Imaging biomarkers in Parkinson's disease and Parkinsonian syndromes: current and emerging concepts.
Identifieur interne : 000064 ( PubMed/Checkpoint ); précédent : 000063; suivant : 000065Imaging biomarkers in Parkinson's disease and Parkinsonian syndromes: current and emerging concepts.
Auteurs : Usman Saeed [Canada] ; Jordana Compagnone [Canada] ; Richard I. Aviv [Canada] ; Antonio P. Strafella [Canada] ; Sandra E. Black [Canada] ; Anthony E. Lang [Canada] ; Mario Masellis [Canada]Source :
- Translational neurodegeneration ; 2017.
Abstract
Two centuries ago in 1817, James Parkinson provided the first medical description of Parkinson's disease, later refined by Jean-Martin Charcot in the mid-to-late 19th century to include the atypical parkinsonian variants (also termed, Parkinson-plus syndromes). Today, Parkinson's disease represents the second most common neurodegenerative disorder with an estimated global prevalence of over 10 million. Conversely, atypical parkinsonian syndromes encompass a group of relatively heterogeneous disorders that may share some clinical features with Parkinson's disease, but are uncommon distinct clinicopathological diseases. Decades of scientific advancements have vastly improved our understanding of these disorders, including improvements in in vivo imaging for biomarker identification. Multimodal imaging for the visualization of structural and functional brain changes is especially important, as it allows a 'window' into the underlying pathophysiological abnormalities. In this article, we first present an overview of the cardinal clinical and neuropathological features of, 1) synucleinopathies: Parkinson's disease and other Lewy body spectrum disorders, as well as multiple system atrophy, and 2) tauopathies: progressive supranuclear palsy, and corticobasal degeneration. A comprehensive presentation of well-established and emerging imaging biomarkers for each disorder are then discussed. Biomarkers for the following imaging modalities are reviewed: 1) structural magnetic resonance imaging (MRI) using T1, T2, and susceptibility-weighted sequences for volumetric and voxel-based morphometric analyses, as well as MRI derived visual signatures, 2) diffusion tensor MRI for the assessment of white matter tract injury and microstructural integrity, 3) proton magnetic resonance spectroscopy for quantifying proton-containing brain metabolites, 4) single photon emission computed tomography for the evaluation of nigrostriatal integrity (as assessed by presynaptic dopamine transporters and postsynaptic dopamine D2 receptors), and cerebral perfusion, 5) positron emission tomography for gauging nigrostriatal functions, glucose metabolism, amyloid and tau molecular imaging, as well as neuroinflammation, 6) myocardial scintigraphy for dysautonomia, and 7) transcranial sonography for measuring substantia nigra and lentiform nucleus echogenicity. Imaging biomarkers, using the 'multimodal approach', may aid in making early, accurate and objective diagnostic decisions, highlight neuroanatomical and pathophysiological mechanisms, as well as assist in evaluating disease progression and therapeutic responses to drugs in clinical trials.
