Bilateral deep brain stimulation of the fornix for Alzheimer's disease: surgical safety in the ADvance trial.
Identifieur interne : 000311 ( PubMed/Checkpoint ); précédent : 000310; suivant : 000312Bilateral deep brain stimulation of the fornix for Alzheimer's disease: surgical safety in the ADvance trial.
Auteurs : Francisco A. Ponce ; Wael F. Asaad ; Kelly D. Foote ; William S. Anderson ; G. Rees Cosgrove ; Gordon H. Baltuch [États-Unis] ; Kara Beasley [États-Unis] ; Donald E. Reymers ; Esther S. Oh ; Steven D. Targum ; Gwenn S. Smith [États-Unis] ; Constantine G. Lyketsos [États-Unis] ; Andres M. Lozano [Canada]Source :
- Journal of neurosurgery [ 1933-0693 ] ; 2016.
Abstract
OBJECT This report describes the stereotactic technique, hospitalization, and 90-day perioperative safety of bilateral deep brain stimulation (DBS) of the fornix in patients who underwent DBS for the treatment of mild, probable Alzheimer's disease (AD). METHODS The ADvance Trial is a multicenter, 12-month, double-blind, randomized, controlled feasibility study being conducted to evaluate the safety, efficacy, and tolerability of DBS of the fornix in patients with mild, probable AD. Intraoperative and perioperative data were collected prospectively. All patients underwent postoperative MRI. Stereotactic analyses were performed in a blinded fashion by a single surgeon. Adverse events (AEs) were reported to an independent clinical events committee and adjudicated to determine the relationship between the AE and the study procedure. RESULTS Between June 6, 2012, and April 28, 2014, a total of 42 patients with mild, probable AD were treated with bilateral fornix DBS (mean age 68.2 ± 7.8 years; range 48.0-79.7 years; 23 men and 19 women). The mean planned target coordinates were x = 5.2 ± 1.0 mm (range 3.0-7.9 mm), y = 9.6 ± 0.9 mm (range 8.0-11.6 mm), z = -7.5 ± 1.2 mm (range -5.4 to -10.0 mm), and the mean postoperative stereotactic radial error on MRI was 1.5 ± 1.0 mm (range 0.2-4.0 mm). The mean length of hospitalization was 1.4 ± 0.8 days. Twenty-six (61.9%) patients experienced 64 AEs related to the study procedure, of which 7 were serious AEs experienced by 5 patients (11.9%). Four (9.5%) patients required return to surgery: 2 patients for explantation due to infection, 1 patient for lead repositioning, and 1 patient for chronic subdural hematoma. No patients experienced neurological deficits as a result of the study, and no deaths were reported. CONCLUSIONS Accurate targeting of DBS to the fornix without direct injury to it is feasible across surgeons and treatment centers. At 90 days after surgery, bilateral fornix DBS was well tolerated by patients with mild, probable AD. Clinical trial registration no.: NCT01608061 ( clinicaltrials.gov ).
