A descending dopamine pathway conserved from basal vertebrates to mammals.
Identifieur interne : 000334 ( PubMed/Checkpoint ); précédent : 000333; suivant : 000335A descending dopamine pathway conserved from basal vertebrates to mammals.
Auteurs : Dimitri Ryczko [Canada] ; Jackson J. Cone [États-Unis] ; Michael H. Alpert [États-Unis] ; Laurent Goetz [Canada] ; François Auclair [Canada] ; Catherine Dubé [Canada] ; Martin Parent [Canada] ; Mitchell F. Roitman [États-Unis] ; Simon Alford [États-Unis] ; Réjean Dubuc [Oman]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 1091-6490 ] ; 2016.
English descriptors
- KwdEn :
- Aged, Animals, Biological Evolution, Brain Stem (physiology), Corpus Striatum (physiology), Dopamine, Dopaminergic Neurons (physiology), Female, Humans, Lampreys (physiology), Locomotion (physiology), Male, Motor Cortex (physiology), Pedunculopontine Tegmental Nucleus (physiology), Rats, Rats, Sprague-Dawley, Rats, Transgenic, Urodela (physiology).
- MESH :
- chemical : Dopamine.
- physiology : Brain Stem, Corpus Striatum, Dopaminergic Neurons, Lampreys, Locomotion, Motor Cortex, Pedunculopontine Tegmental Nucleus, Urodela.
- Aged, Animals, Biological Evolution, Female, Humans, Male, Rats, Rats, Sprague-Dawley, Rats, Transgenic.
Abstract
Dopamine neurons are classically known to modulate locomotion indirectly through ascending projections to the basal ganglia that project down to brainstem locomotor networks. Their loss in Parkinson's disease is devastating. In lampreys, we recently showed that brainstem networks also receive direct descending dopaminergic inputs that potentiate locomotor output. Here, we provide evidence that this descending dopaminergic pathway is conserved to higher vertebrates, including mammals. In salamanders, dopamine neurons projecting to the striatum or brainstem locomotor networks were partly intermingled. Stimulation of the dopaminergic region evoked dopamine release in brainstem locomotor networks and concurrent reticulospinal activity. In rats, some dopamine neurons projecting to the striatum also innervated the pedunculopontine nucleus, a known locomotor center, and stimulation of the dopaminergic region evoked pedunculopontine dopamine release in vivo. Finally, we found dopaminergic fibers in the human pedunculopontine nucleus. The conservation of a descending dopaminergic pathway across vertebrates warrants re-evaluating dopamine's role in locomotion.
DOI: 10.1073/pnas.1600684113
PubMed: 27071118
Affiliations:
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pubmed:27071118Le document en format XML
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Roitman</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychology, University of Illinois, Chicago, IL 60607;</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Psychology, University of Illinois, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Alford, Simon" sort="Alford, Simon" uniqKey="Alford S" first="Simon" last="Alford">Simon Alford</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607;</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Biological Sciences, University of Illinois at Chicago, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Dubuc, Rejean" sort="Dubuc, Rejean" uniqKey="Dubuc R" first="Réjean" last="Dubuc">Réjean Dubuc</name><affiliation wicri:level="1"><nlm:affiliation>Groupe de Recherche sur le Système Nerveux Central, Département de Neurosciences, Université de Montréal, Montreal, QC, Canada H3C 3J7; Département des Sciences de l'Activité Physique, Université du Québec à Montréal, Montreal, QC, Canada H3C 3P8 rejean.dubuc@gmail.com.</nlm:affiliation><country wicri:rule="url">Oman</country><wicri:regionArea>Groupe de Recherche sur le Système Nerveux Central, Département de Neurosciences, Université de Montréal, Montreal, QC, Canada H3C 3J7; Département des Sciences de l'Activité Physique, Université du Québec à Montréal, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="eISSN">1091-6490</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Animals</term><term>Biological Evolution</term><term>Brain Stem (physiology)</term><term>Corpus Striatum (physiology)</term><term>Dopamine</term><term>Dopaminergic Neurons (physiology)</term><term>Female</term><term>Humans</term><term>Lampreys (physiology)</term><term>Locomotion (physiology)</term><term>Male</term><term>Motor Cortex (physiology)</term><term>Pedunculopontine Tegmental Nucleus (physiology)</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Rats, Transgenic</term><term>Urodela (physiology)</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Brain Stem</term><term>Corpus Striatum</term><term>Dopaminergic Neurons</term><term>Lampreys</term><term>Locomotion</term><term>Motor Cortex</term><term>Pedunculopontine Tegmental Nucleus</term><term>Urodela</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Animals</term><term>Biological