Oxidative Stress in Aging-Matters of the Heart and Mind
Identifieur interne : 000C43 ( Pmc/Curation ); précédent : 000C42; suivant : 000C44Oxidative Stress in Aging-Matters of the Heart and Mind
Auteurs : Krishnan Venkataraman ; Sandhya Khurana ; T. C. Tai [Canada]Source :
- International Journal of Molecular Sciences [ 1422-0067 ] ; 2013.
Abstract
Oxidative damage is considered to be the primary cause of several aging associated disease pathologies. Cumulative oxidative damage tends to be pervasive among cellular macromolecules, impacting proteins, lipids, RNA and DNA of cells. At a systemic level, events subsequent to oxidative damage induce an inflammatory response to sites of oxidative damage, often contributing to additional oxidative stress. At a cellular level, oxidative damage to mitochondria results in acidification of the cytoplasm and release of cytochrome c, causing apoptosis. This review summarizes findings in the literature on oxidative stress and consequent damage on cells and tissues of the cardiovascular system and the central nervous system, with a focus on aging-related diseases that have well-documented evidence of oxidative damage in initiation and/or progression of the disease. The current understanding of the cellular mechanisms with a focus on macromolecular damage, impacted cellular pathways and gross morphological changes associated with oxidative damage is also reviewed. Additionally, the impact of calorific restriction with its profound impact on cardiovascular and neuronal aging is addressed.
Url:
DOI: 10.3390/ijms140917897
PubMed: 24002027
PubMed Central: 3794759
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Oxidative Stress in Aging-Matters of the Heart and Mind</title><author><name sortKey="Venkataraman, Krishnan" sort="Venkataraman, Krishnan" uniqKey="Venkataraman K" first="Krishnan" last="Venkataraman">Krishnan Venkataraman</name><affiliation><nlm:aff id="af1-ijms-14-17897">Department of Gerontology, Huntington University, Sudbury, ON P3E 2C6, Canada; E-Mail:<email>kvenkataraman@huntingtonu.ca</email></nlm:aff></affiliation></author><author><name sortKey="Khurana, Sandhya" sort="Khurana, Sandhya" uniqKey="Khurana S" first="Sandhya" last="Khurana">Sandhya Khurana</name><affiliation><nlm:aff id="af2-ijms-14-17897">Medical Sciences Division, Northern Ontario School of Medicine, Sudbury, ON P3E 2C6, Canada; E-Mail:<email>sandhya.khurana@nosm.ca</email></nlm:aff></affiliation></author><author><name sortKey="Tai, T C" sort="Tai, T C" uniqKey="Tai T" first="T. C." last="Tai">T. C. Tai</name><affiliation><nlm:aff id="af2-ijms-14-17897">Medical Sciences Division, Northern Ontario School of Medicine, Sudbury, ON P3E 2C6, Canada; E-Mail:<email>sandhya.khurana@nosm.ca</email></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-ijms-14-17897">Department of Biology, Department of Chemistry and Biochemistry, Biomolecular Sciences Program, Laurentian University, 935 Ramsey Lake Road, Sudbury, ON P3E 2C6, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Biology, Department of Chemistry and Biochemistry, Biomolecular Sciences Program, Laurentian University, 935 Ramsey Lake Road, Sudbury, ON P3E 2C6</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24002027</idno><idno type="pmc">3794759</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794759</idno><idno type="RBID">PMC:3794759</idno><idno type="doi">10.3390/ijms140917897</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000C43</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C43</idno><idno type="wicri:Area/Pmc/Curation">000C43</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C43</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Oxidative Stress in Aging-Matters of the Heart and Mind</title><author><name sortKey="Venkataraman, Krishnan" sort="Venkataraman, Krishnan" uniqKey="Venkataraman K" first="Krishnan" last="Venkataraman">Krishnan Venkataraman</name><affiliation><nlm:aff id="af1-ijms-14-17897">Department of Gerontology, Huntington University, Sudbury, ON P3E 2C6, Canada; E-Mail:<email>kvenkataraman@huntingtonu.ca</email></nlm:aff></affiliation></author><author><name sortKey="Khurana, Sandhya" sort="Khurana, Sandhya" uniqKey="Khurana S" first="Sandhya" last="Khurana">Sandhya Khurana</name><affiliation><nlm:aff id="af2-ijms-14-17897">Medical Sciences Division, Northern Ontario School of Medicine, Sudbury, ON P3E 2C6, Canada; E-Mail:<email>sandhya.khurana@nosm.ca</email></nlm:aff></affiliation></author><author><name sortKey="Tai, T C" sort="Tai, T C" uniqKey="Tai T" first="T. C." last="Tai">T. C. Tai</name><affiliation><nlm:aff id="af2-ijms-14-17897">Medical Sciences Division, Northern Ontario School of Medicine, Sudbury, ON P3E 2C6, Canada; E-Mail:<email>sandhya.khurana@nosm.ca</email></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-ijms-14-17897">Department of Biology, Department of Chemistry and Biochemistry, Biomolecular Sciences Program, Laurentian University, 935 Ramsey Lake Road, Sudbury, ON P3E 2C6, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Biology, Department of Chemistry and Biochemistry, Biomolecular Sciences Program, Laurentian University, 935 Ramsey Lake Road, Sudbury, ON P3E 2C6</wicri:regionArea></affiliation></author></analytic><series><title level="j">International Journal of Molecular Sciences</title><idno type="eISSN">1422-0067</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Oxidative damage is considered to be the primary cause of several aging associated disease pathologies. Cumulative oxidative damage tends to be pervasive among cellular macromolecules, impacting proteins, lipids, RNA and DNA of cells. At a systemic level, events subsequent to oxidative damage induce an inflammatory response to sites of oxidative damage, often contributing to additional oxidative stress. At a cellular level, oxidative damage to mitochondria results in acidification of the cytoplasm and release of cytochrome c, causing apoptosis. This review summarizes findings in the literature on oxidative stress and consequent damage on cells and tissues of the cardiovascular system and the central nervous system, with a focus on aging-related diseases that have well-documented evidence of oxidative damage in initiation and/or progression of the disease. The current understanding of the cellular mechanisms with a focus on macromolecular damage, impacted cellular pathways and gross morphological changes associated with oxidative damage is also reviewed. Additionally, the impact of calorific restriction with its profound impact on cardiovascular and neuronal aging is addressed.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Yu, B P" uniqKey="Yu B">B.P. Yu</name></author><author><name sortKey="Yang, R" uniqKey="Yang R">R. Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schoneich, C" uniqKey="Schoneich C">C. Schoneich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jacob, K D" uniqKey="Jacob K">K.D. Jacob</name></author><author><name sortKey="Noren Hooten, N" uniqKey="Noren Hooten N">N. Noren Hooten</name></author><author><name sortKey="Trzeciak, A R" uniqKey="Trzeciak A">A.R. Trzeciak</name></author><author><name sortKey="Evans, M K" uniqKey="Evans M">M.K. Evans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Singh, R" uniqKey="Singh R">R. Singh</name></author><author><name sortKey="Barden, A" uniqKey="Barden A">A. Barden</name></author><author><name sortKey="Mori, T" uniqKey="Mori T">T. Mori</name></author><author><name sortKey="Beilin, L" uniqKey="Beilin L">L. Beilin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sahin, E" uniqKey="Sahin E">E. Sahin</name></author><author><name sortKey="Depinho, R A" uniqKey="Depinho R">R.A. Depinho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moller, P" uniqKey="Moller P">P. Moller</name></author><author><name sortKey="Lohr, M" uniqKey="Lohr M">M. Lohr</name></author><author><name sortKey="Folkmann, J K" uniqKey="Folkmann J">J.K. Folkmann</name></author><author><name sortKey="Mikkelsen, L" uniqKey="Mikkelsen L">L. Mikkelsen</name></author><author><name sortKey="Loft, S" uniqKey="Loft S">S. Loft</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harman, D" uniqKey="Harman D">D. Harman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Giustarini, D" uniqKey="Giustarini D">D. Giustarini</name></author><author><name sortKey="Dalle Donne, I" uniqKey="Dalle Donne I">I. Dalle-Donne</name></author><author><name sortKey="Tsikas, D" uniqKey="Tsikas D">D. Tsikas</name></author><author><name sortKey="Rossi, R" uniqKey="Rossi R">R. Rossi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rosenfeldt, F" uniqKey="Rosenfeldt F">F. Rosenfeldt</name></author><author><name sortKey="Wilson, M" uniqKey="Wilson M">M. Wilson</name></author><author><name sortKey="Lee, G" uniqKey="Lee G">G. Lee</name></author><author><name sortKey="Kure, C" uniqKey="Kure C">C. Kure</name></author><author><name sortKey="Ou, R" uniqKey="Ou R">R. Ou</name></author><author><name sortKey="Braun, L" uniqKey="Braun L">L. Braun</name></author><author><name sortKey="De Haan, J" uniqKey="De Haan J">J. de Haan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sies, H" uniqKey="Sies H">H. Sies</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prince, M" uniqKey="Prince