DOI: 10.3171/2015.6.JNS15716
PubMed: 26684775
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Bilateral deep brain stimulation of the fornix for Alzheimer's disease: surgical safety in the ADvance trial.</title><author><name sortKey="Ponce, Francisco A" sort="Ponce, Francisco A" uniqKey="Ponce F" first="Francisco A" last="Ponce">Francisco A. Ponce</name><affiliation><nlm:affiliation>Division of Neurological Surgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona; </nlm:affiliation><wicri:noCountry code="subField">Arizona; </wicri:noCountry></affiliation></author><author><name sortKey="Asaad, Wael F" sort="Asaad, Wael F" uniqKey="Asaad W" first="Wael F" last="Asaad">Wael F. Asaad</name><affiliation><nlm:affiliation>Departments of 2 Neurosurgery and.</nlm:affiliation><wicri:noCountry code="no comma">Departments of 2 Neurosurgery and.</wicri:noCountry></affiliation></author><author><name sortKey="Foote, Kelly D" sort="Foote, Kelly D" uniqKey="Foote K" first="Kelly D" last="Foote">Kelly D. Foote</name><affiliation><nlm:affiliation>Department of Neurosurgery, University of Florida, Gainesville, Florida; </nlm:affiliation><wicri:noCountry code="subField">Florida; </wicri:noCountry></affiliation></author><author><name sortKey="Anderson, William S" sort="Anderson, William S" uniqKey="Anderson W" first="William S" last="Anderson">William S. Anderson</name><affiliation><nlm:affiliation>Departments of 5 Neurological Surgery.</nlm:affiliation><wicri:noCountry code="no comma">Departments of 5 Neurological Surgery.</wicri:noCountry></affiliation></author><author><name sortKey="Rees Cosgrove, G" sort="Rees Cosgrove, G" uniqKey="Rees Cosgrove G" first="G" last="Rees Cosgrove">G. Rees Cosgrove</name><affiliation><nlm:affiliation>Departments of 2 Neurosurgery and.</nlm:affiliation><wicri:noCountry code="no comma">Departments of 2 Neurosurgery and.</wicri:noCountry></affiliation></author><author><name sortKey="Baltuch, Gordon H" sort="Baltuch, Gordon H" uniqKey="Baltuch G" first="Gordon H" last="Baltuch">Gordon H. Baltuch</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania;</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Neurosurgery, University of Pennsylvania, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Beasley, Kara" sort="Beasley, Kara" uniqKey="Beasley K" first="Kara" last="Beasley">Kara Beasley</name><affiliation wicri:level="2"><nlm:affiliation>Boulder Neurosurgical & Spine Associates, Boulder, Colorado;</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Colorado</region></placeName><wicri:cityArea>Boulder Neurosurgical & Spine Associates, Boulder</wicri:cityArea></affiliation></author><author><name sortKey="Reymers, Donald E" sort="Reymers, Donald E" uniqKey="Reymers D" first="Donald E" last="Reymers">Donald E. Reymers</name><affiliation><nlm:affiliation>Functional Neuromodulation Ltd., Minneapolis, Minnesota; and.</nlm:affiliation><wicri:noCountry code="subField">Minnesota; and</wicri:noCountry></affiliation></author><author><name sortKey="Oh, Esther S" sort="Oh, Esther S" uniqKey="Oh E" first="Esther S" last="Oh">Esther S. Oh</name><affiliation><nlm:affiliation>Medicine, and.</nlm:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Targum, Steven D" sort="Targum, Steven D" uniqKey="Targum S" first="Steven D" last="Targum">Steven D. Targum</name><affiliation><nlm:affiliation>Functional Neuromodulation Ltd., Minneapolis, Minnesota; and.</nlm:affiliation><wicri:noCountry code="subField">Minnesota; and</wicri:noCountry></affiliation></author><author><name sortKey="Smith, Gwenn S" sort="Smith, Gwenn S" uniqKey="Smith G" first="Gwenn S" last="Smith">Gwenn S. Smith</name><affiliation wicri:level="2"><nlm:affiliation>Psychiatry, Johns Hopkins University, Baltimore, Maryland;</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Psychiatry, Johns Hopkins University, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Lyketsos, Constantine G" sort="Lyketsos, Constantine G" uniqKey="Lyketsos C" first="Constantine G" last="Lyketsos">Constantine G. Lyketsos</name><affiliation wicri:level="2"><nlm:affiliation>Psychiatry, Johns Hopkins University, Baltimore, Maryland;</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Psychiatry, Johns Hopkins University, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name><affiliation wicri:level="4"><nlm:affiliation>Division of Neurosurgery, University of Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurosurgery, University of Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26684775</idno><idno type="pmid">26684775</idno><idno type="doi">10.3171/2015.6.JNS15716</idno><idno type="wicri:Area/PubMed/Corpus">000207</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000207</idno><idno type="wicri:Area/PubMed/Curation">000207</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000207</idno><idno type="wicri:Area/PubMed/Checkpoint">000207</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000207</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Bilateral deep brain stimulation of the fornix for Alzheimer's disease: surgical safety in the ADvance trial.