DOI: 10.1186/s40035-017-0076-6
PubMed: 28360997
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Aviv</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Imaging, University of Toronto and Division of Neuroradiology, Sunnybrook Health Sciences Centre, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Imaging, University of Toronto and Division of Neuroradiology, Sunnybrook Health Sciences Centre, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P" last="Strafella">Antonio P. Strafella</name><affiliation wicri:level="1"><nlm:affiliation>Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Research Imaging Centre, Centre for Addiction and Mental Health, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Black, Sandra E" sort="Black, Sandra E" uniqKey="Black S" first="Sandra E" last="Black">Sandra E. Black</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name><affiliation wicri:level="4"><nlm:affiliation>Division of Neurology, Department of Medicine, University of Toronto, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurology, Department of Medicine, University of Toronto, Toronto</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Masellis, Mario" sort="Masellis, Mario" uniqKey="Masellis M" first="Mario" last="Masellis">Mario Masellis</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author></analytic><series><title level="j">Translational neurodegeneration</title><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Two centuries ago in 1817, James Parkinson provided the first medical description of Parkinson's disease, later refined by Jean-Martin Charcot in the mid-to-late 19th century to include the atypical parkinsonian variants (also termed, Parkinson-plus syndromes). Today, Parkinson's disease represents the second most common neurodegenerative disorder with an estimated global prevalence of over 10 million. Conversely, atypical parkinsonian syndromes encompass a group of relatively heterogeneous disorders that may share some clinical features with Parkinson's disease, but are uncommon distinct clinicopathological diseases. Decades of scientific advancements have vastly improved our understanding of these disorders, including improvements in in vivo imaging for biomarker identification. Multimodal imaging for the visualization of structural and functional brain changes is especially important, as it allows a 'window' into the underlying pathophysiological abnormalities. In this article, we first present an overview of the cardinal clinical and neuropathological features of, 1) synucleinopathies: Parkinson's disease and other Lewy body spectrum disorders, as well as multiple system atrophy, and 2) tauopathies: progressive supranuclear palsy, and corticobasal degeneration. A comprehensive presentation of well-established and emerging imaging biomarkers for each disorder are then discussed. Biomarkers for the following imaging modalities are reviewed: 1) structural magnetic resonance imaging (MRI) using T1, T2, and susceptibility-weighted sequences for volumetric and voxel-based morphometric analyses, as well as MRI derived visual signatures, 2) diffusion tensor MRI for the assessment of white matter tract injury and microstructural integrity, 3) proton magnetic resonance spectroscopy for quantifying proton-containing brain metabolites, 4) single photon emission computed tomography for the evaluation of nigrostriatal integrity (as assessed by presynaptic dopamine transporters and postsynaptic dopamine D2 receptors), and cerebral perfusion, 5) positron emission tomography for gauging nigrostriatal functions, glucose metabolism, amyloid and tau molecular imaging, as well as neuroinflammation, 6) myocardial scintigraphy for dysautonomia, and 7) transcranial sonography for measuring substantia nigra and lentiform nucleus echogenicity. Imaging biomarkers, using the 'multimodal approach', may aid in making early, accurate and objective diagnostic decisions, highlight neuroanatomical and pathophysiological mechanisms, as well as assist in evaluating disease progression and therapeutic responses to drugs in clinical trials.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">28360997</PMID><DateCreated><Year>2017</Year><Month>03</Month><Day>31</Day></DateCreated><DateRevised><Year>2017</Year><Month>04</Month><Day>21</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><JournalIssue CitedMedium="Print"><Volume>6</Volume><PubDate><Year>2017</Year></PubDate></JournalIssue><Title>Translational neurodegeneration</Title><ISOAbbreviation>Transl Neurodegener</ISOAbbreviation></Journal><ArticleTitle>Imaging biomarkers in Parkinson's disease and Parkinsonian syndromes: current and emerging concepts.