TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau.
Identifieur interne : 000138 ( PubMed/Checkpoint ); précédent : 000137; suivant : 000139TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau.
Auteurs : Maxime Wc Rousseaux [États-Unis] ; Maria De Haro [États-Unis] ; Cristian A. Lasagna-Reeves [États-Unis] ; Antonia De Maio [États-Unis] ; Jeehye Park [États-Unis] ; Paymaan Jafar-Nejad [États-Unis] ; Ismael Al-Ramahi [États-Unis] ; Ajay Sharma [États-Unis] ; Lauren See [États-Unis] ; Nan Lu [États-Unis] ; Luis Vilanova-Velez [États-Unis] ; Tiemo J. Klisch [États-Unis] ; Thomas F. Westbrook [États-Unis] ; Juan C. Troncoso [États-Unis] ; Juan Botas [États-Unis] ; Huda Y. Zoghbi [États-Unis]Source :
- eLife [ 2050-084X ] ; 2016.
Abstract
Several neurodegenerative diseases are driven by the toxic gain-of-function of specific proteins within the brain. Elevated levels of alpha-synuclein (α-Syn) appear to drive neurotoxicity in Parkinson's disease (PD); neuronal accumulation of tau is a hallmark of Alzheimer's disease (AD); and their increased levels cause neurodegeneration in humans and model organisms. Despite the clinical differences between AD and PD, several lines of evidence suggest that α-Syn and tau overlap pathologically. The connections between α-Syn and tau led us to ask whether these proteins might be regulated through a shared pathway. We therefore screened for genes that affect post-translational levels of α-Syn and tau. We found that TRIM28 regulates α-Syn and tau levels and that its reduction rescues toxicity in animal models of tau- and α-Syn-mediated degeneration. TRIM28 stabilizes and promotes the nuclear accumulation and toxicity of both proteins. Intersecting screens across comorbid proteinopathies thus reveal shared mechanisms and therapeutic entry points.
DOI: 10.7554/eLife.19809
PubMed: 27779468
Affiliations:
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Lasagna-Reeves</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston</wicri:regionArea><wicri:noRegion>Houston</wicri:noRegion></affiliation></author><author><name sortKey="De Maio, Antonia" sort="De Maio, Antonia" uniqKey="De Maio A" first="Antonia" last="De Maio">Antonia De Maio</name><affiliation wicri:level="1"><nlm:affiliation>Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston</wicri:regionArea><wicri:noRegion>Houston</wicri:noRegion></affiliation></author><author><name sortKey="Park, Jeehye" sort="Park, Jeehye" uniqKey="Park J" first="Jeehye" last="Park">Jeehye Park</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston</wicri:regionArea><wicri:noRegion>Houston</wicri:noRegion></affiliation></author><author><name sortKey="Jafar Nejad, Paymaan" sort="Jafar Nejad, Paymaan" uniqKey="Jafar Nejad P" first="Paymaan" last="Jafar-Nejad">Paymaan Jafar-Nejad</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston</wicri:regionArea><wicri:noRegion>Houston</wicri:noRegion></affiliation></author><author><name sortKey="Al Ramahi, Ismael" sort="Al Ramahi, Ismael" uniqKey="Al Ramahi I" first="Ismael" last="Al-Ramahi">Ismael Al-Ramahi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston</wicri:regionArea><wicri:noRegion>Houston</wicri:noRegion></affiliation></author><author><name sortKey="Sharma, Ajay" sort="Sharma, Ajay" uniqKey="Sharma A" first="Ajay" last="Sharma">Ajay Sharma</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston</wicri:regionArea><wicri:noRegion>Houston</wicri:noRegion></affiliation></author><author><name sortKey="See, Lauren" sort="See, Lauren" uniqKey="See L" first="Lauren" last="See">Lauren See</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston</wicri:regionArea><wicri:noRegion>Houston</wicri:noRegion></affiliation></author><author><name sortKey="Lu, Nan" sort="Lu, Nan" uniqKey="Lu N" first="Nan" last="Lu">Nan Lu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston</wicri:regionArea><wicri:noRegion>Houston</wicri:noRegion></affiliation></author><author><name sortKey="Vilanova Velez, Luis" sort="Vilanova Velez, Luis" uniqKey="Vilanova Velez L" first="Luis" last="Vilanova-Velez">Luis Vilanova-Velez</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston</wicri:regionArea><wicri:noRegion>Houston</wicri:noRegion></affiliation></author><author><name sortKey="Klisch, Tiemo J" sort="Klisch, Tiemo J" uniqKey="Klisch T" first="Tiemo J" last="Klisch">Tiemo J. Klisch</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston</wicri:regionArea><wicri:noRegion>Houston</wicri:noRegion></affiliation></author><author><name sortKey="Westbrook, Thomas F" sort="Westbrook, Thomas F" uniqKey="Westbrook T" first="Thomas F" last="Westbrook">Thomas F. Westbrook</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston</wicri:regionArea><wicri:noRegion>Houston</wicri:noRegion></affiliation></author><author><name sortKey="Troncoso, Juan C" sort="Troncoso, Juan