Curation
Pmc
Racine
Curation
Checkpoint
Pmc
Racine
Pmc
Exploration
Accueil
Racine
Racine

La maladie de Parkinson au Canada (serveur d'exploration)

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

A NOVEL ALZHEIMER DISEASE LOCUS LOCATED NEAR THE GENE ENCODING TAU PROTEIN

Identifieur interne : 000B59 ( Pmc/Curation ); précédent : 000B58; suivant : 000B60

A NOVEL ALZHEIMER DISEASE LOCUS LOCATED NEAR THE GENE ENCODING TAU PROTEIN

Auteurs : Gyungah Jun [États-Unis] ; Carla A. Ibrahim-Verbaas [Pays-Bas] ; Maria Vronskaya [Royaume-Uni] ; Jean-Charles Lambert [France] ; Jaeyoon Chung [États-Unis] ; Adam C. Naj [États-Unis] ; Brian W. Kunkle [États-Unis] ; Li-San Wang [États-Unis] ; Joshua C. Bis [États-Unis] ; Céline Bellenguez [France] ; Denise Harold [Irlande (pays)] ; Kathryn L. Lunetta [États-Unis] ; Anita L. Destefano [États-Unis] ; Benjamin Grenier-Boley [France] ; Rebecca Sims [Royaume-Uni] ; Gary W. Beecham [États-Unis] ; Albert V. Smith [Islande] ; Vincent Chouraki [États-Unis] ; Kara L. Hamilton-Nelson [États-Unis] ; M. Arfan Ikram [Pays-Bas] ; Nathalie Fievet [France] ; Nicola Denning [Royaume-Uni] ; Eden R. Martin [États-Unis] ; Helena Schmidt [Autriche] ; Yochiro Kamatani [Japon, France] ; Melanie L. Dunstan [Royaume-Uni] ; Otto Valladares [États-Unis] ; Agustin Ruiz Laza [Espagne] ; Diana Zelenika ; Alfredo Ramirez [Allemagne] ; Tatiana M. Foroud [États-Unis] ; Seung-Hoan Choi [États-Unis] ; Anne Boland [France] ; Tim Becker [Allemagne] ; Walter A. Kukull [États-Unis] ; Sven J. Van Der Lee [Pays-Bas] ; Florence Pasquier [France] ; Carlos Cruchaga [États-Unis] ; Duane Beekly [États-Unis] ; Annette L. Fitzpatrick [États-Unis] ; Oliver Hanon [France] ; Michael Gill [Irlande (pays)] ; Robert Barber [États-Unis] ; Vilmundur Gudnason [Islande] ; Dominique Campion [France] ; Seth Love [Royaume-Uni] ; David A. Bennett [États-Unis] ; Najaf Amin [Pays-Bas] ; Claudine Berr [France] ; Magda Tsolaki [Grèce] ; Joseph D. Buxbaum [États-Unis] ; Oscar L. Lopez [États-Unis] ; Vincent Deramecourt [France] ; Nick C. Fox [Royaume-Uni] ; Laura B. Cantwell [États-Unis] ; Lluis Tárraga [Espagne] ; Carole Dufouil [France] ; John Hardy [Royaume-Uni] ; Paul K. Crane [États-Unis] ; Gudny Eiriksdottir [Islande] ; Didier Hannequin [France] ; Robert Clarke [Royaume-Uni] ; Denis Evans [États-Unis] ; Thomas H. Mosley [États-Unis] ; Luc Letenneur [France] ; Carol Brayne [Royaume-Uni] ; Wolfgang Maier [Allemagne] ; Philip De Jager [États-Unis, Pays-Bas] ; Valur Emilsson [Islande] ; Jean-François Dartigues [France] ; Harald Hampel [Allemagne] ; M. Ilyas Kamboh [États-Unis] ; Renee F. A. G. De Bruijn [Pays-Bas] ; Christophe Tzourio [France] ; Pau Pastor [Espagne] ; Eric B. Larson [États-Unis] ; Jerome I. Rotter [États-Unis] ; Michael C. O Onovan [Royaume-Uni] ; Thomas J. Montine [États-Unis] ; Michael A. Nalls [États-Unis] ; Simon Mead [Royaume-Uni] ; Eric M. Reiman [États-Unis] ; Palmi V. Jonsson [Islande] ; Clive Holmes [Royaume-Uni] ; Peter H. St George-Hyslop [Canada, Royaume-Uni] ; Mercè Boada [Espagne] ; Peter Passmore [Royaume-Uni] ; Jens R. Wendland [États-Unis] ; Reinhold Schmidt [Autriche] ; Kevin Morgan [Royaume-Uni] ; Ashley R. Winslow [États-Unis] ; John F. Powell [Royaume-Uni] ; Minerva Carasquillo [États-Unis] ; Steven G. Younkin [États-Unis] ; J Hanna Jakobsd Ttir [Islande] ; John Sk Kauwe [États-Unis] ; Kirk C. Wilhelmsen [États-Unis] ; Dan Rujescu ; Markus M. Nöthen [Allemagne] ; Albert Hofman [Pays-Bas] ; Lesley Jones [Royaume-Uni] ; Jonathan L. Haines [États-Unis] ; Bruce M. Psaty [États-Unis] ; Christine Van Broeckhoven [Belgique] ; Peter Holmans [Royaume-Uni] ; Lenore J. Launer [États-Unis] ; Richard Mayeux [États-Unis] ; Mark Lathrop [France, Canada] ; Alison M. Goate [États-Unis] ; Valentina Escott-Price [Royaume-Uni] ; Sudha Seshadri [États-Unis] ; Margaret A. Pericak-Vance [États-Unis] ; Philippe Amouyel [France] ; Julie Williams [Royaume-Uni] ; Cornelia M. Van Duijn [Pays-Bas] ; Gerard D. Schellenberg [États-Unis] ; Lindsay A. Farrer [États-Unis]

Source :

RBID : PMC:4573764

Abstract

APOE ε4, the most significant genetic risk factor for Alzheimer disease (AD), may mask effects of other loci. We re-analyzed genome-wide association study (GWAS) data from the International Genomics of Alzheimer’s Project (IGAP) Consortium in APOE ε4+ (10,352 cases and 9,207 controls) and APOE ε4− (7,184 cases and 26,968 controls) subgroups as well as in the total sample testing for interaction between a SNP and APOE ε4 status. Suggestive associations (P<1x10−4) in stage 1 were evaluated in an independent sample (stage 2) containing 4,203 subjects (APOE ε4+: 1,250 cases and 536 controls; APOE ε4-: 718 cases and 1,699 controls). Among APOE ε4− subjects, novel genome-wide significant (GWS) association was observed with 17 SNPs (all between KANSL1 and LRRC37A on chromosome 17 near MAPT) in a meta-analysis of the stage 1 and stage 2 datasets (best SNP, rs2732703, P=5·8x10−9). Conditional analysis revealed that rs2732703 accounted for association signals in the entire 100 kilobase region that includes MAPT. Except for previously identified AD loci showing stronger association in APOE ε4+ subjects (CR1 and CLU) or APOE ε4− subjects (MS4A6A/MS4A4A/ MS4A6E), no other SNPs were significantly associated with AD in a specific APOE genotype subgroup. In addition, the finding in the stage 1 sample that AD risk is significantly influenced by the interaction of APOE with rs1595014 in TMEM106B (P=1·6x10−7) is noteworthy because TMEM106B variants have previously been associated with risk of frontotemporal dementia. Expression quantitative trait locus analysis revealed that rs113986870, one of the GWS SNPs near rs2732703, is significantly associated with four KANSL1 probes that target transcription of the first translated exon and an untranslated exon in hippocampus (P≤1.3x10−8), frontal cortex (P≤1.3x10−9), and temporal cortex (P≤1.2x10−11). Rs113986870 is also strongly associated with a MAPT probe that targets transcription of alternatively spliced exon 3 in frontal cortex (P=9.2x10−6) and temporal cortex (P=2.6x10−6). Our APOE-stratified GWAS is the first to show GWS association for AD with SNPs in the chromosome 17q21.31 region. Replication of this finding in independent samples is needed to verify that SNPs in this region have significantly stronger effects on AD risk in persons lacking APOE ε4 compared to persons carrying this allele, and if this is found to hold, further examination of this region and studies aimed at deciphering the mechanism(s) are warranted.


Url:
DOI: 10.1038/mp.2015.23
PubMed: 25778476
PubMed Central: 4573764

Links toward previous steps (curation, corpus...)

