Development and implementation of microsimulation models of neurological conditions.
Identifieur interne : 000284 ( PubMed/Checkpoint ); précédent : 000283; suivant : 000285Development and implementation of microsimulation models of neurological conditions.
Auteurs : Philippe Finès [Canada] ; Rochelle Garner [Canada] ; Christina Bancej [Canada] ; Julie Bernier [Canada] ; Douglas G. ManuelSource :
- Health reports [ 1209-1367 ] ; 2016.
English descriptors
- KwdEn :
- MESH :
- epidemiology : Nervous System Diseases.
- Canada, Caregivers, Computer Simulation, Humans, Long-Term Care, Models, Theoretical, Prevalence, Risk Factors.
Abstract
As part of a program of the first National Population Health Study of Neurological Conditions launched in 2009, a series of microsimulation models of neurological conditions (called POHEM-Neurological meta-model) was developed to project health and economic impacts of seven neurological conditions (NCs)-Alzheimer's disease and other dementias, cerebral palsy, epilepsy, multiple sclerosis, Parkinson's disease, traumatic brain injury, and traumatic spinal cord injury-over a 20-year horizon.
PubMed: 26983006
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Development and implementation of microsimulation models of neurological conditions.</title><author><name sortKey="Fines, Philippe" sort="Fines, Philippe" uniqKey="Fines P" first="Philippe" last="Finès">Philippe Finès</name><affiliation wicri:level="2"><nlm:affiliation>Health Analysis Division, Statistics Canada, Ottawa, Ontario.</nlm:affiliation><country>Canada</country><placeName><region type="province">Ontario</region></placeName><wicri:cityArea>Health Analysis Division, Statistics Canada, Ottawa</wicri:cityArea></affiliation></author><author><name sortKey="Garner, Rochelle" sort="Garner, Rochelle" uniqKey="Garner R" first="Rochelle" last="Garner">Rochelle Garner</name><affiliation wicri:level="2"><nlm:affiliation>Health Analysis Division, Statistics Canada, Ottawa, Ontario.</nlm:affiliation><country>Canada</country><placeName><region type="province">Ontario</region></placeName><wicri:cityArea>Health Analysis Division, Statistics Canada, Ottawa</wicri:cityArea></affiliation></author><author><name sortKey="Bancej, Christina" sort="Bancej, Christina" uniqKey="Bancej C" first="Christina" last="Bancej">Christina Bancej</name><affiliation wicri:level="2"><nlm:affiliation>Public Health Agency of Canada, Ottawa, Ontario.</nlm:affiliation><country>Canada</country><placeName><region type="province">Ontario</region></placeName><wicri:cityArea>Public Health Agency of Canada, Ottawa</wicri:cityArea></affiliation></author><author><name sortKey="Bernier, Julie" sort="Bernier, Julie" uniqKey="Bernier J" first="Julie" last="Bernier">Julie Bernier</name><affiliation wicri:level="2"><nlm:affiliation>Health Analysis Division, Statistics Canada, Ottawa, Ontario.</nlm:affiliation><country>Canada</country><placeName><region type="province">Ontario</region></placeName><wicri:cityArea>Health Analysis Division, Statistics Canada, Ottawa</wicri:cityArea></affiliation></author><author><name sortKey="Manuel, Douglas G" sort="Manuel, Douglas G" uniqKey="Manuel D" first="Douglas G" last="Manuel">Douglas G. Manuel</name><affiliation><nlm:affiliation>Health Analysis Division, Statistics Canada; Ottawa Hospital Research Institute; Bruyère Research Institute; Institute for Clinical Evaluative Sciences.</nlm:affiliation><wicri:noCountry code="subField">Statistics Canada; Ottawa Hospital Research Institute; Bruyère Research Institute; Institute for Clinical Evaluative Sciences</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26983006</idno><idno type="pmid">26983006</idno><idno type="wicri:Area/PubMed/Corpus">000270</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000270</idno><idno type="wicri:Area/PubMed/Curation">000270</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000270</idno><idno type="wicri:Area/PubMed/Checkpoint">000270</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000270</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Development and implementation of microsimulation models of neurological conditions.</title><author><name sortKey="Fines, Philippe" sort="Fines, Philippe" uniqKey="Fines P" first="Philippe" last="Finès">Philippe Finès</name><affiliation wicri:level="2"><nlm:affiliation>Health Analysis Division, Statistics Canada, Ottawa, Ontario.