M">M. Prince</name></author><author><name sortKey="Bryce, R" uniqKey="Bryce R">R. Bryce</name></author><author><name sortKey="Albanese, E" uniqKey="Albanese E">E. Albanese</name></author><author><name sortKey="Wimo, A" uniqKey="Wimo A">A. Wimo</name></author><author><name sortKey="Ribeiro, W" uniqKey="Ribeiro W">W. Ribeiro</name></author><author><name sortKey="Ferri, C P" uniqKey="Ferri C">C.P. Ferri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karavidas, A" uniqKey="Karavidas A">A. Karavidas</name></author><author><name sortKey="Lazaros, G" uniqKey="Lazaros G">G. Lazaros</name></author><author><name sortKey="Tsiachris, D" uniqKey="Tsiachris D">D. Tsiachris</name></author><author><name sortKey="Pyrgakis, V" uniqKey="Pyrgakis V">V. Pyrgakis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raina, P S" uniqKey="Raina P">P.S. Raina</name></author><author><name sortKey="Wolfson, C" uniqKey="Wolfson C">C. Wolfson</name></author><author><name sortKey="Kirkland, S A" uniqKey="Kirkland S">S.A. Kirkland</name></author><author><name sortKey="Griffith, L E" uniqKey="Griffith L">L.E. Griffith</name></author><author><name sortKey="Oremus, M" uniqKey="Oremus M">M. Oremus</name></author><author><name sortKey="Patterson, C" uniqKey="Patterson C">C. Patterson</name></author><author><name sortKey="Tuokko, H" uniqKey="Tuokko H">H. Tuokko</name></author><author><name sortKey="Penning, M" uniqKey="Penning M">M. Penning</name></author><author><name sortKey="Balion, C M" uniqKey="Balion C">C.M. Balion</name></author><author><name sortKey="Hogan, D" uniqKey="Hogan D">D. Hogan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muqtadar, H" uniqKey="Muqtadar H">H. Muqtadar</name></author><author><name sortKey="Testai, F D" uniqKey="Testai F">F.D. Testai</name></author><author><name sortKey="Gorelick, P B" uniqKey="Gorelick P">P.B. Gorelick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Newman, A B" uniqKey="Newman A">A.B. Newman</name></author><author><name sortKey="Fitzpatrick, A L" uniqKey="Fitzpatrick A">A.L. Fitzpatrick</name></author><author><name sortKey="Lopez, O" uniqKey="Lopez O">O. Lopez</name></author><author><name sortKey="Jackson, S" uniqKey="Jackson S">S. Jackson</name></author><author><name sortKey="Lyketsos, C" uniqKey="Lyketsos C">C. Lyketsos</name></author><author><name sortKey="Jagust, W" uniqKey="Jagust W">W. Jagust</name></author><author><name sortKey="Ives, D" uniqKey="Ives D">D. Ives</name></author><author><name sortKey="Dekosky, S T" uniqKey="Dekosky S">S.T. Dekosky</name></author><author><name sortKey="Kuller, L H" uniqKey="Kuller L">L.H. Kuller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matsuzaki, S" uniqKey="Matsuzaki S">S. Matsuzaki</name></author><author><name sortKey="Szweda, P A" uniqKey="Szweda P">P.A. Szweda</name></author><author><name sortKey="Szweda, L I" uniqKey="Szweda L">L.I. Szweda</name></author><author><name sortKey="Humphries, K M" uniqKey="Humphries K">K.M. Humphries</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Castro, L" uniqKey="Castro L">L. Castro</name></author><author><name sortKey="Demicheli, V" uniqKey="Demicheli V">V. Demicheli</name></author><author><name sortKey="Tortora, V" uniqKey="Tortora V">V. Tortora</name></author><author><name sortKey="Radi, R" uniqKey="Radi R">R. Radi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pollack, M" uniqKey="Pollack M">M. Pollack</name></author><author><name sortKey="Leeuwenburgh, C" uniqKey="Leeuwenburgh C">C. Leeuwenburgh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sohal, R" uniqKey="Sohal R">R. Sohal</name></author><author><name sortKey="Orr, W" uniqKey="Orr W">W. Orr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drummond, G" uniqKey="Drummond G">G. Drummond</name></author><author><name sortKey="Selemidis, S" uniqKey="Selemidis S">S. Selemidis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yu, B P" uniqKey="Yu B">B.P. Yu</name></author><author><name sortKey="Chung, H Y" uniqKey="Chung H">H.Y. Chung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eiserich, J P" uniqKey="Eiserich J">J.P. Eiserich</name></author><author><name sortKey="Patel, R P" uniqKey="Patel R">R.P. Patel</name></author><author><name sortKey="O Onnell, V B" uniqKey="O Onnell V">V.B. O’Donnell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paravicini, T M" uniqKey="Paravicini T">T.M. Paravicini</name></author><author><name sortKey="Touyz, R M" uniqKey="Touyz R">R.M. Touyz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lacy, F" uniqKey="Lacy F">F. Lacy</name></author><author><name sortKey="Gough, D A" uniqKey="Gough D">D.A. Gough</name></author><author><name sortKey="Schmid Schonbein, G W" uniqKey="Schmid Schonbein G">G.W. Schmid-Schonbein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Catala, A" uniqKey="Catala A">A. Catala</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vallyathan, V" uniqKey="Vallyathan V">V. Vallyathan</name></author><author><name sortKey="Shi, X" uniqKey="Shi X">X. Shi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dizdaroglu, M" uniqKey="Dizdaroglu M">M. Dizdaroglu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shan, X" uniqKey="Shan X">X. Shan</name></author><author><name sortKey="Lin, C L G" uniqKey="Lin C">C.-L.G. Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name></author><author><name sortKey="Perry, G" uniqKey="Perry G">G. Perry</name></author><author><name sortKey="Smith, M A" uniqKey="Smith M">M.A. Smith</name></author><author><name sortKey="Robertson, D" uniqKey="Robertson D">D. Robertson</name></author><author><name sortKey="Olson, S J" uniqKey="Olson S">S.J. Olson</name></author><author><name sortKey="Graham, D G" uniqKey="Graham D">D.G. Graham</name></author><author><name sortKey="Montine, T J" uniqKey="Montine T">T.J. Montine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Widmer, R" uniqKey="Widmer R">R. Widmer</name></author><author><name sortKey="Ziaja, I" uniqKey="Ziaja I">I. Ziaja</name></author><author><name sortKey="Grune, T" uniqKey="Grune T">T. Grune</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jung, T" uniqKey="Jung T">T. Jung</name></author><author><name sortKey="Catalgol, B" uniqKey="Catalgol B">B. Catalgol</name></author><author><name sortKey="Grune, T" uniqKey="Grune T">T. Grune</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Orlandi, A" uniqKey="Orlandi A">A. Orlandi</name></author><author><name sortKey="Bochaton Piallat, M L" uniqKey="Bochaton Piallat M">M.-L. Bochaton-Piallat</name></author><author><name sortKey="Gabbiani, G" uniqKey="Gabbiani G">G. Gabbiani</name></author><author><name sortKey="Spagnoli, L G" uniqKey="Spagnoli L">L.G. Spagnoli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De La Haba, C" uniqKey="De La Haba C">C. De la Haba</name></author><author><name sortKey="Palacio, J R" uniqKey="Palacio J">J.R. Palacio</name></author><author><name sortKey="Martinez, P" uniqKey="Martinez P">P. Martinez</name></author><author><name sortKey="Morros, A" uniqKey="Morros A">A. Morros</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Freikman, I" uniqKey="Freikman I">I. Freikman</name></author><author><name sortKey="Amer, J" uniqKey="Amer J">J. Amer</name></author><author><name sortKey="Cohen, J S" uniqKey="Cohen J">J.S. Cohen</name></author><author><name sortKey="Ringel, I" uniqKey="Ringel I">I. Ringel</name></author><author><name sortKey="Fibach, E" uniqKey="Fibach E">E. Fibach</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clement, A B" uniqKey="Clement A">A.B. Clement</name></author><author><name sortKey="Gimpl, G" uniqKey="Gimpl G">G. Gimpl</name></author><author><name sortKey="Behl, C" uniqKey="Behl C">C. Behl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saxena, S" uniqKey="Saxena S">S. Saxena</name></author><author><name sortKey="Srivastava, P" uniqKey="Srivastava P">P. Srivastava</name></author><author><name sortKey="Kumar, D" uniqKey="Kumar D">D. Kumar</name></author><author><name sortKey="Khanna, V K" uniqKey="Khanna V">V.K. Khanna</name></author><author><name sortKey="Seth, P K" uniqKey="Seth P">P.K. Seth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Johnson, P" uniqKey="Johnson P">P. Johnson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Das, M" uniqKey="Das M">M. Das</name></author><author><name sortKey="Babu, K" uniqKey="Babu K">K. Babu</name></author><author><name sortKey="Reddy, N P" uniqKey="Reddy N">N.P. Reddy</name></author><author><name sortKey="Srivastava, L M" uniqKey="Srivastava L">L.M. Srivastava</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harper, M E" uniqKey="Harper M">M.E. Harper</name></author><author><name sortKey="Bevilacqua, L" uniqKey="Bevilacqua L">L. Bevilacqua</name></author><author><name sortKey="Hagopian, K" uniqKey="Hagopian K">K. Hagopian</name></author><author><name sortKey="Weindruch, R" uniqKey="Weindruch R">R. Weindruch</name></author><author><name sortKey="Ramsey, J J" uniqKey="Ramsey J">J.J. Ramsey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Echtay, K S" uniqKey="Echtay K">K.S. Echtay</name></author><author><name sortKey="Roussel, D" uniqKey="Roussel D">D. Roussel</name></author><author><name sortKey="St Pierre, J" uniqKey="St Pierre