Links to Exploration step

PMC:4573764

Curation

No country items

Dan Rujescu
<affiliation>
<nlm:aff id="A92">Department of Psychiatry, Psychotherapy and Psychosomatics Martin-Luther-University Halle-Wittenberg, Julius-Kühn-Str. 706112 Halle Germany</nlm:aff>
<wicri:noCountry code="subfield">Julius-Kühn-Str. 706112 Halle Germany</wicri:noCountry>
</affiliation>

Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">A NOVEL ALZHEIMER DISEASE LOCUS LOCATED NEAR THE GENE ENCODING TAU PROTEIN</title>
<author>
<name sortKey="Jun, Gyungah" sort="Jun, Gyungah" uniqKey="Jun G" first="Gyungah" last="Jun">Gyungah Jun</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A2">Department of Ophthalmology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A3">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Ibrahim Verbaas, Carla A" sort="Ibrahim Verbaas, Carla A" uniqKey="Ibrahim Verbaas C" first="Carla A." last="Ibrahim-Verbaas">Carla A. Ibrahim-Verbaas</name>
<affiliation wicri:level="1">
<nlm:aff id="A4">Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A5">Department of Neurology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Vronskaya, Maria" sort="Vronskaya, Maria" uniqKey="Vronskaya M" first="Maria" last="Vronskaya">Maria Vronskaya</name>
<affiliation wicri:level="1">
<nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name>
<affiliation wicri:level="1">
<nlm:aff id="A7">Inserm U744, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U744, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A8">Université Lille 2, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille 2, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A9">Institut Pasteur de Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Chung, Jaeyoon" sort="Chung, Jaeyoon" uniqKey="Chung J" first="Jaeyoon" last="Chung">Jaeyoon Chung</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Naj, Adam C" sort="Naj, Adam C" uniqKey="Naj A" first="Adam C." last="Naj">Adam C. Naj</name>
<affiliation wicri:level="1">
<nlm:aff id="A10">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kunkle, Brian W" sort="Kunkle, Brian W" uniqKey="Kunkle B" first="Brian W." last="Kunkle">Brian W. Kunkle</name>
<affiliation wicri:level="1">
<nlm:aff id="A11">The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Wang, Li San" sort="Wang, Li San" uniqKey="Wang L" first="Li-San" last="Wang">Li-San Wang</name>
<affiliation wicri:level="1">
<nlm:aff id="A10">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name>
<affiliation wicri:level="1">
<nlm:aff id="A12">Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Bellenguez, Celine" sort="Bellenguez, Celine" uniqKey="Bellenguez C" first="Céline" last="Bellenguez">Céline Bellenguez</name>
<affiliation wicri:level="1">
<nlm:aff id="A7">Inserm U744, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U744, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A8">Université Lille 2, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille 2, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A9">Institut Pasteur de Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Harold, Denise" sort="Harold, Denise" uniqKey="Harold D" first="Denise" last="Harold">Denise Harold</name>
<affiliation wicri:level="1">
<nlm:aff id="A13">Trinity College, University of Dublin, Dublin, Ireland</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Trinity College, University of Dublin, Dublin</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lunetta, Kathryn L" sort="Lunetta, Kathryn L" uniqKey="Lunetta K" first="Kathryn L." last="Lunetta">Kathryn L. Lunetta</name>
<affiliation wicri:level="1">
<nlm:aff id="A3">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name>
<affiliation wicri:level="1">
<nlm:aff id="A3">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Grenier Boley, Benjamin" sort="Grenier Boley, Benjamin" uniqKey="Grenier Boley B" first="Benjamin" last="Grenier-Boley">Benjamin Grenier-Boley</name>
<affiliation wicri:level="1">
<nlm:aff id="A7">Inserm U744, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U744, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A8">Université Lille 2, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille 2, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A9">Institut Pasteur de Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Sims, Rebecca" sort="Sims, Rebecca" uniqKey="Sims R" first="Rebecca" last="Sims">Rebecca Sims</name>
<affiliation wicri:level="1">
<nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Beecham, Gary W" sort="Beecham, Gary W" uniqKey="Beecham G" first="Gary W." last="Beecham">Gary W. Beecham</name>
<affiliation wicri:level="1">
<nlm:aff id="A11">The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A14">Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V." last="Smith">Albert V. Smith</name>
<affiliation wicri:level="1">
<nlm:aff id="A15">University of Iceland, Faculty of Medicine, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>University of Iceland, Faculty of Medicine, Reykjavik</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A16">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Chouraki, Vincent" sort="Chouraki, Vincent" uniqKey="Chouraki V" first="Vincent" last="Chouraki">Vincent Chouraki</name>
<affiliation wicri:level="1">
<nlm:aff id="A17">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hamilton Nelson, Kara L" sort="Hamilton Nelson, Kara L" uniqKey="Hamilton Nelson K" first="Kara L." last="Hamilton-Nelson">Kara L. Hamilton-Nelson</name>
<affiliation wicri:level="1">
<nlm:aff id="A11">The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M. Arfan" last="Ikram">M. Arfan Ikram</name>
<affiliation wicri:level="1">
<nlm:aff id="A4">Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A18">Netherlands Consortium for Healthy Aging, Leiden, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium for Healthy Aging, Leiden</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A19">Department of Radiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Fievet, Nathalie" sort="Fievet, Nathalie" uniqKey="Fievet N" first="Nathalie" last="Fievet">Nathalie Fievet</name>
<affiliation wicri:level="1">
<nlm:aff id="A7">Inserm U744, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U744, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A8">Université Lille 2, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille 2, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A9">Institut Pasteur de Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Denning, Nicola" sort="Denning, Nicola" uniqKey="Denning N" first="Nicola" last="Denning">Nicola Denning</name>
<affiliation wicri:level="1">
<nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Martin, Eden R" sort="Martin, Eden R" uniqKey="Martin E" first="Eden R." last="Martin">Eden R. Martin</name>
<affiliation wicri:level="1">
<nlm:aff id="A11">The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A14">Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name>
<affiliation wicri:level="1">
<nlm:aff id="A20">Institute for Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Institute for Molecular Biology and Biochemistry, Medical University of Graz, Graz</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kamatani, Yochiro" sort="Kamatani, Yochiro" uniqKey="Kamatani Y" first="Yochiro" last="Kamatani">Yochiro Kamatani</name>
<affiliation wicri:level="1">
<nlm:aff id="A21">Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, Riken, Kanagawa, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, Riken, Kanagawa</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A22">Foundation Jean Dausset – CEPH, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Foundation Jean Dausset – CEPH, Paris</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Dunstan, Melanie L" sort="Dunstan, Melanie L" uniqKey="Dunstan M" first="Melanie L" last="Dunstan">Melanie L. Dunstan</name>
<affiliation wicri:level="1">
<nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Valladares, Otto" sort="Valladares, Otto" uniqKey="Valladares O" first="Otto" last="Valladares">Otto Valladares</name>
<affiliation wicri:level="1">
<nlm:aff id="A10">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Laza, Agustin Ruiz" sort="Laza, Agustin Ruiz" uniqKey="Laza A" first="Agustin Ruiz" last="Laza">Agustin Ruiz Laza</name>
<affiliation wicri:level="1">
<nlm:aff id="A23">Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Zelenika, Diana" sort="Zelenika, Diana" uniqKey="Zelenika D" first="Diana" last="Zelenika">Diana Zelenika</name>
</author>
<author>
<name sortKey="Ramirez, Alfredo" sort="Ramirez, Alfredo" uniqKey="Ramirez A" first="Alfredo" last="Ramirez">Alfredo Ramirez</name>
<affiliation wicri:level="1">
<nlm:aff id="A25">Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, University of Bonn, Bonn</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A26">Institute of Human Genetics, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Foroud, Tatiana M" sort="Foroud, Tatiana M" uniqKey="Foroud T" first="Tatiana M." last="Foroud">Tatiana M. Foroud</name>
<affiliation wicri:level="1">
<nlm:aff id="A27">Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Choi, Seung Hoan" sort="Choi, Seung Hoan" uniqKey="Choi S" first="Seung-Hoan" last="Choi">Seung-Hoan Choi</name>
<affiliation wicri:level="1">
<nlm:aff id="A3">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Boland, Anne" sort="Boland, Anne" uniqKey="Boland A" first="Anne" last="Boland">Anne Boland</name>
<affiliation wicri:level="1">
<nlm:aff id="A24">Centre National de Genotypage, Institut Genomique, Commissariat a l’energie Atomique, Evry, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de Genotypage, Institut Genomique, Commissariat a l’energie Atomique, Evry</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Becker, Tim" sort="Becker, Tim" uniqKey="Becker T" first="Tim" last="Becker">Tim Becker</name>
<affiliation wicri:level="1">
<nlm:aff id="A28">German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Center for Neurodegenerative Diseases (DZNE), Bonn</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A29">Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kukull, Walter A" sort="Kukull, Walter A" uniqKey="Kukull W" first="Walter A." last="Kukull">Walter A. Kukull</name>
<affiliation wicri:level="1">
<nlm:aff id="A30">Department of Epidemiology, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, WA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Van Der Lee, Sven J" sort="Van Der Lee, Sven J" uniqKey="Van Der Lee S" first="Sven J." last="Van Der Lee">Sven J. Van Der Lee</name>
<affiliation wicri:level="1">
<nlm:aff id="A4">Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Pasquier, Florence" sort="Pasquier, Florence" uniqKey="Pasquier F" first="Florence" last="Pasquier">Florence Pasquier</name>
<affiliation wicri:level="1">
<nlm:aff id="A8">Université Lille 2, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille 2, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A31">Centre National de Reference pour les Malades Alzheimer Jeunes (CNR-MAJ), Centre Hospitalier Régional Universitaire de Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de Reference pour les Malades Alzheimer Jeunes (CNR-MAJ), Centre Hospitalier Régional Universitaire de Lille, Lille</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Cruchaga, Carlos" sort="Cruchaga, Carlos" uniqKey="Cruchaga C" first="Carlos" last="Cruchaga">Carlos Cruchaga</name>
