Motor Sequence Learning and Consolidation in Unilateral De Novo Patients with Parkinson's Disease.
Identifieur interne : 000462 ( PubMed/Checkpoint ); précédent : 000461; suivant : 000463Motor Sequence Learning and Consolidation in Unilateral De Novo Patients with Parkinson's Disease.
Auteurs : Xiaojuan Dan [République populaire de Chine] ; Bradley R. King [Canada] ; Julien Doyon [Canada] ; Piu Chan [République populaire de Chine]Source :
- PloS one [ 1932-6203 ] ; 2015.
English descriptors
- KwdEn :
- Aged, Case-Control Studies, Female, Functional Laterality (physiology), Hand, Humans, Learning (physiology), Male, Memory Consolidation (physiology), Middle Aged, Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Parkinson Disease (psychology), Psychomotor Performance (physiology).
- MESH :
- diagnosis : Parkinson Disease.
- physiology : Functional Laterality, Learning, Memory Consolidation, Psychomotor Performance.
- physiopathology : Parkinson Disease.
- psychology : Parkinson Disease.
- Aged, Case-Control Studies, Female, Hand, Humans, Male, Middle Aged.
Abstract
Previous research investigating motor sequence learning (MSL) and consolidation in patients with Parkinson's disease (PD) has predominantly included heterogeneous participant samples with early and advanced disease stages; thus, little is known about the onset of potential behavioral impairments. We employed a multisession MSL paradigm to investigate whether behavioral deficits in learning and consolidation appear immediately after or prior to the detection of clinical symptoms in the tested (left) hand. Specifically, our patient sample was limited to recently diagnosed patients with pure unilateral PD. The left hand symptomatic (LH-S) patients provided an assessment of performance following the onset of clinical symptoms in the tested hand. Conversely, right hand affected (left hand asymptomatic, LH-A) patients served to investigate whether MSL impairments appear before symptoms in the tested hand. LH-S patients demonstrated impaired learning during the initial training session and both LH-S and LH-A patients demonstrated decreased performance compared to controls during the next-day retest. Critically, the impairments in later learning stages in the LH-A patients were evident even before the appearance of traditional clinical symptoms in the tested hand. Results may be explained by the progression of disease-related alterations in relevant corticostriatal networks.
DOI: 10.1371/journal.pone.0134291
PubMed: 26222151
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:26222151Le document en format XML
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King</name><affiliation wicri:level="1"><nlm:affiliation>Functional Neuroimaging Unit, Department of Psychology, Université de Montréal, Montréal, Quebec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Functional Neuroimaging Unit, Department of Psychology, Université de Montréal, Montréal, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Doyon, Julien" sort="Doyon, Julien" uniqKey="Doyon J" first="Julien" last="Doyon">Julien Doyon</name><affiliation wicri:level="1"><nlm:affiliation>Functional Neuroimaging Unit, Department of Psychology, Université de Montréal, Montréal, Quebec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Functional Neuroimaging Unit, Department of Psychology, Université de Montréal, Montréal, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Chan, Piu" sort="Chan, Piu" uniqKey="Chan P" first="Piu" last="Chan">Piu Chan</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurobiology and Neurology, Key Laboratory of Ministry of Education on Neurodegenerative Disorders, Beijing Key Laboratory on Parkinson's Disease, Xuanwu Hospital of Capital Medical University, Beijing, China; Parkinson's Disease Center of Beijing Institute for Brain Disorders, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Neurobiology and Neurology, Key Laboratory of Ministry of Education on Neurodegenerative Disorders, Beijing Key Laboratory on Parkinson's Disease, Xuanwu Hospital of Capital Medical University, Beijing, China; Parkinson's Disease Center of Beijing Institute for Brain Disorders, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Case-Control Studies</term><term>Female</term><term>Functional Laterality (physiology)</term><term>Hand</term><term>Humans</term><term>Learning (physiology)</term><term>Male</term><term>Memory Consolidation (physiology)</term><term>Middle Aged</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (psychology)</term><term>Psychomotor Performance (physiology)</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Functional Laterality</term><term>Learning</term><term>Memory Consolidation</term><term>Psychomotor Performance</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Case-Control Studies</term><term>Female</term><term>Hand</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Previous research investigating motor sequence learning (MSL) and consolidation in patients with Parkinson's disease (PD) has predominantly included heterogeneous participant samples with early and advanced disease stages; thus, little is known about the onset of potential behavioral impairments. We employed a multisession MSL paradigm to investigate whether behavioral deficits in learning and consolidation appear immediately after or prior to the detection of clinical symptoms in the tested (left) hand. Specifically, our patient sample was limited to recently diagnosed patients with pure unilateral PD. The left hand symptomatic (LH-S) patients provided an assessment of performance following the onset of clinical symptoms in the tested hand. Conversely, right hand affected (left hand asymptomatic, LH-A) patients served to investigate whether MSL impairments appear before symptoms in the tested hand. LH-S patients demonstrated impaired learning during the initial training session and both LH-S and LH-A patients demonstrated decreased performance compared to controls during the next-day retest. Critically, the impairments in later learning stages in the LH-A patients were evident even before the appearance of traditional clinical symptoms in the tested hand. Results may be explained by the progression of disease-related alterations in relevant corticostriatal networks.