</nlm:affiliation><country>Canada</country><placeName><region type="province">Ontario</region></placeName><wicri:cityArea>Health Analysis Division, Statistics Canada, Ottawa</wicri:cityArea></affiliation></author><author><name sortKey="Garner, Rochelle" sort="Garner, Rochelle" uniqKey="Garner R" first="Rochelle" last="Garner">Rochelle Garner</name><affiliation wicri:level="2"><nlm:affiliation>Health Analysis Division, Statistics Canada, Ottawa, Ontario.</nlm:affiliation><country>Canada</country><placeName><region type="province">Ontario</region></placeName><wicri:cityArea>Health Analysis Division, Statistics Canada, Ottawa</wicri:cityArea></affiliation></author><author><name sortKey="Bancej, Christina" sort="Bancej, Christina" uniqKey="Bancej C" first="Christina" last="Bancej">Christina Bancej</name><affiliation wicri:level="2"><nlm:affiliation>Public Health Agency of Canada, Ottawa, Ontario.</nlm:affiliation><country>Canada</country><placeName><region type="province">Ontario</region></placeName><wicri:cityArea>Public Health Agency of Canada, Ottawa</wicri:cityArea></affiliation></author><author><name sortKey="Bernier, Julie" sort="Bernier, Julie" uniqKey="Bernier J" first="Julie" last="Bernier">Julie Bernier</name><affiliation wicri:level="2"><nlm:affiliation>Health Analysis Division, Statistics Canada, Ottawa, Ontario.</nlm:affiliation><country>Canada</country><placeName><region type="province">Ontario</region></placeName><wicri:cityArea>Health Analysis Division, Statistics Canada, Ottawa</wicri:cityArea></affiliation></author><author><name sortKey="Manuel, Douglas G" sort="Manuel, Douglas G" uniqKey="Manuel D" first="Douglas G" last="Manuel">Douglas G. Manuel</name><affiliation><nlm:affiliation>Health Analysis Division, Statistics Canada; Ottawa Hospital Research Institute; Bruyère Research Institute; Institute for Clinical Evaluative Sciences.</nlm:affiliation><wicri:noCountry code="subField">Statistics Canada; Ottawa Hospital Research Institute; Bruyère Research Institute; Institute for Clinical Evaluative Sciences</wicri:noCountry></affiliation></author></analytic><series><title level="j">Health reports</title><idno type="eISSN">1209-1367</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Canada</term><term>Caregivers</term><term>Computer Simulation</term><term>Humans</term><term>Long-Term Care</term><term>Models, Theoretical</term><term>Nervous System Diseases (epidemiology)</term><term>Prevalence</term><term>Risk Factors</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Nervous System Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Canada</term><term>Caregivers</term><term>Computer Simulation</term><term>Humans</term><term>Long-Term Care</term><term>Models, Theoretical</term><term>Prevalence</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">As part of a program of the first National Population Health Study of Neurological Conditions launched in 2009, a series of microsimulation models of neurological conditions (called POHEM-Neurological meta-model) was developed to project health and economic impacts of seven neurological conditions (NCs)-Alzheimer's disease and other dementias, cerebral palsy, epilepsy, multiple sclerosis, Parkinson's disease, traumatic brain injury, and traumatic spinal cord injury-over a 20-year horizon.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26983006</PMID><DateCreated><Year>2016</Year><Month>03</Month><Day>17</Day></DateCreated><DateCompleted><Year>2016</Year><Month>12</Month><Day>22</Day></DateCompleted><DateRevised><Year>2016</Year><Month>12</Month><Day>30</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1209-1367</ISSN><JournalIssue CitedMedium="Internet"><Volume>27</Volume><Issue>3</Issue><PubDate><Year>2016</Year><Month>Mar</Month><Day>16</Day></PubDate></JournalIssue><Title>Health reports</Title><ISOAbbreviation>Health Rep</ISOAbbreviation></Journal><ArticleTitle>Development and implementation of microsimulation models of neurological conditions.</ArticleTitle><Pagination><MedlinePgn>3-9</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">As part of a program of the first National Population Health Study of Neurological Conditions launched in 2009, a series of microsimulation models of neurological conditions (called POHEM-Neurological meta-model) was developed to project health and economic impacts of seven neurological conditions (NCs)-Alzheimer's disease and other dementias, cerebral palsy, epilepsy, multiple sclerosis, Parkinson's disease, traumatic brain injury, and traumatic spinal cord injury-over a 20-year horizon.