<affiliation wicri:level="1">
<nlm:aff id="A32">Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A33">Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, Washington University School of Medicine, St. Louis, MO</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Beekly, Duane" sort="Beekly, Duane" uniqKey="Beekly D" first="Duane" last="Beekly">Duane Beekly</name>
<affiliation wicri:level="1">
<nlm:aff id="A34">National Alzheimer’s Coordinating Center, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Alzheimer’s Coordinating Center, University of Washington, Seattle, WA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Fitzpatrick, Annette L" sort="Fitzpatrick, Annette L" uniqKey="Fitzpatrick A" first="Annette L." last="Fitzpatrick">Annette L. Fitzpatrick</name>
<affiliation wicri:level="1">
<nlm:aff id="A30">Department of Epidemiology, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, WA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A35">Departments of Health Services, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Health Services, University of Washington, Seattle, WA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hanon, Oliver" sort="Hanon, Oliver" uniqKey="Hanon O" first="Oliver" last="Hanon">Oliver Hanon</name>
<affiliation wicri:level="1">
<nlm:aff id="A36">University Paris Descartes, Sorbonne Paris V, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Paris Descartes, Sorbonne Paris V</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A37">Broca Hospital, Geriatrics Department, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Broca Hospital, Geriatrics Department, Paris</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Gill, Michael" sort="Gill, Michael" uniqKey="Gill M" first="Michael" last="Gill">Michael Gill</name>
<affiliation wicri:level="1">
<nlm:aff id="A38">Mercer’s Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Mercer’s Institute for Research on Aging, St. James Hospital and Trinity College, Dublin</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Barber, Robert" sort="Barber, Robert" uniqKey="Barber R" first="Robert" last="Barber">Robert Barber</name>
<affiliation wicri:level="1">
<nlm:aff id="A39">Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name>
<affiliation wicri:level="1">
<nlm:aff id="A15">University of Iceland, Faculty of Medicine, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>University of Iceland, Faculty of Medicine, Reykjavik</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A16">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Campion, Dominique" sort="Campion, Dominique" uniqKey="Campion D" first="Dominique" last="Campion">Dominique Campion</name>
<affiliation wicri:level="1">
<nlm:aff id="A40">CNR-MAJ, Inserm U1079, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CNR-MAJ, Inserm U1079, Rouen</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A41">University Hospital, 76031 Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Hospital, 76031 Rouen</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Love, Seth" sort="Love, Seth" uniqKey="Love S" first="Seth" last="Love">Seth Love</name>
<affiliation wicri:level="1">
<nlm:aff id="A42">University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A." last="Bennett">David A. Bennett</name>
<affiliation wicri:level="1">
<nlm:aff id="A43">Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A44">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name>
<affiliation wicri:level="1">
<nlm:aff id="A4">Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Berr, Claudine" sort="Berr, Claudine" uniqKey="Berr C" first="Claudine" last="Berr">Claudine Berr</name>
<affiliation wicri:level="1">
<nlm:aff id="A45">Inserm U888, Hôpital La Colombière, Montpellier, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U888, Hôpital La Colombière, Montpellier</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Tsolaki, Magda" sort="Tsolaki, Magda" uniqKey="Tsolaki M" first="Magda" last="Tsolaki">Magda Tsolaki</name>
<affiliation wicri:level="1">
<nlm:aff id="A46">Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Buxbaum, Joseph D" sort="Buxbaum, Joseph D" uniqKey="Buxbaum J" first="Joseph D." last="Buxbaum">Joseph D. Buxbaum</name>
<affiliation wicri:level="1">
<nlm:aff id="A47">Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mount Sinai School of Medicine, New York, NY</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A48">Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, Mount Sinai School of Medicine, New York, NY</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A49">Departments of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lopez, Oscar L" sort="Lopez, Oscar L" uniqKey="Lopez O" first="Oscar L." last="Lopez">Oscar L. Lopez</name>
<affiliation wicri:level="1">
<nlm:aff id="A50">University of Pittsburgh Alzheimer’s Disease Research Center, Pittsburgh, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pittsburgh Alzheimer’s Disease Research Center, Pittsburgh, PA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A51">Departments of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Deramecourt, Vincent" sort="Deramecourt, Vincent" uniqKey="Deramecourt V" first="Vincent" last="Deramecourt">Vincent Deramecourt</name>
<affiliation wicri:level="1">
<nlm:aff id="A8">Université Lille 2, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille 2, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A31">Centre National de Reference pour les Malades Alzheimer Jeunes (CNR-MAJ), Centre Hospitalier Régional Universitaire de Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de Reference pour les Malades Alzheimer Jeunes (CNR-MAJ), Centre Hospitalier Régional Universitaire de Lille, Lille</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Fox, Nick C" sort="Fox, Nick C" uniqKey="Fox N" first="Nick C" last="Fox">Nick C. Fox</name>
<affiliation wicri:level="1">
<nlm:aff id="A52">Dementia Research Centre, Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Dementia Research Centre, Department of Neurodegenerative Disease, University College London Institute of Neurology, London</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Cantwell, Laura B" sort="Cantwell, Laura B" uniqKey="Cantwell L" first="Laura B." last="Cantwell">Laura B. Cantwell</name>
<affiliation wicri:level="1">
<nlm:aff id="A10">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Tarraga, Lluis" sort="Tarraga, Lluis" uniqKey="Tarraga L" first="Lluis" last="Tárraga">Lluis Tárraga</name>
<affiliation wicri:level="1">
<nlm:aff id="A53">Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name>
<affiliation wicri:level="1">
<nlm:aff id="A54">Inserm U897, Victor Segalen University, F-33076, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name>
<affiliation wicri:level="1">
<nlm:aff id="A55">Department of Molecular Neuroscience, Institute of Neurology, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Molecular Neuroscience, Institute of Neurology, London</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A56">Reta Lilla Weston Laboratories, Institute of Neurology, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Reta Lilla Weston Laboratories, Institute of Neurology, London</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Crane, Paul K" sort="Crane, Paul K" uniqKey="Crane P" first="Paul K." last="Crane">Paul K. Crane</name>
<affiliation wicri:level="1">
<nlm:aff id="A57">Department of Medicine, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, University of Washington, Seattle, WA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name>
<affiliation wicri:level="1">
<nlm:aff id="A16">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name>
<affiliation wicri:level="1">
<nlm:aff id="A40">CNR-MAJ, Inserm U1079, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CNR-MAJ, Inserm U1079, Rouen</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A54">Inserm U897, Victor Segalen University, F-33076, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name>
<affiliation wicri:level="1">
<nlm:aff id="A58">Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of Oxford, Oxford</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Evans, Denis" sort="Evans, Denis" uniqKey="Evans D" first="Denis" last="Evans">Denis Evans</name>
<affiliation wicri:level="1">
<nlm:aff id="A59">Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H." last="Mosley">Thomas H. Mosley</name>
<affiliation wicri:level="1">
<nlm:aff id="A60">Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, MS, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, MS</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Letenneur, Luc" sort="Letenneur, Luc" uniqKey="Letenneur L" first="Luc" last="Letenneur">Luc Letenneur</name>
<affiliation wicri:level="1">
<nlm:aff id="A54">Inserm U897, Victor Segalen University, F-33076, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Brayne, Carol" sort="Brayne, Carol" uniqKey="Brayne C" first="Carol" last="Brayne">Carol Brayne</name>
<affiliation wicri:level="1">
<nlm:aff id="A61">Institute of Public Health, University of Cambridge, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Public Health, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Maier, Wolfgang" sort="Maier, Wolfgang" uniqKey="Maier W" first="Wolfgang" last="Maier">Wolfgang Maier</name>
<affiliation wicri:level="1">
<nlm:aff id="A25">Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, University of Bonn, Bonn</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A28">German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Center for Neurodegenerative Diseases (DZNE), Bonn</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="De Jager, Philip" sort="De Jager, Philip" uniqKey="De Jager P" first="Philip" last="De Jager">Philip De Jager</name>
<affiliation wicri:level="1">
<nlm:aff id="A62">Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A5">Department of Neurology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A63">Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Medical and Population Genetics, Broad Institute, Cambridge, MA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Emilsson, Valur" sort="Emilsson, Valur" uniqKey="Emilsson V" first="Valur" last="Emilsson">Valur Emilsson</name>
<affiliation wicri:level="1">
<nlm:aff id="A16">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A64">Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavik</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name>
<affiliation wicri:level="1">
<nlm:aff id="A54">Inserm U897, Victor Segalen University, F-33076, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A65">Centre de Mémoire de Ressources et de Recherche de Bordeaux, CHU de Bordeaux, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre de Mémoire de Ressources et de Recherche de Bordeaux, CHU de Bordeaux, Bordeaux</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hampel, Harald" sort="Hampel, Harald" uniqKey="Hampel H" first="Harald" last="Hampel">Harald Hampel</name>
<affiliation wicri:level="1">
<nlm:aff id="A66">Department of Psychiatry, University of Frankfurt, Frankfurt am Main, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry, University of Frankfurt, Frankfurt am Main</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A67">Department of Psychiatry, Ludwig Maximilians University, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry, Ludwig Maximilians University, Munich</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kamboh, M Ilyas" sort="Kamboh, M Ilyas" uniqKey="Kamboh M" first="M. Ilyas" last="Kamboh">M. Ilyas Kamboh</name>
