Lithium Use in Older Adults is Associated with Increased Prescribing of Parkinson Medications.
Identifieur interne : 000221 ( PubMed/Checkpoint ); précédent : 000220; suivant : 000222Lithium Use in Older Adults is Associated with Increased Prescribing of Parkinson Medications.
Auteurs : Connie Marras [Canada] ; Nathan Herrmann [Canada] ; Hadas D. Fischer [Canada] ; Kinwah Fung [Canada] ; Andrea Gruneir [Canada] ; Paula A. Rochon [Canada] ; Soham Rej [Canada] ; Simone Vigod [Canada] ; Dallas Seitz [Canada] ; Kenneth I. Shulman [Canada]Source :
- The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry [ 1545-7214 ] ; 2016.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Antidepressive Agents (therapeutic use), Antimanic Agents (therapeutic use), Antiparkinson Agents (therapeutic use), Dopamine Agents (therapeutic use), Female, Humans, Lithium Compounds (therapeutic use), Male, Ontario (epidemiology), Parkinson Disease (drug therapy), Parkinson Disease (epidemiology), Retrospective Studies, Valproic Acid (therapeutic use).
- MESH :
- chemical , therapeutic use : Antidepressive Agents, Antimanic Agents, Antiparkinson Agents, Dopamine Agents, Lithium Compounds, Valproic Acid.
- drug therapy : Parkinson Disease.
- epidemiology : Ontario, Parkinson Disease.
- Aged, Aged, 80 and over, Female, Humans, Male, Retrospective Studies.
Abstract
To test the hypothesis of an increased incidence of antiparkinson drug prescribing or Parkinson disease (PD) diagnostic codes after chronic lithium treatment compared with chronic valproic acid or antidepressant treatment among older adults.
DOI: 10.1016/j.jagp.2015.11.004
PubMed: 27037047
Affiliations:
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pubmed:27037047Le document en format XML
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Safra Program in Parkinson's Disease, Toronto, Ontario, Canada; University of Toronto, Toronto, Ontario, Canada. Electronic address: cmarras@uhnresearch.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital and The Edmond J. Safra Program in Parkinson's Disease, Toronto, Ontario, Canada; University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Herrmann, Nathan" sort="Herrmann, Nathan" uniqKey="Herrmann N" first="Nathan" last="Herrmann">Nathan Herrmann</name><affiliation wicri:level="4"><nlm:affiliation>University of Toronto, Toronto, Ontario, Canada; Division of Geriatric Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of Toronto, Toronto, Ontario, Canada; Division of Geriatric Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Fischer, Hadas D" sort="Fischer, Hadas D" uniqKey="Fischer H" first="Hadas D" last="Fischer">Hadas D. Fischer</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Institute for Clinical Evaluative Sciences, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Fung, Kinwah" sort="Fung, Kinwah" uniqKey="Fung K" first="Kinwah" last="Fung">Kinwah Fung</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada; Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada; Women's College Research Institute, Women's College Hospital, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Gruneir, Andrea" sort="Gruneir, Andrea" uniqKey="Gruneir A" first="Andrea" last="Gruneir">Andrea Gruneir</name><affiliation wicri:level="4"><nlm:affiliation>University of Toronto, Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada; Department of Family Medicine, University of Alberta, Edmonton, Alberta, Canada; Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of Toronto, Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada; Department of Family Medicine, University of Alberta, Edmonton, Alberta, Canada; Women's College Research Institute, Women's College Hospital, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Rochon, Paula A" sort="Rochon, Paula A" uniqKey="Rochon P" first="Paula A" last="Rochon">Paula A. Rochon</name><affiliation wicri:level="4"><nlm:affiliation>University of Toronto, Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada; Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of Toronto, Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada; Women's College Research Institute, Women's College Hospital, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Rej, Soham" sort="Rej, Soham" uniqKey="Rej S" first="Soham" last="Rej">Soham Rej</name><affiliation wicri:level="4"><nlm:affiliation>University of Toronto, Toronto, Ontario, Canada; Division of Geriatric Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of Toronto, Toronto, Ontario, Canada; Division of Geriatric Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Vigod, Simone" sort="Vigod, Simone" uniqKey="Vigod S" first="Simone" last="Vigod">Simone Vigod</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada; Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada; Women's College Research Institute, Women's College Hospital, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Seitz, Dallas" sort="Seitz, Dallas" uniqKey="Seitz D" first="Dallas" last="Seitz">Dallas Seitz</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Clinical Evaluative Sciences, Queen's University, Kingston, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Institute for Clinical Evaluative