</title><author><name sortKey="Ponce, Francisco A" sort="Ponce, Francisco A" uniqKey="Ponce F" first="Francisco A" last="Ponce">Francisco A. Ponce</name><affiliation><nlm:affiliation>Division of Neurological Surgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona; </nlm:affiliation><wicri:noCountry code="subField">Arizona; </wicri:noCountry></affiliation></author><author><name sortKey="Asaad, Wael F" sort="Asaad, Wael F" uniqKey="Asaad W" first="Wael F" last="Asaad">Wael F. Asaad</name><affiliation><nlm:affiliation>Departments of 2 Neurosurgery and.</nlm:affiliation><wicri:noCountry code="no comma">Departments of 2 Neurosurgery and.</wicri:noCountry></affiliation></author><author><name sortKey="Foote, Kelly D" sort="Foote, Kelly D" uniqKey="Foote K" first="Kelly D" last="Foote">Kelly D. Foote</name><affiliation><nlm:affiliation>Department of Neurosurgery, University of Florida, Gainesville, Florida; </nlm:affiliation><wicri:noCountry code="subField">Florida; </wicri:noCountry></affiliation></author><author><name sortKey="Anderson, William S" sort="Anderson, William S" uniqKey="Anderson W" first="William S" last="Anderson">William S. Anderson</name><affiliation><nlm:affiliation>Departments of 5 Neurological Surgery.</nlm:affiliation><wicri:noCountry code="no comma">Departments of 5 Neurological Surgery.</wicri:noCountry></affiliation></author><author><name sortKey="Rees Cosgrove, G" sort="Rees Cosgrove, G" uniqKey="Rees Cosgrove G" first="G" last="Rees Cosgrove">G. Rees Cosgrove</name><affiliation><nlm:affiliation>Departments of 2 Neurosurgery and.</nlm:affiliation><wicri:noCountry code="no comma">Departments of 2 Neurosurgery and.</wicri:noCountry></affiliation></author><author><name sortKey="Baltuch, Gordon H" sort="Baltuch, Gordon H" uniqKey="Baltuch G" first="Gordon H" last="Baltuch">Gordon H. Baltuch</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania;</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Neurosurgery, University of Pennsylvania, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Beasley, Kara" sort="Beasley, Kara" uniqKey="Beasley K" first="Kara" last="Beasley">Kara Beasley</name><affiliation wicri:level="2"><nlm:affiliation>Boulder Neurosurgical & Spine Associates, Boulder, Colorado;</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Colorado</region></placeName><wicri:cityArea>Boulder Neurosurgical & Spine Associates, Boulder</wicri:cityArea></affiliation></author><author><name sortKey="Reymers, Donald E" sort="Reymers, Donald E" uniqKey="Reymers D" first="Donald E" last="Reymers">Donald E. Reymers</name><affiliation><nlm:affiliation>Functional Neuromodulation Ltd., Minneapolis, Minnesota; and.</nlm:affiliation><wicri:noCountry code="subField">Minnesota; and</wicri:noCountry></affiliation></author><author><name sortKey="Oh, Esther S" sort="Oh, Esther S" uniqKey="Oh E" first="Esther S" last="Oh">Esther S. Oh</name><affiliation><nlm:affiliation>Medicine, and.</nlm:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Targum, Steven D" sort="Targum, Steven D" uniqKey="Targum S" first="Steven D" last="Targum">Steven D. Targum</name><affiliation><nlm:affiliation>Functional Neuromodulation Ltd., Minneapolis, Minnesota; and.</nlm:affiliation><wicri:noCountry code="subField">Minnesota; and</wicri:noCountry></affiliation></author><author><name sortKey="Smith, Gwenn S" sort="Smith, Gwenn S" uniqKey="Smith G" first="Gwenn S" last="Smith">Gwenn S. Smith</name><affiliation wicri:level="2"><nlm:affiliation>Psychiatry, Johns Hopkins University, Baltimore, Maryland;</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Psychiatry, Johns Hopkins University, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Lyketsos, Constantine G" sort="Lyketsos, Constantine G" uniqKey="Lyketsos C" first="Constantine G" last="Lyketsos">Constantine G. Lyketsos</name><affiliation wicri:level="2"><nlm:affiliation>Psychiatry, Johns Hopkins University, Baltimore, Maryland;</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Psychiatry, Johns Hopkins University, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name><affiliation