REM sleep behavior disorder and neuropathology in Parkinson's disease.
Identifieur interne : 000408 ( PubMed/Checkpoint ); précédent : 000407; suivant : 000409REM sleep behavior disorder and neuropathology in Parkinson's disease.
Auteurs : Ronald B. Postuma [Canada] ; Charles H. Adler [États-Unis] ; Brittany N. Dugger [États-Unis] ; Joseph G. Hentz [États-Unis] ; Holly A. Shill [États-Unis] ; Erika Driver-Dunckley [États-Unis] ; Marwan N. Sabbagh [États-Unis] ; Sandra A. Jacobson [États-Unis] ; Christine M. Belden [États-Unis] ; Lucia I. Sue [États-Unis] ; Geidy Serrano [États-Unis] ; Thomas G. Beach [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Autopsy, Cohort Studies, Female, Humans, Male, Parkinson Disease (complications), Parkinson Disease (metabolism), Parkinson Disease (pathology), REM Sleep Behavior Disorder (etiology), REM Sleep Behavior Disorder (metabolism), REM Sleep Behavior Disorder (pathology), alpha-Synuclein (metabolism).
- MESH :
- chemical , metabolism : alpha-Synuclein.
- complications : Parkinson Disease.
- etiology : REM Sleep Behavior Disorder.
- metabolism : Parkinson Disease, REM Sleep Behavior Disorder.
- pathology : Parkinson Disease, REM Sleep Behavior Disorder.
- Aged, Aged, 80 and over, Autopsy, Cohort Studies, Female, Humans, Male.
Abstract
Rapid eye movement (REM) sleep behavior disorder (RBD) in Parkinson's disease (PD) is associated with differences in clinical phenotype, including dementia, autonomic loss, and gait dysfunction. The pathological basis for this remains unclear.
DOI: 10.1002/mds.26347
PubMed: 26265105
Affiliations:
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Postuma</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada, Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada, Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Adler, Charles H" sort="Adler, Charles H" uniqKey="Adler C" first="Charles H" last="Adler">Charles H. 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Dugger</name><affiliation wicri:level="2"><nlm:affiliation>Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea>Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City</wicri:cityArea></affiliation></author><author><name sortKey="Hentz, Joseph G" sort="Hentz, Joseph G" uniqKey="Hentz J" first="Joseph G" last="Hentz">Joseph G. Hentz</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biostatistics, Mayo Clinic, Scottsdale, AZ.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea>Department of Biostatistics, Mayo Clinic, Scottsdale</wicri:cityArea></affiliation></author><author><name sortKey="Shill, Holly A" sort="Shill, Holly A" uniqKey="Shill H" first="Holly A" last="Shill">Holly A. Shill</name><affiliation wicri:level="2"><nlm:affiliation>Cleo Roberts Center, Banner Sun Health Research Institute, Sun City, AZ.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea>Cleo Roberts Center, Banner Sun Health Research Institute, Sun City</wicri:cityArea></affiliation></author><author><name sortKey="Driver Dunckley, Erika" sort="Driver Dunckley, Erika" uniqKey="Driver Dunckley E" first="Erika" last="Driver-Dunckley">Erika Driver-Dunckley</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Mayo Clinic College of Medicine, Scottsdale, AZ.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea>Department of Neurology, Mayo Clinic College of Medicine, Scottsdale</wicri:cityArea></affiliation></author><author><name sortKey="Sabbagh, Marwan N" sort="Sabbagh, Marwan N" uniqKey="Sabbagh M" first="Marwan N" last="Sabbagh">Marwan N. Sabbagh</name><affiliation wicri:level="2"><nlm:affiliation>Cleo Roberts Center, Banner Sun Health Research Institute, Sun City, AZ.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea>Cleo Roberts Center, Banner Sun Health Research Institute, Sun City</wicri:cityArea></affiliation></author><author><name sortKey="Jacobson, Sandra A" sort="Jacobson, Sandra A" uniqKey="Jacobson S" first="Sandra A" last="Jacobson">Sandra A. Jacobson</name><affiliation wicri:level="2"><nlm:affiliation>Cleo Roberts Center, Banner Sun Health Research Institute, Sun City, AZ.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea>Cleo Roberts Center, Banner Sun Health Research Institute, Sun City</wicri:cityArea></affiliation></author><author><name sortKey="Belden, Christine M" sort="Belden, Christine M" uniqKey="Belden C" first="Christine M" last="Belden">Christine M. Belden</name><affiliation wicri:level="2"><nlm:affiliation>Cleo Roberts Center, Banner Sun Health Research Institute, Sun City, AZ.