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26222151</PMID><DateCreated><Year>2015</Year><Month>07</Month><Day>30</Day></DateCreated><DateCompleted><Year>2016</Year><Month>05</Month><Day>13</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>10</Volume><Issue>7</Issue><PubDate><Year>2015</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>Motor Sequence Learning and Consolidation in Unilateral De Novo Patients with Parkinson's Disease.</ArticleTitle><Pagination><MedlinePgn>e0134291</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0134291</ELocationID><Abstract><AbstractText>Previous research investigating motor sequence learning (MSL) and consolidation in patients with Parkinson's disease (PD) has predominantly included heterogeneous participant samples with early and advanced disease stages; thus, little is known about the onset of potential behavioral impairments. We employed a multisession MSL paradigm to investigate whether behavioral deficits in learning and consolidation appear immediately after or prior to the detection of clinical symptoms in the tested (left) hand. Specifically, our patient sample was limited to recently diagnosed patients with pure unilateral PD. The left hand symptomatic (LH-S) patients provided an assessment of performance following the onset of clinical symptoms in the tested hand. Conversely, right hand affected (left hand asymptomatic, LH-A) patients served to investigate whether MSL impairments appear before symptoms in the tested hand. LH-S patients demonstrated impaired learning during the initial training session and both LH-S and LH-A patients demonstrated decreased performance compared to controls during the next-day retest. Critically, the impairments in later learning stages in the LH-A patients were evident even before the appearance of traditional clinical symptoms in the tested hand. Results may be explained by the progression of disease-related alterations in relevant corticostriatal networks.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dan</LastName><ForeName>Xiaojuan</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Neurobiology and Neurology, Key Laboratory of Ministry of Education on Neurodegenerative Disorders, Beijing Key Laboratory on Parkinson's Disease, Xuanwu Hospital of Capital Medical University, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>King</LastName><ForeName>Bradley R</ForeName><Initials>BR</Initials><AffiliationInfo><Affiliation>Functional Neuroimaging Unit, Department of Psychology, Université de Montréal, Montréal, Quebec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Doyon</LastName><ForeName>Julien</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Functional Neuroimaging Unit, Department of Psychology, Université de Montréal, Montréal, Quebec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chan</LastName><ForeName>Piu</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Neurobiology and Neurology, Key Laboratory of Ministry of Education on Neurodegenerative Disorders, Beijing Key Laboratory on Parkinson's Disease, Xuanwu Hospital of Capital Medical University, Beijing, China; Parkinson's Disease Center of Beijing Institute for Brain Disorders, Beijing, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>07</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Neuroimage. 2015 Mar;108:423-34</RefSource><PMID Version="1">25542533</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuropsychologia. 2006;44(10):1653-62</RefSource><PMID Version="1">16674983</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12566-71</RefSource><PMID Version="1">16107540</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Exp Brain Res. 2002 Sep;146(1):122-6</RefSource><PMID Version="1">12192586</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):861-8</RefSource><PMID Version="1">9448252</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Behav Brain Res. 2009 Apr 12;199(1):61-75</RefSource><PMID Version="1">19061920</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 2001 Oct;58(10):1611-5</RefSource><PMID Version="1">11594919</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain Cogn. 2011 Mar;75(2):135-40</RefSource><PMID Version="1">21134706</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hippocampus. 2013 Nov;23(11):985-1004</RefSource><PMID Version="1">23929594</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cortex. 2015 Apr;65:102-12</RefSource><PMID Version="1">25681652</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurophysiol. 2010 Feb;103(2):942-9</RefSource><PMID Version="1">20018839</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Behav Brain Res. 2012 Apr 21;230(1):116-24</RefSource><PMID Version="1">22343069</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Exp Brain Res. 1997 Jun;115(1):1-5</RefSource><PMID Version="1">9224828</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain Cogn. 2001 Apr;45(3):378-91</RefSource><PMID Version="1">11305880</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Exp Brain Res. 2009 May;195(1):15-26</RefSource><PMID Version="1">19277618</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurol Sci. 1985 Jul;69(3):223-30</RefSource><PMID Version="1">3928823</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2002 Feb 15;22(4):1397-406</RefSource><PMID Version="1">11850466</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 1988 Apr 7;318(14):876-80</RefSource><PMID Version="1">3352672</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Parkinsonism Relat Disord. 