<affiliation wicri:level="1">
<nlm:aff id="A50">University of Pittsburgh Alzheimer’s Disease Research Center, Pittsburgh, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pittsburgh Alzheimer’s Disease Research Center, Pittsburgh, PA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A68">Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="De Bruijn, Renee F A G" sort="De Bruijn, Renee F A G" uniqKey="De Bruijn R" first="Renee F. A. G." last="De Bruijn">Renee F. A. G. De Bruijn</name>
<affiliation wicri:level="1">
<nlm:aff id="A4">Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name>
<affiliation wicri:level="1">
<nlm:aff id="A54">Inserm U897, Victor Segalen University, F-33076, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Pastor, Pau" sort="Pastor, Pau" uniqKey="Pastor P" first="Pau" last="Pastor">Pau Pastor</name>
<affiliation wicri:level="1">
<nlm:aff id="A69">Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A70">CIBERNED, Instituto de Salud Carlos III, Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBERNED, Instituto de Salud Carlos III, Madrid</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Larson, Eric B" sort="Larson, Eric B" uniqKey="Larson E" first="Eric B." last="Larson">Eric B. Larson</name>
<affiliation wicri:level="1">
<nlm:aff id="A57">Department of Medicine, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, University of Washington, Seattle, WA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A71">Group Health, Group Health Research Institute, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Group Health, Group Health Research Institute, Seattle, WA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I." last="Rotter">Jerome I. Rotter</name>
<affiliation wicri:level="1">
<nlm:aff id="A72">Institute for Translational Genomics and Population Sciences. Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Institute for Translational Genomics and Population Sciences. Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A73">Division of Genetic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Genetic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="O Onovan, Michael C" sort="O Onovan, Michael C" uniqKey="O Onovan M" first="Michael C" last="O Onovan">Michael C. O Onovan</name>
<affiliation wicri:level="1">
<nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Montine, Thomas J" sort="Montine, Thomas J" uniqKey="Montine T" first="Thomas J." last="Montine">Thomas J. Montine</name>
<affiliation wicri:level="1">
<nlm:aff id="A74">Department of Pathology, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A." last="Nalls">Michael A. Nalls</name>
<affiliation wicri:level="1">
<nlm:aff id="A75">Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, MD</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Mead, Simon" sort="Mead, Simon" uniqKey="Mead S" first="Simon" last="Mead">Simon Mead</name>
<affiliation wicri:level="1">
<nlm:aff id="A55">Department of Molecular Neuroscience, Institute of Neurology, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Molecular Neuroscience, Institute of Neurology, London</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Reiman, Eric M" sort="Reiman, Eric M" uniqKey="Reiman E" first="Eric M." last="Reiman">Eric M. Reiman</name>
<affiliation wicri:level="1">
<nlm:aff id="A76">Arizona Alzheimer’s Consortium, Phoenix, AZ, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arizona Alzheimer’s Consortium, Phoenix, AZ</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A77">Department of Psychiatry, University of Arizona, Phoenix, AZ, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of Arizona, Phoenix, AZ</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A78">Banner Alzheimer’s Institute, Phoenix, AZ, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Banner Alzheimer’s Institute, Phoenix, AZ</wicri:regionArea>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A79">Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Arizona</region>
</placeName>
<wicri:cityArea>Neurogenomics Division, Translational Genomics Research Institute, Phoenix</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Jonsson, Palmi V" sort="Jonsson, Palmi V" uniqKey="Jonsson P" first="Palmi V." last="Jonsson">Palmi V. Jonsson</name>
<affiliation wicri:level="1">
<nlm:aff id="A15">University of Iceland, Faculty of Medicine, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>University of Iceland, Faculty of Medicine, Reykjavik</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A80">Department of Geriatrics, Landspitali National University Hospital, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Department of Geriatrics, Landspitali National University Hospital, Reykjavik</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Holmes, Clive" sort="Holmes, Clive" uniqKey="Holmes C" first="Clive" last="Holmes">Clive Holmes</name>
<affiliation wicri:level="1">
<nlm:aff id="A81">Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="St George Hyslop, Peter H" sort="St George Hyslop, Peter H" uniqKey="St George Hyslop P" first="Peter H." last="St George-Hyslop">Peter H. St George-Hyslop</name>
<affiliation wicri:level="1">
<nlm:aff id="A82">Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A83">Cambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Boada, Merce" sort="Boada, Merce" uniqKey="Boada M" first="Mercè" last="Boada">Mercè Boada</name>
<affiliation wicri:level="1">
<nlm:aff id="A53">Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Passmore, Peter" sort="Passmore, Peter" uniqKey="Passmore P" first="Peter" last="Passmore">Peter Passmore</name>
<affiliation wicri:level="1">
<nlm:aff id="A84">Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University, Belfast, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University, Belfast</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Wendland, Jens R" sort="Wendland, Jens R" uniqKey="Wendland J" first="Jens R." last="Wendland">Jens R. Wendland</name>
<affiliation wicri:level="1">
<nlm:aff id="A85">PharmaTherapeutics Clinical Research, Pfizer Worldwide Research and Development, Cambridge, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>PharmaTherapeutics Clinical Research, Pfizer Worldwide Research and Development, Cambridge, MA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name>
<affiliation wicri:level="1">
<nlm:aff id="A86">Department of Neurology, Medical University of Graz, Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, Medical University of Graz, Graz</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Morgan, Kevin" sort="Morgan, Kevin" uniqKey="Morgan K" first="Kevin" last="Morgan">Kevin Morgan</name>
<affiliation wicri:level="1">
<nlm:aff id="A87">Institute of Genetics, Queen’s Medical Centre, University of Nottingham, Nottingham, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Genetics, Queen’s Medical Centre, University of Nottingham, Nottingham</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Winslow, Ashley R" sort="Winslow, Ashley R" uniqKey="Winslow A" first="Ashley R." last="Winslow">Ashley R. Winslow</name>
<affiliation wicri:level="1">
<nlm:aff id="A85">PharmaTherapeutics Clinical Research, Pfizer Worldwide Research and Development, Cambridge, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>PharmaTherapeutics Clinical Research, Pfizer Worldwide Research and Development, Cambridge, MA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Powell, John F" sort="Powell, John F" uniqKey="Powell J" first="John F" last="Powell">John F. Powell</name>
<affiliation wicri:level="1">
<nlm:aff id="A88">King’s College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>King’s College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Carasquillo, Minerva" sort="Carasquillo, Minerva" uniqKey="Carasquillo M" first="Minerva" last="Carasquillo">Minerva Carasquillo</name>
<affiliation wicri:level="1">
<nlm:aff id="A89">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Younkin, Steven G" sort="Younkin, Steven G" uniqKey="Younkin S" first="Steven G." last="Younkin">Steven G. Younkin</name>
<affiliation wicri:level="1">
<nlm:aff id="A89">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Jakobsd Ttir, J Hanna" sort="Jakobsd Ttir, J Hanna" uniqKey="Jakobsd Ttir J" first="J Hanna" last="Jakobsd Ttir">J Hanna Jakobsd Ttir</name>
<affiliation wicri:level="1">
<nlm:aff id="A16">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kauwe, John Sk" sort="Kauwe, John Sk" uniqKey="Kauwe J" first="John Sk" last="Kauwe">John Sk Kauwe</name>
<affiliation wicri:level="1">
<nlm:aff id="A90">Department of Biology, Brigham Young University, Provo, Utah, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biology, Brigham Young University, Provo, Utah</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Wilhelmsen, Kirk C" sort="Wilhelmsen, Kirk C" uniqKey="Wilhelmsen K" first="Kirk C." last="Wilhelmsen">Kirk C. Wilhelmsen</name>
<affiliation wicri:level="1">
<nlm:aff id="A91">Department of Genetics, University of North Carolina Chapel Hill, Chapel Hill, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, University of North Carolina Chapel Hill, Chapel Hill, NC</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Rujescu, Dan" sort="Rujescu, Dan" uniqKey="Rujescu D" first="Dan" last="Rujescu">Dan Rujescu</name>
<affiliation>
<nlm:aff id="A92">Department of Psychiatry, Psychotherapy and Psychosomatics Martin-Luther-University Halle-Wittenberg, Julius-Kühn-Str. 706112 Halle Germany</nlm:aff>
<wicri:noCountry code="subfield">Julius-Kühn-Str. 706112 Halle Germany</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M" last="Nöthen">Markus M. Nöthen</name>
<affiliation wicri:level="1">
<nlm:aff id="A26">Institute of Human Genetics, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A93">Institute of Human Genetics, Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, Department of Genomics, Life and Brain Center, University of Bonn, Bonn</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation wicri:level="1">
<nlm:aff id="A4">Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A19">Department of Radiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Jones, Lesley" sort="Jones, Lesley" uniqKey="Jones L" first="Lesley" last="Jones">Lesley Jones</name>
<affiliation wicri:level="1">
<nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L." last="Haines">Jonathan L. Haines</name>
<affiliation wicri:level="1">
<nlm:aff id="A94">Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name>
<affiliation wicri:level="1">
<nlm:aff id="A12">Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A30">Department of Epidemiology, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, WA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A35">Departments of Health Services, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Health Services, University of Washington, Seattle, WA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A71">Group Health, Group Health Research Institute, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Group Health, Group Health Research Institute, Seattle, WA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name>
<affiliation wicri:level="1">