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea>Cleo Roberts Center, Banner Sun Health Research Institute, Sun City</wicri:cityArea></affiliation></author><author><name sortKey="Sue, Lucia I" sort="Sue, Lucia I" uniqKey="Sue L" first="Lucia I" last="Sue">Lucia I. Sue</name><affiliation wicri:level="2"><nlm:affiliation>Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea>Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City</wicri:cityArea></affiliation></author><author><name sortKey="Serrano, Geidy" sort="Serrano, Geidy" uniqKey="Serrano G" first="Geidy" last="Serrano">Geidy Serrano</name><affiliation wicri:level="2"><nlm:affiliation>Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea>Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City</wicri:cityArea></affiliation></author><author><name sortKey="Beach, Thomas G" sort="Beach, Thomas G" uniqKey="Beach T" first="Thomas G" last="Beach">Thomas G. Beach</name><affiliation wicri:level="2"><nlm:affiliation>Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea>Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City</wicri:cityArea></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Autopsy</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (pathology)</term><term>REM Sleep Behavior Disorder (etiology)</term><term>REM Sleep Behavior Disorder (metabolism)</term><term>REM Sleep Behavior Disorder (pathology)</term><term>alpha-Synuclein (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>alpha-Synuclein</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>REM Sleep Behavior Disorder</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Parkinson Disease</term><term>REM Sleep Behavior Disorder</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term><term>REM Sleep Behavior Disorder</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Autopsy</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Male</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Rapid eye movement (REM) sleep behavior disorder (RBD) in Parkinson's disease (PD) is associated with differences in clinical phenotype, including dementia, autonomic loss, and gait dysfunction. The pathological basis for this remains unclear.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26265105</PMID><DateCreated><Year>2015</Year><Month>09</Month><Day>03</Day></DateCreated><DateCompleted><Year>2016</Year><Month>06</Month><Day>17</Day></DateCompleted><DateRevised><Year>2015</Year><Month>09</Month><Day>03</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>30</Volume><Issue>10</Issue><PubDate><Year>2015</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>REM sleep behavior disorder and neuropathology in Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>1413-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.26347</ELocationID><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Rapid eye movement (REM) sleep behavior disorder (RBD) in Parkinson's disease (PD) is associated with differences in clinical phenotype, including dementia, autonomic loss, and gait dysfunction. The pathological basis for this remains unclear.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Parkinson's disease subjects in a longitudinal clinicopathologic study were screened for probable RBD with the Mayo Sleep Questionnaire. After death, semiquantitative analyses were conducted for synuclein, amyloid, neurofibrillary tangles, and cerebrovascular lesions.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Forty cases had probable RBD (PD+RBD), and 41 did not (PD-RBD). Despite similar age at death (∼80 y) and disease duration (∼14.5 y), PD+RBD had increased synuclein deposition in all regions examined, with nine of 10 regions significantly different. The Lewy body 10-region total score (scale = 0-40) was 29.5 in PD+RBD versus 24.5 in PD-RBD (Cohen-d effect size = 0.79, P = 0.002). Cerebrovascular lesion burden was slightly higher in PD-RBD.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Although overlap occurs between groups, PD patients with probable RBD may have greater density and range of synuclein pathology on autopsy.</AbstractText><CopyrightInformation>© 2015 International Parkinson and Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Postuma</LastName><ForeName>Ronald B</ForeName><Initials>RB</Initials><AffiliationInfo><Affiliation>Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada, Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adler</LastName><ForeName>Charles H</ForeName><Initials>CH</Initials><AffiliationInfo><Affiliation>Department of Neurology, Mayo Clinic College of Medicine, Scottsdale, AZ.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dugger</LastName><ForeName>Brittany N</ForeName><Initials>BN</Initials><AffiliationInfo><Affiliation>Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hentz</LastName><ForeName>Joseph G</ForeName><Initials>JG</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, Mayo Clinic, Scottsdale, AZ.