Neural tissue engineering using embryonic and induced pluripotent stem cells
Identifieur interne : 000C82 ( Pmc/Curation ); précédent : 000C81; suivant : 000C83Neural tissue engineering using embryonic and induced pluripotent stem cells
Auteurs : Stephanie M. Willerth [Canada]Source :
- Stem Cell Research & Therapy [ 1757-6512 ] ; 2011.
Abstract
With the recent start of the first clinical trial evaluating a human embryonic stem cell-derived therapy for the treatment of acute spinal cord injury, it is important to review the current literature examining the use of embryonic stem cells for neural tissue engineering applications with a focus on diseases and disorders that affect the central nervous system. Embryonic stem cells exhibit pluripotency and thus can differentiate into any cell type found in the body, including those found in the nervous system. A range of studies have investigated how to direct the differentiation of embryonic cells into specific neural phenotypes using a variety of cues to achieve the goal of replacing diseased or damaged neural tissue. Additionally, the recent development of induced pluripotent stem cells provides an intriguing alternative to the use of human embryonic stem cell lines for these applications. This review will discuss relevant studies that have used embryonic stem cells to replicate the tissue found in the central nervous system as well as evaluate the potential of induced pluripotent stem cells for the aforementioned applications.
Url:
DOI: 10.1186/scrt58
PubMed: 21539726
PubMed Central: 3226288
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Stephanie M. Willerth<affiliation><nlm:aff id="I1">Department of Mechanical Engineering, University of Victoria, PO Box 3055, STN CSC, Victoria, British Columbia, V8W 3P6 Canada</nlm:aff><wicri:noCountry code="subfield">V8W 3P6 Canada</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Division of Medical Sciences, University of Victoria, PO Box 3055, STN CSC, Victoria, British Columbia, V8W 3P6, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Medical Sciences, University of Victoria, PO Box 3055, STN CSC, Victoria, British Columbia, V8W 3P6</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="I3">International Collaboration on Repair Discoveries (iCORD), Vancouver, British Columbia, V8W 3P6, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>International Collaboration on Repair Discoveries (iCORD), Vancouver, British Columbia, V8W 3P6</wicri:regionArea></affiliation>Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Neural tissue engineering using embryonic and induced pluripotent stem cells</title><author><name sortKey="Willerth, Stephanie M" sort="Willerth, Stephanie M" uniqKey="Willerth S" first="Stephanie M" last="Willerth">Stephanie M. Willerth</name><affiliation><nlm:aff id="I1">Department of Mechanical Engineering, University of Victoria, PO Box 3055, STN CSC, Victoria, British Columbia, V8W 3P6 Canada</nlm:aff><wicri:noCountry code="subfield">V8W 3P6 Canada</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Division of Medical Sciences, University of Victoria, PO Box 3055, STN CSC, Victoria, British Columbia, V8W 3P6, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Medical Sciences, University of Victoria, PO Box 3055, STN CSC, Victoria, British Columbia, V8W 3P6</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="I3">International Collaboration on Repair Discoveries (iCORD), Vancouver, British Columbia, V8W 3P6, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>International Collaboration on Repair Discoveries (iCORD), Vancouver, British Columbia, V8W 3P6</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21539726</idno><idno type="pmc">3226288</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226288</idno><idno type="RBID">PMC:3226288</idno><idno type="doi">10.1186/scrt58</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000C82</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C82</idno><idno type="wicri:Area/Pmc/Curation">000C82</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C82</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Neural tissue engineering using embryonic and induced pluripotent stem cells</title><author><name sortKey="Willerth, Stephanie M" sort="Willerth, Stephanie M" uniqKey="Willerth S" first="Stephanie M" last="Willerth">Stephanie M. Willerth</name><affiliation><nlm:aff id="I1">Department of Mechanical Engineering, University of Victoria, PO Box 3055, STN CSC, Victoria, British Columbia, V8W 3P6 Canada</nlm:aff><wicri:noCountry code="subfield">V8W 3P6 Canada</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Division of Medical Sciences, University of Victoria, PO Box 3055, STN CSC, Victoria, British Columbia, V8W 3P6, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Medical Sciences, University of Victoria, PO Box 3055, STN CSC, Victoria, British Columbia, V8W 3P6</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="I3">International Collaboration on Repair Discoveries (iCORD), Vancouver, British Columbia, V8W 3P6, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>International Collaboration on Repair Discoveries (iCORD), Vancouver, British Columbia, V8W 3P6</wicri:regionArea></affiliation></author></analytic><series><title level="j">Stem Cell Research & Therapy</title><idno type="eISSN">1757-6512</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>With the recent start of the