<nlm:aff id="A95">Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A96">Institute Born-Bunge, University of Antwerp, Antwerp, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Institute Born-Bunge, University of Antwerp, Antwerp</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Holmans, Peter" sort="Holmans, Peter" uniqKey="Holmans P" first="Peter" last="Holmans">Peter Holmans</name>
<affiliation wicri:level="1">
<nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name>
<affiliation wicri:level="1">
<nlm:aff id="A97">Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, MD</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Mayeux, Richard" sort="Mayeux, Richard" uniqKey="Mayeux R" first="Richard" last="Mayeux">Richard Mayeux</name>
<affiliation wicri:level="1">
<nlm:aff id="A98">Taub Institute on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Taub Institute on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A99">Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Gertrude H. Sergievsky Center, Columbia University, New York, NY</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A100">Department of Neurology, Columbia University, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Columbia University, New York, NY</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name>
<affiliation wicri:level="1">
<nlm:aff id="A24">Centre National de Genotypage, Institut Genomique, Commissariat a l’energie Atomique, Evry, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de Genotypage, Institut Genomique, Commissariat a l’energie Atomique, Evry</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A101">McGill University and Génome Québec Innovation Centre, Montreal, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>McGill University and Génome Québec Innovation Centre, Montreal</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A102">Fondation Jean Dausset- CEPH, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Fondation Jean Dausset- CEPH, Paris</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Goate, Alison M" sort="Goate, Alison M" uniqKey="Goate A" first="Alison M." last="Goate">Alison M. Goate</name>
<affiliation wicri:level="1">
<nlm:aff id="A32">Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A33">Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, Washington University School of Medicine, St. Louis, MO</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Escott Price, Valentina" sort="Escott Price, Valentina" uniqKey="Escott Price V" first="Valentina" last="Escott-Price">Valentina Escott-Price</name>
<affiliation wicri:level="1">
<nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name>
<affiliation wicri:level="1">
<nlm:aff id="A17">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Pericak Vance, Margaret A" sort="Pericak Vance, Margaret A" uniqKey="Pericak Vance M" first="Margaret A." last="Pericak-Vance">Margaret A. Pericak-Vance</name>
<affiliation wicri:level="1">
<nlm:aff id="A11">The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A14">Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name>
<affiliation wicri:level="1">
<nlm:aff id="A7">Inserm U744, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U744, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A8">Université Lille 2, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille 2, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A9">Institut Pasteur de Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A103">University Hospital, CHRU Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Hospital, CHRU Lille, Lille</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Williams, Julie" sort="Williams, Julie" uniqKey="Williams J" first="Julie" last="Williams">Julie Williams</name>
<affiliation wicri:level="1">
<nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name>
<affiliation wicri:level="1">
<nlm:aff id="A4">Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schellenberg, Gerard D" sort="Schellenberg, Gerard D" uniqKey="Schellenberg G" first="Gerard D." last="Schellenberg">Gerard D. Schellenberg</name>
<affiliation wicri:level="1">
<nlm:aff id="A10">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A." last="Farrer">Lindsay A. Farrer</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A2">Department of Ophthalmology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A3">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A17">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A104">Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Boston University School of Public Health, Boston, MA</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PMC</idno>
<idno type="pmid">25778476</idno>
<idno type="pmc">4573764</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573764</idno>
<idno type="RBID">PMC:4573764</idno>
<idno type="doi">10.1038/mp.2015.23</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">000B59</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000B59</idno>
<idno type="wicri:Area/Pmc/Curation">000B59</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000B59</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en" level="a" type="main">A NOVEL ALZHEIMER DISEASE LOCUS LOCATED NEAR THE GENE ENCODING TAU PROTEIN</title>
<author>
<name sortKey="Jun, Gyungah" sort="Jun, Gyungah" uniqKey="Jun G" first="Gyungah" last="Jun">Gyungah Jun</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A2">Department of Ophthalmology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A3">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Ibrahim Verbaas, Carla A" sort="Ibrahim Verbaas, Carla A" uniqKey="Ibrahim Verbaas C" first="Carla A." last="Ibrahim-Verbaas">Carla A. Ibrahim-Verbaas</name>
<affiliation wicri:level="1">
<nlm:aff id="A4">Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A5">Department of Neurology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Vronskaya, Maria" sort="Vronskaya, Maria" uniqKey="Vronskaya M" first="Maria" last="Vronskaya">Maria Vronskaya</name>
<affiliation wicri:level="1">
<nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name>
<affiliation wicri:level="1">
<nlm:aff id="A7">Inserm U744, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U744, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A8">Université Lille 2, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille 2, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A9">Institut Pasteur de Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Chung, Jaeyoon" sort="Chung, Jaeyoon" uniqKey="Chung J" first="Jaeyoon" last="Chung">Jaeyoon Chung</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Naj, Adam C" sort="Naj, Adam C" uniqKey="Naj A" first="Adam C." last="Naj">Adam C. Naj</name>
<affiliation wicri:level="1">
<nlm:aff id="A10">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kunkle, Brian W" sort="Kunkle, Brian W" uniqKey="Kunkle B" first="Brian W." last="Kunkle">Brian W. Kunkle</name>
<affiliation wicri:level="1">
<nlm:aff id="A11">The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Wang, Li San" sort="Wang, Li San" uniqKey="Wang L" first="Li-San" last="Wang">Li-San Wang</name>
<affiliation wicri:level="1">
<nlm:aff id="A10">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name>
<affiliation wicri:level="1">
<nlm:aff id="A12">Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Bellenguez, Celine" sort="Bellenguez, Celine" uniqKey="Bellenguez C" first="Céline" last="Bellenguez">Céline Bellenguez</name>
<affiliation wicri:level="1">
<nlm:aff id="A7">Inserm U744, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U744, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A8">Université Lille 2, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille 2, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A9">Institut Pasteur de Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Harold, Denise" sort="Harold, Denise" uniqKey="Harold D" first="Denise" last="Harold">Denise Harold</name>
<affiliation wicri:level="1">
<nlm:aff id="A13">Trinity College, University of Dublin, Dublin, Ireland</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Trinity College, University of Dublin, Dublin</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lunetta, Kathryn L" sort="Lunetta, Kathryn L" uniqKey="Lunetta K" first="Kathryn L." last="Lunetta">Kathryn L. Lunetta</name>
<affiliation wicri:level="1">
<nlm:aff id="A3">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name>
<affiliation wicri:level="1">
<nlm:aff id="A3">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Grenier Boley, Benjamin" sort="Grenier Boley, Benjamin" uniqKey="Grenier Boley B" first="Benjamin" last="Grenier-Boley">Benjamin Grenier-Boley</name>
<affiliation wicri:level="1">
<nlm:aff id="A7">Inserm U744, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U744, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A8">Université Lille 2, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille 2, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A9">Institut Pasteur de Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Sims, Rebecca" sort="Sims, Rebecca" uniqKey="Sims R" first="Rebecca" last="Sims">Rebecca Sims</name>
<affiliation wicri:level="1">
<nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Beecham, Gary W" sort="Beecham, Gary W" uniqKey="Beecham G" first="Gary W." last="Beecham">Gary W. Beecham</name>
<affiliation wicri:level="1">
<nlm:aff id="A11">The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A14">Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V." last="Smith">Albert V. Smith</name>
<affiliation wicri:level="1">
<nlm:aff id="A15">University of Iceland, Faculty of Medicine, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>University of Iceland, Faculty of Medicine, Reykjavik</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A16">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Chouraki, Vincent" sort="Chouraki, Vincent" uniqKey="Chouraki V" first="Vincent" last="Chouraki">Vincent Chouraki</name>
<affiliation wicri:level="1">
<nlm:aff id="A17">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hamilton Nelson, Kara L" sort="Hamilton Nelson, Kara L" uniqKey="Hamilton Nelson K" first="Kara L." last="Hamilton-Nelson">Kara L. Hamilton-Nelson</name>
<affiliation wicri:level="1">
<nlm:aff id="A11">The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M. Arfan" last="Ikram">M. Arfan Ikram</name>
<affiliation wicri:level="1">
<nlm:aff id="A4">Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A18">Netherlands Consortium for Healthy Aging, Leiden, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium for Healthy Aging, Leiden</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A19">Department of Radiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Fievet, Nathalie" sort="Fievet, Nathalie" uniqKey="Fievet N" first="Nathalie" last="Fievet">Nathalie Fievet</name>
<affiliation wicri:level="1">
<nlm:aff id="A7">Inserm U744, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U744, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A8">Université Lille 2, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille 2, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A9">Institut Pasteur de Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Denning, Nicola" sort="Denning, Nicola" uniqKey="Denning N" first="Nicola" last="Denning">Nicola Denning</name>
<affiliation wicri:level="1">
<nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Martin, Eden R" sort="Martin, Eden R" uniqKey="Martin E" first="Eden R." last="Martin">Eden R. Martin</name>