Evolution</term><term>Female</term><term>Humans</term><term>Male</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Rats, Transgenic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dopamine neurons are classically known to modulate locomotion indirectly through ascending projections to the basal ganglia that project down to brainstem locomotor networks. Their loss in Parkinson's disease is devastating. In lampreys, we recently showed that brainstem networks also receive direct descending dopaminergic inputs that potentiate locomotor output. Here, we provide evidence that this descending dopaminergic pathway is conserved to higher vertebrates, including mammals. In salamanders, dopamine neurons projecting to the striatum or brainstem locomotor networks were partly intermingled. Stimulation of the dopaminergic region evoked dopamine release in brainstem locomotor networks and concurrent reticulospinal activity. In rats, some dopamine neurons projecting to the striatum also innervated the pedunculopontine nucleus, a known locomotor center, and stimulation of the dopaminergic region evoked pedunculopontine dopamine release in vivo. Finally, we found dopaminergic fibers in the human pedunculopontine nucleus. The conservation of a descending dopaminergic pathway across vertebrates warrants re-evaluating dopamine's role in locomotion.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27071118</PMID><DateCreated><Year>2016</Year><Month>04</Month><Day>27</Day></DateCreated><DateCompleted><Year>2016</Year><Month>12</Month><Day>13</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1091-6490</ISSN><JournalIssue CitedMedium="Internet"><Volume>113</Volume><Issue>17</Issue><PubDate><Year>2016</Year><Month>Apr</Month><Day>26</Day></PubDate></JournalIssue><Title>Proceedings of the National Academy of Sciences of the United States of America</Title><ISOAbbreviation>Proc. Natl. Acad. Sci. U.S.A.</ISOAbbreviation></Journal><ArticleTitle>A descending dopamine pathway conserved from basal vertebrates to mammals.</ArticleTitle><Pagination><MedlinePgn>E2440-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1073/pnas.1600684113</ELocationID><Abstract><AbstractText>Dopamine neurons are classically known to modulate locomotion indirectly through ascending projections to the basal ganglia that project down to brainstem locomotor networks. Their loss in Parkinson's disease is devastating. In lampreys, we recently showed that brainstem networks also receive direct descending dopaminergic inputs that potentiate locomotor output. Here, we provide evidence that this descending dopaminergic pathway is conserved to higher vertebrates, including mammals. In salamanders, dopamine neurons projecting to the striatum or brainstem locomotor networks were partly intermingled. Stimulation of the dopaminergic region evoked dopamine release in brainstem locomotor networks and concurrent reticulospinal activity. In rats, some dopamine neurons projecting to the striatum also innervated the pedunculopontine nucleus, a known locomotor center, and stimulation of the dopaminergic region evoked pedunculopontine dopamine release in vivo. Finally, we found dopaminergic fibers in the human pedunculopontine nucleus. The conservation of a descending dopaminergic pathway across vertebrates warrants re-evaluating dopamine's role in locomotion.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ryczko</LastName><ForeName>Dimitri</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Groupe de Recherche sur le Système Nerveux Central, Département de Neurosciences, Université de Montréal, Montreal, QC, Canada H3C 3J7;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cone</LastName><ForeName>Jackson J</ForeName><Initials>JJ</Initials><AffiliationInfo><Affiliation>Department of Psychology, University of Illinois, Chicago, IL 60607;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alpert</LastName><ForeName>Michael H</ForeName><Initials>MH</Initials><AffiliationInfo><Affiliation>Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goetz</LastName><ForeName>Laurent</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Neuroscience, Faculty of Medicine, Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec, Université Laval, Quebec, QC, Canada G1J 2G3;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Auclair</LastName><ForeName>François</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Groupe de Recherche sur le Système Nerveux Central, Département de Neurosciences, Université de Montréal, Montreal, QC, Canada H3C 3J7;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dubé</LastName><ForeName>Catherine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Groupe de Recherche sur le Système Nerveux Central, Département de Neurosciences, Université de Montréal, Montreal, QC, Canada H3C 3J7;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Parent</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Neuroscience, Faculty of Medicine, Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec, Université