Genomics of apicomplexan parasites.
Identifieur interne : 000067 ( PubMed/Checkpoint ); précédent : 000066; suivant : 000068Genomics of apicomplexan parasites.
Auteurs : Lakshmipuram Seshadri Swapna [Canada] ; John Parkinson [Canada]Source :
- Critical reviews in biochemistry and molecular biology [ 1549-7798 ] ; 2017.
Abstract
The increasing prevalence of infections involving intracellular apicomplexan parasites such as Plasmodium, Toxoplasma, and Cryptosporidium (the causative agents of malaria, toxoplasmosis, and cryptosporidiosis, respectively) represent a significant global healthcare burden. Despite their significance, few treatments are available; a situation that is likely to deteriorate with the emergence of new resistant strains of parasites. To lay the foundation for programs of drug discovery and vaccine development, genome sequences for many of these organisms have been generated, together with large-scale expression and proteomic datasets. Comparative analyses of these datasets are beginning to identify the molecular innovations supporting both conserved processes mediating fundamental roles in parasite survival and persistence, as well as lineage-specific adaptations associated with divergent life-cycle strategies. The challenge is how best to exploit these data to derive insights into parasite virulence and identify those genes representing the most amenable targets. In this review, we outline genomic datasets currently available for apicomplexans and discuss biological insights that have emerged as a consequence of their analysis. Of particular interest are systems-based resources, focusing on areas of metabolism and host invasion that are opening up opportunities for discovering new therapeutic targets.
DOI: 10.1080/10409238.2017.1290043
PubMed: 28276701
Affiliations:
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Despite their significance, few treatments are available; a situation that is likely to deteriorate with the emergence of new resistant strains of parasites. To lay the foundation for programs of drug discovery and vaccine development, genome sequences for many of these organisms have been generated, together with large-scale expression and proteomic datasets. Comparative analyses of these datasets are beginning to identify the molecular innovations supporting both conserved processes mediating fundamental roles in parasite survival and persistence, as well as lineage-specific adaptations associated with divergent life-cycle strategies. The challenge is how best to exploit these data to derive insights into parasite virulence and identify those genes representing the most amenable targets. In this review, we outline genomic datasets currently available for apicomplexans and discuss biological insights that have emerged as a consequence of their analysis. Of particular interest are systems-based resources, focusing on areas of metabolism and host invasion that are opening up opportunities for discovering new therapeutic targets.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28276701</PMID><DateCreated><Year>2017</Year><Month>03</Month><Day>09</Day></DateCreated><DateRevised><Year>2017</Year><Month>05</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1549-7798</ISSN><JournalIssue CitedMedium="Internet"><Volume>52</Volume><Issue>3</Issue><PubDate><Year>2017</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Critical reviews in biochemistry and molecular biology</Title><ISOAbbreviation>Crit. Rev. Biochem. Mol. Biol.</ISOAbbreviation></Journal><ArticleTitle>Genomics of apicomplexan parasites.</ArticleTitle><Pagination><MedlinePgn>254-273</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/10409238.2017.1290043</ELocationID><Abstract><AbstractText>The increasing prevalence of infections involving intracellular apicomplexan parasites such as Plasmodium, Toxoplasma, and Cryptosporidium (the causative agents of malaria, toxoplasmosis, and cryptosporidiosis, respectively) represent a significant global healthcare burden. Despite their significance, few treatments are available; a situation that is likely to deteriorate with the emergence of new resistant strains of parasites. To lay the foundation for programs of drug discovery and vaccine development, genome sequences for many of these organisms have been generated, together with large-scale expression and proteomic datasets. Comparative analyses of these datasets are beginning to identify the molecular innovations supporting both conserved processes mediating fundamental roles in parasite survival and persistence, as well as lineage-specific adaptations associated with divergent life-cycle strategies. The challenge is how best to exploit these data to derive insights into parasite virulence and identify those genes representing the most amenable targets. In this review, we outline genomic datasets currently available for apicomplexans and discuss biological insights that have emerged as a consequence of their analysis. Of particular interest are systems-based resources, focusing on areas of metabolism and host invasion that are opening up opportunities for discovering new therapeutic targets.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Swapna</LastName><ForeName>Lakshmipuram Seshadri</ForeName><Initials>LS</Initials><AffiliationInfo><Affiliation>a Program in Molecular Structure and Function , Hospital for Sick Children , Toronto , Ontario , Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Parkinson</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>a Program in Molecular Structure and Function , Hospital for Sick Children , Toronto , Ontario , Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>b Departments of Biochemistry, Molecular Genetics and Computer Science , University of Toronto , Toronto , Ontario , Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>02</Month><Day>22</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Crit Rev Biochem Mol Biol</MedlineTA><NlmUniqueID>8903774</NlmUniqueID><ISSNLinking>1040-9238</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Metabolism</Keyword><Keyword MajorTopicYN="N">apicomplexan genomics</Keyword><Keyword MajorTopicYN="N">genomics of apicomplexan parasites</Keyword><Keyword MajorTopicYN="N">host cell modulation</Keyword><Keyword MajorTopicYN="N">host invasion</Keyword><Keyword MajorTopicYN="N">parasite genomics</Keyword><Keyword MajorTopicYN="N">systems-based approaches</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>3</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>3</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>3</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28276701</ArticleId><ArticleId IdType="doi">10.1080/10409238.2017.1290043</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Swapna, Lakshmipuram Seshadri" sort="Swapna, Lakshmipuram Seshadri" uniqKey="Swapna L" first="Lakshmipuram Seshadri" last="Swapna">Lakshmipuram Seshadri Swapna</name></noRegion><name sortKey="Parkinson, John" sort="Parkinson, John" uniqKey="Parkinson J" first="John" last="Parkinson">John Parkinson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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