Circulating biomarkers in acute myofascial pain: A case-control study.
Identifieur interne : 000299 ( PubMed/Checkpoint ); précédent : 000298; suivant : 000300Circulating biomarkers in acute myofascial pain: A case-control study.
Auteurs : Liza Grosman-Rimon [Canada] ; William Parkinson ; Suneel Upadhye ; Hance Clarke ; Joel Katz ; John Flannery ; Philip Peng ; Dinesh KumbhareSource :
- Medicine [ 1536-5964 ] ; 2016.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Biomarkers, Cytokines, Intercellular Signaling Peptides and Proteins.
- blood : Myofascial Pain Syndromes.
- Adult, Case-Control Studies, Female, Humans, Male, Middle Aged.
Abstract
The aims of the present study were to compare levels of circulating inflammatory biomarkers and growth factors between patients with myofascial pain syndrome (MPS) and healthy control participants, and to assess the relationship among inflammatory markers and growth factors in the two groups.Biomarkers levels were assessed in patients (n = 37) with myofascial pain complaints recruited from the hospital emergency department and non-MPS controls (n = 21), recruited via advertisements in the hospital and community.Blood levels of the cytokines, namely, interleukin-6 (IL-6), tumor necrosis factor (TNF), and interleukin-12 (IL-12), and the chemokine, namely, monocyte chemoattractant protein-1 (MCP-1), macrophage-derived chemokine (MDC), eotaxin, granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-8 (IL-8), and macrophage inflammatory proteins-1β (MIP-1β) were significantly higher in patients with MPS than controls. The results of the growth factor analyses revealed significantly higher levels of fibroblast growth factor-2 (FGF-2), platelet-derived growth factor (PDGF), and vascular endothelial growth factor (VEGF) in MPS patients versus controls. The pattern of correlation coefficients between cytokines and growth factors differed considerably for MPS patients and controls with far fewer significant positive coefficients observed in the controls. Serum inflammatory and growth factor biomarkers were elevated in MPS patients.Inflammatory biomarkers and growth factor levels may play an important role in the onset and maintenance of MPS and therefore may be useful in the diagnosis and treatment of MPS. Understanding the mechanisms of inflammation in MPS necessitates future research.
DOI: 10.1097/MD.0000000000004650
PubMed: 27631214
Affiliations:
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xml:lang="en">Circulating biomarkers in acute myofascial pain: A case-control study.</title><author><name sortKey="Grosman Rimon, Liza" sort="Grosman Rimon, Liza" uniqKey="Grosman Rimon L" first="Liza" last="Grosman-Rimon">Liza Grosman-Rimon</name><affiliation wicri:level="1"><nlm:affiliation>aToronto Rehabilitation Institute, University Health Network bDepartment of Anesthesia, University of Toronto cMcMaster University, Hamilton dDepartment of Anesthesia and Pain Management, Toronto General Hospital, University Health Network eDepartment of Psychology, York University fDepartment of Medicine, Division of Physical Medicine and Rehabilitation, University of Toronto, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>aToronto Rehabilitation Institute, University Health Network bDepartment of Anesthesia, University of Toronto cMcMaster University, Hamilton dDepartment of Anesthesia and Pain Management, Toronto General Hospital, University Health Network eDepartment of Psychology, York University fDepartment of Medicine, Division of Physical Medicine and Rehabilitation, University of Toronto, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Parkinson, William" sort="Parkinson, William" uniqKey="Parkinson W" first="William" last="Parkinson">William Parkinson</name></author><author><name sortKey="Upadhye, Suneel" sort="Upadhye, Suneel" uniqKey="Upadhye S" first="Suneel" last="Upadhye">Suneel Upadhye</name></author><author><name sortKey="Clarke, Hance" sort="Clarke, Hance" uniqKey="Clarke H" first="Hance" last="Clarke">Hance Clarke</name></author><author><name sortKey="Katz, Joel" sort="Katz, Joel" uniqKey="Katz J" first="Joel" last="Katz">Joel Katz</name></author><author><name sortKey="Flannery, John" sort="Flannery, John" uniqKey="Flannery J" first="John" last="Flannery">John Flannery</name></author><author><name sortKey="Peng, Philip" sort="Peng, Philip" uniqKey="Peng P" first="Philip" last="Peng">Philip Peng</name></author><author><name sortKey="Kumbhare, Dinesh" sort="Kumbhare, Dinesh" uniqKey="Kumbhare D" first="Dinesh" last="Kumbhare">Dinesh Kumbhare</name></author></analytic><series><title level="j">Medicine</title><idno type="eISSN">1536-5964</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Biomarkers (blood)</term><term>Case-Control Studies</term><term>Cytokines (blood)</term><term>Female</term><term>Humans</term><term>Intercellular Signaling Peptides and Proteins (blood)</term><term>Male</term><term>Middle Aged</term><term>Myofascial Pain Syndromes (blood)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term><term>Cytokines</term><term>Intercellular Signaling Peptides and Proteins</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Myofascial Pain Syndromes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aims of the present study were to compare levels of circulating inflammatory biomarkers and growth factors between patients with myofascial pain syndrome (MPS) and healthy control participants, and to assess the relationship among inflammatory markers and growth factors in the two groups.Biomarkers levels were assessed in patients (n = 37) with myofascial pain complaints recruited from the hospital emergency department and non-MPS controls (n = 21), recruited via advertisements in the hospital and community.Blood levels of the cytokines, namely, interleukin-6 (IL-6), tumor necrosis factor (TNF), and interleukin-12 (IL-12), and the chemokine, namely, monocyte chemoattractant protein-1 (MCP-1), macrophage-derived chemokine (MDC), eotaxin, granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-8 (IL-8), and macrophage inflammatory proteins-1β (MIP-1β) were significantly higher in patients with MPS than controls. The results of the growth factor analyses revealed significantly higher levels of fibroblast growth factor-2 (FGF-2), platelet-derived growth factor (PDGF), and vascular endothelial growth factor (VEGF) in MPS patients versus controls. The pattern of correlation coefficients between cytokines and growth factors differed considerably for MPS patients and controls with far fewer significant positive coefficients observed in the controls. Serum inflammatory and growth factor biomarkers were elevated in MPS patients.Inflammatory biomarkers and growth factor levels may play an important role in the onset and maintenance of MPS and therefore may be useful in the diagnosis and treatment of MPS. Understanding the mechanisms of inflammation in MPS necessitates future research.