Rats anticipate damaged rungs on the elevated ladder: Applications for rodent models of Parkinson's disease.
Identifieur interne : 000406 ( PubMed/Checkpoint ); précédent : 000405; suivant : 000407Rats anticipate damaged rungs on the elevated ladder: Applications for rodent models of Parkinson's disease.
Auteurs : Daniel Lopatin [Canada] ; Nicole Caputo ; Chelsey Damphousse ; Siyaram Pandey ; Jerome CohenSource :
- Journal of integrative neuroscience [ 0219-6352 ] ; 2015.
English descriptors
- KwdEn :
- Analysis of Variance, Animals, Biomechanical Phenomena, Conditioning, Classical, Disease Models, Animal, Fear, Locomotion (physiology), Male, Motor Activity (physiology), Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Psychomotor Performance (physiology), Rats, Rats, Long-Evans, Time Factors.
- MESH :
- diagnosis : Parkinson Disease.
- physiology : Locomotion, Motor Activity, Psychomotor Performance.
- physiopathology : Parkinson Disease.
- Analysis of Variance, Animals, Biomechanical Phenomena, Conditioning, Classical, Disease Models, Animal, Fear, Male, Rats, Rats, Long-Evans, Time Factors.
Abstract
The present study examined rats' ability to anticipate undetectable wider gaps between rungs produced when they stepped on and dislodged damaged rungs while they traversed a slightly inclined elevated ladder. Rats in the first of three experiments reduced running speeds when they encountered four evenly spaced damaged rungs either always placed on the first or second half of the ladder (the break-a-way (BW) phase) but quickly recovered to their baseline (BL) levels when damaged rungs where replaced with intact rungs (the recovery phase). Rats previously exposed to damaged rungs over the first half of the ladder increased their speeds above BL on its second "safer" half during the recovery phase, a delayed "relief-like" positive contrast effect. In Experiment 2, other rats decreased their speeds more as they approached a single damaged rung at a fixed location when it occurred before than after the mid-point of the ladder. Although they quickly recovered to BL speeds on the portion of the ladder after the damaged rung or replaced intact rung, they never showed any "relief-like"/escape effects. Rats also reduced their likelihood of dislodging the damaged rung with a fore paw over extended BW training. In the third experiment rats encountered a more easily dislodged damaged rung that was signaled by a closer intact rung on half the trials. Under these conditions rats displayed a more reliable positive contrast "relief-like" effect. We discussed how traditional associative and cognitive theories of aversive conditioning account for these findings and their relationship to normal changes in dopamine production and possible effects of reduced production from the substantia nigra pars compacta (SNpc) in the Basal ganglia in rodent models of Parkinson's disease.
DOI: 10.1142/S0219635215500041
PubMed: 25747570
Affiliations:
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Chelsey" uniqKey="Damphousse C" first="Chelsey" last="Damphousse">Chelsey Damphousse</name></author><author><name sortKey="Pandey, Siyaram" sort="Pandey, Siyaram" uniqKey="Pandey S" first="Siyaram" last="Pandey">Siyaram Pandey</name></author><author><name sortKey="Cohen, Jerome" sort="Cohen, Jerome" uniqKey="Cohen J" first="Jerome" last="Cohen">Jerome Cohen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25747570</idno><idno type="pmid">25747570</idno><idno type="doi">10.1142/S0219635215500041</idno><idno type="wicri:Area/PubMed/Corpus">000556</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000556</idno><idno type="wicri:Area/PubMed/Curation">000556</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000556</idno><idno type="wicri:Area/PubMed/Checkpoint">000556</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" 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sortKey="Damphousse, Chelsey" sort="Damphousse, Chelsey" uniqKey="Damphousse C" first="Chelsey" last="Damphousse">Chelsey Damphousse</name></author><author><name sortKey="Pandey, Siyaram" sort="Pandey, Siyaram" uniqKey="Pandey S" first="Siyaram" last="Pandey">Siyaram Pandey</name></author><author><name sortKey="Cohen, Jerome" sort="Cohen, Jerome" uniqKey="Cohen J" first="Jerome" last="Cohen">Jerome Cohen</name></author></analytic><series><title level="j">Journal of integrative neuroscience</title><idno type="ISSN">0219-6352</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analysis of Variance</term><term>Animals</term><term>Biomechanical Phenomena</term><term>Conditioning, Classical</term><term>Disease Models, Animal</term><term>Fear</term><term>Locomotion (physiology)</term><term>Male</term><term>Motor Activity (physiology)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (physiopathology)</term><term>Psychomotor Performance (physiology)</term><term>Rats</term><term>Rats, Long-Evans</term><term>Time Factors</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Locomotion</term><term>Motor Activity</term><term>Psychomotor Performance</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term><term>Animals</term><term>Biomechanical Phenomena</term><term>Conditioning, Classical</term><term>Disease Models, Animal</term><term>Fear</term><term>Male</term><term>Rats</term><term>Rats, Long-Evans</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The present study examined rats' ability to anticipate undetectable wider gaps between rungs produced when they stepped on and dislodged damaged rungs while they traversed a slightly inclined elevated ladder. Rats in the first of three experiments reduced running speeds when they encountered four evenly spaced damaged rungs either always placed on the first or second half of the ladder (the break-a-way (BW) phase) but quickly recovered to their baseline (BL) levels when damaged rungs where replaced with intact rungs (the recovery phase). Rats previously exposed to damaged rungs over the first half of the ladder increased their speeds above BL on its second "safer" half during the recovery phase, a delayed "relief-like" positive contrast effect. In Experiment 2, other rats decreased their speeds more as they approached a single damaged rung at a fixed location when it occurred before than after the mid-point of the ladder. Although they quickly recovered to BL speeds on the portion of the ladder after the damaged rung or replaced intact rung, they never showed any "relief-like"/escape effects. Rats also reduced their likelihood of dislodging the damaged rung with a fore paw over extended BW training. In the third experiment rats encountered a more easily dislodged damaged rung that was signaled by a closer intact rung on half the trials. Under these conditions rats displayed a more reliable positive contrast "relief-like" effect. We discussed how traditional associative and cognitive theories of aversive conditioning account for these findings and their relationship to normal changes in dopamine production and possible effects of reduced production from the substantia nigra pars compacta (SNpc) in the Basal ganglia in rodent models of Parkinson's disease.