J">J. St-Pierre</name></author><author><name sortKey="Jekabsons, M B" uniqKey="Jekabsons M">M.B. Jekabsons</name></author><author><name sortKey="Cadenas, S" uniqKey="Cadenas S">S. Cadenas</name></author><author><name sortKey="Stuart, J A" uniqKey="Stuart J">J.A. Stuart</name></author><author><name sortKey="Harper, J A" uniqKey="Harper J">J.A. Harper</name></author><author><name sortKey="Roebuck, S J" uniqKey="Roebuck S">S.J. Roebuck</name></author><author><name sortKey="Morrison, A" uniqKey="Morrison A">A. Morrison</name></author><author><name sortKey="Pickering, S" uniqKey="Pickering S">S. Pickering</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Webb, R C" uniqKey="Webb R">R.C. Webb</name></author><author><name sortKey="Inscho, E W" uniqKey="Inscho E">E.W. Inscho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oxenham, H" uniqKey="Oxenham H">H. Oxenham</name></author><author><name sortKey="Sharpe, N" uniqKey="Sharpe N">N. Sharpe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Benjamin, E" uniqKey="Benjamin E">E. Benjamin</name></author><author><name sortKey="Plehn, J" uniqKey="Plehn J">J. Plehn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dai, D F" uniqKey="Dai D">D.F. Dai</name></author><author><name sortKey="Rabinovitch, P S" uniqKey="Rabinovitch P">P.S. Rabinovitch</name></author><author><name sortKey="Ungvari, Z" uniqKey="Ungvari Z">Z. Ungvari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Navarro, A" uniqKey="Navarro A">A. Navarro</name></author><author><name sortKey="Boveris, A" uniqKey="Boveris A">A. Boveris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Herrera, M D" uniqKey="Herrera M">M.D. Herrera</name></author><author><name sortKey="Mingorance, C" uniqKey="Mingorance C">C. Mingorance</name></author><author><name sortKey="Rodriguez Rodriguez, R" uniqKey="Rodriguez Rodriguez R">R. Rodriguez-Rodriguez</name></author><author><name sortKey="Alvarez De Sotomayor, M" uniqKey="Alvarez De Sotomayor M">M. Alvarez de Sotomayor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pierce, G L" uniqKey="Pierce G">G.L. Pierce</name></author><author><name sortKey="Larocca, T J" uniqKey="Larocca T">T.J. Larocca</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bode Boger, S M" uniqKey="Bode Boger S">S.M. Bode-Boger</name></author><author><name sortKey="Scalera, F" uniqKey="Scalera F">F. Scalera</name></author><author><name sortKey="Ignarro, L J" uniqKey="Ignarro L">L.J. Ignarro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Z" uniqKey="Yang Z">Z. Yang</name></author><author><name sortKey="Ming, X F" uniqKey="Ming X">X.-F. Ming</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, J H" uniqKey="Kim J">J.H. Kim</name></author><author><name sortKey="Bugaj, L J" uniqKey="Bugaj L">L.J. Bugaj</name></author><author><name sortKey="Oh, Y J" uniqKey="Oh Y">Y.J. Oh</name></author><author><name sortKey="Bivalacqua, T J" uniqKey="Bivalacqua T">T.J. Bivalacqua</name></author><author><name sortKey="Ryoo, S" uniqKey="Ryoo S">S. Ryoo</name></author><author><name sortKey="Soucy, K G" uniqKey="Soucy K">K.G. Soucy</name></author><author><name sortKey="Santhanam, L" uniqKey="Santhanam L">L. Santhanam</name></author><author><name sortKey="Webb, A" uniqKey="Webb A">A. Webb</name></author><author><name sortKey="Camara, A" uniqKey="Camara A">A. Camara</name></author><author><name sortKey="Sikka, G" uniqKey="Sikka G">G. Sikka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bode Boger, S M" uniqKey="Bode Boger S">S.M. Bode-Boger</name></author><author><name sortKey="Muke, J" uniqKey="Muke J">J. Muke</name></author><author><name sortKey="Surdacki, A" uniqKey="Surdacki A">A. Surdacki</name></author><author><name sortKey="Brabant, G" uniqKey="Brabant G">G. Brabant</name></author><author><name sortKey="Boger, R H" uniqKey="Boger R">R.H. Boger</name></author><author><name sortKey="Frolich, J C" uniqKey="Frolich J">J.C. Frolich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Susic, D" uniqKey="Susic D">D. Susic</name></author><author><name sortKey="Varagic, J" uniqKey="Varagic J">J. Varagic</name></author><author><name sortKey="Frohlich, E D" uniqKey="Frohlich E">E.D. Frohlich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Susic, D" uniqKey="Susic D">D. Susic</name></author><author><name sortKey="Francischetti, A" uniqKey="Francischetti A">A. Francischetti</name></author><author><name sortKey="Frohlich, E D" uniqKey="Frohlich E">E.D. Frohlich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qian, H" uniqKey="Qian H">H. Qian</name></author><author><name sortKey="Luo, N" uniqKey="Luo N">N. Luo</name></author><author><name sortKey="Chi, Y" uniqKey="Chi Y">Y. Chi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Singh, N" uniqKey="Singh N">N. Singh</name></author><author><name sortKey="Prasad, S" uniqKey="Prasad S">S. Prasad</name></author><author><name sortKey="Singer, D R" uniqKey="Singer D">D.R. Singer</name></author><author><name sortKey="Macallister, R J" uniqKey="Macallister R">R.J. MacAllister</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, N" uniqKey="Li N">N. Li</name></author><author><name sortKey="Karin, M" uniqKey="Karin M">M. Karin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Csiszar, A" uniqKey="Csiszar A">A. Csiszar</name></author><author><name sortKey="Ungvari, Z" uniqKey="Ungvari Z">Z. Ungvari</name></author><author><name sortKey="Koller, A" uniqKey="Koller A">A. Koller</name></author><author><name sortKey="Edwards, J G" uniqKey="Edwards J">J.G. Edwards</name></author><author><name sortKey="Kaley, G" uniqKey="Kaley G">G. Kaley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bruunsgaard, H" uniqKey="Bruunsgaard H">H. Bruunsgaard</name></author><author><name sortKey="Skinhoj, P" uniqKey="Skinhoj P">P. Skinhoj</name></author><author><name sortKey="Pedersen, A N" uniqKey="Pedersen A">A.N. Pedersen</name></author><author><name sortKey="Schroll, M" uniqKey="Schroll M">M. Schroll</name></author><author><name sortKey="Pedersen, B K" uniqKey="Pedersen B">B.K. Pedersen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Belmin, J" uniqKey="Belmin J">J. Belmin</name></author><author><name sortKey="Bernard, C" uniqKey="Bernard C">C. Bernard</name></author><author><name sortKey="Corman, B" uniqKey="Corman B">B. Corman</name></author><author><name sortKey="Merval, R" uniqKey="Merval R">R. Merval</name></author><author><name sortKey="Esposito, B" uniqKey="Esposito B">B. Esposito</name></author><author><name sortKey="Tedgui, A" uniqKey="Tedgui A">A. Tedgui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Csiszar, A" uniqKey="Csiszar A">A. Csiszar</name></author><author><name sortKey="Wang, M" uniqKey="Wang M">M. Wang</name></author><author><name sortKey="Lakatta, E G" uniqKey="Lakatta E">E.G. Lakatta</name></author><author><name sortKey="Ungvari, Z" uniqKey="Ungvari Z">Z. Ungvari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Donato, A J" uniqKey="Donato A">A.J. Donato</name></author><author><name sortKey="Eskurza, I" uniqKey="Eskurza I">I. Eskurza</name></author><author><name sortKey="Silver, A E" uniqKey="Silver A">A.E. Silver</name></author><author><name sortKey="Levy, A S" uniqKey="Levy A">A.S. Levy</name></author><author><name sortKey="Pierce, G L" uniqKey="Pierce G">G.L. Pierce</name></author><author><name sortKey="Gates, P E" uniqKey="Gates P">P.E. Gates</name></author><author><name sortKey="Seals, D R" uniqKey="Seals D">D.R. Seals</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Libby, P" uniqKey="Libby P">P. Libby</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marui, N" uniqKey="Marui N">N. Marui</name></author><author><name sortKey="Offermann, M K" uniqKey="Offermann M">M.K. Offermann</name></author><author><name sortKey="Swerlick, R" uniqKey="Swerlick R">R. Swerlick</name></author><author><name sortKey="Kunsch, C" uniqKey="Kunsch C">C. Kunsch</name></author><author><name sortKey="Rosen, C A" uniqKey="Rosen C">C.A. Rosen</name></author><author><name sortKey="Ahmad, M" uniqKey="Ahmad M">M. Ahmad</name></author><author><name sortKey="Alexander, R W" uniqKey="Alexander R">R.W. Alexander</name></author><author><name sortKey="Medford, R M" uniqKey="Medford R">R.M. Medford</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hansson, G K" uniqKey="Hansson G">G.K. Hansson</name></author><author><name sortKey="Libby, P" uniqKey="Libby P">P. Libby</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Richter, V" uniqKey="Richter V">V. Richter</name></author><author><name sortKey="Rassoul, F" uniqKey="Rassoul F">F. Rassoul</name></author><author><name sortKey="Purschwitz, K" uniqKey="Purschwitz K">K. Purschwitz</name></author><author><name sortKey="Hentschel, B" uniqKey="Hentschel B">B. Hentschel</name></author><author><name sortKey="Reuter, W" uniqKey="Reuter W">W. Reuter</name></author><author><name sortKey="Kuntze, T" uniqKey="Kuntze T">T. Kuntze</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morisaki, N" uniqKey="Morisaki N">N. Morisaki</name></author><author><name sortKey="Saito, I" uniqKey="Saito I">I. Saito</name></author><author><name sortKey="Tamura, K" uniqKey="Tamura K">K. Tamura</name></author><author><name sortKey="Tashiro, J" uniqKey="Tashiro J">J. Tashiro</name></author><author><name