wicri:level="4"><nlm:affiliation>Division of Neurosurgery, University of Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurosurgery, University of Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author></analytic><series><title level="j">Journal of neurosurgery</title><idno type="eISSN">1933-0693</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">OBJECT This report describes the stereotactic technique, hospitalization, and 90-day perioperative safety of bilateral deep brain stimulation (DBS) of the fornix in patients who underwent DBS for the treatment of mild, probable Alzheimer's disease (AD). METHODS The ADvance Trial is a multicenter, 12-month, double-blind, randomized, controlled feasibility study being conducted to evaluate the safety, efficacy, and tolerability of DBS of the fornix in patients with mild, probable AD. Intraoperative and perioperative data were collected prospectively. All patients underwent postoperative MRI. Stereotactic analyses were performed in a blinded fashion by a single surgeon. Adverse events (AEs) were reported to an independent clinical events committee and adjudicated to determine the relationship between the AE and the study procedure. RESULTS Between June 6, 2012, and April 28, 2014, a total of 42 patients with mild, probable AD were treated with bilateral fornix DBS (mean age 68.2 ± 7.8 years; range 48.0-79.7 years; 23 men and 19 women). The mean planned target coordinates were x = 5.2 ± 1.0 mm (range 3.0-7.9 mm), y = 9.6 ± 0.9 mm (range 8.0-11.6 mm), z = -7.5 ± 1.2 mm (range -5.4 to -10.0 mm), and the mean postoperative stereotactic radial error on MRI was 1.5 ± 1.0 mm (range 0.2-4.0 mm). The mean length of hospitalization was 1.4 ± 0.8 days. Twenty-six (61.9%) patients experienced 64 AEs related to the study procedure, of which 7 were serious AEs experienced by 5 patients (11.9%). Four (9.5%) patients required return to surgery: 2 patients for explantation due to infection, 1 patient for lead repositioning, and 1 patient for chronic subdural hematoma. No patients experienced neurological deficits as a result of the study, and no deaths were reported. CONCLUSIONS Accurate targeting of DBS to the fornix without direct injury to it is feasible across surgeons and treatment centers. At 90 days after surgery, bilateral fornix DBS was well tolerated by patients with mild, probable AD. Clinical trial registration no.: NCT01608061 ( clinicaltrials.gov ).</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">26684775</PMID><DateCreated><Year>2016</Year><Month>07</Month><Day>01</Day></DateCreated><DateRevised><Year>2017</Year><Month>02</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1933-0693</ISSN><JournalIssue CitedMedium="Internet"><Volume>125</Volume><Issue>1</Issue><PubDate><Year>2016</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Journal of neurosurgery</Title><ISOAbbreviation>J. Neurosurg.</ISOAbbreviation></Journal><ArticleTitle>Bilateral deep brain stimulation of the fornix for Alzheimer's disease: surgical safety in the ADvance trial.</ArticleTitle><Pagination><MedlinePgn>75-84</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3171/2015.6.JNS15716</ELocationID><Abstract><AbstractText>OBJECT This report describes the stereotactic technique, hospitalization, and 90-day perioperative safety of bilateral deep brain stimulation (DBS) of the fornix in patients who underwent DBS for the treatment of mild, probable Alzheimer's disease (AD). METHODS The ADvance Trial is a multicenter, 12-month, double-blind, randomized, controlled feasibility study being conducted to evaluate the safety, efficacy, and tolerability of DBS of the fornix in patients with mild, probable AD. Intraoperative and perioperative data were collected prospectively. All patients underwent postoperative MRI. Stereotactic analyses were performed in a blinded fashion by a single surgeon. Adverse events (AEs) were reported to an independent clinical events committee and adjudicated to determine the relationship between the AE and the study procedure. RESULTS Between June 6, 2012, and April 28, 2014, a total of 42 patients with mild, probable AD were treated with bilateral fornix DBS (mean age 68.2 ± 7.8 years; range 48.0-79.7 years; 23 men and 19 women). The mean planned target coordinates were x = 5.2 ± 1.0 mm (range 3.0-7.9 mm), y = 9.6 ± 0.9 mm (range 8.0-11.6 mm), z = -7.5 ± 1.2 mm (range -5.4 to -10.0 mm), and the mean postoperative stereotactic radial error on MRI was 1.5 ± 1.0 mm (range 0.2-4.0 mm). The mean length of hospitalization was 1.4 ± 0.8 days. Twenty-six (61.9%) patients experienced 64 AEs related to the study procedure, of which 7 were serious AEs experienced by 5 patients (11.9%). Four (9.5%) patients required return to surgery: 2 patients for explantation due to infection, 1 patient for lead repositioning, and 1 patient for chronic subdural hematoma. No patients experienced neurological deficits as a result of the study, and no deaths were reported. CONCLUSIONS Accurate targeting of DBS to the fornix without direct injury to it is feasible across surgeons and treatment centers. At 90 days after surgery, bilateral fornix DBS was well tolerated by patients with mild, probable AD. Clinical trial registration no.: NCT01608061 ( clinicaltrials.gov ).