Compensatory striatal-cerebellar connectivity in mild-moderate Parkinson's disease.
Identifieur interne : 000295 ( PubMed/Checkpoint ); précédent : 000294; suivant : 000296Compensatory striatal-cerebellar connectivity in mild-moderate Parkinson's disease.
Auteurs : Alison C. Simioni [Canada] ; Alain Dagher [Canada] ; Lesley K. Fellows [Canada]Source :
- NeuroImage. Clinical [ 2213-1582 ] ; 2016.
English descriptors
- KwdEn :
- Aged, Brain Mapping, Carbidopa (administration & dosage), Carbidopa (therapeutic use), Caudate Nucleus (drug effects), Caudate Nucleus (physiopathology), Cerebellum (drug effects), Cerebellum (physiopathology), Drug Combinations, Humans, Levodopa (administration & dosage), Levodopa (therapeutic use), Magnetic Resonance Imaging, Middle Aged, Motor Activity, Motor Cortex (drug effects), Motor Cortex (physiopathology), Neural Pathways (drug effects), Neural Pathways (physiopathology), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Putamen (drug effects), Putamen (physiopathology), Severity of Illness Index.
- MESH :
- chemical , administration & dosage : Carbidopa, Levodopa.
- chemical , therapeutic use : Carbidopa, Levodopa.
- drug effects : Caudate Nucleus, Cerebellum, Motor Cortex, Neural Pathways, Putamen.
- drug therapy : Parkinson Disease.
- physiopathology : Caudate Nucleus, Cerebellum, Motor Cortex, Neural Pathways, Parkinson Disease, Putamen.
- Aged, Brain Mapping, Drug Combinations, Humans, Magnetic Resonance Imaging, Middle Aged, Motor Activity, Severity of Illness Index.
Abstract
Dopamine depletion in the putamen is associated with altered motor network functional connectivity in people with Parkinson's disease (PD), but the functional significance of these changes remains unclear, attributed to either pathological or compensatory mechanisms in different studies. Here, we examined the effects of PD on dorsal caudal putamen functional connectivity, off and on dopamine replacement therapy (DRT), using resting state fMRI. Motor performance was assessed with the Purdue pegboard task. Twenty-one patients with mild-moderate Parkinson's disease were studied twice, once after an overnight DRT washout and once after the administration of a standard dose of levodopa (Sinemet), and compared to 20 demographically-matched healthy control participants. PD patients off DRT showed increased putamen functional connectivity with both the cerebellum (lobule V) and primary motor cortex (M1), relative to healthy controls. Greater putamen-cerebellar functional connectivity was significantly correlated with better motor performance, whereas greater putamen-M1 functional connectivity was predictive of poorer motor performance. The administration of levodopa improved motor performance in the PD group, as expected, and reduced putamen-cerebellar connectivity to levels comparable to the healthy control group. The strength of putamen-cerebellar functional connectivity continued to predict motor performance in the PD group while on levodopa. These findings argue that increased putamen-M1 functional connectivity reflects a pathological change, deleterious to motor performance. In contrast, increased putamen-cerebellar connectivity reflects a compensatory mechanism.
DOI: 10.1016/j.nicl.2015.11.005
PubMed: 26702396
Affiliations:
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pubmed:26702396Le document en format XML
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Fellows</name><affiliation wicri:level="4"><nlm:affiliation>Montreal Neurological Institute, McGill University, 3801 University Street, Rm 276, Montreal, QC H3A 2B4, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Neurological Institute, McGill University, 3801 University Street, Rm 276, Montreal, QC H3A 2B4</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author></analytic><series><title level="j">NeuroImage. Clinical</title><idno type="eISSN">2213-1582</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Brain Mapping</term><term>Carbidopa (administration & dosage)</term><term>Carbidopa (therapeutic use)</term><term>Caudate Nucleus (drug effects)</term><term>Caudate Nucleus (physiopathology)</term><term>Cerebellum (drug effects)</term><term>Cerebellum (physiopathology)</term><term>Drug Combinations</term><term>Humans</term><term>Levodopa (administration & dosage)</term><term>Levodopa (therapeutic use)</term><term>Magnetic Resonance Imaging</term><term>Middle Aged</term><term>Motor Activity</term><term>Motor Cortex (drug effects)</term><term>Motor Cortex (physiopathology)</term><term>Neural Pathways (drug effects)</term><term>Neural Pathways (physiopathology)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (physiopathology)</term><term>Putamen (drug effects)</term><term>Putamen (physiopathology)</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Carbidopa</term><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Carbidopa</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Caudate Nucleus</term><term>Cerebellum</term><term>Motor Cortex</term><term>Neural Pathways</term><term>Putamen</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Caudate Nucleus</term><term>Cerebellum</term><term>Motor Cortex</term><term>Neural Pathways</term><term>Parkinson Disease</term><term>Putamen</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Brain Mapping</term><term>Drug Combinations</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Middle Aged</term><term>Motor Activity</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dopamine depletion in the putamen is associated with altered motor network functional connectivity in people with Parkinson's disease (PD), but the functional significance of these changes remains unclear, attributed to either pathological or compensatory mechanisms in different studies. Here, we examined the effects of PD on dorsal caudal putamen functional connectivity, off and on dopamine replacement therapy (DRT), using resting state fMRI. Motor performance was assessed with the Purdue pegboard task. Twenty-one patients with mild-moderate Parkinson's disease were studied twice, once after an overnight DRT washout and once after the administration of a standard dose of levodopa (Sinemet), and compared to 20 demographically-matched healthy control participants. PD patients off DRT showed increased putamen functional connectivity with both the cerebellum (lobule V) and primary motor cortex (M1), relative to healthy controls. Greater putamen-cerebellar functional connectivity was significantly correlated with better motor performance, whereas greater putamen-M1 functional connectivity was predictive of poorer motor performance. The administration of levodopa improved motor performance in the PD group, as expected, and reduced putamen-cerebellar connectivity to levels comparable to the healthy control group. The strength of putamen-cerebellar functional connectivity continued to predict motor performance in the PD group while on levodopa. These findings argue that increased putamen-M1 functional connectivity reflects a pathological change, deleterious to motor performance. In contrast, increased putamen-cerebellar connectivity reflects a compensatory mechanism.