C" uniqKey="Troncoso J" first="Juan C" last="Troncoso">Juan C. Troncoso</name><affiliation wicri:level="3"><nlm:affiliation>Division of Neuropathology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Neuropathology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore</wicri:regionArea><placeName><settlement type="city">Baltimore</settlement><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Botas, Juan" sort="Botas, Juan" uniqKey="Botas J" first="Juan" last="Botas">Juan Botas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston</wicri:regionArea><wicri:noRegion>Houston</wicri:noRegion></affiliation></author><author><name sortKey="Zoghbi, Huda Y" sort="Zoghbi, Huda Y" uniqKey="Zoghbi H" first="Huda Y" last="Zoghbi">Huda Y. Zoghbi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston</wicri:regionArea><wicri:noRegion>Houston</wicri:noRegion></affiliation></author></analytic><series><title level="j">eLife</title><idno type="eISSN">2050-084X</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Several neurodegenerative diseases are driven by the toxic gain-of-function of specific proteins within the brain. Elevated levels of alpha-synuclein (α-Syn) appear to drive neurotoxicity in Parkinson's disease (PD); neuronal accumulation of tau is a hallmark of Alzheimer's disease (AD); and their increased levels cause neurodegeneration in humans and model organisms. Despite the clinical differences between AD and PD, several lines of evidence suggest that α-Syn and tau overlap pathologically. The connections between α-Syn and tau led us to ask whether these proteins might be regulated through a shared pathway. We therefore screened for genes that affect post-translational levels of α-Syn and tau. We found that TRIM28 regulates α-Syn and tau levels and that its reduction rescues toxicity in animal models of tau- and α-Syn-mediated degeneration. TRIM28 stabilizes and promotes the nuclear accumulation and toxicity of both proteins. Intersecting screens across comorbid proteinopathies thus reveal shared mechanisms and therapeutic entry points.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">27779468</PMID><DateCreated><Year>2016</Year><Month>10</Month><Day>25</Day></DateCreated><DateRevised><Year>2017</Year><Month>02</Month><Day>24</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2050-084X</ISSN><JournalIssue CitedMedium="Internet"><Volume>5</Volume><PubDate><Year>2016</Year><Month>Oct</Month><Day>25</Day></PubDate></JournalIssue><Title>eLife</Title><ISOAbbreviation>Elife</ISOAbbreviation></Journal><ArticleTitle>TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.7554/eLife.19809</ELocationID><ELocationID EIdType="pii" ValidYN="Y">e19809</ELocationID><Abstract><AbstractText>Several neurodegenerative diseases are driven by the toxic gain-of-function of specific proteins within the brain. Elevated levels of alpha-synuclein (α-Syn) appear to drive neurotoxicity in Parkinson's disease (PD); neuronal accumulation of tau is a hallmark of Alzheimer's disease (AD); and their increased levels cause neurodegeneration in humans and model organisms. Despite the clinical differences between AD and PD, several lines of evidence suggest that α-Syn and tau overlap pathologically. The connections between α-Syn and tau led us to ask whether these proteins might be regulated through a shared pathway. We therefore screened for genes that affect post-translational levels of α-Syn and tau. We found that TRIM28 regulates α-Syn and tau levels and that its reduction rescues toxicity in animal models of tau- and α-Syn-mediated degeneration. TRIM28 stabilizes and promotes the nuclear accumulation and toxicity of both proteins. Intersecting screens across comorbid proteinopathies thus reveal shared mechanisms and therapeutic entry points.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rousseaux</LastName><ForeName>Maxime Wc</ForeName><Initials>MW</Initials><AffiliationInfo><Affiliation>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Haro</LastName><ForeName>Maria</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lasagna-Reeves</LastName><ForeName>Cristian A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>De Maio</LastName><ForeName>Antonia</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Program in Developmental Biology, Baylor College of Medicine, Houston, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Park</LastName><ForeName>Jeehye</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jafar-Nejad</LastName><ForeName>Paymaan</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Al-Ramahi</LastName><ForeName>Ismael</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sharma</LastName><ForeName>Ajay</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>See</LastName><ForeName>Lauren</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lu</LastName><ForeName>Nan</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vilanova-Velez</LastName><ForeName>Luis</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Klisch</LastName><ForeName>Tiemo