<affiliation wicri:level="1">
<nlm:aff id="A11">The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A14">Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name>
<affiliation wicri:level="1">
<nlm:aff id="A20">Institute for Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Institute for Molecular Biology and Biochemistry, Medical University of Graz, Graz</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kamatani, Yochiro" sort="Kamatani, Yochiro" uniqKey="Kamatani Y" first="Yochiro" last="Kamatani">Yochiro Kamatani</name>
<affiliation wicri:level="1">
<nlm:aff id="A21">Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, Riken, Kanagawa, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, Riken, Kanagawa</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A22">Foundation Jean Dausset – CEPH, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Foundation Jean Dausset – CEPH, Paris</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Dunstan, Melanie L" sort="Dunstan, Melanie L" uniqKey="Dunstan M" first="Melanie L" last="Dunstan">Melanie L. Dunstan</name>
<affiliation wicri:level="1">
<nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Valladares, Otto" sort="Valladares, Otto" uniqKey="Valladares O" first="Otto" last="Valladares">Otto Valladares</name>
<affiliation wicri:level="1">
<nlm:aff id="A10">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Laza, Agustin Ruiz" sort="Laza, Agustin Ruiz" uniqKey="Laza A" first="Agustin Ruiz" last="Laza">Agustin Ruiz Laza</name>
<affiliation wicri:level="1">
<nlm:aff id="A23">Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Zelenika, Diana" sort="Zelenika, Diana" uniqKey="Zelenika D" first="Diana" last="Zelenika">Diana Zelenika</name>
</author>
<author>
<name sortKey="Ramirez, Alfredo" sort="Ramirez, Alfredo" uniqKey="Ramirez A" first="Alfredo" last="Ramirez">Alfredo Ramirez</name>
<affiliation wicri:level="1">
<nlm:aff id="A25">Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, University of Bonn, Bonn</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A26">Institute of Human Genetics, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Foroud, Tatiana M" sort="Foroud, Tatiana M" uniqKey="Foroud T" first="Tatiana M." last="Foroud">Tatiana M. Foroud</name>
<affiliation wicri:level="1">
<nlm:aff id="A27">Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Choi, Seung Hoan" sort="Choi, Seung Hoan" uniqKey="Choi S" first="Seung-Hoan" last="Choi">Seung-Hoan Choi</name>
<affiliation wicri:level="1">
<nlm:aff id="A3">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Boland, Anne" sort="Boland, Anne" uniqKey="Boland A" first="Anne" last="Boland">Anne Boland</name>
<affiliation wicri:level="1">
<nlm:aff id="A24">Centre National de Genotypage, Institut Genomique, Commissariat a l’energie Atomique, Evry, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de Genotypage, Institut Genomique, Commissariat a l’energie Atomique, Evry</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Becker, Tim" sort="Becker, Tim" uniqKey="Becker T" first="Tim" last="Becker">Tim Becker</name>
<affiliation wicri:level="1">
<nlm:aff id="A28">German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Center for Neurodegenerative Diseases (DZNE), Bonn</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A29">Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kukull, Walter A" sort="Kukull, Walter A" uniqKey="Kukull W" first="Walter A." last="Kukull">Walter A. Kukull</name>
<affiliation wicri:level="1">
<nlm:aff id="A30">Department of Epidemiology, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, WA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Van Der Lee, Sven J" sort="Van Der Lee, Sven J" uniqKey="Van Der Lee S" first="Sven J." last="Van Der Lee">Sven J. Van Der Lee</name>
<affiliation wicri:level="1">
<nlm:aff id="A4">Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Pasquier, Florence" sort="Pasquier, Florence" uniqKey="Pasquier F" first="Florence" last="Pasquier">Florence Pasquier</name>
<affiliation wicri:level="1">
<nlm:aff id="A8">Université Lille 2, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille 2, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A31">Centre National de Reference pour les Malades Alzheimer Jeunes (CNR-MAJ), Centre Hospitalier Régional Universitaire de Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de Reference pour les Malades Alzheimer Jeunes (CNR-MAJ), Centre Hospitalier Régional Universitaire de Lille, Lille</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Cruchaga, Carlos" sort="Cruchaga, Carlos" uniqKey="Cruchaga C" first="Carlos" last="Cruchaga">Carlos Cruchaga</name>
<affiliation wicri:level="1">
<nlm:aff id="A32">Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A33">Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, Washington University School of Medicine, St. Louis, MO</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Beekly, Duane" sort="Beekly, Duane" uniqKey="Beekly D" first="Duane" last="Beekly">Duane Beekly</name>
<affiliation wicri:level="1">
<nlm:aff id="A34">National Alzheimer’s Coordinating Center, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Alzheimer’s Coordinating Center, University of Washington, Seattle, WA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Fitzpatrick, Annette L" sort="Fitzpatrick, Annette L" uniqKey="Fitzpatrick A" first="Annette L." last="Fitzpatrick">Annette L. Fitzpatrick</name>
<affiliation wicri:level="1">
<nlm:aff id="A30">Department of Epidemiology, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, WA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A35">Departments of Health Services, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Health Services, University of Washington, Seattle, WA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hanon, Oliver" sort="Hanon, Oliver" uniqKey="Hanon O" first="Oliver" last="Hanon">Oliver Hanon</name>
<affiliation wicri:level="1">
<nlm:aff id="A36">University Paris Descartes, Sorbonne Paris V, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Paris Descartes, Sorbonne Paris V</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A37">Broca Hospital, Geriatrics Department, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Broca Hospital, Geriatrics Department, Paris</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Gill, Michael" sort="Gill, Michael" uniqKey="Gill M" first="Michael" last="Gill">Michael Gill</name>
<affiliation wicri:level="1">
<nlm:aff id="A38">Mercer’s Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Mercer’s Institute for Research on Aging, St. James Hospital and Trinity College, Dublin</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Barber, Robert" sort="Barber, Robert" uniqKey="Barber R" first="Robert" last="Barber">Robert Barber</name>
<affiliation wicri:level="1">
<nlm:aff id="A39">Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name>
<affiliation wicri:level="1">
<nlm:aff id="A15">University of Iceland, Faculty of Medicine, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>University of Iceland, Faculty of Medicine, Reykjavik</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A16">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Campion, Dominique" sort="Campion, Dominique" uniqKey="Campion D" first="Dominique" last="Campion">Dominique Campion</name>
<affiliation wicri:level="1">
<nlm:aff id="A40">CNR-MAJ, Inserm U1079, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CNR-MAJ, Inserm U1079, Rouen</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A41">University Hospital, 76031 Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Hospital, 76031 Rouen</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Love, Seth" sort="Love, Seth" uniqKey="Love S" first="Seth" last="Love">Seth Love</name>
<affiliation wicri:level="1">
<nlm:aff id="A42">University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A." last="Bennett">David A. Bennett</name>
<affiliation wicri:level="1">
<nlm:aff id="A43">Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A44">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name>
<affiliation wicri:level="1">
<nlm:aff id="A4">Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Berr, Claudine" sort="Berr, Claudine" uniqKey="Berr C" first="Claudine" last="Berr">Claudine Berr</name>
<affiliation wicri:level="1">
<nlm:aff id="A45">Inserm U888, Hôpital La Colombière, Montpellier, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U888, Hôpital La Colombière, Montpellier</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Tsolaki, Magda" sort="Tsolaki, Magda" uniqKey="Tsolaki M" first="Magda" last="Tsolaki">Magda Tsolaki</name>
<affiliation wicri:level="1">
<nlm:aff id="A46">Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Buxbaum, Joseph D" sort="Buxbaum, Joseph D" uniqKey="Buxbaum J" first="Joseph D." last="Buxbaum">Joseph D. Buxbaum</name>
<affiliation wicri:level="1">
<nlm:aff id="A47">Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mount Sinai School of Medicine, New York, NY</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A48">Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, Mount Sinai School of Medicine, New York, NY</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A49">Departments of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lopez, Oscar L" sort="Lopez, Oscar L" uniqKey="Lopez O" first="Oscar L." last="Lopez">Oscar L. Lopez</name>
<affiliation wicri:level="1">
<nlm:aff id="A50">University of Pittsburgh Alzheimer’s Disease Research Center, Pittsburgh, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pittsburgh Alzheimer’s Disease Research Center, Pittsburgh, PA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A51">Departments of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Deramecourt, Vincent" sort="Deramecourt, Vincent" uniqKey="Deramecourt V" first="Vincent" last="Deramecourt">Vincent Deramecourt</name>
<affiliation wicri:level="1">
<nlm:aff id="A8">Université Lille 2, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille 2, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A31">Centre National de Reference pour les Malades Alzheimer Jeunes (CNR-MAJ), Centre Hospitalier Régional Universitaire de Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de Reference pour les Malades Alzheimer Jeunes (CNR-MAJ), Centre Hospitalier Régional Universitaire de Lille, Lille</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Fox, Nick C" sort="Fox, Nick C" uniqKey="Fox N" first="Nick C" last="Fox">Nick C. Fox</name>
<affiliation wicri:level="1">
<nlm:aff id="A52">Dementia Research Centre, Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Dementia Research Centre, Department of Neurodegenerative Disease, University College London Institute of Neurology, London</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Cantwell, Laura B" sort="Cantwell, Laura B" uniqKey="Cantwell L" first="Laura B." last="Cantwell">Laura B. Cantwell</name>
<affiliation wicri:level="1">
<nlm:aff id="A10">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Tarraga, Lluis" sort="Tarraga, Lluis" uniqKey="Tarraga L" first="Lluis" last="Tárraga">Lluis Tárraga</name>
<affiliation wicri:level="1">
<nlm:aff id="A53">Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name>
<affiliation wicri:level="1">
<nlm:aff id="A54">Inserm U897, Victor Segalen University, F-33076, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name>