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26702396</PMID><DateCreated><Year>2015</Year><Month>12</Month><Day>24</Day></DateCreated><DateCompleted><Year>2016</Year><Month>10</Month><Day>06</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">2213-1582</ISSN><JournalIssue CitedMedium="Internet"><Volume>10</Volume><PubDate><Year>2016</Year></PubDate></JournalIssue><Title>NeuroImage. Clinical</Title><ISOAbbreviation>Neuroimage Clin</ISOAbbreviation></Journal><ArticleTitle>Compensatory striatal-cerebellar connectivity in mild-moderate Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>54-62</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.nicl.2015.11.005</ELocationID><Abstract><AbstractText>Dopamine depletion in the putamen is associated with altered motor network functional connectivity in people with Parkinson's disease (PD), but the functional significance of these changes remains unclear, attributed to either pathological or compensatory mechanisms in different studies. Here, we examined the effects of PD on dorsal caudal putamen functional connectivity, off and on dopamine replacement therapy (DRT), using resting state fMRI. Motor performance was assessed with the Purdue pegboard task. Twenty-one patients with mild-moderate Parkinson's disease were studied twice, once after an overnight DRT washout and once after the administration of a standard dose of levodopa (Sinemet), and compared to 20 demographically-matched healthy control participants. PD patients off DRT showed increased putamen functional connectivity with both the cerebellum (lobule V) and primary motor cortex (M1), relative to healthy controls. Greater putamen-cerebellar functional connectivity was significantly correlated with better motor performance, whereas greater putamen-M1 functional connectivity was predictive of poorer motor performance. The administration of levodopa improved motor performance in the PD group, as expected, and reduced putamen-cerebellar connectivity to levels comparable to the healthy control group. The strength of putamen-cerebellar functional connectivity continued to predict motor performance in the PD group while on levodopa. These findings argue that increased putamen-M1 functional connectivity reflects a pathological change, deleterious to motor performance. In contrast, increased putamen-cerebellar connectivity reflects a compensatory mechanism.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Simioni</LastName><ForeName>Alison C</ForeName><Initials>AC</Initials><AffiliationInfo><Affiliation>Montreal Neurological Institute, McGill University, 3801 University Street, Rm 276, Montreal, QC H3A 2B4, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dagher</LastName><ForeName>Alain</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Montreal Neurological Institute, McGill University, 3801 University Street, Rm 276, Montreal, QC H3A 2B4, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fellows</LastName><ForeName>Lesley K</ForeName><Initials>LK</Initials><AffiliationInfo><Affiliation>Montreal Neurological Institute, McGill University, 3801 University Street, Rm 276, Montreal, QC H3A 2B4, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>MOP 97821</GrantID><Agency>Canadian Institutes of Health Research</Agency><Country>Canada</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>11</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Neuroimage Clin</MedlineTA><NlmUniqueID>101597070</NlmUniqueID><ISSNLinking>2213-1582</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004338">Drug Combinations</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C009265">carbidopa, levodopa drug 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UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011699" MajorTopicYN="N">Putamen</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4669533</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Basal ganglia</Keyword><Keyword MajorTopicYN="N">Cerebellum</Keyword><Keyword MajorTopicYN="N">Dopamine</Keyword><Keyword MajorTopicYN="N">Motor cortex</Keyword><Keyword MajorTopicYN="N">Putamen</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>07</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>11</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>11</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>12</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>12</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>10</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26702396</ArticleId><ArticleId IdType="doi">10.1016/j.nicl.2015.11.005</ArticleId><ArticleId IdType="pii">S2213-1582(15)30022-X</ArticleId><ArticleId IdType="pmc">PMC4669533</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country><region><li>Québec</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université McGill</li></orgName></list><tree><country name="Canada"><region name="Québec"><name sortKey="Simioni, Alison C" sort="Simioni, Alison C" uniqKey="Simioni A" first="Alison C" last="Simioni">Alison C. Simioni</name></region><name sortKey="Dagher, Alain" sort="Dagher, Alain" uniqKey="Dagher A" first="Alain" last="Dagher">Alain Dagher</name><name sortKey="Fellows, Lesley K" sort="Fellows, Lesley K" uniqKey="Fellows L" first="Lesley K" last="Fellows">Lesley K. Fellows</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
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|type= RBID
|clé= pubmed:26702396
|texte= Compensatory striatal-cerebellar connectivity in mild-moderate Parkinson's disease.
}}
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| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
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