Laval, Quebec, QC, Canada G1J 2G3;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Roitman</LastName><ForeName>Mitchell F</ForeName><Initials>MF</Initials><AffiliationInfo><Affiliation>Department of Psychology, University of Illinois, Chicago, IL 60607;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alford</LastName><ForeName>Simon</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dubuc</LastName><ForeName>Réjean</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Groupe de Recherche sur le Système Nerveux Central, Département de Neurosciences, Université de Montréal, Montreal, QC, Canada H3C 3J7; Département des Sciences de l'Activité Physique, Université du Québec à Montréal, Montreal, QC, Canada H3C 3P8 rejean.dubuc@gmail.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>15129</GrantID><Agency>CIHR</Agency><Country>Canada</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>04</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Proc Natl Acad Sci U S A</MedlineTA><NlmUniqueID>7505876</NlmUniqueID><ISSNLinking>0027-8424</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>VTD58H1Z2X</RegistryNumber><NameOfSubstance UI="D004298">Dopamine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Science. 1997 Mar 14;275(5306):1593-9</RefSource><PMID Version="1">9054347</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lab Chip. 2012 Jul 7;12(13):2403-8</RefSource><PMID Version="1">22522908</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Comp Neurol. 1988 Jul 8;273(2):187-206</RefSource><PMID Version="1">2458392</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2004 Jun 2;24(22):5131-9</RefSource><PMID Version="1">15175382</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Anal Chem. 2010 Jun 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MajorTopicYN="N">Dopamine</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D059290" MajorTopicYN="N">Dopaminergic Neurons</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007798" MajorTopicYN="N">Lampreys</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008124" MajorTopicYN="N">Locomotion</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009044" MajorTopicYN="N">Motor Cortex</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045042" MajorTopicYN="N">Pedunculopontine Tegmental Nucleus</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017207" MajorTopicYN="N">Rats, Sprague-Dawley</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055647" MajorTopicYN="N">Rats, Transgenic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014562" MajorTopicYN="N">Urodela</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4855556</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Parkinson disease</Keyword><Keyword MajorTopicYN="N">brainstem</Keyword><Keyword MajorTopicYN="N">conservation</Keyword><Keyword MajorTopicYN="N">dopamine</Keyword><Keyword MajorTopicYN="N">motor system</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>4</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>4</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>12</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27071118</ArticleId><ArticleId IdType="pii">1600684113</ArticleId><ArticleId IdType="doi">10.1073/pnas.1600684113</ArticleId><ArticleId IdType="pmc">PMC4855556</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li><li>Oman</li><li>États-Unis</li></country><region><li>Illinois</li></region></list><tree><country name="Canada"><noRegion><name sortKey="Ryczko, Dimitri" sort="Ryczko, Dimitri" uniqKey="Ryczko D" first="Dimitri" last="Ryczko">Dimitri Ryczko</name></noRegion><name sortKey="Auclair, Francois" sort="Auclair, Francois" uniqKey="Auclair F" first="François" last="Auclair">François Auclair</name><name sortKey="Dube, Catherine" sort="Dube, Catherine" uniqKey="Dube C" first="Catherine" last="Dubé">Catherine Dubé</name><name sortKey="Goetz, Laurent" sort="Goetz, Laurent" uniqKey="Goetz L" first="Laurent" last="Goetz">Laurent Goetz</name><name sortKey="Parent, Martin" sort="Parent, Martin" uniqKey="Parent M" first="Martin" last="Parent">Martin Parent</name></country><country name="États-Unis"><region name="Illinois"><name sortKey="Cone, Jackson J" sort="Cone, Jackson J" uniqKey="Cone J" first="Jackson J" last="Cone">Jackson J. Cone</name></region><name sortKey="Alford, Simon" sort="Alford, Simon" uniqKey="Alford S" first="Simon" last="Alford">Simon Alford</name><name sortKey="Alpert, Michael H" sort="Alpert, Michael H" uniqKey="Alpert M" first="Michael H" last="Alpert">Michael H. Alpert</name><name sortKey="Roitman, Mitchell F" sort="Roitman, Mitchell F" uniqKey="Roitman M" first="Mitchell F" last="Roitman">Mitchell F. Roitman</name></country><country name="Oman"><noRegion><name sortKey="Dubuc, Rejean" sort="Dubuc, Rejean" uniqKey="Dubuc R" first="Réjean" last="Dubuc">Réjean Dubuc</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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