<affiliation wicri:level="1">
<nlm:aff id="A55">Department of Molecular Neuroscience, Institute of Neurology, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Molecular Neuroscience, Institute of Neurology, London</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A56">Reta Lilla Weston Laboratories, Institute of Neurology, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Reta Lilla Weston Laboratories, Institute of Neurology, London</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Crane, Paul K" sort="Crane, Paul K" uniqKey="Crane P" first="Paul K." last="Crane">Paul K. Crane</name>
<affiliation wicri:level="1">
<nlm:aff id="A57">Department of Medicine, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, University of Washington, Seattle, WA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name>
<affiliation wicri:level="1">
<nlm:aff id="A16">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name>
<affiliation wicri:level="1">
<nlm:aff id="A40">CNR-MAJ, Inserm U1079, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CNR-MAJ, Inserm U1079, Rouen</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A54">Inserm U897, Victor Segalen University, F-33076, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name>
<affiliation wicri:level="1">
<nlm:aff id="A58">Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of Oxford, Oxford</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Evans, Denis" sort="Evans, Denis" uniqKey="Evans D" first="Denis" last="Evans">Denis Evans</name>
<affiliation wicri:level="1">
<nlm:aff id="A59">Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H." last="Mosley">Thomas H. Mosley</name>
<affiliation wicri:level="1">
<nlm:aff id="A60">Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, MS, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, MS</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Letenneur, Luc" sort="Letenneur, Luc" uniqKey="Letenneur L" first="Luc" last="Letenneur">Luc Letenneur</name>
<affiliation wicri:level="1">
<nlm:aff id="A54">Inserm U897, Victor Segalen University, F-33076, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Brayne, Carol" sort="Brayne, Carol" uniqKey="Brayne C" first="Carol" last="Brayne">Carol Brayne</name>
<affiliation wicri:level="1">
<nlm:aff id="A61">Institute of Public Health, University of Cambridge, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Public Health, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Maier, Wolfgang" sort="Maier, Wolfgang" uniqKey="Maier W" first="Wolfgang" last="Maier">Wolfgang Maier</name>
<affiliation wicri:level="1">
<nlm:aff id="A25">Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, University of Bonn, Bonn</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A28">German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Center for Neurodegenerative Diseases (DZNE), Bonn</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="De Jager, Philip" sort="De Jager, Philip" uniqKey="De Jager P" first="Philip" last="De Jager">Philip De Jager</name>
<affiliation wicri:level="1">
<nlm:aff id="A62">Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A5">Department of Neurology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A63">Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Medical and Population Genetics, Broad Institute, Cambridge, MA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Emilsson, Valur" sort="Emilsson, Valur" uniqKey="Emilsson V" first="Valur" last="Emilsson">Valur Emilsson</name>
<affiliation wicri:level="1">
<nlm:aff id="A16">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A64">Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavik</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name>
<affiliation wicri:level="1">
<nlm:aff id="A54">Inserm U897, Victor Segalen University, F-33076, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A65">Centre de Mémoire de Ressources et de Recherche de Bordeaux, CHU de Bordeaux, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre de Mémoire de Ressources et de Recherche de Bordeaux, CHU de Bordeaux, Bordeaux</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hampel, Harald" sort="Hampel, Harald" uniqKey="Hampel H" first="Harald" last="Hampel">Harald Hampel</name>
<affiliation wicri:level="1">
<nlm:aff id="A66">Department of Psychiatry, University of Frankfurt, Frankfurt am Main, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry, University of Frankfurt, Frankfurt am Main</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A67">Department of Psychiatry, Ludwig Maximilians University, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry, Ludwig Maximilians University, Munich</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kamboh, M Ilyas" sort="Kamboh, M Ilyas" uniqKey="Kamboh M" first="M. Ilyas" last="Kamboh">M. Ilyas Kamboh</name>
<affiliation wicri:level="1">
<nlm:aff id="A50">University of Pittsburgh Alzheimer’s Disease Research Center, Pittsburgh, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pittsburgh Alzheimer’s Disease Research Center, Pittsburgh, PA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A68">Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="De Bruijn, Renee F A G" sort="De Bruijn, Renee F A G" uniqKey="De Bruijn R" first="Renee F. A. G." last="De Bruijn">Renee F. A. G. De Bruijn</name>
<affiliation wicri:level="1">
<nlm:aff id="A4">Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name>
<affiliation wicri:level="1">
<nlm:aff id="A54">Inserm U897, Victor Segalen University, F-33076, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Pastor, Pau" sort="Pastor, Pau" uniqKey="Pastor P" first="Pau" last="Pastor">Pau Pastor</name>
<affiliation wicri:level="1">
<nlm:aff id="A69">Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A70">CIBERNED, Instituto de Salud Carlos III, Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBERNED, Instituto de Salud Carlos III, Madrid</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Larson, Eric B" sort="Larson, Eric B" uniqKey="Larson E" first="Eric B." last="Larson">Eric B. Larson</name>
<affiliation wicri:level="1">
<nlm:aff id="A57">Department of Medicine, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, University of Washington, Seattle, WA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A71">Group Health, Group Health Research Institute, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Group Health, Group Health Research Institute, Seattle, WA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I." last="Rotter">Jerome I. Rotter</name>
<affiliation wicri:level="1">
<nlm:aff id="A72">Institute for Translational Genomics and Population Sciences. Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Institute for Translational Genomics and Population Sciences. Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A73">Division of Genetic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Genetic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="O Onovan, Michael C" sort="O Onovan, Michael C" uniqKey="O Onovan M" first="Michael C" last="O Onovan">Michael C. O Onovan</name>
<affiliation wicri:level="1">
<nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Montine, Thomas J" sort="Montine, Thomas J" uniqKey="Montine T" first="Thomas J." last="Montine">Thomas J. Montine</name>
<affiliation wicri:level="1">
<nlm:aff id="A74">Department of Pathology, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A." last="Nalls">Michael A. Nalls</name>
<affiliation wicri:level="1">
<nlm:aff id="A75">Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, MD</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Mead, Simon" sort="Mead, Simon" uniqKey="Mead S" first="Simon" last="Mead">Simon Mead</name>
<affiliation wicri:level="1">
<nlm:aff id="A55">Department of Molecular Neuroscience, Institute of Neurology, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Molecular Neuroscience, Institute of Neurology, London</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Reiman, Eric M" sort="Reiman, Eric M" uniqKey="Reiman E" first="Eric M." last="Reiman">Eric M. Reiman</name>
<affiliation wicri:level="1">
<nlm:aff id="A76">Arizona Alzheimer’s Consortium, Phoenix, AZ, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arizona Alzheimer’s Consortium, Phoenix, AZ</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A77">Department of Psychiatry, University of Arizona, Phoenix, AZ, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of Arizona, Phoenix, AZ</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A78">Banner Alzheimer’s Institute, Phoenix, AZ, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Banner Alzheimer’s Institute, Phoenix, AZ</wicri:regionArea>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A79">Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Arizona</region>
</placeName>
<wicri:cityArea>Neurogenomics Division, Translational Genomics Research Institute, Phoenix</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Jonsson, Palmi V" sort="Jonsson, Palmi V" uniqKey="Jonsson P" first="Palmi V." last="Jonsson">Palmi V. Jonsson</name>
<affiliation wicri:level="1">
<nlm:aff id="A15">University of Iceland, Faculty of Medicine, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>University of Iceland, Faculty of Medicine, Reykjavik</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A80">Department of Geriatrics, Landspitali National University Hospital, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Department of Geriatrics, Landspitali National University Hospital, Reykjavik</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Holmes, Clive" sort="Holmes, Clive" uniqKey="Holmes C" first="Clive" last="Holmes">Clive Holmes</name>
<affiliation wicri:level="1">
<nlm:aff id="A81">Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="St George Hyslop, Peter H" sort="St George Hyslop, Peter H" uniqKey="St George Hyslop P" first="Peter H." last="St George-Hyslop">Peter H. St George-Hyslop</name>
<affiliation wicri:level="1">
<nlm:aff id="A82">Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A83">Cambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Boada, Merce" sort="Boada, Merce" uniqKey="Boada M" first="Mercè" last="Boada">Mercè Boada</name>
<affiliation wicri:level="1">
<nlm:aff id="A53">Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Passmore, Peter" sort="Passmore, Peter" uniqKey="Passmore P" first="Peter" last="Passmore">Peter Passmore</name>
<affiliation wicri:level="1">
<nlm:aff id="A84">Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University, Belfast, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University, Belfast</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Wendland, Jens R" sort="Wendland, Jens R" uniqKey="Wendland J" first="Jens R." last="Wendland">Jens R. Wendland</name>
<affiliation wicri:level="1">
<nlm:aff id="A85">PharmaTherapeutics Clinical Research, Pfizer Worldwide Research and Development, Cambridge, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>PharmaTherapeutics Clinical Research, Pfizer Worldwide Research and Development, Cambridge, MA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name>
<affiliation wicri:level="1">
<nlm:aff id="A86">Department of Neurology, Medical University of Graz, Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, Medical University of Graz, Graz</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Morgan, Kevin" sort="Morgan, Kevin" uniqKey="Morgan K" first="Kevin" last="Morgan">Kevin Morgan</name>