</ArticleTitle><Pagination><MedlinePgn>8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s40035-017-0076-6</ELocationID><Abstract><AbstractText>Two centuries ago in 1817, James Parkinson provided the first medical description of Parkinson's disease, later refined by Jean-Martin Charcot in the mid-to-late 19th century to include the atypical parkinsonian variants (also termed, Parkinson-plus syndromes). Today, Parkinson's disease represents the second most common neurodegenerative disorder with an estimated global prevalence of over 10 million. Conversely, atypical parkinsonian syndromes encompass a group of relatively heterogeneous disorders that may share some clinical features with Parkinson's disease, but are uncommon distinct clinicopathological diseases. Decades of scientific advancements have vastly improved our understanding of these disorders, including improvements in in vivo imaging for biomarker identification. Multimodal imaging for the visualization of structural and functional brain changes is especially important, as it allows a 'window' into the underlying pathophysiological abnormalities. In this article, we first present an overview of the cardinal clinical and neuropathological features of, 1) synucleinopathies: Parkinson's disease and other Lewy body spectrum disorders, as well as multiple system atrophy, and 2) tauopathies: progressive supranuclear palsy, and corticobasal degeneration. A comprehensive presentation of well-established and emerging imaging biomarkers for each disorder are then discussed. Biomarkers for the following imaging modalities are reviewed: 1) structural magnetic resonance imaging (MRI) using T1, T2, and susceptibility-weighted sequences for volumetric and voxel-based morphometric analyses, as well as MRI derived visual signatures, 2) diffusion tensor MRI for the assessment of white matter tract injury and microstructural integrity, 3) proton magnetic resonance spectroscopy for quantifying proton-containing brain metabolites, 4) single photon emission computed tomography for the evaluation of nigrostriatal integrity (as assessed by presynaptic dopamine transporters and postsynaptic dopamine D2 receptors), and cerebral perfusion, 5) positron emission tomography for gauging nigrostriatal functions, glucose metabolism, amyloid and tau molecular imaging, as well as neuroinflammation, 6) myocardial scintigraphy for dysautonomia, and 7) transcranial sonography for measuring substantia nigra and lentiform nucleus echogenicity. Imaging biomarkers, using the 'multimodal approach', may aid in making early, accurate and objective diagnostic decisions, highlight neuroanatomical and pathophysiological mechanisms, as well as assist in evaluating disease progression and therapeutic responses to drugs in clinical trials.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Saeed</LastName><ForeName>Usman</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Canada.</Affiliation><Identifier Source="GRID">grid.17063.33</Identifier></AffiliationInfo><AffiliationInfo><Affiliation>LC Campbell Cognitive Neurology Research Unit, Sunnybrook Research Institute, Toronto, Canada.</Affiliation><Identifier Source="GRID">grid.17063.33</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Compagnone</LastName><ForeName>Jordana</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Canada.</Affiliation><Identifier Source="GRID">grid.17063.33</Identifier></AffiliationInfo><AffiliationInfo><Affiliation>LC Campbell Cognitive Neurology Research Unit, Sunnybrook Research Institute, Toronto, Canada.</Affiliation><Identifier Source="GRID">grid.17063.33</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aviv</LastName><ForeName>Richard I</ForeName><Initials>RI</Initials><AffiliationInfo><Affiliation>Department of Medical Imaging, University of Toronto and Division of Neuroradiology, Sunnybrook Health Sciences Centre, Toronto, Canada.</Affiliation><Identifier Source="ISNI">0000 0000 9743 1587</Identifier><Identifier Source="GRID">grid.413104.3</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Strafella</LastName><ForeName>Antonio P</ForeName><Initials>AP</Initials><AffiliationInfo><Affiliation>Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada.</Affiliation><Identifier Source="ISNI">0000 0000 8793 5925</Identifier><Identifier Source="GRID">grid.155956.b</Identifier></AffiliationInfo><AffiliationInfo><Affiliation>Division of Brain, Imaging & Behaviour - Systems Neuroscience, Toronto Western Hospital, Toronto, Canada.</Affiliation><Identifier Source="ISNI">0000 0001 0012 4167</Identifier><Identifier Source="GRID">grid.417188.3</Identifier></AffiliationInfo><AffiliationInfo><Affiliation>Division of Neurology, Department of Medicine, University of Toronto, Toronto, Canada.</Affiliation><Identifier Source="GRID">grid.17063.33</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Black</LastName><ForeName>Sandra E</ForeName><Initials>SE</Initials><AffiliationInfo><Affiliation>Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Canada.