</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ponce</LastName><ForeName>Francisco A</ForeName><Initials>FA</Initials><AffiliationInfo><Affiliation>Division of Neurological Surgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona; </Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Asaad</LastName><ForeName>Wael F</ForeName><Initials>WF</Initials><AffiliationInfo><Affiliation>Departments of 2 Neurosurgery and.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Neuroscience, Brown University and Rhode Island Hospital, Providence, Rhode Island;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Foote</LastName><ForeName>Kelly D</ForeName><Initials>KD</Initials><AffiliationInfo><Affiliation>Department of Neurosurgery, University of Florida, Gainesville, Florida; </Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Anderson</LastName><ForeName>William S</ForeName><Initials>WS</Initials><AffiliationInfo><Affiliation>Departments of 5 Neurological Surgery.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rees Cosgrove</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Departments of 2 Neurosurgery and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baltuch</LastName><ForeName>Gordon H</ForeName><Initials>GH</Initials><AffiliationInfo><Affiliation>Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beasley</LastName><ForeName>Kara</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Boulder Neurosurgical & Spine Associates, Boulder, Colorado;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reymers</LastName><ForeName>Donald E</ForeName><Initials>DE</Initials><AffiliationInfo><Affiliation>Functional Neuromodulation Ltd., Minneapolis, Minnesota; and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oh</LastName><ForeName>Esther S</ForeName><Initials>ES</Initials><AffiliationInfo><Affiliation>Medicine, and.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Psychiatry, Johns Hopkins University, Baltimore, Maryland;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Targum</LastName><ForeName>Steven D</ForeName><Initials>SD</Initials><AffiliationInfo><Affiliation>Functional Neuromodulation Ltd., Minneapolis, Minnesota; and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>Gwenn S</ForeName><Initials>GS</Initials><AffiliationInfo><Affiliation>Psychiatry, Johns Hopkins University, Baltimore, Maryland;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lyketsos</LastName><ForeName>Constantine G</ForeName><Initials>CG</Initials><AffiliationInfo><Affiliation>Psychiatry, Johns Hopkins University, Baltimore, Maryland;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lozano</LastName><ForeName>Andres M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Division of Neurosurgery, University of Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName> for The ADvance Research Group</CollectiveName></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT01608061</AccessionNumber></AccessionNumberList></DataBank></DataBankList><GrantList CompleteYN="Y"><Grant><GrantID>R01 AG042165</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AG041633</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AG038893</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R33 AG037298</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 MH086881</GrantID><Acronym>MH</Acronym><Agency>NIMH NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R21 AG037298</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>12</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Neurosurg</MedlineTA><NlmUniqueID>0253357</NlmUniqueID><ISSNLinking>0022-3085</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Stereotact Funct Neurosurg. 2012;90(1):20-4</RefSource><PMID Version="1">22190056</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Front Neurol. 2012 Apr 26;3:66</RefSource><PMID Version="1">22557991</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Epilepsia. 