sortKey="Masuda, M" uniqKey="Masuda M">M. Masuda</name></author><author><name sortKey="Kanzaki, T" uniqKey="Kanzaki T">T. Kanzaki</name></author><author><name sortKey="Watanabe, S" uniqKey="Watanabe S">S. Watanabe</name></author><author><name sortKey="Masuda, Y" uniqKey="Masuda Y">Y. Masuda</name></author><author><name sortKey="Saito, Y" uniqKey="Saito Y">Y. Saito</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schmidt, A M" uniqKey="Schmidt A">A.M. Schmidt</name></author><author><name sortKey="Hori, O" uniqKey="Hori O">O. Hori</name></author><author><name sortKey="Chen, J X" uniqKey="Chen J">J.X. Chen</name></author><author><name sortKey="Li, J F" uniqKey="Li J">J.F. Li</name></author><author><name sortKey="Crandall, J" uniqKey="Crandall J">J. Crandall</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name></author><author><name sortKey="Cao, R" uniqKey="Cao R">R. Cao</name></author><author><name sortKey="Yan, S D" uniqKey="Yan S">S.D. Yan</name></author><author><name sortKey="Brett, J" uniqKey="Brett J">J. Brett</name></author><author><name sortKey="Stern, D" uniqKey="Stern D">D. Stern</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, M" uniqKey="Wang M">M. Wang</name></author><author><name sortKey="Takagi, G" uniqKey="Takagi G">G. Takagi</name></author><author><name sortKey="Asai, K" uniqKey="Asai K">K. Asai</name></author><author><name sortKey="Resuello, R G" uniqKey="Resuello R">R.G. Resuello</name></author><author><name sortKey="Natividad, F F" uniqKey="Natividad F">F.F. Natividad</name></author><author><name sortKey="Vatner, D E" uniqKey="Vatner D">D.E. Vatner</name></author><author><name sortKey="Vatner, S F" uniqKey="Vatner S">S.F. Vatner</name></author><author><name sortKey="Lakatta, E G" uniqKey="Lakatta E">E.G. Lakatta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamamoto, K" uniqKey="Yamamoto K">K. Yamamoto</name></author><author><name sortKey="Takeshita, K" uniqKey="Takeshita K">K. Takeshita</name></author><author><name sortKey="Kojima, T" uniqKey="Kojima T">T. Kojima</name></author><author><name sortKey="Takamatsu, J" uniqKey="Takamatsu J">J. Takamatsu</name></author><author><name sortKey="Saito, H" uniqKey="Saito H">H. Saito</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamamoto, K" uniqKey="Yamamoto K">K. Yamamoto</name></author><author><name sortKey="Takeshita, K" uniqKey="Takeshita K">K. Takeshita</name></author><author><name sortKey="Shimokawa, T" uniqKey="Shimokawa T">T. Shimokawa</name></author><author><name sortKey="Yi, H" uniqKey="Yi H">H. Yi</name></author><author><name sortKey="Isobe, K" uniqKey="Isobe K">K. Isobe</name></author><author><name sortKey="Loskutoff, D J" uniqKey="Loskutoff D">D.J. Loskutoff</name></author><author><name sortKey="Saito, H" uniqKey="Saito H">H. Saito</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chung, H" uniqKey="Chung H">H. Chung</name></author><author><name sortKey="Sung, B" uniqKey="Sung B">B. Sung</name></author><author><name sortKey="Jung, K" uniqKey="Jung K">K. Jung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cernadas, M R" uniqKey="Cernadas M">M.R. Cernadas</name></author><author><name sortKey="De Miguel, L S" uniqKey="De Miguel L">L.S. de Miguel</name></author><author><name sortKey="Garcia Duran, M" uniqKey="Garcia Duran M">M. Garcia-Duran</name></author><author><name sortKey="Gonzalez Fernandez, F" uniqKey="Gonzalez Fernandez F">F. Gonzalez-Fernandez</name></author><author><name sortKey="Millas, I" uniqKey="Millas I">I. Millas</name></author><author><name sortKey="Monton, M" uniqKey="Monton M">M. Monton</name></author><author><name sortKey="Rodrigo, J" uniqKey="Rodrigo J">J. Rodrigo</name></author><author><name sortKey="Rico, L" uniqKey="Rico L">L. Rico</name></author><author><name sortKey="Fernandez, P" uniqKey="Fernandez P">P. Fernandez</name></author><author><name sortKey="De Frutos, T" uniqKey="De Frutos T">T. de Frutos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, D" uniqKey="Li D">D. Li</name></author><author><name sortKey="Qu, Y" uniqKey="Qu Y">Y. Qu</name></author><author><name sortKey="Tao, L" uniqKey="Tao L">L. Tao</name></author><author><name sortKey="Liu, H" uniqKey="Liu H">H. Liu</name></author><author><name sortKey="Hu, A" uniqKey="Hu A">A. Hu</name></author><author><name sortKey="Gao, F" uniqKey="Gao F">F. Gao</name></author><author><name sortKey="Sharifi Azad, S" uniqKey="Sharifi Azad S">S. Sharifi-Azad</name></author><author><name sortKey="Grunwald, Z" uniqKey="Grunwald Z">Z. Grunwald</name></author><author><name sortKey="Ma, X L" uniqKey="Ma X">X.L. Ma</name></author><author><name sortKey="Sun, J Z" uniqKey="Sun J">J.Z. Sun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hayashi, T" uniqKey="Hayashi T">T. Hayashi</name></author><author><name sortKey="Yano, K" uniqKey="Yano K">K. Yano</name></author><author><name sortKey="Matsui Hirai, H" uniqKey="Matsui Hirai H">H. Matsui-Hirai</name></author><author><name sortKey="Yokoo, H" uniqKey="Yokoo H">H. Yokoo</name></author><author><name sortKey="Hattori, Y" uniqKey="Hattori Y">Y. Hattori</name></author><author><name sortKey="Iguchi, A" uniqKey="Iguchi A">A. Iguchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Von Zglinicki, T" uniqKey="Von Zglinicki T">T. Von Zglinicki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chung, J H" uniqKey="Chung J">J.H. Chung</name></author><author><name sortKey="Seo, A Y" uniqKey="Seo A">A.Y. Seo</name></author><author><name sortKey="Chung, S W" uniqKey="Chung S">S.W. Chung</name></author><author><name sortKey="Kim, M K" uniqKey="Kim M">M.K. Kim</name></author><author><name sortKey="Leeuwenburgh, C" uniqKey="Leeuwenburgh C">C. Leeuwenburgh</name></author><author><name sortKey="Yu, B P" uniqKey="Yu B">B.P. Yu</name></author><author><name sortKey="Chung, H Y" uniqKey="Chung H">H.Y. Chung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Delerive, P" uniqKey="Delerive P">P. Delerive</name></author><author><name sortKey="De Bosscher, K" uniqKey="De Bosscher K">K. de Bosscher</name></author><author><name sortKey="Besnard, S" uniqKey="Besnard S">S. Besnard</name></author><author><name sortKey="Vanden Berghe, W" uniqKey="Vanden Berghe W">W. vanden Berghe</name></author><author><name sortKey="Peters, J M" uniqKey="Peters J">J.M. Peters</name></author><author><name sortKey="Gonzalez, F J" uniqKey="Gonzalez F">F.J. Gonzalez</name></author><author><name sortKey="Fruchart, J C" uniqKey="Fruchart J">J.C. Fruchart</name></author><author><name sortKey="Tedgui, A" uniqKey="Tedgui A">A. Tedgui</name></author><author><name sortKey="Haegeman, G" uniqKey="Haegeman G">G. Haegeman</name></author><author><name sortKey="Staels, B" uniqKey="Staels B">B. Staels</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sung, B" uniqKey="Sung B">B. Sung</name></author><author><name sortKey="Park, S" uniqKey="Park S">S. Park</name></author><author><name sortKey="Yu, B P" uniqKey="Yu B">B.P. Yu</name></author><author><name sortKey="Chung, H Y" uniqKey="Chung H">H.Y. Chung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Han, L" uniqKey="Han L">L. Han</name></author><author><name sortKey="Li, M" uniqKey="Li M">M. Li</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y. Liu</name></author><author><name sortKey="Han, C" uniqKey="Han C">C. Han</name></author><author><name sortKey="Ye, P" uniqKey="Ye P">P. Ye</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sung, B" uniqKey="Sung B">B. Sung</name></author><author><name sortKey="Park, S" uniqKey="Park S">S. Park</name></author><author><name sortKey="Yu, B P" uniqKey="Yu B">B.P. Yu</name></author><author><name sortKey="Chung, H Y" uniqKey="Chung H">H.Y. Chung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chung, H Y" uniqKey="Chung H">H.Y. Chung</name></author><author><name sortKey="Cesari, M" uniqKey="Cesari M">M. Cesari</name></author><author><name sortKey="Anton, S" uniqKey="Anton S">S. Anton</name></author><author><name sortKey="Marzetti, E" uniqKey="Marzetti E">E. Marzetti</name></author><author><name sortKey="Giovannini, S" uniqKey="Giovannini S">S. Giovannini</name></author><author><name sortKey="Seo, A Y" uniqKey="Seo A">A.Y. Seo</name></author><author><name sortKey="Carter, C" uniqKey="Carter C">C. Carter</name></author><author><name sortKey="Yu, B P" uniqKey="Yu B">B.P. Yu</name></author><author><name sortKey="Leeuwenburgh, C" uniqKey="Leeuwenburgh C">C. Leeuwenburgh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rippe, C" uniqKey="Rippe C">C. Rippe</name></author><author><name sortKey="Lesniewski, L" uniqKey="Lesniewski L">L. Lesniewski</name></author><author><name sortKey="Connell, M" uniqKey="Connell M">M. Connell</name></author><author><name sortKey="Larocca, T" uniqKey="Larocca T">T. LaRocca</name></author><author><name sortKey="Donato, A" uniqKey="Donato A">A. Donato</name></author><author><name sortKey="Seals, D" uniqKey="Seals D">D. Seals</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Csiszar, A" uniqKey="Csiszar A">A. Csiszar</name></author><author><name sortKey="Labinskyy, N" uniqKey="Labinskyy N">N. Labinskyy</name></author><author><name sortKey="Jimenez, R" uniqKey="Jimenez R">R. Jimenez</name></author><author><name sortKey="Pinto, J T" uniqKey="Pinto J">J.T. Pinto</name></author><author><name