2013 Feb;19(2):265-8</RefSource><PMID Version="1">22901957</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Curr Opin Neurol. 2008 Aug;21(4):478-83</RefSource><PMID Version="1">18607210</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2006 Dec;21(12):2042-51</RefSource><PMID Version="1">17078043</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 1990 Apr 21;335(8695):948-52</RefSource><PMID Version="1">1691427</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2003 Apr 22;60(8):1313-9</RefSource><PMID Version="1">12707435</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuropsychologia. 1971 Mar;9(1):97-113</RefSource><PMID Version="1">5146491</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain Res Brain Res Rev. 2000 Mar;31(2-3):236-50</RefSource><PMID Version="1">10719151</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain Res. 2007 Mar 16;1137(1):104-10</RefSource><PMID Version="1">17239828</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Neurosci. 2004 Jul;5(7):576-82</RefSource><PMID Version="1">15208699</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hum Brain Mapp. 2014 Aug;35(8):3625-45</RefSource><PMID Version="1">24302373</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 2000 Feb;57(2):205-8</RefSource><PMID Version="1">10681078</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2003 Oct 9;425(6958):616-20</RefSource><PMID Version="1">14534587</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurobiol Aging. 2012 May;33(5):991-1000</RefSource><PMID Version="1">22244090</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 1996 Jan;46(1):231-7</RefSource><PMID Version="1">8559382</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain. 2005 Oct;128(Pt 10):2250-9</RefSource><PMID Version="1">15958505</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2009;4(8):e6683</RefSource><PMID Version="1">19690610</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuropsychologia. 1998 Jul;36(7):625-41</RefSource><PMID Version="1">9723934</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuropsychologia. 2000;38(11):1443-51</RefSource><PMID Version="1">10906370</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Neurosci. 2007 Sep;10(9):1206-13</RefSource><PMID Version="1">17694051</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuropsychology. 2006 Jul;20(4):490-5</RefSource><PMID Version="1">16846267</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain. 1991 Oct;114 ( Pt 5):2283-301</RefSource><PMID Version="1">1933245</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Learn Mem. 2007 Jul;14(7):480-4</RefSource><PMID Version="1">17622650</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Psychopharmacol Bull. 1988;24(4):689-92</RefSource><PMID Version="1">3249771</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2000 Nov;15(6):1095-103</RefSource><PMID Version="1">11104191</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2012 Mar 27;78(13):998-1006</RefSource><PMID Version="1">22422897</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain. 1994 Aug;117 ( Pt 4):877-97</RefSource><PMID Version="1">7922472</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain Cogn. 1997 Jul;34(2):218-45</RefSource><PMID Version="1">9220087</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain. 2007 Nov;130(Pt 11):2887-97</RefSource><PMID Version="1">17855374</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2004 Nov;19(11):1285-93</RefSource><PMID Version="1">15390058</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurobiol Aging. 2003 Mar-Apr;24(2):197-211</RefSource><PMID Version="1">12498954</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Front Hum Neurosci. 2013 Apr 17;7:142</RefSource><PMID Version="1">23616757</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17839-44</RefSource><PMID Version="1">20876115</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 1995 Sep 14;377(6545):155-8</RefSource><PMID Version="1">7675082</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Curr Opin Neurobiol. 2005 Apr;15(2):161-7</RefSource><PMID Version="1">15831397</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2012 Apr 15;27(5):608-16</RefSource><PMID Version="1">22508279</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Psychiatr Res. 1982-1983;17(1):37-49</RefSource><PMID Version="1">7183759</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Sleep Res. 2013 Aug;22(4):398-405</RefSource><PMID Version="1">23398021</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Mot Behav. 2013;45(5):423-9</RefSource><PMID Version="1">23971968</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" 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sortKey="Dan, Xiaojuan" sort="Dan, Xiaojuan" uniqKey="Dan X" first="Xiaojuan" last="Dan">Xiaojuan Dan</name></noRegion><name sortKey="Chan, Piu" sort="Chan, Piu" uniqKey="Chan P" first="Piu" last="Chan">Piu Chan</name></country><country name="Canada"><noRegion><name sortKey="King, Bradley R" sort="King, Bradley R" uniqKey="King B" first="Bradley R" last="King">Bradley R. King</name></noRegion><name sortKey="Doyon, Julien" sort="Doyon, Julien" uniqKey="Doyon J" first="Julien" last="Doyon">Julien Doyon</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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