Parkinson Disease: The Relationship Between Non-motor Symptoms and Motor Phenotype.
Identifieur interne : 000186 ( PubMed/Checkpoint ); précédent : 000185; suivant : 000187Parkinson Disease: The Relationship Between Non-motor Symptoms and Motor Phenotype.
Auteurs : Fang Ba [Canada] ; Mona Obaid [Canada] ; Marguerite Wieler [Canada] ; Richard Camicioli [Canada] ; W R Wayne Martin [Canada]Source :
- The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques [ 0317-1671 ] ; 2016.
English descriptors
- KwdEn :
- MESH :
- complications : Parkinson Disease.
- etiology : Gait Disorders, Neurologic, Tremor.
- Aged, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Phenotype, Postural Balance, Retrospective Studies.
Abstract
Parkinson disease (PD) presents with motor and non-motor symptoms (NMS). The NMS often precede the onset of motor symptoms, but may progress throughout the disease course. Tremor dominant, postural instability gait difficulty (PIGD), and indeterminate phenotypes can be distinguished using Unified PD Rating scales (UPDRS-III). We hypothesized that the PIGD phenotype would be more likely to develop NMS, and that the non-dopamine-responsive axial signs would correlate with NMS severity.
DOI: 10.1017/cjn.2015.328
PubMed: 26949837
Affiliations:
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last="Ba">Fang Ba</name><affiliation wicri:level="1"><nlm:affiliation>1Movement Disorder Program,Division of Neurology,University of Alberta,Kaye Edmonton Clinic,Edmonton,Alberta,Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>1Movement Disorder Program,Division of Neurology,University of Alberta,Kaye Edmonton Clinic,Edmonton,Alberta</wicri:regionArea><wicri:noRegion>Alberta</wicri:noRegion></affiliation></author><author><name sortKey="Obaid, Mona" sort="Obaid, Mona" uniqKey="Obaid M" first="Mona" last="Obaid">Mona Obaid</name><affiliation wicri:level="1"><nlm:affiliation>1Movement Disorder Program,Division of Neurology,University of Alberta,Kaye Edmonton Clinic,Edmonton,Alberta,Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>1Movement Disorder Program,Division of Neurology,University of Alberta,Kaye Edmonton Clinic,Edmonton,Alberta</wicri:regionArea><wicri:noRegion>Alberta</wicri:noRegion></affiliation></author><author><name sortKey="Wieler, Marguerite" sort="Wieler, Marguerite" uniqKey="Wieler M" first="Marguerite" last="Wieler">Marguerite Wieler</name><affiliation wicri:level="1"><nlm:affiliation>1Movement Disorder Program,Division of Neurology,University of Alberta,Kaye Edmonton Clinic,Edmonton,Alberta,Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>1Movement Disorder Program,Division of Neurology,University of Alberta,Kaye Edmonton Clinic,Edmonton,Alberta</wicri:regionArea><wicri:noRegion>Alberta</wicri:noRegion></affiliation></author><author><name sortKey="Camicioli, Richard" sort="Camicioli, Richard" uniqKey="Camicioli R" first="Richard" last="Camicioli">Richard Camicioli</name><affiliation wicri:level="1"><nlm:affiliation>1Movement Disorder Program,Division of Neurology,University of Alberta,Kaye Edmonton Clinic,Edmonton,Alberta,Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>1Movement Disorder Program,Division of Neurology,University of Alberta,Kaye Edmonton Clinic,Edmonton,Alberta</wicri:regionArea><wicri:noRegion>Alberta</wicri:noRegion></affiliation></author><author><name sortKey="Martin, W R Wayne" sort="Martin, W R Wayne" uniqKey="Martin W" first="W R Wayne" last="Martin">W R Wayne Martin</name><affiliation wicri:level="1"><nlm:affiliation>1Movement Disorder Program,Division of Neurology,University of Alberta,Kaye Edmonton Clinic,Edmonton,Alberta,Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>1Movement Disorder Program,Division of Neurology,University of Alberta,Kaye Edmonton Clinic,Edmonton,Alberta</wicri:regionArea><wicri:noRegion>Alberta</wicri:noRegion></affiliation></author></analytic><series><title level="j">The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques</title><idno type="ISSN">0317-1671</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Cross-Sectional Studies</term><term>Female</term><term>Gait Disorders, Neurologic (etiology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Parkinson Disease (complications)</term><term>Phenotype</term><term>Postural Balance</term><term>Retrospective Studies</term><term>Tremor (etiology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Gait Disorders, Neurologic</term><term>Tremor</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Phenotype</term><term>Postural Balance</term><term>Retrospective Studies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson disease (PD) presents with motor and non-motor symptoms (NMS). The NMS often precede the onset of motor symptoms, but may progress throughout the disease course. Tremor dominant, postural instability gait difficulty (PIGD), and indeterminate phenotypes can be distinguished using Unified PD Rating scales (UPDRS-III). We hypothesized that the PIGD phenotype would be more likely to develop NMS, and that the non-dopamine-responsive axial signs would correlate with NMS severity.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26949837</PMID><DateCreated><Year>2016</Year><Month>03</Month><Day>08</Day></DateCreated><DateCompleted><Year>2016</Year><Month>12</Month><Day>13</Day></DateCompleted><DateRevised><Year>2016</Year><Month>12</Month><Day>30</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0317-1671</ISSN><JournalIssue CitedMedium="Internet"><Volume>43</Volume><Issue>2</Issue><PubDate><Year>2016</Year><Month>Mar</Month></PubDate></JournalIssue><Title>The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques</Title><ISOAbbreviation>Can J Neurol Sci</ISOAbbreviation></Journal><ArticleTitle>Parkinson Disease: The Relationship Between Non-motor Symptoms and Motor Phenotype.