sortKey="Ballabh, P" uniqKey="Ballabh P">P. Ballabh</name></author><author><name sortKey="Losonczy, G" uniqKey="Losonczy G">G. Losonczy</name></author><author><name sortKey="Pearson, K J" uniqKey="Pearson K">K.J. Pearson</name></author><author><name sortKey="De Cabo, R" uniqKey="De Cabo R">R. de Cabo</name></author><author><name sortKey="Ungvari, Z" uniqKey="Ungvari Z">Z. Ungvari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fusco, S" uniqKey="Fusco S">S. Fusco</name></author><author><name sortKey="Maulucci, G" uniqKey="Maulucci G">G. Maulucci</name></author><author><name sortKey="Pani, G" uniqKey="Pani G">G. Pani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dai, D F" uniqKey="Dai D">D.F. Dai</name></author><author><name sortKey="Chen, T" uniqKey="Chen T">T. Chen</name></author><author><name sortKey="Johnson, S C" uniqKey="Johnson S">S.C. Johnson</name></author><author><name sortKey="Szeto, H" uniqKey="Szeto H">H. Szeto</name></author><author><name sortKey="Rabinovitch, P S" uniqKey="Rabinovitch P">P.S. Rabinovitch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eggers, K M" uniqKey="Eggers K">K.M. Eggers</name></author><author><name sortKey="Lind, L" uniqKey="Lind L">L. Lind</name></author><author><name sortKey="Ahlstrom, H" uniqKey="Ahlstrom H">H. Ahlstrom</name></author><author><name sortKey="Bjerner, T" uniqKey="Bjerner T">T. Bjerner</name></author><author><name sortKey="Ebeling Barbier, C" uniqKey="Ebeling Barbier C">C. Ebeling Barbier</name></author><author><name sortKey="Larsson, A" uniqKey="Larsson A">A. Larsson</name></author><author><name sortKey="Venge, P" uniqKey="Venge P">P. Venge</name></author><author><name sortKey="Lindahl, B" uniqKey="Lindahl B">B. Lindahl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Lemos, J A" uniqKey="De Lemos J">J.A. De Lemos</name></author><author><name sortKey="Drazner, M H" uniqKey="Drazner M">M.H. Drazner</name></author><author><name sortKey="Omland, T" uniqKey="Omland T">T. Omland</name></author><author><name sortKey="Ayers, C R" uniqKey="Ayers C">C.R. Ayers</name></author><author><name sortKey="Khera, A" uniqKey="Khera A">A. Khera</name></author><author><name sortKey="Rohatgi, A" uniqKey="Rohatgi A">A. Rohatgi</name></author><author><name sortKey="Hashim, I" uniqKey="Hashim I">I. Hashim</name></author><author><name sortKey="Berry, J D" uniqKey="Berry J">J.D. Berry</name></author><author><name sortKey="Das, S R" uniqKey="Das S">S.R. Das</name></author><author><name sortKey="Morrow, D A" uniqKey="Morrow D">D.A. Morrow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, A H" uniqKey="Wu A">A.H. Wu</name></author><author><name sortKey="Ford, L" uniqKey="Ford L">L. Ford</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Centurione, L" uniqKey="Centurione L">L. Centurione</name></author><author><name sortKey="Antonucci, A" uniqKey="Antonucci A">A. Antonucci</name></author><author><name sortKey="Miscia, S" uniqKey="Miscia S">S. Miscia</name></author><author><name sortKey="Grilli, A" uniqKey="Grilli A">A. Grilli</name></author><author><name sortKey="Rapino, M" uniqKey="Rapino M">M. Rapino</name></author><author><name sortKey="Grifone, G" uniqKey="Grifone G">G. Grifone</name></author><author><name sortKey="Di Giacomo, V" uniqKey="Di Giacomo V">V. di Giacomo</name></author><author><name sortKey="Di Giulio, C" uniqKey="Di Giulio C">C. di Giulio</name></author><author><name sortKey="Falconi, M" uniqKey="Falconi M">M. Falconi</name></author><author><name sortKey="Cataldi, A" uniqKey="Cataldi A">A. Cataldi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bodyak, N" uniqKey="Bodyak N">N. Bodyak</name></author><author><name sortKey="Kang, P" uniqKey="Kang P">P. Kang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, S Y" uniqKey="Li S">S.Y. Li</name></author><author><name sortKey="Du, M" uniqKey="Du M">M. Du</name></author><author><name sortKey="Dolence, E K" uniqKey="Dolence E">E.K. Dolence</name></author><author><name sortKey="Fang, C X" uniqKey="Fang C">C.X. Fang</name></author><author><name sortKey="Mayer, G E" uniqKey="Mayer G">G.E. Mayer</name></author><author><name sortKey="Ceylan Isik, A F" uniqKey="Ceylan Isik A">A.F. Ceylan-Isik</name></author><author><name sortKey="Lacour, K H" uniqKey="Lacour K">K.H. LaCour</name></author><author><name sortKey="Yang, X" uniqKey="Yang X">X. Yang</name></author><author><name sortKey="Wilbert, C J" uniqKey="Wilbert C">C.J. Wilbert</name></author><author><name sortKey="Sreejayan, N" uniqKey="Sreejayan N">N. Sreejayan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hegab, Z" uniqKey="Hegab Z">Z. Hegab</name></author><author><name sortKey="Gibbons, S" uniqKey="Gibbons S">S. Gibbons</name></author><author><name sortKey="Neyses, L" uniqKey="Neyses L">L. Neyses</name></author><author><name sortKey="Mamas, A" uniqKey="Mamas A">A. Mamas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Essick, E E" uniqKey="Essick E">E.E. Essick</name></author><author><name sortKey="Sam, F" uniqKey="Sam F">F. Sam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chiong, M" uniqKey="Chiong M">M. Chiong</name></author><author><name sortKey="Wang, Z V" uniqKey="Wang Z">Z.V. Wang</name></author><author><name sortKey="Pedrozo, Z" uniqKey="Pedrozo Z">Z. Pedrozo</name></author><author><name sortKey="Cao, D J" uniqKey="Cao D">D.J. Cao</name></author><author><name sortKey="Troncoso, R" uniqKey="Troncoso R">R. Troncoso</name></author><author><name sortKey="Ibacache, M" uniqKey="Ibacache M">M. Ibacache</name></author><author><name sortKey="Criollo, A" uniqKey="Criollo A">A. Criollo</name></author><author><name sortKey="Nemchenko, A" uniqKey="Nemchenko A">A. Nemchenko</name></author><author><name sortKey="Hill, J A" uniqKey="Hill J">J.A. Hill</name></author><author><name sortKey="Lavandero, S" uniqKey="Lavandero S">S. Lavandero</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peng, L" uniqKey="Peng L">L. Peng</name></author><author><name sortKey="Zhuang, X" uniqKey="Zhuang X">X. Zhuang</name></author><author><name sortKey="Liao, L" uniqKey="Liao L">L. Liao</name></author><author><name sortKey="He, X" uniqKey="He X">X. He</name></author><author><name sortKey="Li, J" uniqKey="Li J">J. Li</name></author><author><name sortKey="Chen, X" uniqKey="Chen X">X. Chen</name></author><author><name sortKey="Lu, G" uniqKey="Lu G">G. Lu</name></author><author><name sortKey="Ma, H" uniqKey="Ma H">H. Ma</name></author><author><name sortKey="Gao, X" uniqKey="Gao X">X. Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wohlgemuth, S E" uniqKey="Wohlgemuth S">S.E. Wohlgemuth</name></author><author><name sortKey="Julian, D" uniqKey="Julian D">D. Julian</name></author><author><name sortKey="Akin, D E" uniqKey="Akin D">D.E. Akin</name></author><author><name sortKey="Fried, J" uniqKey="Fried J">J. Fried</name></author><author><name sortKey="Toscano, K" uniqKey="Toscano K">K. Toscano</name></author><author><name sortKey="Leeuwenburgh, C" uniqKey="Leeuwenburgh C">C. Leeuwenburgh</name></author><author><name sortKey="Dunn, W A" uniqKey="Dunn W">W.A. Dunn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Niemann, B" uniqKey="Niemann B">B. Niemann</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. Chen</name></author><author><name sortKey="Issa, H" uniqKey="Issa H">H. Issa</name></author><author><name sortKey="Silber, R E" uniqKey="Silber R">R.E. Silber</name></author><author><name sortKey="Rohrbach, S" uniqKey="Rohrbach S">S. Rohrbach</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, C K" uniqKey="Lee C">C.K. Lee</name></author><author><name sortKey="Pugh, T D" uniqKey="Pugh T">T.D. Pugh</name></author><author><name sortKey="Klopp, R G" uniqKey="Klopp R">R.G. Klopp</name></author><author><name sortKey="Edwards, J" uniqKey="Edwards J">J. Edwards</name></author><author><name sortKey="Allison, D B" uniqKey="Allison D">D.B. Allison</name></author><author><name sortKey="Weindruch, R" uniqKey="Weindruch R">R. Weindruch</name></author><author><name sortKey="Prolla, T A" uniqKey="Prolla T">T.A. Prolla</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, C K" uniqKey="Lee C">C.K. Lee</name></author><author><name sortKey="Allison, D B" uniqKey="Allison D">D.B. Allison</name></author><author><name sortKey="Brand, J" uniqKey="Brand J">J. Brand</name></author><author><name sortKey="Weindruch, R" uniqKey="Weindruch R">R. Weindruch</name></author><author><name sortKey="Prolla, T A" uniqKey="Prolla T">T.A. Prolla</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, S K" uniqKey="Park S">S.K. Park</name></author><author><name sortKey="Prolla, T A" uniqKey="Prolla T">T.A. Prolla</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ren, J" uniqKey="Ren J">J. Ren</name></author><author><name sortKey="Pulakat, L" uniqKey="Pulakat L">L. Pulakat</name></author><author><name sortKey="Whaley Connell, A" uniqKey="Whaley Connell A">A. Whaley-Connell</name></author><author><name sortKey="Sowers, J R" uniqKey="Sowers J">J.R. Sowers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lesnefsky, E J" uniqKey="Lesnefsky E">E.J. Lesnefsky</name></author><author><name sortKey="Moghaddas, S" uniqKey="Moghaddas S">S. Moghaddas</name></author><author><name sortKey="Tandler, B" uniqKey="Tandler B">B. Tandler</name></author><author><name