</Affiliation><Identifier Source="GRID">grid.17063.33</Identifier></AffiliationInfo><AffiliationInfo><Affiliation>LC Campbell Cognitive Neurology Research Unit, Sunnybrook Research Institute, Toronto, Canada.</Affiliation><Identifier Source="GRID">grid.17063.33</Identifier></AffiliationInfo><AffiliationInfo><Affiliation>Division of Neurology, Department of Medicine, University of Toronto, Toronto, Canada.</Affiliation><Identifier Source="GRID">grid.17063.33</Identifier></AffiliationInfo><AffiliationInfo><Affiliation>Heart & Stroke Foundation Canadian Partnership for Stroke Recovery, Sunnybrook Health Sciences Centre, Toronto, Canada.</Affiliation><Identifier Source="ISNI">0000 0000 9743 1587</Identifier><Identifier Source="GRID">grid.413104.3</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lang</LastName><ForeName>Anthony E</ForeName><Initials>AE</Initials><AffiliationInfo><Affiliation>Division of Neurology, Department of Medicine, University of Toronto, Toronto, Canada.</Affiliation><Identifier Source="GRID">grid.17063.33</Identifier></AffiliationInfo><AffiliationInfo><Affiliation>Movement Disorders Centre, Toronto Western Hospital, Toronto, Canada.</Affiliation><Identifier Source="ISNI">0000 0001 0012 4167</Identifier><Identifier Source="GRID">grid.417188.3</Identifier></AffiliationInfo><AffiliationInfo><Affiliation>Edmond J. Safra Program in Parkinson's Disease, University Health Network, Toronto, Canada.</Affiliation><Identifier Source="ISNI">0000 0004 0474 0428</Identifier><Identifier Source="GRID">grid.231844.8</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Masellis</LastName><ForeName>Mario</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Canada.</Affiliation><Identifier Source="GRID">grid.17063.33</Identifier></AffiliationInfo><AffiliationInfo><Affiliation>LC Campbell Cognitive Neurology Research Unit, Sunnybrook Research Institute, Toronto, Canada.</Affiliation><Identifier Source="GRID">grid.17063.33</Identifier></AffiliationInfo><AffiliationInfo><Affiliation>Division of Neurology, Department of Medicine, University of Toronto, Toronto, Canada.</Affiliation><Identifier Source="GRID">grid.17063.33</Identifier></AffiliationInfo><AffiliationInfo><Affiliation>Cognitive & Movement Disorders Clinic, Sunnybrook Health Sciences Centre, 2075 Bayview Ave., Room A4-55, Toronto, Ontario M4N 3 M5 Canada.</Affiliation><Identifier Source="ISNI">0000 0000 9743 1587</Identifier><Identifier Source="GRID">grid.413104.3</Identifier></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>03</Month><Day>28</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Transl Neurodegener</MedlineTA><NlmUniqueID>101591861</NlmUniqueID><ISSNLinking>2047-9158</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>J Neurol. 2006 Apr;253(4):448-54</RefSource><PMID Version="1">16267638</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 2006 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syndrome</Keyword><Keyword MajorTopicYN="N">Biomarkers</Keyword><Keyword MajorTopicYN="N">Diffusion tensor imaging</Keyword><Keyword MajorTopicYN="N">MRI</Keyword><Keyword MajorTopicYN="N">Molecular imaging</Keyword><Keyword MajorTopicYN="N">Myocardial scintigraphy</Keyword><Keyword MajorTopicYN="N">PET</Keyword><Keyword MajorTopicYN="N">Parkinson’s disease</Keyword><Keyword MajorTopicYN="N">SPECT</Keyword><Keyword MajorTopicYN="N">Transcranial sonography</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>01</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>02</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>4</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>4</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>4</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28360997</ArticleId><ArticleId IdType="doi">10.1186/s40035-017-0076-6</ArticleId><ArticleId IdType="pii">76</ArticleId><ArticleId IdType="pmc">PMC5370489</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><region name="Ontario"><name sortKey="Saeed, Usman" sort="Saeed, Usman" uniqKey="Saeed U" first="Usman" last="Saeed">Usman Saeed</name></region><name sortKey="Aviv, Richard I" sort="Aviv, Richard I" uniqKey="Aviv R" first="Richard I" last="Aviv">Richard I. Aviv</name><name sortKey="Black, Sandra E" sort="Black, Sandra E" uniqKey="Black S" first="Sandra E" last="Black">Sandra E. Black</name><name sortKey="Compagnone, Jordana" sort="Compagnone, Jordana" uniqKey="Compagnone J" first="Jordana" last="Compagnone">Jordana Compagnone</name><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name><name sortKey="Masellis, Mario" sort="Masellis, Mario" uniqKey="Masellis M" first="Mario" last="Masellis">Mario Masellis</name><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P" last="Strafella">Antonio P. Strafella</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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