</AbstractText><AbstractText Label="DATA AND METHODS" NlmCategory="METHODS">The common framework of the seven models allows for dynamic, continuous-time, discrete-event simulation of synthetic large populations in which persons are subject to the risk of developing the NC under study and are assigned a value of functional health and a probability of receiving a caregiver and of entering long-term care. Calculations for transitions are done every year over the life course, and costs are accumulated throughout the life of the synthetic person. The need to reconcile empirical estimates of incidence and mortality with prevalence required implementation of "cure" parameters for two of the NCs.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The POHEM-Neurological meta-model integrates the latest Canadian microdata on neurological conditions and satisfies most criteria for validation of microsimulation models, including conceptualization, computer implementation, assessment of output plausibility, and comparison with external data. Limitations include an absence of risk factors and the lack of uncertainty measures.</AbstractText><AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">The POHEM-Neurological meta-model has been useful for projections of health and economic impacts of NCs on persons affected and their caregivers, and allows for comparison of specific scenarios to the base case.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Finès</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Health Analysis Division, Statistics Canada, Ottawa, Ontario.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Garner</LastName><ForeName>Rochelle</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Health Analysis Division, Statistics Canada, Ottawa, Ontario.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bancej</LastName><ForeName>Christina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Public Health Agency of Canada, Ottawa, Ontario.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bernier</LastName><ForeName>Julie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Health Analysis Division, Statistics Canada, Ottawa, Ontario.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Manuel</LastName><ForeName>Douglas G</ForeName><Initials>DG</Initials><AffiliationInfo><Affiliation>Health Analysis Division, Statistics Canada; Ottawa Hospital Research Institute; Bruyère Research Institute; Institute for Clinical Evaluative Sciences.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Canada</Country><MedlineTA>Health Rep</MedlineTA><NlmUniqueID>9012854</NlmUniqueID><ISSNLinking>0840-6529</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D002170" MajorTopicYN="N">Canada</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017028" MajorTopicYN="N">Caregivers</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003198" MajorTopicYN="Y">Computer Simulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008134" MajorTopicYN="N">Long-Term Care</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008962" MajorTopicYN="Y">Models, Theoretical</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009422" MajorTopicYN="Y">Nervous System Diseases</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Alzheimer's disease and other dementias</Keyword><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">cerebral palsy</Keyword><Keyword MajorTopicYN="N">epilepsy</Keyword><Keyword MajorTopicYN="N">health costs</Keyword><Keyword MajorTopicYN="N">microsimulation</Keyword><Keyword MajorTopicYN="N">multiple sclerosis</Keyword><Keyword MajorTopicYN="N">traumatic brain injury</Keyword><Keyword MajorTopicYN="N">traumatic spinal cord injury</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>3</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>3</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>12</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26983006</ArticleId><ArticleId IdType="pii">82-003-X201600314338</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region></list><tree><noCountry><name sortKey="Manuel, Douglas G" sort="Manuel, Douglas G" uniqKey="Manuel D" first="Douglas G" last="Manuel">Douglas G. Manuel</name></noCountry><country name="Canada"><region name="Ontario"><name sortKey="Fines, Philippe" sort="Fines, Philippe" uniqKey="Fines P" first="Philippe" last="Finès">Philippe Finès</name></region><name sortKey="Bancej, Christina" sort="Bancej, Christina" uniqKey="Bancej C" first="Christina" last="Bancej">Christina Bancej</name><name sortKey="Bernier, Julie" sort="Bernier, Julie" uniqKey="Bernier J" first="Julie" last="Bernier">Julie Bernier</name><name sortKey="Garner, Rochelle" sort="Garner, Rochelle" uniqKey="Garner R" first="Rochelle" last="Garner">Rochelle Garner</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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