sortKey="Kerner, J" uniqKey="Kerner J">J. Kerner</name></author><author><name sortKey="Hoppel, C L" uniqKey="Hoppel C">C.L. Hoppel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Turdi, S" uniqKey="Turdi S">S. Turdi</name></author><author><name sortKey="Fan, X" uniqKey="Fan X">X. Fan</name></author><author><name sortKey="Li, J" uniqKey="Li J">J. Li</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J. Zhao</name></author><author><name sortKey="Huff, A F" uniqKey="Huff A">A.F. Huff</name></author><author><name sortKey="Du, M" uniqKey="Du M">M. Du</name></author><author><name sortKey="Ren, J" uniqKey="Ren J">J. Ren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dillon, L M" uniqKey="Dillon L">L.M. Dillon</name></author><author><name sortKey="Rebelo, A P" uniqKey="Rebelo A">A.P. Rebelo</name></author><author><name sortKey="Moraes, C T" uniqKey="Moraes C">C.T. Moraes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wojtovich, A P" uniqKey="Wojtovich A">A.P. Wojtovich</name></author><author><name sortKey="Nadtochiy, S M" uniqKey="Nadtochiy S">S.M. Nadtochiy</name></author><author><name sortKey="Brookes, P S" uniqKey="Brookes P">P.S. Brookes</name></author><author><name sortKey="Nehrke, K" uniqKey="Nehrke K">K. Nehrke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lucas, D T" uniqKey="Lucas D">D.T. Lucas</name></author><author><name sortKey="Szweda, L I" uniqKey="Szweda L">L.I. Szweda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, M" uniqKey="Liu M">M. Liu</name></author><author><name sortKey="Zhang, P" uniqKey="Zhang P">P. Zhang</name></author><author><name sortKey="Chen, M" uniqKey="Chen M">M. Chen</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W. Zhang</name></author><author><name sortKey="Yu, L" uniqKey="Yu L">L. Yu</name></author><author><name sortKey="Yang, X C" uniqKey="Yang X">X.C. Yang</name></author><author><name sortKey="Fan, Q" uniqKey="Fan Q">Q. Fan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Simkhovich, B Z" uniqKey="Simkhovich B">B.Z. Simkhovich</name></author><author><name sortKey="Marjoram, P" uniqKey="Marjoram P">P. Marjoram</name></author><author><name sortKey="Poizat, C" uniqKey="Poizat C">C. Poizat</name></author><author><name sortKey="Kedes, L" uniqKey="Kedes L">L. Kedes</name></author><author><name sortKey="Kloner, R A" uniqKey="Kloner R">R.A. Kloner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abete, P" uniqKey="Abete P">P. Abete</name></author><author><name sortKey="Testa, G" uniqKey="Testa G">G. Testa</name></author><author><name sortKey="Cacciatore, F" uniqKey="Cacciatore F">F. Cacciatore</name></author><author><name sortKey="Della Morte, D" uniqKey="Della Morte D">D. Della-Morte</name></author><author><name sortKey="Galizia, G" uniqKey="Galizia G">G. Galizia</name></author><author><name sortKey="Langellotto, A" uniqKey="Langellotto A">A. Langellotto</name></author><author><name sortKey="Rengo, F" uniqKey="Rengo F">F. Rengo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Benigni, A" uniqKey="Benigni A">A. Benigni</name></author><author><name sortKey="Cassis, P" uniqKey="Cassis P">P. Cassis</name></author><author><name sortKey="Remuzzi, G" uniqKey="Remuzzi G">G. Remuzzi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baylis, C" uniqKey="Baylis C">C. Baylis</name></author><author><name sortKey="Engels, K" uniqKey="Engels K">K. Engels</name></author><author><name sortKey="Hymel, A" uniqKey="Hymel A">A. Hymel</name></author><author><name sortKey="Navar, L" uniqKey="Navar L">L. Navar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thompson, M" uniqKey="Thompson M">M. Thompson</name></author><author><name sortKey="Oyama, T" uniqKey="Oyama T">T. Oyama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nguyen Dinh Cat, A" uniqKey="Nguyen Dinh Cat A">A. Nguyen Dinh Cat</name></author><author><name sortKey="Touyz, R M" uniqKey="Touyz R">R.M. Touyz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rajagopalan, S" uniqKey="Rajagopalan S">S. Rajagopalan</name></author><author><name sortKey="Kurz, S" uniqKey="Kurz S">S. Kurz</name></author><author><name sortKey="Munzel, T" uniqKey="Munzel T">T. Munzel</name></author><author><name sortKey="Tarpey, M" uniqKey="Tarpey M">M. Tarpey</name></author><author><name sortKey="Freeman, B A" uniqKey="Freeman B">B.A. Freeman</name></author><author><name sortKey="Griendling, K K" uniqKey="Griendling K">K.K. Griendling</name></author><author><name sortKey="Harrison, D G" uniqKey="Harrison D">D.G. Harrison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Williams, B" uniqKey="Williams B">B. Williams</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mohamed, M A" uniqKey="Mohamed M">M.A. Mohamed</name></author><author><name sortKey="Weir, M R" uniqKey="Weir M">M.R. Weir</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Benigni, A" uniqKey="Benigni A">A. Benigni</name></author><author><name sortKey="Corna, D" uniqKey="Corna D">D. Corna</name></author><author><name sortKey="Zoja, C" uniqKey="Zoja C">C. Zoja</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Cavanagh, E M V" uniqKey="De Cavanagh E">E.M.V. De Cavanagh</name></author><author><name sortKey="Inserra, F" uniqKey="Inserra F">F. Inserra</name></author><author><name sortKey="Ferder, L" uniqKey="Ferder L">L. Ferder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jia, L" uniqKey="Jia L">L. Jia</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name></author><author><name sortKey="Xiao, C" uniqKey="Xiao C">C. Xiao</name></author><author><name sortKey="Du, J" uniqKey="Du J">J. Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Santulli, G" uniqKey="Santulli G">G. Santulli</name></author><author><name sortKey="Iaccarino, G" uniqKey="Iaccarino G">G. Iaccarino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kang, K B" uniqKey="Kang K">K.B. Kang</name></author><author><name sortKey="Rajanayagam, M A S" uniqKey="Rajanayagam M">M.A.S. Rajanayagam</name></author><author><name sortKey="Van Der Zypp, A" uniqKey="Van Der Zypp A">A. van der Zypp</name></author><author><name sortKey="Majewski, H" uniqKey="Majewski H">H. Majewski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yan, L" uniqKey="Yan L">L. Yan</name></author><author><name sortKey="Vatner, D E" uniqKey="Vatner D">D.E. Vatner</name></author><author><name sortKey="O Onnor, J P" uniqKey="O Onnor J">J.P. O’Connor</name></author><author><name sortKey="Ivessa, A" uniqKey="Ivessa A">A. Ivessa</name></author><author><name sortKey="Ge, H" uniqKey="Ge H">H. Ge</name></author><author><name sortKey="Chen, W" uniqKey="Chen W">W. Chen</name></author><author><name sortKey="Hirotani, S" uniqKey="Hirotani S">S. Hirotani</name></author><author><name sortKey="Ishikawa, Y" uniqKey="Ishikawa Y">Y. Ishikawa</name></author><author><name sortKey="Sadoshima, J" uniqKey="Sadoshima J">J. Sadoshima</name></author><author><name sortKey="Vatner, S F" uniqKey="Vatner S">S.F. Vatner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Okumura, S" uniqKey="Okumura S">S. Okumura</name></author><author><name sortKey="Vatner, D E" uniqKey="Vatner D">D.E. Vatner</name></author><author><name sortKey="Kurotani, R" uniqKey="Kurotani R">R. Kurotani</name></author><author><name sortKey="Bai, Y" uniqKey="Bai Y">Y. Bai</name></author><author><name sortKey="Gao, S" uniqKey="Gao S">S. Gao</name></author><author><name sortKey="Yuan, Z" uniqKey="Yuan Z">Z. Yuan</name></author><author><name sortKey="Iwatsubo, K" uniqKey="Iwatsubo K">K. Iwatsubo</name></author><author><name sortKey="Ulucan, C" uniqKey="Ulucan C">C. Ulucan</name></author><author><name sortKey="Kawabe, J" uniqKey="Kawabe J">J. Kawabe</name></author><author><name sortKey="Ghosh, K" uniqKey="Ghosh K">K. Ghosh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Remondino, A" uniqKey="Remondino A">A. Remondino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bishop, N A" uniqKey="Bishop N">N.A. Bishop</name></author><author><name sortKey="Lu, T" uniqKey="Lu T">T. Lu</name></author><author><name sortKey="Yankner, B A" uniqKey="Yankner B">B.A. Yankner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mariani, E" uniqKey="Mariani E">E. Mariani</name></author><author><name sortKey="Polidori, M C" uniqKey="Polidori M">M.C. Polidori</name></author><author><name sortKey="Cherubini, A" uniqKey="Cherubini A">A. Cherubini</name></author><author><name sortKey="Mecocci, P" uniqKey="Mecocci P">P. Mecocci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Freeman, L R" uniqKey="Freeman L">L.R. Freeman</name></author><author><name sortKey="Keller, J N" uniqKey="Keller J">J.N. Keller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alikunju, S" uniqKey="Alikunju S">S. Alikunju</name></author><author><name sortKey="Abdul Muneer, P M" uniqKey="Abdul Muneer P">P.M. Abdul Muneer</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name></author><author><name sortKey="Szlachetka, A M" uniqKey="Szlachetka A">A.M. Szlachetka</name></author><author><name sortKey="Haorah, J" uniqKey="Haorah J">J. Haorah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perfeito, R" uniqKey="Perfeito R">R. Perfeito</name></author><author><name sortKey="Cunha Oliveira, T" uniqKey="Cunha Oliveira T">T. Cunha-Oliveira</name></author><author><name