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27631214</PMID><DateCreated><Year>2016</Year><Month>09</Month><Day>16</Day></DateCreated><DateCompleted><Year>2017</Year><Month>02</Month><Day>17</Day></DateCompleted><DateRevised><Year>2017</Year><Month>04</Month><Day>28</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1536-5964</ISSN><JournalIssue CitedMedium="Internet"><Volume>95</Volume><Issue>37</Issue><PubDate><Year>2016</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Medicine</Title><ISOAbbreviation>Medicine (Baltimore)</ISOAbbreviation></Journal><ArticleTitle>Circulating biomarkers in acute myofascial pain: A case-control study.</ArticleTitle><Pagination><MedlinePgn>e4650</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/MD.0000000000004650</ELocationID><Abstract><AbstractText>The aims of the present study were to compare levels of circulating inflammatory biomarkers and growth factors between patients with myofascial pain syndrome (MPS) and healthy control participants, and to assess the relationship among inflammatory markers and growth factors in the two groups.Biomarkers levels were assessed in patients (n = 37) with myofascial pain complaints recruited from the hospital emergency department and non-MPS controls (n = 21), recruited via advertisements in the hospital and community.Blood levels of the cytokines, namely, interleukin-6 (IL-6), tumor necrosis factor (TNF), and interleukin-12 (IL-12), and the chemokine, namely, monocyte chemoattractant protein-1 (MCP-1), macrophage-derived chemokine (MDC), eotaxin, granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-8 (IL-8), and macrophage inflammatory proteins-1β (MIP-1β) were significantly higher in patients with MPS than controls. The results of the growth factor analyses revealed significantly higher levels of fibroblast growth factor-2 (FGF-2), platelet-derived growth factor (PDGF), and vascular endothelial growth factor (VEGF) in MPS patients versus controls. The pattern of correlation coefficients between cytokines and growth factors differed considerably for MPS patients and controls with far fewer significant positive coefficients observed in the controls. Serum inflammatory and growth factor biomarkers were elevated in MPS patients.Inflammatory biomarkers and growth factor levels may play an important role in the onset and maintenance of MPS and therefore may be useful in the diagnosis and treatment of MPS. Understanding the mechanisms of inflammation in MPS necessitates future research.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Grosman-Rimon</LastName><ForeName>Liza</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>aToronto Rehabilitation Institute, University Health Network bDepartment of Anesthesia, University of Toronto cMcMaster University, Hamilton dDepartment of Anesthesia and Pain Management, Toronto General Hospital, University Health Network eDepartment of Psychology, York University fDepartment of Medicine, Division of Physical Medicine and Rehabilitation, University of Toronto, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Parkinson</LastName><ForeName>William</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Upadhye</LastName><ForeName>Suneel</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Clarke</LastName><ForeName>Hance</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Katz</LastName><ForeName>Joel</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Flannery</LastName><ForeName>John</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Peng</LastName><ForeName>Philip</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Kumbhare</LastName><ForeName>Dinesh</ForeName><Initials>D</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Medicine (Baltimore)</MedlineTA><NlmUniqueID>2985248R</NlmUniqueID><ISSNLinking>0025-7974</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance 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Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D036341" MajorTopicYN="N">Intercellular Signaling Peptides and Proteins</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009209" MajorTopicYN="N">Myofascial Pain Syndromes</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>9</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>9</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>2</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27631214</ArticleId><ArticleId IdType="doi">10.1097/MD.0000000000004650</ArticleId><ArticleId IdType="pii">00005792-201609130-00016</ArticleId><ArticleId IdType="pmc">PMC5402557</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Clarke, Hance" sort="Clarke, Hance" uniqKey="Clarke H" first="Hance" last="Clarke">Hance Clarke</name><name sortKey="Flannery, John" sort="Flannery, John" uniqKey="Flannery J" first="John" last="Flannery">John Flannery</name><name sortKey="Katz, Joel" sort="Katz, Joel" uniqKey="Katz J" first="Joel" last="Katz">Joel Katz</name><name sortKey="Kumbhare, Dinesh" sort="Kumbhare, Dinesh" uniqKey="Kumbhare D" first="Dinesh" last="Kumbhare">Dinesh Kumbhare</name><name sortKey="Parkinson, William" sort="Parkinson, William" uniqKey="Parkinson W" first="William" last="Parkinson">William Parkinson</name><name sortKey="Peng, Philip" sort="Peng, Philip" uniqKey="Peng P" first="Philip" last="Peng">Philip Peng</name><name sortKey="Upadhye, Suneel" sort="Upadhye, Suneel" uniqKey="Upadhye S" first="Suneel" last="Upadhye">Suneel Upadhye</name></noCountry><country name="Canada"><noRegion><name sortKey="Grosman Rimon, Liza" sort="Grosman Rimon, Liza" uniqKey="Grosman Rimon L" first="Liza" last="Grosman-Rimon">Liza 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