-Montpetit, Montreal, QC, H3T 1J4, Canada, david.mongeon@umontreal.ca.</nlm:affiliation><country wicri:rule="url">Canada</country><wicri:regionArea>Département de Kinésiologie, Université de Montréal, 2100, boul. Édouard-Montpetit, Montreal, QC, H3T 1J4, Canada</wicri:regionArea><wicri:noRegion>Canada</wicri:noRegion></affiliation></author><author><name sortKey="Blanchet, Pierre" sort="Blanchet, Pierre" uniqKey="Blanchet P" first="Pierre" last="Blanchet">Pierre Blanchet</name></author><author><name sortKey="Bergeron, Stephanie" sort="Bergeron, Stephanie" uniqKey="Bergeron S" first="Stéphanie" last="Bergeron">Stéphanie Bergeron</name></author><author><name sortKey="Messier, Julie" sort="Messier, Julie" uniqKey="Messier J" first="Julie" last="Messier">Julie Messier</name></author></analytic><series><title level="j">Experimental brain research</title><idno type="eISSN">1432-1106</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Biomechanical Phenomena</term><term>Dopamine Agents (pharmacology)</term><term>Dopamine Agents (therapeutic use)</term><term>Female</term><term>Hand (physiopathology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Movement (physiology)</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (drug therapy)</term><term>Photic Stimulation</term><term>Proprioception (drug effects)</term><term>Proprioception (physiology)</term><term>Psychomotor Performance (drug effects)</term><term>Range of Motion, Articular (drug effects)</term><term>Range of Motion, Articular (physiology)</term><term>Sensation Disorders (drug therapy)</term><term>Sensation Disorders (etiology)</term><term>Visual Perception (drug effects)</term><term>Visual Perception (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Dopamine Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Dopamine Agents</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Proprioception</term><term>Psychomotor Performance</term><term>Range of Motion, Articular</term><term>Visual Perception</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term><term>Sensation Disorders</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Sensation Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Movement</term><term>Proprioception</term><term>Range of Motion, Articular</term><term>Visual Perception</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Hand</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Biomechanical Phenomena</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Photic Stimulation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Evidence suggests that Parkinson's disease (PD) patients produce large spatial errors when reaching to proprioceptively defined targets. Here, we examined whether these movement inaccuracies result mainly from impaired use of proprioceptive inputs for movement planning mechanisms or from on-line movement guidance. Medicated and non-medicated PD patients and healthy controls performed three-dimensional reaching movements in four sensorimotor conditions that increase proprioceptive processing requirements. We assessed the influence of these sensorimotor conditions on the final accuracy and initial kinematics of the movements. If the patterns of final errors are primarily determined by planning processes before the initiation of the movement, the initial kinematics of reaching movements should show similar trends and predict the pattern of final errors. Medicated and non-medicated PD patients showed a greater mean level of final 3D errors than healthy controls when proprioception was the sole source of information guiding the movement, but this difference reached significance only for medicated PD patients. However, the pattern of initial kinematics and final spatial errors were markedly different both between sensorimotor conditions and between groups. Furthermore, medicated and non-medicated PD patients were less efficient than healthy controls in compensating for their initial spatial errors (hand distance from target location at peak velocity) when aiming at proprioceptively defined compared to visually defined targets. Considered together, the results are consistent with a selective deficit in proprioceptively based movement guidance in PD. Furthermore, dopaminergic medication did not improve proprioceptively guided movements in PD patients, indicating that dopaminergic dysfunction within the basal ganglia is not solely responsible for these deficits.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26055990</PMID><DateCreated><Year>2015</Year><Month>08</Month><Day>13</Day></DateCreated><DateCompleted><Year>2016</Year><Month>10</Month><Day>28</Day></DateCompleted><DateRevised><Year>2016</Year><Month>12</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1432-1106</ISSN><JournalIssue CitedMedium="Internet"><Volume>233</Volume><Issue>9</Issue><PubDate><Year>2015</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Experimental brain research</Title><ISOAbbreviation>Exp Brain Res</ISOAbbreviation></Journal><ArticleTitle>Impact of Parkinson's disease on proprioceptively based on-line movement control.</ArticleTitle><Pagination><MedlinePgn>2707-21</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00221-015-4343-4</ELocationID><Abstract><AbstractText>Evidence suggests that Parkinson's disease (PD) patients produce large spatial errors when reaching to proprioceptively defined targets. Here, we examined whether these movement inaccuracies result mainly from impaired use of proprioceptive inputs for movement planning mechanisms or from on-line movement guidance. Medicated and non-medicated PD patients and healthy controls performed three-dimensional reaching movements in four sensorimotor conditions that increase proprioceptive processing requirements. We assessed the influence of these sensorimotor conditions on the final accuracy and initial kinematics of the movements. If the patterns of final errors are primarily determined by planning processes before the initiation of the movement, the initial kinematics of reaching movements should show similar trends and predict the pattern of final errors. Medicated and non-medicated PD patients showed a greater mean level of final 3D errors than healthy controls when proprioception was the sole source of information guiding the movement, but this difference reached significance only for medicated PD patients. However, the pattern of initial kinematics and final spatial errors were markedly different both between sensorimotor conditions and between groups. Furthermore, medicated and non-medicated PD patients were less efficient than healthy controls in compensating for their initial spatial errors (hand distance from target location at peak velocity) when aiming at proprioceptively defined compared to visually defined targets. Considered together, the results are consistent with a selective deficit in proprioceptively based movement guidance in PD. Furthermore, dopaminergic medication did not improve proprioceptively guided movements in PD patients, indicating that dopaminergic dysfunction within the basal ganglia is not solely responsible for these deficits.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mongeon</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Département de Kinésiologie, Université de Montréal, 2100, boul. Édouard-Montpetit, Montreal, QC, H3T 1J4, Canada, david.mongeon@umontreal.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blanchet</LastName><ForeName>Pierre</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Bergeron</LastName><ForeName>Stéphanie</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Messier</LastName><ForeName>Julie</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><Agency>Canadian Institutes of Health Research</Agency><Country>Canada</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>06</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Exp Brain Res</MedlineTA><NlmUniqueID>0043312</NlmUniqueID><ISSNLinking>0014-4819</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015259">Dopamine Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000704" MajorTopicYN="N">Analysis of Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001696" MajorTopicYN="N">Biomechanical Phenomena</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015259" MajorTopicYN="N">Dopamine Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName 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IdType="doi">10.1007/s00221-015-4343-4</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Bergeron, Stephanie" sort="Bergeron, Stephanie" uniqKey="Bergeron S" first="Stéphanie" last="Bergeron">Stéphanie Bergeron</name><name sortKey="Blanchet, Pierre" sort="Blanchet, Pierre" uniqKey="Blanchet P" first="Pierre" last="Blanchet">Pierre Blanchet</name><name sortKey="Messier, Julie" sort="Messier, Julie" uniqKey="Messier J" first="Julie" last="Messier">Julie Messier</name></noCountry><country name="Canada"><noRegion><name sortKey="Mongeon, David" sort="Mongeon, David" uniqKey="Mongeon D" first="David" last="Mongeon">David Mongeon</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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