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25747570</PMID><DateCreated><Year>2015</Year><Month>03</Month><Day>19</Day></DateCreated><DateCompleted><Year>2016</Year><Month>01</Month><Day>19</Day></DateCompleted><DateRevised><Year>2015</Year><Month>03</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0219-6352</ISSN><JournalIssue CitedMedium="Internet"><Volume>14</Volume><Issue>1</Issue><PubDate><Year>2015</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Journal of integrative neuroscience</Title><ISOAbbreviation>J. Integr. Neurosci.</ISOAbbreviation></Journal><ArticleTitle>Rats anticipate damaged rungs on the elevated ladder: Applications for rodent models of Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>97-120</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1142/S0219635215500041</ELocationID><Abstract><AbstractText>The present study examined rats' ability to anticipate undetectable wider gaps between rungs produced when they stepped on and dislodged damaged rungs while they traversed a slightly inclined elevated ladder. Rats in the first of three experiments reduced running speeds when they encountered four evenly spaced damaged rungs either always placed on the first or second half of the ladder (the break-a-way (BW) phase) but quickly recovered to their baseline (BL) levels when damaged rungs where replaced with intact rungs (the recovery phase). Rats previously exposed to damaged rungs over the first half of the ladder increased their speeds above BL on its second "safer" half during the recovery phase, a delayed "relief-like" positive contrast effect. In Experiment 2, other rats decreased their speeds more as they approached a single damaged rung at a fixed location when it occurred before than after the mid-point of the ladder. Although they quickly recovered to BL speeds on the portion of the ladder after the damaged rung or replaced intact rung, they never showed any "relief-like"/escape effects. Rats also reduced their likelihood of dislodging the damaged rung with a fore paw over extended BW training. In the third experiment rats encountered a more easily dislodged damaged rung that was signaled by a closer intact rung on half the trials. Under these conditions rats displayed a more reliable positive contrast "relief-like" effect. We discussed how traditional associative and cognitive theories of aversive conditioning account for these findings and their relationship to normal changes in dopamine production and possible effects of reduced production from the substantia nigra pars compacta (SNpc) in the Basal ganglia in rodent models of Parkinson's disease.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lopatin</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Departments of Psychology and Biology (Behaviour, Cognition & Neuroscience Program), University of Windsor, Windsor, Ontario, N9B 3P4, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Caputo</LastName><ForeName>Nicole</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Damphousse</LastName><ForeName>Chelsey</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Pandey</LastName><ForeName>Siyaram</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Cohen</LastName><ForeName>Jerome</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><Agency>Canadian Institutes of Health Research</Agency><Country>Canada</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>03</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Integr Neurosci</MedlineTA><NlmUniqueID>101156357</NlmUniqueID><ISSNLinking>0219-6352</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000704" MajorTopicYN="N">Analysis of 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MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011597" MajorTopicYN="N">Psychomotor Performance</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020318" MajorTopicYN="N">Rats, Long-Evans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Rattus norvegicus</Keyword><Keyword MajorTopicYN="N">anticipation</Keyword><Keyword MajorTopicYN="N">associative processes</Keyword><Keyword MajorTopicYN="N">elevated ladder</Keyword><Keyword MajorTopicYN="N">skilled walking</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>3</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>3</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>1</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25747570</ArticleId><ArticleId IdType="doi">10.1142/S0219635215500041</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Caputo, Nicole" sort="Caputo, Nicole" uniqKey="Caputo N" first="Nicole" last="Caputo">Nicole Caputo</name><name sortKey="Cohen, Jerome" sort="Cohen, Jerome" uniqKey="Cohen J" first="Jerome" last="Cohen">Jerome Cohen</name><name sortKey="Damphousse, Chelsey" sort="Damphousse, Chelsey" uniqKey="Damphousse C" first="Chelsey" last="Damphousse">Chelsey Damphousse</name><name sortKey="Pandey, Siyaram" sort="Pandey, Siyaram" uniqKey="Pandey S" first="Siyaram" last="Pandey">Siyaram Pandey</name></noCountry><country name="Canada"><noRegion><name sortKey="Lopatin, Daniel" sort="Lopatin, Daniel" uniqKey="Lopatin D" first="Daniel" last="Lopatin">Daniel Lopatin</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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