Sciences, Queen's University, Kingston, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Shulman, Kenneth I" sort="Shulman, Kenneth I" uniqKey="Shulman K" first="Kenneth I" last="Shulman">Kenneth I. Shulman</name><affiliation wicri:level="4"><nlm:affiliation>University of Toronto, Toronto, Ontario, Canada; Division of Geriatric Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of Toronto, Toronto, Ontario, Canada; Division of Geriatric Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author></analytic><series><title level="j">The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry</title><idno type="eISSN">1545-7214</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Antidepressive Agents (therapeutic use)</term><term>Antimanic Agents (therapeutic use)</term><term>Antiparkinson Agents (therapeutic use)</term><term>Dopamine Agents (therapeutic use)</term><term>Female</term><term>Humans</term><term>Lithium Compounds (therapeutic use)</term><term>Male</term><term>Ontario (epidemiology)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (epidemiology)</term><term>Retrospective Studies</term><term>Valproic Acid (therapeutic use)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antidepressive Agents</term><term>Antimanic Agents</term><term>Antiparkinson Agents</term><term>Dopamine Agents</term><term>Lithium Compounds</term><term>Valproic Acid</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Ontario</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Retrospective Studies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To test the hypothesis of an increased incidence of antiparkinson drug prescribing or Parkinson disease (PD) diagnostic codes after chronic lithium treatment compared with chronic valproic acid or antidepressant treatment among older adults.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27037047</PMID><DateCreated><Year>2016</Year><Month>04</Month><Day>02</Day></DateCreated><DateCompleted><Year>2017</Year><Month>01</Month><Day>02</Day></DateCompleted><DateRevised><Year>2017</Year><Month>01</Month><Day>04</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1545-7214</ISSN><JournalIssue CitedMedium="Internet"><Volume>24</Volume><Issue>4</Issue><PubDate><Year>2016</Year><Month>Apr</Month></PubDate></JournalIssue><Title>The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry</Title><ISOAbbreviation>Am J Geriatr Psychiatry</ISOAbbreviation></Journal><ArticleTitle>Lithium Use in Older Adults is Associated with Increased Prescribing of Parkinson Medications.</ArticleTitle><Pagination><MedlinePgn>301-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jagp.2015.11.004</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1064-7481(15)00286-9</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To test the hypothesis of an increased incidence of antiparkinson drug prescribing or Parkinson disease (PD) diagnostic codes after chronic lithium treatment compared with chronic valproic acid or antidepressant treatment among older adults.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A retrospective cohort study using healthcare administrative databases in Ontario, Canada included 1,749 lithium users, 1,787 valproic acid users, and 285,154 other antidepressant users ≥ 66 years old having used the drug continuously in monotherapy for at least 1 year. Outcome measures were start of (1) a dopaminergic medication (levodopa or a dopamine agonist), (2) any antiparkinson drug (levodopa, dopamine agonists, anticholinergic medication, amantadine, monoamine oxidase B inhibitors), (3) any antiparkinson drug or a diagnostic code for PD, and (4) any antiparkinson drug in the absence of a diagnostic code for PD.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">For patients with no previous antipsychotic use, lithium monotherapy was associated with an increased incidence of dopaminergic drug use (adjusted HR: 1.87; 95% CI: 1.06-3.30) and an increased incidence of antiparkinson drug use or a PD diagnosis (adjusted HR: 1. 68; 95% CI: 1.13-2.48) compared with antidepressant monotherapy.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Chronic lithium use is associated with an increased incidence of dopaminergic drug use compared with antidepressants, identifying a prescribing cascade related to lithium use in the elderly. Whether this reflects inappropriate treatment of action tremor or treatment of drug-induced parkinsonism should be addressed by a close examination of prescribing practices.</AbstractText><CopyrightInformation>Copyright © 2016 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Marras</LastName><ForeName>Connie</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital and The Edmond J. Safra Program in Parkinson's Disease, Toronto, Ontario, Canada; University of Toronto, Toronto, Ontario, Canada. Electronic address: cmarras@uhnresearch.