Development and application of neural stem cells for treating various human neurological diseases in animal models
Identifieur interne : 000C56 ( Pmc/Curation ); précédent : 000C55; suivant : 000C57Development and application of neural stem cells for treating various human neurological diseases in animal models
Auteurs : Bo-Rim Yi [Corée du Sud] ; Seung U. Kim [Canada, Corée du Sud] ; Kyung-Chul Choi [Corée du Sud]Source :
- Laboratory Animal Research [ 1738-6055 ] ; 2013.
Abstract
Stem cells derived from adult tissues or the inner cell mass (ICM) of embryos in the mammalian blastocyst (BL) stage are capable of self-renewal and have remarkable potential for undergoing lineage-specific differentiation under
Url:
DOI: 10.5625/lar.2013.29.3.131
PubMed: 24106507
PubMed Central: 3791346
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Development and application of neural stem cells for treating various human neurological diseases in animal models</title><author><name sortKey="Yi, Bo Rim" sort="Yi, Bo Rim" uniqKey="Yi B" first="Bo-Rim" last="Yi">Bo-Rim Yi</name><affiliation wicri:level="1"><nlm:aff id="A1">Laboratory of Veterinary Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Laboratory of Veterinary Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Seung U" sort="Kim, Seung U" uniqKey="Kim S" first="Seung U." last="Kim">Seung U. Kim</name><affiliation wicri:level="1"><nlm:aff id="A2">Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Canada</country><wicri:regionArea>Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, British Columbia</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Medical Research Institute, College of Medicine, Chung-Ang University, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Medical Research Institute, College of Medicine, Chung-Ang University, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Choi, Kyung Chul" sort="Choi, Kyung Chul" uniqKey="Choi K" first="Kyung-Chul" last="Choi">Kyung-Chul Choi</name><affiliation wicri:level="1"><nlm:aff id="A1">Laboratory of Veterinary Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Laboratory of Veterinary Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24106507</idno><idno type="pmc">3791346</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791346</idno><idno type="RBID">PMC:3791346</idno><idno type="doi">10.5625/lar.2013.29.3.131</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000C56</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C56</idno><idno type="wicri:Area/Pmc/Curation">000C56</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C56</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Development and application of neural stem cells for treating various human neurological diseases in animal models</title><author><name sortKey="Yi, Bo Rim" sort="Yi, Bo Rim" uniqKey="Yi B" first="Bo-Rim" last="Yi">Bo-Rim Yi</name><affiliation wicri:level="1"><nlm:aff id="A1">Laboratory of Veterinary Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Laboratory of Veterinary Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Seung U" sort="Kim, Seung U" uniqKey="Kim S" first="Seung U." last="Kim">Seung U. Kim</name><affiliation wicri:level="1"><nlm:aff id="A2">Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Canada</country><wicri:regionArea>Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, British Columbia</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Medical Research Institute, College of Medicine, Chung-Ang University, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Medical Research Institute, College of Medicine, Chung-Ang University, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Choi, Kyung Chul" sort="Choi, Kyung Chul" uniqKey="Choi K" first="Kyung-Chul" last="Choi">Kyung-Chul Choi</name><affiliation wicri:level="1"><nlm:aff id="A1">Laboratory of Veterinary Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Laboratory of Veterinary Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju</wicri:regionArea></affiliation></author></analytic><series><title level="j">Laboratory Animal Research</title><idno type="ISSN">1738-6055</idno><idno type="eISSN">2233-7660</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Stem cells derived from adult tissues or the inner cell mass (ICM) of embryos in the mammalian blastocyst (BL) stage are capable of self-renewal and have remarkable potential for undergoing lineage-specific differentiation under <italic>in vitro</italic> culturing conditions. In particular, neural stem cells (NSCs) that self-renew and differentiate into major cell types of the brain exist in the developing and adult central nervous system (CNS). The exact function and distribution of NSCs has been assessed, and they represent an interesting population that includes astrocytes, oligodendrocytes, and neurons. Many researchers have demonstrated functional recovery in animal models of various neurological diseases such as stroke, Parkinson's disease (PD), brain tumors, and metastatic tumors. The safety and efficacy of stem cell-based therapies (SCTs) are also being evaluated in humans. The therapeutic efficacy of NSCs has been shown in the brain disorder-induced animal models, and animal models may be well established to perform the test before clinical stage. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Lab Anim Res</journal-id><journal-id journal-id-type="iso-abbrev">Lab Anim Res</journal-id><journal-id journal-id-type="publisher-id">LAR</journal-id><journal-title-group><journal-title>Laboratory Animal Research</journal-title></journal-title-group><issn pub-type="ppub">1738-6055</issn><issn pub-type="epub">2233-7660</issn><publisher><publisher-name>Korean Association for Laboratory Animal Science</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24106507</article-id><article-id pub-id-type="pmc">3791346</article-id><article-id pub-id-type="doi">10.5625/lar.2013.29.3.131</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Development and application of neural stem cells for treating various human neurological diseases in animal models</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Yi</surname><given-names>Bo-Rim</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Seung U.</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Choi</surname><given-names>Kyung-Chul</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label>Laboratory of Veterinary Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea.</aff><aff id="A2"><label>2</label>Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.</aff><aff id="A3"><label>3</label>Medical Research Institute, College of Medicine, Chung-Ang University, Seoul, Korea.</aff><author-notes><corresp>Corresponding author: Kyung-Chul Choi, Laboratory of Veterinary Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 361-763, Korea. Tel: +82-43-261-3664; Fax: +82-43-267-3150; <email>kchoi@cbu.ac.kr</email></corresp></author-notes><pub-date pub-type="ppub"><month>9</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>27</day><month>9</month><year>2013</year></pub-date><volume>29</volume><issue>3</issue><fpage>131</fpage><lpage>137</lpage><history><date date-type="received"><day>20</day><month>5</month><year>2013</year></date><date date-type="rev-recd"><day>08</day><month>7</month><year>2013</year></date><date date-type="accepted"><day>12</day><month>7</month><year>2013</year></date></history><permissions><copyright-statement>Copyright © 2013 Korean Association for Laboratory Animal Science</copyright-statement><copyright-year>2013</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>Stem cells derived from adult tissues or the inner cell mass (ICM) of embryos in the mammalian blastocyst (BL) stage are capable of self-renewal and have remarkable potential for undergoing lineage-specific differentiation under <italic>in vitro</italic> culturing conditions. In particular, neural stem cells (NSCs) that self-renew and differentiate into major cell types of the brain exist in the developing and adult central nervous system (CNS). The exact function and distribution of NSCs has been assessed, and they represent an interesting population that includes astrocytes, oligodendrocytes, and neurons. Many researchers have demonstrated functional recovery in animal models of various neurological diseases such as stroke, Parkinson's disease (PD), brain tumors, and metastatic tumors. The safety and efficacy of stem cell-based therapies (SCTs) are also being evaluated in humans. The therapeutic efficacy of NSCs has been shown in the brain disorder-induced animal models, and animal models may be well established to perform the test before clinical stage. Taken together, data from the literature have indicated that therapeutic NSCs may be useful for selectively treating diverse types of human brain diseases without incurring adverse effects.</p></abstract><kwd-group><kwd>Neural stem cells</kwd><kwd>Parkinson's disease</kwd><kwd>stroke</kwd><kwd>brain tumor</kwd><kwd>metastatic tumor</kwd></kwd-group></article-meta></front><floats-group><fig id="F1" orientation="portrait" position="float"><label>Figure 1</label><caption><p>Application of neural stem cells (NSCs) therapies. NSCs the self-renew and differentiate into major cell types of the brain exist, such as astrocytes, oligodendrocytes, and neurons, in the developing and adult central nervous system (CNS). There have been describing the effects of NSC transplantation for achieving functional recovery from CNS damage. Therefore, NSCs may be a suitable component for treating neurological diseases such as stroke, Parkinson's diseases (PD), brain tumors, primary and metastatic tumors. GFAP; glial fibrillary acidic protein, RC2: radial glial cell marker, 6-OHDA; 6-hydroxydopamine, MPTP; 1-methyl-4-phenyl-1,2,3,6,-tetrahydropyridine.</p></caption><graphic xlink:href="lar-29-131-g001"></graphic></fig></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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