sortKey="Rego, A C" uniqKey="Rego A">A.C. Rego</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, C M" uniqKey="Chen C">C.M. Chen</name></author><author><name sortKey="Liu, J L" uniqKey="Liu J">J.L. Liu</name></author><author><name sortKey="Wu, Y R" uniqKey="Wu Y">Y.R. Wu</name></author><author><name sortKey="Chen, Y C" uniqKey="Chen Y">Y.C. Chen</name></author><author><name sortKey="Cheng, H S" uniqKey="Cheng H">H.S. Cheng</name></author><author><name sortKey="Cheng, M L" uniqKey="Cheng M">M.L. Cheng</name></author><author><name sortKey="Chiu, D T Y" uniqKey="Chiu D">D.T.Y. Chiu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rogakou, E P" uniqKey="Rogakou E">E.P. Rogakou</name></author><author><name sortKey="Boon, C" uniqKey="Boon C">C. Boon</name></author><author><name sortKey="Redon, C" uniqKey="Redon C">C. Redon</name></author><author><name sortKey="Bonner, W M" uniqKey="Bonner W">W.M. Bonner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pandey, K B" uniqKey="Pandey K">K.B. Pandey</name></author><author><name sortKey="Rizvi, S I" uniqKey="Rizvi S">S.I. Rizvi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Milne, G L" uniqKey="Milne G">G.L. Milne</name></author><author><name sortKey="Sanchez, S C" uniqKey="Sanchez S">S.C. Sanchez</name></author><author><name sortKey="Musiek, E S" uniqKey="Musiek E">E.S. Musiek</name></author><author><name sortKey="Morrow, J D" uniqKey="Morrow J">J.D. Morrow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, C D" uniqKey="Smith C">C.D. Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morley, J E" uniqKey="Morley J">J.E. Morley</name></author><author><name sortKey="Armbrecht, H J" uniqKey="Armbrecht H">H.J. Armbrecht</name></author><author><name sortKey="Farr, S A" uniqKey="Farr S">S.A. Farr</name></author><author><name sortKey="Kumar, V B" uniqKey="Kumar V">V.B. Kumar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Medeiros, R" uniqKey="Medeiros R">R. Medeiros</name></author><author><name sortKey="Baglietto Vargas, D" uniqKey="Baglietto Vargas D">D. Baglietto-Vargas</name></author><author><name sortKey="Laferla, F M" uniqKey="Laferla F">F.M. LaFerla</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jack, C R" uniqKey="Jack C">C.R. Jack</name></author><author><name sortKey="Garwood, M" uniqKey="Garwood M">M. Garwood</name></author><author><name sortKey="Wengenack, T M" uniqKey="Wengenack T">T.M. Wengenack</name></author><author><name sortKey="Curran, G L" uniqKey="Curran G">G.L. Curran</name></author><author><name sortKey="Lin, J" uniqKey="Lin J">J. Lin</name></author><author><name sortKey="Adriany, G" uniqKey="Adriany G">G. Adriany</name></author><author><name sortKey="Grohn, H J" uniqKey="Grohn H">H.J. Grohn</name></author><author><name sortKey="Grimm, R" uniqKey="Grimm R">R. Grimm</name></author><author><name sortKey="Poduslo, J F" uniqKey="Poduslo J">J.F. Poduslo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coskun, P E" uniqKey="Coskun P">P.E. Coskun</name></author><author><name sortKey="Beal, M F" uniqKey="Beal M">M.F. Beal</name></author><author><name sortKey="Wallace, D C" uniqKey="Wallace D">D.C. Wallace</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Glenner, G" uniqKey="Glenner G">G. Glenner</name></author><author><name sortKey="Wong, C" uniqKey="Wong C">C. Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karran, E" uniqKey="Karran E">E. Karran</name></author><author><name sortKey="Mercken, M" uniqKey="Mercken M">M. Mercken</name></author><author><name sortKey="De Strooper, B" uniqKey="De Strooper B">B. de Strooper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Swerdlow, R" uniqKey="Swerdlow R">R. Swerdlow</name></author><author><name sortKey="Khan, S" uniqKey="Khan S">S. Khan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Napoli, C" uniqKey="Napoli C">C. Napoli</name></author><author><name sortKey="Palinski, W" uniqKey="Palinski W">W. Palinski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taylor, J M" uniqKey="Taylor J">J.M. Taylor</name></author><author><name sortKey="Main, B S" uniqKey="Main B">B.S. Main</name></author><author><name sortKey="Crack, P J" uniqKey="Crack P">P.J. Crack</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ahlskog, J E" uniqKey="Ahlskog J">J.E. Ahlskog</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Srinivasan, V" uniqKey="Srinivasan V">V. Srinivasan</name></author><author><name sortKey="Cardinali, D P" uniqKey="Cardinali D">D.P. Cardinali</name></author><author><name sortKey="Srinivasan, U S" uniqKey="Srinivasan U">U.S. Srinivasan</name></author><author><name sortKey="Kaur, C" uniqKey="Kaur C">C. Kaur</name></author><author><name sortKey="Brown, G M" uniqKey="Brown G">G.M. Brown</name></author><author><name sortKey="Spence, D W" uniqKey="Spence D">D.W. Spence</name></author><author><name sortKey="Hardeland, R" uniqKey="Hardeland R">R. Hardeland</name></author><author><name sortKey="Pandi Perumal, S R" uniqKey="Pandi Perumal S">S.R. Pandi-Perumal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bueler, H" uniqKey="Bueler H">H. Bueler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mangialasche, F" uniqKey="Mangialasche F">F. Mangialasche</name></author><author><name sortKey="Polidori, M C" uniqKey="Polidori M">M.C. Polidori</name></author><author><name sortKey="Monastero, R" uniqKey="Monastero R">R. Monastero</name></author><author><name sortKey="Ercolani, S" uniqKey="Ercolani S">S. Ercolani</name></author><author><name sortKey="Camarda, C" uniqKey="Camarda C">C. Camarda</name></author><author><name sortKey="Cecchetti, R" uniqKey="Cecchetti R">R. Cecchetti</name></author><author><name sortKey="Mecocci, P" uniqKey="Mecocci P">P. Mecocci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luckhaus, C" uniqKey="Luckhaus C">C. Luckhaus</name></author><author><name sortKey="Cohnen, M" uniqKey="Cohnen M">M. Cohnen</name></author><author><name sortKey="Fluss, M O" uniqKey="Fluss M">M.O. Fluss</name></author><author><name sortKey="Janner, M" uniqKey="Janner M">M. Janner</name></author><author><name sortKey="Grass Kapanke, B" uniqKey="Grass Kapanke B">B. Grass-Kapanke</name></author><author><name sortKey="Teipel, S J" uniqKey="Teipel S">S.J. Teipel</name></author><author><name sortKey="Grothe, M" uniqKey="Grothe M">M. Grothe</name></author><author><name sortKey="Hampel, H" uniqKey="Hampel H">H. Hampel</name></author><author><name sortKey="Peters, O" uniqKey="Peters O">O. Peters</name></author><author><name sortKey="Kornhuber, J" uniqKey="Kornhuber J">J. Kornhuber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hampel, H" uniqKey="Hampel H">H. Hampel</name></author><author><name sortKey="Teipel, S J" uniqKey="Teipel S">S.J. Teipel</name></author><author><name sortKey="Fuchsberger, T" uniqKey="Fuchsberger T">T. Fuchsberger</name></author><author><name sortKey="Andreasen, N" uniqKey="Andreasen N">N. Andreasen</name></author><author><name sortKey="Wiltfang, J" uniqKey="Wiltfang J">J. Wiltfang</name></author><author><name sortKey="Otto, M" uniqKey="Otto M">M. Otto</name></author><author><name sortKey="Shen, Y" uniqKey="Shen Y">Y. Shen</name></author><author><name sortKey="Dodel, R" uniqKey="Dodel R">R. Dodel</name></author><author><name sortKey="Blennow, K" uniqKey="Blennow K">K. Blennow</name></author><author><name sortKey="Buerger, K" uniqKey="Buerger K">K. Buerger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hampel, H" uniqKey="Hampel H">H. Hampel</name></author><author><name sortKey="Burger, K" uniqKey="Burger K">K. Burger</name></author><author><name sortKey="Teipel, S J" uniqKey="Teipel S">S.J. Teipel</name></author><author><name sortKey="Bokde, A L W" uniqKey="Bokde A">A.L.W. Bokde</name></author><author><name sortKey="Zetterberg, H" uniqKey="Zetterberg H">H. Zetterberg</name></author><author><name sortKey="Blennow, K" uniqKey="Blennow K">K. Blennow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hampel, H" uniqKey="Hampel H">H. Hampel</name></author><author><name sortKey="Prvulovic, D" uniqKey="Prvulovic D">D. Prvulovic</name></author><author><name sortKey="Teipel, S" uniqKey="Teipel S">S. Teipel</name></author><author><name sortKey="Jessen, F" uniqKey="Jessen F">F. Jessen</name></author><author><name sortKey="Luckhaus, C" uniqKey="Luckhaus C">C. Luckhaus</name></author><author><name sortKey="Frolich, L" uniqKey="Frolich L">L. Frolich</name></author><author><name sortKey="Riepe, M W" uniqKey="Riepe M">M.W. Riepe</name></author><author><name sortKey="Dodel, R" uniqKey="Dodel R">R. Dodel</name></author><author><name sortKey="Leyhe, T" uniqKey="Leyhe T">T. Leyhe</name></author><author><name sortKey="Bertram, L" uniqKey="Bertram L">L. Bertram</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fox, J H" uniqKey="Fox J">J.H. Fox</name></author><author><name sortKey="Connor, T" uniqKey="Connor T">T. Connor</name></author><author><name sortKey="Stiles, M" uniqKey="Stiles M">M. Stiles</name></author><author><name sortKey="Kama, J" uniqKey="Kama J">J. Kama</name></author><author><name sortKey="Lu, Z" uniqKey="Lu Z">Z. Lu</name></author><author><name sortKey="Dorsey, K" uniqKey="Dorsey K">K. Dorsey</name></author><author><name sortKey="Lieberman, G" uniqKey="Lieberman G">G. Lieberman</name></author><author><name