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Herrmann</LastName><ForeName>Nathan</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>University of Toronto, Toronto, Ontario, Canada; Division of Geriatric Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fischer</LastName><ForeName>Hadas D</ForeName><Initials>HD</Initials><AffiliationInfo><Affiliation>Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fung</LastName><ForeName>Kinwah</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada; Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gruneir</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>University of Toronto, Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada; Department of Family Medicine, University of Alberta, Edmonton, Alberta, Canada; Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rochon</LastName><ForeName>Paula A</ForeName><Initials>PA</Initials><AffiliationInfo><Affiliation>University of Toronto, Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada; Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rej</LastName><ForeName>Soham</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>University of Toronto, Toronto, Ontario, Canada; Division of Geriatric Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vigod</LastName><ForeName>Simone</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada; Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seitz</LastName><ForeName>Dallas</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Institute for Clinical Evaluative Sciences, Queen's University, Kingston, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shulman</LastName><ForeName>Kenneth I</ForeName><Initials>KI</Initials><AffiliationInfo><Affiliation>University of Toronto, Toronto, Ontario, Canada; Division of Geriatric Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>CHL-126215</GrantID><Agency>Canadian Institutes of Health Research</Agency><Country>Canada</Country></Grant><Grant><GrantID>OTG-88591</GrantID><Agency>Canadian Institutes of Health Research</Agency><Country>Canada</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>12</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Am J Geriatr Psychiatry</MedlineTA><NlmUniqueID>9309609</NlmUniqueID><ISSNLinking>1064-7481</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000928">Antidepressive Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018692">Antimanic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000978">Antiparkinson Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015259">Dopamine Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018020">Lithium Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>614OI1Z5WI</RegistryNumber><NameOfSubstance UI="D014635">Valproic Acid</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000928" MajorTopicYN="N">Antidepressive Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018692" MajorTopicYN="N">Antimanic Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000978" MajorTopicYN="N">Antiparkinson Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015259" MajorTopicYN="N">Dopamine Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018020" MajorTopicYN="N">Lithium Compounds</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009864" MajorTopicYN="N">Ontario</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014635" MajorTopicYN="N">Valproic Acid</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">bipolar disorder</Keyword><Keyword MajorTopicYN="N">dopaminergic medication</Keyword><Keyword MajorTopicYN="N">lithium</Keyword><Keyword MajorTopicYN="N">treatment</Keyword><Keyword MajorTopicYN="N">tremor</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>05</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>11</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>11</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>4</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>4</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>1</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27037047</ArticleId><ArticleId IdType="pii">S1064-7481(15)00286-9</ArticleId><ArticleId IdType="doi">10.1016/j.jagp.2015.11.004</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><region name="Ontario"><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name></region><name sortKey="Fischer, Hadas D" sort="Fischer, Hadas D" uniqKey="Fischer H" first="Hadas D" last="Fischer">Hadas D. Fischer</name><name sortKey="Fung, Kinwah" sort="Fung, Kinwah" uniqKey="Fung K" first="Kinwah" last="Fung">Kinwah Fung</name><name sortKey="Gruneir, Andrea" sort="Gruneir, Andrea" uniqKey="Gruneir A" first="Andrea" last="Gruneir">Andrea Gruneir</name><name sortKey="Herrmann, Nathan" sort="Herrmann, Nathan" uniqKey="Herrmann N" first="Nathan" last="Herrmann">Nathan Herrmann</name><name sortKey="Rej, Soham" sort="Rej, Soham" uniqKey="Rej S" first="Soham" last="Rej">Soham Rej</name><name sortKey="Rochon, Paula A" sort="Rochon, Paula A" uniqKey="Rochon P" first="Paula A" last="Rochon">Paula A. Rochon</name><name sortKey="Seitz, Dallas" sort="Seitz, Dallas" uniqKey="Seitz D" first="Dallas" last="Seitz">Dallas Seitz</name><name sortKey="Shulman, Kenneth I" sort="Shulman, Kenneth I" uniqKey="Shulman K" first="Kenneth I" last="Shulman">Kenneth I. Shulman</name><name sortKey="Vigod, Simone" sort="Vigod, Simone" uniqKey="Vigod S" first="Simone" last="Vigod">Simone Vigod</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Lithium Use in Older Adults is Associated with Increased Prescribing of Parkinson Medications.
}}
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