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shill</LastName><ForeName>Holly A</ForeName><Initials>HA</Initials><AffiliationInfo><Affiliation>Cleo Roberts Center, Banner Sun Health Research Institute, Sun City, AZ.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Arizona College of Medicine, Phoenix, AZ.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Driver-Dunckley</LastName><ForeName>Erika</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Neurology, Mayo Clinic College of Medicine, Scottsdale, AZ.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sabbagh</LastName><ForeName>Marwan N</ForeName><Initials>MN</Initials><AffiliationInfo><Affiliation>Cleo Roberts Center, Banner Sun Health Research Institute, Sun City, AZ.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jacobson</LastName><ForeName>Sandra A</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>Cleo Roberts Center, Banner Sun Health Research Institute, Sun City, AZ.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Belden</LastName><ForeName>Christine M</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>Cleo Roberts Center, Banner Sun Health Research Institute, Sun City, AZ.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sue</LastName><ForeName>Lucia I</ForeName><Initials>LI</Initials><AffiliationInfo><Affiliation>Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Serrano</LastName><ForeName>Geidy</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beach</LastName><ForeName>Thomas G</ForeName><Initials>TG</Initials><AffiliationInfo><Affiliation>Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>P30 AG19610</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U24 NS072026</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>08</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051844">alpha-Synuclein</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001344" MajorTopicYN="N">Autopsy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020187" MajorTopicYN="N">REM Sleep Behavior Disorder</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051844" MajorTopicYN="N">alpha-Synuclein</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">REM sleep behavior disorder</Keyword><Keyword MajorTopicYN="N">diagnosis</Keyword><Keyword MajorTopicYN="N">pathology</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>03</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>06</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>06</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>8</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>8</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>6</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26265105</ArticleId><ArticleId IdType="doi">10.1002/mds.26347</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Arizona</li><li>Québec</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université McGill</li></orgName></list><tree><country name="Canada"><region name="Québec"><name sortKey="Postuma, Ronald B" sort="Postuma, Ronald B" uniqKey="Postuma R" first="Ronald B" last="Postuma">Ronald B. Postuma</name></region></country><country name="États-Unis"><region name="Arizona"><name sortKey="Adler, Charles H" sort="Adler, Charles H" uniqKey="Adler C" first="Charles H" last="Adler">Charles H. Adler</name></region><name sortKey="Beach, Thomas G" sort="Beach, Thomas G" uniqKey="Beach T" first="Thomas G" last="Beach">Thomas G. Beach</name><name sortKey="Belden, Christine M" sort="Belden, Christine M" uniqKey="Belden C" first="Christine M" last="Belden">Christine M. Belden</name><name sortKey="Driver Dunckley, Erika" sort="Driver Dunckley, Erika" uniqKey="Driver Dunckley E" first="Erika" last="Driver-Dunckley">Erika Driver-Dunckley</name><name sortKey="Dugger, Brittany N" sort="Dugger, Brittany N" uniqKey="Dugger B" first="Brittany N" last="Dugger">Brittany N. Dugger</name><name sortKey="Hentz, Joseph G" sort="Hentz, Joseph G" uniqKey="Hentz J" first="Joseph G" last="Hentz">Joseph G. Hentz</name><name sortKey="Jacobson, Sandra A" sort="Jacobson, Sandra A" uniqKey="Jacobson S" first="Sandra A" last="Jacobson">Sandra A. Jacobson</name><name sortKey="Sabbagh, Marwan N" sort="Sabbagh, Marwan N" uniqKey="Sabbagh M" first="Marwan N" last="Sabbagh">Marwan N. Sabbagh</name><name sortKey="Serrano, Geidy" sort="Serrano, Geidy" uniqKey="Serrano G" first="Geidy" last="Serrano">Geidy Serrano</name><name sortKey="Shill, Holly A" sort="Shill, Holly A" uniqKey="Shill H" first="Holly A" last="Shill">Holly A. Shill</name><name sortKey="Sue, Lucia I" sort="Sue, Lucia I" uniqKey="Sue L" first="Lucia I" last="Sue">Lucia I. Sue</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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