2006 Jul;47(7):1203-12</RefSource><PMID Version="1">16886984</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurologist. 2007 Sep;13(5):253-60</RefSource><PMID Version="1">17848865</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>AJNR Am J Neuroradiol. 1991 Nov-Dec;12(6):1217-22</RefSource><PMID Version="1">1763757</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain Stimul. 2015 May-Jun;8(3):645-54</RefSource><PMID Version="1">25814404</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurosurgery. 2008 Feb;62(2):360-6; 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discussion 762-3</RefSource><PMID Version="1">19349834</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosurg. 2013 Aug;119(2):301-6</RefSource><PMID Version="1">23724986</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 2012 Sep;69(9):1141-8</RefSource><PMID Version="1">22566505</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosurg. 2014 Jan;120(1):132-9</RefSource><PMID Version="1">24236657</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Psychiatry. 1984 Nov;141(11):1356-64</RefSource><PMID Version="1">6496779</PMID></CommentsCorrections></CommentsCorrectionsList><OtherID Source="NLM">NIHMS771557 [Available on 07/01/17]</OtherID><OtherID Source="NLM">PMC4912949 [Available on 07/01/17]</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">AD = Alzheimer's disease</Keyword><Keyword MajorTopicYN="N">ADAS-cog-11 = Alzheimer's Disease Assessment Scale cognitive subscale</Keyword><Keyword MajorTopicYN="N">AE = adverse event</Keyword><Keyword MajorTopicYN="N">Alzheimer's disease</Keyword><Keyword MajorTopicYN="N">DBS = deep brain stimulation</Keyword><Keyword MajorTopicYN="N">DBS-f = deep brain stimulation of the fornix</Keyword><Keyword MajorTopicYN="N">IPG = internal pulse generator</Keyword><Keyword MajorTopicYN="N">PD = Parkinson's disease</Keyword><Keyword MajorTopicYN="N">SAE = serious adverse event</Keyword><Keyword MajorTopicYN="N">deep brain stimulation</Keyword><Keyword MajorTopicYN="N">dementia</Keyword><Keyword MajorTopicYN="N">fornix</Keyword><Keyword MajorTopicYN="N">functional neurosurgery</Keyword><Keyword MajorTopicYN="N">memory</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pmc-release"><Year>2017</Year><Month>07</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>12</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>12</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>12</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26684775</ArticleId><ArticleId IdType="doi">10.3171/2015.6.JNS15716</ArticleId><ArticleId IdType="pmc">PMC4912949</ArticleId><ArticleId IdType="mid">NIHMS771557</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Colorado</li><li>Maryland</li><li>Ontario</li><li>Pennsylvanie</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><noCountry><name sortKey="Anderson, William S" sort="Anderson, William S" uniqKey="Anderson W" first="William S" last="Anderson">William S. Anderson</name><name sortKey="Asaad, Wael F" sort="Asaad, Wael F" uniqKey="Asaad W" first="Wael F" last="Asaad">Wael F. Asaad</name><name sortKey="Foote, Kelly D" sort="Foote, Kelly D" uniqKey="Foote K" first="Kelly D" last="Foote">Kelly D. Foote</name><name sortKey="Oh, Esther S" sort="Oh, Esther S" uniqKey="Oh E" first="Esther S" last="Oh">Esther S. Oh</name><name sortKey="Ponce, Francisco A" sort="Ponce, Francisco A" uniqKey="Ponce F" first="Francisco A" last="Ponce">Francisco A. Ponce</name><name sortKey="Rees Cosgrove, G" sort="Rees Cosgrove, G" uniqKey="Rees Cosgrove G" first="G" last="Rees Cosgrove">G. Rees Cosgrove</name><name sortKey="Reymers, Donald E" sort="Reymers, Donald E" uniqKey="Reymers D" first="Donald E" last="Reymers">Donald E. Reymers</name><name sortKey="Targum, Steven D" sort="Targum, Steven D" uniqKey="Targum S" first="Steven D" last="Targum">Steven D. Targum</name></noCountry><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Baltuch, Gordon H" sort="Baltuch, Gordon H" uniqKey="Baltuch G" first="Gordon H" last="Baltuch">Gordon H. Baltuch</name></region><name sortKey="Beasley, Kara" sort="Beasley, Kara" uniqKey="Beasley K" first="Kara" last="Beasley">Kara Beasley</name><name sortKey="Lyketsos, Constantine G" sort="Lyketsos, Constantine G" uniqKey="Lyketsos C" first="Constantine G" last="Lyketsos">Constantine G. Lyketsos</name><name sortKey="Smith, Gwenn S" sort="Smith, Gwenn S" uniqKey="Smith G" first="Gwenn S" last="Smith">Gwenn S. Smith</name></country><country name="Canada"><region name="Ontario"><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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