</ArticleTitle><Pagination><MedlinePgn>261-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1017/cjn.2015.328</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Parkinson disease (PD) presents with motor and non-motor symptoms (NMS). The NMS often precede the onset of motor symptoms, but may progress throughout the disease course. Tremor dominant, postural instability gait difficulty (PIGD), and indeterminate phenotypes can be distinguished using Unified PD Rating scales (UPDRS-III). We hypothesized that the PIGD phenotype would be more likely to develop NMS, and that the non-dopamine-responsive axial signs would correlate with NMS severity.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We conducted a retrospective cross-sectional chart review to assess the relationship between NMS and PD motor phenotypes. PD patients were administered the NMS Questionnaire, the UPDRS-III, and the Mini-Mental State Examination score. The relationship between NMS burden and PD subtypes was examined using linear regression models. The prevalence of each NMS among difference PD motor subtypes was analyzed using chi-square test.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">PD patients with more advanced disease based on their UPDRS-III had higher NMS Questionnaire scores. The axial component of UPDRS-III correlated with higher NMS. There was no correlation between NMS and tremor scores. There was a significant correlation between PIGD score and higher NMS burden. PIGD group had higher prevalence in most NMS domains when compared with tremor dominant and indeterminate groups independent of disease duration and severity.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">NMS profile and severity vary according to motor phenotype. We conclude that in the PD population, patients with a PIGD phenotype who have more axial involvement, associated with advanced disease and poor motor response, have a higher risk for a higher NMS burden.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ba</LastName><ForeName>Fang</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>1Movement Disorder Program,Division of Neurology,University of Alberta,Kaye Edmonton Clinic,Edmonton,Alberta,Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Obaid</LastName><ForeName>Mona</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>1Movement Disorder Program,Division of Neurology,University of Alberta,Kaye Edmonton Clinic,Edmonton,Alberta,Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wieler</LastName><ForeName>Marguerite</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>1Movement Disorder Program,Division of Neurology,University of Alberta,Kaye Edmonton Clinic,Edmonton,Alberta,Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Camicioli</LastName><ForeName>Richard</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>1Movement Disorder Program,Division of Neurology,University of Alberta,Kaye Edmonton Clinic,Edmonton,Alberta,Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martin</LastName><ForeName>W R Wayne</ForeName><Initials>WR</Initials><AffiliationInfo><Affiliation>1Movement Disorder Program,Division of Neurology,University of Alberta,Kaye Edmonton Clinic,Edmonton,Alberta,Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><Agency>Canadian Institutes of Health Research</Agency><Country>Canada</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Can J Neurol Sci</MedlineTA><NlmUniqueID>0415227</NlmUniqueID><ISSNLinking>0317-1671</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003430" MajorTopicYN="N">Cross-Sectional Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020233" MajorTopicYN="N">Gait Disorders, Neurologic</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009483" MajorTopicYN="N">Neuropsychological Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010641" MajorTopicYN="N">Phenotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004856" MajorTopicYN="N">Postural Balance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014202" MajorTopicYN="N">Tremor</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Parkinson’s disease</Keyword><Keyword MajorTopicYN="N">motor subtype</Keyword><Keyword MajorTopicYN="N">non-motor symptoms</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>3</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>3</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>12</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26949837</ArticleId><ArticleId IdType="pii">S0317167115003285</ArticleId><ArticleId IdType="doi">10.1017/cjn.2015.328</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Ba, Fang" sort="Ba, Fang" uniqKey="Ba F" first="Fang" last="Ba">Fang Ba</name></noRegion><name sortKey="Camicioli, Richard" sort="Camicioli, Richard" uniqKey="Camicioli R" first="Richard" last="Camicioli">Richard Camicioli</name><name sortKey="Martin, W R Wayne" sort="Martin, W R Wayne" uniqKey="Martin W" first="W R Wayne" last="Martin">W R Wayne Martin</name><name sortKey="Obaid, Mona" sort="Obaid, Mona" uniqKey="Obaid M" first="Mona" last="Obaid">Mona Obaid</name><name sortKey="Wieler, Marguerite" sort="Wieler, Marguerite" uniqKey="Wieler M" first="Marguerite" last="Wieler">Marguerite Wieler</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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