sortKey="Sapp, E" uniqKey="Sapp E">E. Sapp</name></author><author><name sortKey="Cherny, R A" uniqKey="Cherny R">R.A. Cherny</name></author><author><name sortKey="Banks, M" uniqKey="Banks M">M. Banks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sorolla, M A" uniqKey="Sorolla M">M.A. Sorolla</name></author><author><name sortKey="Rodriguez Colman, M J" uniqKey="Rodriguez Colman M">M.J. Rodriguez-Colman</name></author><author><name sortKey="Tamarit, J" uniqKey="Tamarit J">J. Tamarit</name></author><author><name sortKey="Ortega, Z" uniqKey="Ortega Z">Z. Ortega</name></author><author><name sortKey="Lucas, J J" uniqKey="Lucas J">J.J. Lucas</name></author><author><name sortKey="Ferrer, I" uniqKey="Ferrer I">I. Ferrer</name></author><author><name sortKey="Ros, J" uniqKey="Ros J">J. Ros</name></author><author><name sortKey="Cabiscol, E" uniqKey="Cabiscol E">E. Cabiscol</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sorolla, M A" uniqKey="Sorolla M">M.A. Sorolla</name></author><author><name sortKey="Rodriguez Colman, M J" uniqKey="Rodriguez Colman M">M.J. Rodriguez-Colman</name></author><author><name sortKey="Vall Llaura, N" uniqKey="Vall Llaura N">N. Vall-Llaura</name></author><author><name sortKey="Tamarit, J" uniqKey="Tamarit J">J. Tamarit</name></author><author><name sortKey="Ros, J" uniqKey="Ros J">J. Ros</name></author><author><name sortKey="Cabiscol, E" uniqKey="Cabiscol E">E. Cabiscol</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barja, G" uniqKey="Barja G">G. Barja</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Willcox, B J" uniqKey="Willcox B">B.J. Willcox</name></author><author><name sortKey="Willcox, D C" uniqKey="Willcox D">D.C. Willcox</name></author><author><name sortKey="Todoriki, H" uniqKey="Todoriki H">H. Todoriki</name></author><author><name sortKey="Fujiyoshi, A" uniqKey="Fujiyoshi A">A. Fujiyoshi</name></author><author><name sortKey="Yano, K" uniqKey="Yano K">K. Yano</name></author><author><name sortKey="He, Q" uniqKey="He Q">Q. He</name></author><author><name sortKey="Curb, J D" uniqKey="Curb J">J.D. Curb</name></author><author><name sortKey="Suzuki, M" uniqKey="Suzuki M">M. Suzuki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wolf, F I" uniqKey="Wolf F">F.I. Wolf</name></author><author><name sortKey="Fasanella, S" uniqKey="Fasanella S">S. Fasanella</name></author><author><name sortKey="Tedesco, B" uniqKey="Tedesco B">B. Tedesco</name></author><author><name sortKey="Cavallini, G" uniqKey="Cavallini G">G. Cavallini</name></author><author><name sortKey="Donati, A" uniqKey="Donati A">A. Donati</name></author><author><name sortKey="Bergamini, E" uniqKey="Bergamini E">E. Bergamini</name></author><author><name sortKey="Cittadini, A" uniqKey="Cittadini A">A. Cittadini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Contestabile, A" uniqKey="Contestabile A">A. Contestabile</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oien, D B" uniqKey="Oien D">D.B. Oien</name></author><author><name sortKey="Osterhaus, G L" uniqKey="Osterhaus G">G.L. Osterhaus</name></author><author><name sortKey="Lundquist, B L" uniqKey="Lundquist B">B.L. Lundquist</name></author><author><name sortKey="Fowler, S C" uniqKey="Fowler S">S.C. Fowler</name></author><author><name sortKey="Moskovitz, J" uniqKey="Moskovitz J">J. Moskovitz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pamplona, R" uniqKey="Pamplona R">R. Pamplona</name></author><author><name sortKey="Barja, G" uniqKey="Barja G">G. Barja</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gillette Guyonnet, S" uniqKey="Gillette Guyonnet S">S. Gillette-Guyonnet</name></author><author><name sortKey="Vellas, B" uniqKey="Vellas B">B. Vellas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ungvari, Z" uniqKey="Ungvari Z">Z. Ungvari</name></author><author><name sortKey="Parrado Fernandez, C" uniqKey="Parrado Fernandez C">C. Parrado-Fernandez</name></author><author><name sortKey="Csiszar, A" uniqKey="Csiszar A">A. Csiszar</name></author><author><name sortKey="De Cabo, R" uniqKey="De Cabo R">R. de Cabo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shinmura, K" uniqKey="Shinmura K">K. Shinmura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Halagappa, V K M" uniqKey="Halagappa V">V.K.M. Halagappa</name></author><author><name sortKey="Guo, Z" uniqKey="Guo Z">Z. Guo</name></author><author><name sortKey="Pearson, M" uniqKey="Pearson M">M. Pearson</name></author><author><name sortKey="Matsuoka, Y" uniqKey="Matsuoka Y">Y. Matsuoka</name></author><author><name sortKey="Cutler, R G" uniqKey="Cutler R">R.G. Cutler</name></author><author><name sortKey="Laferla, F M" uniqKey="Laferla F">F.M. Laferla</name></author><author><name sortKey="Mattson, M P" uniqKey="Mattson M">M.P. Mattson</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Mol Sci</journal-id><journal-id journal-id-type="iso-abbrev">Int J Mol Sci</journal-id><journal-id journal-id-type="publisher-id">ijms</journal-id><journal-title-group><journal-title>International Journal of Molecular Sciences</journal-title></journal-title-group><issn pub-type="epub">1422-0067</issn><publisher><publisher-name>MDPI</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24002027</article-id><article-id pub-id-type="pmc">3794759</article-id><article-id pub-id-type="doi">10.3390/ijms140917897</article-id><article-id pub-id-type="publisher-id">ijms-14-17897</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Oxidative Stress in Aging-Matters of the Heart and Mind</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Venkataraman</surname><given-names>Krishnan</given-names></name><xref ref-type="aff" rid="af1-ijms-14-17897">1</xref></contrib><contrib contrib-type="author"><name><surname>Khurana</surname><given-names>Sandhya</given-names></name><xref ref-type="aff" rid="af2-ijms-14-17897">2</xref></contrib><contrib contrib-type="author"><name><surname>Tai</surname><given-names>T. C.</given-names></name><xref ref-type="aff" rid="af2-ijms-14-17897">2</xref><xref ref-type="aff" rid="af3-ijms-14-17897">3</xref><xref rid="c1-ijms-14-17897" ref-type="corresp">*</xref></contrib></contrib-group><aff id="af1-ijms-14-17897"><label>1</label>Department of Gerontology, Huntington University, Sudbury, ON P3E 2C6, Canada; E-Mail:<email>kvenkataraman@huntingtonu.ca</email></aff><aff id="af2-ijms-14-17897"><label>2</label>Medical Sciences Division, Northern Ontario School of Medicine, Sudbury, ON P3E 2C6, Canada; E-Mail:<email>sandhya.khurana@nosm.ca</email></aff><aff id="af3-ijms-14-17897"><label>3</label>Department of Biology, Department of Chemistry and Biochemistry, Biomolecular Sciences Program, Laurentian University, 935 Ramsey Lake Road, Sudbury, ON P3E 2C6, Canada</aff><author-notes><corresp id="c1-ijms-14-17897"><label>*</label>Author to whom correspondence should be addressed; E-Mail: <email>tc.tai@nosm.ca</email>; Tel.: +1-705-662-7239; Fax: +1-705-675-4858.</corresp></author-notes><pub-date pub-type="collection"><month>9</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>02</day><month>9</month><year>2013</year></pub-date><volume>14</volume><issue>9</issue><fpage>17897</fpage><lpage>17925</lpage><history><date date-type="received"><day>17</day><month>7</month><year>2013</year></date><date date-type="rev-recd"><day>10</day><month>8</month><year>2013</year></date><date date-type="accepted"><day>15</day><month>8</month><year>2013</year></date></history><permissions><copyright-statement>© 2013 by the authors; licensee MDPI, Basel, Switzerland</copyright-statement><copyright-year>2013</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/3.0"><license-p><pmc-comment>CREATIVE COMMONS</pmc-comment>This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/3.0/">http://creativecommons.org/licenses/by/3.0/</ext-link>).</license-p></license></permissions><abstract><p>Oxidative damage is considered to be the primary cause of several aging associated disease pathologies. Cumulative oxidative damage tends to be pervasive among cellular macromolecules, impacting proteins, lipids, RNA and DNA of cells. At a systemic level, events subsequent to oxidative damage induce an inflammatory response to sites of oxidative damage, often contributing to additional oxidative stress. At a cellular level, oxidative damage to mitochondria results in acidification of the cytoplasm and release of cytochrome c, causing apoptosis. This review summarizes findings in the literature on oxidative stress and consequent damage on cells and tissues of the cardiovascular system and the central nervous system, with a focus on aging-related diseases that have well-documented evidence of oxidative damage in initiation and/or progression of the disease. The current understanding of the cellular mechanisms with a focus on macromolecular damage, impacted cellular pathways and gross morphological changes associated with oxidative damage is also reviewed. Additionally, the impact of calorific restriction with its profound impact on cardiovascular and neuronal aging is addressed.</p></abstract><kwd-group><kwd>oxidative stress</kwd><kwd>RONS</kwd><kwd>cardiovascular</kwd><kwd>aging</kwd><kwd>brain</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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