J</ForeName><Initials>TJ</Initials><AffiliationInfo><Affiliation>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Westbrook</LastName><ForeName>Thomas F</ForeName><Initials>TF</Initials><AffiliationInfo><Affiliation>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Troncoso</LastName><ForeName>Juan C</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Division of Neuropathology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Botas</LastName><ForeName>Juan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zoghbi</LastName><ForeName>Huda Y</ForeName><Initials>HY</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-0700-3349</Identifier><AffiliationInfo><Affiliation>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Program in Developmental Biology, Baylor College of Medicine, Houston, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Howard Hughes Medical Institute, Baylor College of Medicine, Houston, United States.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>P50 AG005146</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>K22 NS092688</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U54 HD083092</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P50 NS038377</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 NS027699</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>10</Month><Day>25</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Elife</MedlineTA><NlmUniqueID>101579614</NlmUniqueID><ISSNLinking>2050-084X</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2011 Feb 11;286(6):4566-75</RefSource><PMID Version="1">21131359</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biochem Soc Trans. 2012 Aug;40(4):667-71</RefSource><PMID Version="1">22817713</PMID></CommentsCorrections><CommentsCorrections 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The other authors declare that no competing interests exist.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>07</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>10</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>10</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>10</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>10</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27779468</ArticleId><ArticleId IdType="doi">10.7554/eLife.19809</ArticleId><ArticleId IdType="pmc">PMC5104516</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region><settlement><li>Baltimore</li></settlement></list><tree><country name="États-Unis"><noRegion><name sortKey="Rousseaux, Maxime Wc" sort="Rousseaux, Maxime Wc" uniqKey="Rousseaux M" first="Maxime Wc" last="Rousseaux">Maxime Wc Rousseaux</name></noRegion><name sortKey="Al Ramahi, Ismael" sort="Al Ramahi, Ismael" uniqKey="Al Ramahi I" first="Ismael" last="Al-Ramahi">Ismael Al-Ramahi</name><name sortKey="Botas, Juan" sort="Botas, Juan" uniqKey="Botas J" first="Juan" last="Botas">Juan Botas</name><name sortKey="De Haro, Maria" sort="De Haro, Maria" uniqKey="De Haro M" first="Maria" last="De Haro">Maria De Haro</name><name sortKey="De Maio, Antonia" sort="De Maio, Antonia" uniqKey="De Maio A" first="Antonia" last="De Maio">Antonia De Maio</name><name sortKey="Jafar Nejad, Paymaan" sort="Jafar Nejad, Paymaan" uniqKey="Jafar Nejad P" first="Paymaan" last="Jafar-Nejad">Paymaan Jafar-Nejad</name><name sortKey="Klisch, Tiemo J" sort="Klisch, Tiemo J" uniqKey="Klisch T" first="Tiemo J" last="Klisch">Tiemo J. Klisch</name><name sortKey="Lasagna Reeves, Cristian A" sort="Lasagna Reeves, Cristian A" uniqKey="Lasagna Reeves C" first="Cristian A" last="Lasagna-Reeves">Cristian A. Lasagna-Reeves</name><name sortKey="Lu, Nan" sort="Lu, Nan" uniqKey="Lu N" first="Nan" last="Lu">Nan Lu</name><name sortKey="Park, Jeehye" sort="Park, Jeehye" uniqKey="Park J" first="Jeehye" last="Park">Jeehye Park</name><name sortKey="See, Lauren" sort="See, Lauren" uniqKey="See L" first="Lauren" last="See">Lauren See</name><name sortKey="Sharma, Ajay" sort="Sharma, Ajay" uniqKey="Sharma A" first="Ajay" last="Sharma">Ajay Sharma</name><name sortKey="Troncoso, Juan C" sort="Troncoso, Juan C" uniqKey="Troncoso J" first="Juan C" last="Troncoso">Juan C. Troncoso</name><name sortKey="Vilanova Velez, Luis" sort="Vilanova Velez, Luis" uniqKey="Vilanova Velez L" first="Luis" last="Vilanova-Velez">Luis Vilanova-Velez</name><name sortKey="Westbrook, Thomas F" sort="Westbrook, Thomas F" uniqKey="Westbrook T" first="Thomas F" last="Westbrook">Thomas F. Westbrook</name><name sortKey="Zoghbi, Huda Y" sort="Zoghbi, Huda Y" uniqKey="Zoghbi H" first="Huda Y" last="Zoghbi">Huda Y. Zoghbi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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