first clinical trial evaluating a human embryonic stem cell-derived therapy for the treatment of acute spinal cord injury, it is important to review the current literature examining the use of embryonic stem cells for neural tissue engineering applications with a focus on diseases and disorders that affect the central nervous system. Embryonic stem cells exhibit pluripotency and thus can differentiate into any cell type found in the body, including those found in the nervous system. A range of studies have investigated how to direct the differentiation of embryonic cells into specific neural phenotypes using a variety of cues to achieve the goal of replacing diseased or damaged neural tissue. Additionally, the recent development of induced pluripotent stem cells provides an intriguing alternative to the use of human embryonic stem cell lines for these applications. This review will discuss relevant studies that have used embryonic stem cells to replicate the tissue found in the central nervous system as well as evaluate the potential of induced pluripotent stem cells for the aforementioned applications.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Greg Hall, D" uniqKey="Greg Hall D">D Greg Hall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roux, F" uniqKey="Roux F">F Roux</name></author><author><name sortKey="Couraud, Po" uniqKey="Couraud P">PO Couraud</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parker, D" uniqKey="Parker D">D Parker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Madduri, S" uniqKey="Madduri S">S Madduri</name></author><author><name sortKey="Gander, B" uniqKey="Gander B">B Gander</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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Vierbuchen</name></author><author><name sortKey="Ostermeier, A" uniqKey="Ostermeier A">A Ostermeier</name></author><author><name sortKey="Pang, Zp" uniqKey="Pang Z">ZP Pang</name></author><author><name sortKey="Kokubu, Y" uniqKey="Kokubu Y">Y Kokubu</name></author><author><name sortKey="Sudhof, Tc" uniqKey="Sudhof T">TC Sudhof</name></author><author><name sortKey="Wernig, M" uniqKey="Wernig M">M Wernig</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Stem Cell Res Ther</journal-id><journal-title-group><journal-title>Stem Cell Research & Therapy</journal-title></journal-title-group><issn pub-type="epub">1757-6512</issn><publisher><publisher-name>BioMed Central</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21539726</article-id><article-id pub-id-type="pmc">3226288</article-id><article-id pub-id-type="publisher-id">scrt58</article-id><article-id pub-id-type="doi">10.1186/scrt58</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Neural tissue engineering using embryonic and induced pluripotent stem cells</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes" id="A1"><name><surname>Willerth</surname><given-names>Stephanie M</given-names></name><xref ref-type="aff" rid="I1">1</xref><xref ref-type="aff" rid="I2">2</xref><xref ref-type="aff" rid="I3">3</xref><email>willerth@uvic.ca</email></contrib></contrib-group><aff id="I1"><label>1</label>Department of Mechanical Engineering, University of Victoria, PO Box 3055, STN CSC, Victoria, British Columbia, V8W 3P6 Canada</aff><aff id="I2"><label>2</label>Division of Medical Sciences, University of Victoria, PO Box 3055, STN CSC, Victoria, British Columbia, V8W 3P6, Canada</aff><aff id="I3"><label>3</label>International Collaboration on Repair Discoveries (iCORD), Vancouver, British Columbia, V8W 3P6, Canada</aff><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>15</day><month>4</month><year>2011</year></pub-date><pmc-comment> PMC Release delay is 12 months and 0 days and was based on the epub date.</pmc-comment>
<pub-date pub-type="pmc-release"><day>15</day><month>4</month><year>2012</year></pub-date><volume>2</volume><issue>2</issue><fpage>17</fpage><lpage>17</lpage><permissions><copyright-statement>Copyright ©2011 BioMed Central Ltd</copyright-statement><copyright-year>2011</copyright-year><copyright-holder>BioMed Central Ltd</copyright-holder></permissions><self-uri xlink:href="http://stemcellres.com/content/2/2/17"></self-uri><abstract><p>With the recent start of the first clinical trial evaluating a human embryonic stem cell-derived therapy for the treatment of acute spinal cord injury, it is important to review the current literature examining the use of embryonic stem cells for neural tissue engineering applications with a focus on diseases and disorders that affect the central nervous system. Embryonic stem cells exhibit pluripotency and thus can differentiate into any cell type found in the body, including those found in the nervous system. A range of studies have investigated how to direct the differentiation of embryonic cells into specific neural phenotypes using a variety of cues to achieve the goal of replacing diseased or damaged neural tissue. Additionally, the recent development of induced pluripotent stem cells provides an intriguing alternative to the use of human embryonic stem cell lines for these applications. This review will discuss relevant studies that have used embryonic stem cells to replicate the tissue found in the central nervous system as well as evaluate the potential of induced pluripotent stem cells for the aforementioned applications.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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