<affiliation wicri:level="1">
<nlm:aff id="A87">Institute of Genetics, Queen’s Medical Centre, University of Nottingham, Nottingham, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Genetics, Queen’s Medical Centre, University of Nottingham, Nottingham</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Winslow, Ashley R" sort="Winslow, Ashley R" uniqKey="Winslow A" first="Ashley R." last="Winslow">Ashley R. Winslow</name>
<affiliation wicri:level="1">
<nlm:aff id="A85">PharmaTherapeutics Clinical Research, Pfizer Worldwide Research and Development, Cambridge, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>PharmaTherapeutics Clinical Research, Pfizer Worldwide Research and Development, Cambridge, MA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Powell, John F" sort="Powell, John F" uniqKey="Powell J" first="John F" last="Powell">John F. Powell</name>
<affiliation wicri:level="1">
<nlm:aff id="A88">King’s College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>King’s College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Carasquillo, Minerva" sort="Carasquillo, Minerva" uniqKey="Carasquillo M" first="Minerva" last="Carasquillo">Minerva Carasquillo</name>
<affiliation wicri:level="1">
<nlm:aff id="A89">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Younkin, Steven G" sort="Younkin, Steven G" uniqKey="Younkin S" first="Steven G." last="Younkin">Steven G. Younkin</name>
<affiliation wicri:level="1">
<nlm:aff id="A89">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Jakobsd Ttir, J Hanna" sort="Jakobsd Ttir, J Hanna" uniqKey="Jakobsd Ttir J" first="J Hanna" last="Jakobsd Ttir">J Hanna Jakobsd Ttir</name>
<affiliation wicri:level="1">
<nlm:aff id="A16">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kauwe, John Sk" sort="Kauwe, John Sk" uniqKey="Kauwe J" first="John Sk" last="Kauwe">John Sk Kauwe</name>
<affiliation wicri:level="1">
<nlm:aff id="A90">Department of Biology, Brigham Young University, Provo, Utah, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biology, Brigham Young University, Provo, Utah</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Wilhelmsen, Kirk C" sort="Wilhelmsen, Kirk C" uniqKey="Wilhelmsen K" first="Kirk C." last="Wilhelmsen">Kirk C. Wilhelmsen</name>
<affiliation wicri:level="1">
<nlm:aff id="A91">Department of Genetics, University of North Carolina Chapel Hill, Chapel Hill, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, University of North Carolina Chapel Hill, Chapel Hill, NC</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Rujescu, Dan" sort="Rujescu, Dan" uniqKey="Rujescu D" first="Dan" last="Rujescu">Dan Rujescu</name>
<affiliation>
<nlm:aff id="A92">Department of Psychiatry, Psychotherapy and Psychosomatics Martin-Luther-University Halle-Wittenberg, Julius-Kühn-Str. 706112 Halle Germany</nlm:aff>
<wicri:noCountry code="subfield">Julius-Kühn-Str. 706112 Halle Germany</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M" last="Nöthen">Markus M. Nöthen</name>
<affiliation wicri:level="1">
<nlm:aff id="A26">Institute of Human Genetics, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A93">Institute of Human Genetics, Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, Department of Genomics, Life and Brain Center, University of Bonn, Bonn</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation wicri:level="1">
<nlm:aff id="A4">Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A19">Department of Radiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Jones, Lesley" sort="Jones, Lesley" uniqKey="Jones L" first="Lesley" last="Jones">Lesley Jones</name>
<affiliation wicri:level="1">
<nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L." last="Haines">Jonathan L. Haines</name>
<affiliation wicri:level="1">
<nlm:aff id="A94">Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name>
<affiliation wicri:level="1">
<nlm:aff id="A12">Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A30">Department of Epidemiology, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, WA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A35">Departments of Health Services, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Health Services, University of Washington, Seattle, WA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A71">Group Health, Group Health Research Institute, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Group Health, Group Health Research Institute, Seattle, WA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name>
<affiliation wicri:level="1">
<nlm:aff id="A95">Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A96">Institute Born-Bunge, University of Antwerp, Antwerp, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Institute Born-Bunge, University of Antwerp, Antwerp</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Holmans, Peter" sort="Holmans, Peter" uniqKey="Holmans P" first="Peter" last="Holmans">Peter Holmans</name>
<affiliation wicri:level="1">
<nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name>
<affiliation wicri:level="1">
<nlm:aff id="A97">Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, MD</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Mayeux, Richard" sort="Mayeux, Richard" uniqKey="Mayeux R" first="Richard" last="Mayeux">Richard Mayeux</name>
<affiliation wicri:level="1">
<nlm:aff id="A98">Taub Institute on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Taub Institute on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A99">Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Gertrude H. Sergievsky Center, Columbia University, New York, NY</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A100">Department of Neurology, Columbia University, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Columbia University, New York, NY</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name>
<affiliation wicri:level="1">
<nlm:aff id="A24">Centre National de Genotypage, Institut Genomique, Commissariat a l’energie Atomique, Evry, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de Genotypage, Institut Genomique, Commissariat a l’energie Atomique, Evry</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A101">McGill University and Génome Québec Innovation Centre, Montreal, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>McGill University and Génome Québec Innovation Centre, Montreal</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A102">Fondation Jean Dausset- CEPH, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Fondation Jean Dausset- CEPH, Paris</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Goate, Alison M" sort="Goate, Alison M" uniqKey="Goate A" first="Alison M." last="Goate">Alison M. Goate</name>
<affiliation wicri:level="1">
<nlm:aff id="A32">Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A33">Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, Washington University School of Medicine, St. Louis, MO</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Escott Price, Valentina" sort="Escott Price, Valentina" uniqKey="Escott Price V" first="Valentina" last="Escott-Price">Valentina Escott-Price</name>
<affiliation wicri:level="1">
<nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name>
<affiliation wicri:level="1">
<nlm:aff id="A17">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Pericak Vance, Margaret A" sort="Pericak Vance, Margaret A" uniqKey="Pericak Vance M" first="Margaret A." last="Pericak-Vance">Margaret A. Pericak-Vance</name>
<affiliation wicri:level="1">
<nlm:aff id="A11">The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A14">Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name>
<affiliation wicri:level="1">
<nlm:aff id="A7">Inserm U744, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U744, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A8">Université Lille 2, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille 2, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A9">Institut Pasteur de Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A103">University Hospital, CHRU Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Hospital, CHRU Lille, Lille</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Williams, Julie" sort="Williams, Julie" uniqKey="Williams J" first="Julie" last="Williams">Julie Williams</name>
<affiliation wicri:level="1">
<nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name>
<affiliation wicri:level="1">
<nlm:aff id="A4">Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schellenberg, Gerard D" sort="Schellenberg, Gerard D" uniqKey="Schellenberg G" first="Gerard D." last="Schellenberg">Gerard D. Schellenberg</name>
<affiliation wicri:level="1">
<nlm:aff id="A10">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A." last="Farrer">Lindsay A. Farrer</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A2">Department of Ophthalmology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A3">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A17">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A104">Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Boston University School of Public Health, Boston, MA</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Molecular psychiatry</title>
<idno type="ISSN">1359-4184</idno>
<idno type="eISSN">1476-5578</idno>
<imprint>
<date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass></textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<p id="P1">
<italic>APOE</italic>
ε4, the most significant genetic risk factor for Alzheimer disease (AD), may mask effects of other loci. We re-analyzed genome-wide association study (GWAS) data from the International Genomics of Alzheimer’s Project (IGAP) Consortium in
<italic>APOE</italic>
ε4+ (10,352 cases and 9,207 controls) and
<italic>APOE</italic>
ε4− (7,184 cases and 26,968 controls) subgroups as well as in the total sample testing for interaction between a SNP and
<italic>APOE</italic>
ε4 status. Suggestive associations (P<1x10
<sup>−4</sup>
) in stage 1 were evaluated in an independent sample (stage 2) containing 4,203 subjects (
<italic>APOE</italic>
ε4+: 1,250 cases and 536 controls;
<italic>APOE</italic>
ε4-: 718 cases and 1,699 controls). Among
<italic>APOE</italic>
ε4− subjects, novel genome-wide significant (GWS) association was observed with 17 SNPs (all between
<italic>KANSL1</italic>
and
<italic>LRRC37A</italic>
on chromosome 17 near
<italic>MAPT</italic>
) in a meta-analysis of the stage 1 and stage 2 datasets (best SNP, rs2732703, P=5·8x10
<sup>−9</sup>
). Conditional analysis revealed that rs2732703 accounted for association signals in the entire 100 kilobase region that includes
<italic>MAPT</italic>
. Except for previously identified AD loci showing stronger association in
<italic>APOE</italic>
ε4+ subjects (
<italic>CR1</italic>
and
<italic>CLU</italic>
) or
<italic>APOE</italic>
ε4− subjects (
<italic>MS4A6A/MS4A4A/ MS4A6E</italic>
), no other SNPs were significantly associated with AD in a specific
<italic>APOE</italic>
genotype subgroup. In addition, the finding in the stage 1 sample that AD risk is significantly influenced by the interaction of
<italic>APOE</italic>
with rs1595014 in
<italic>TMEM106B</italic>
(P=1·6x10
<sup>−7</sup>
) is noteworthy because
<italic>TMEM106B</italic>
variants have previously been associated with risk of frontotemporal dementia. Expression quantitative trait locus analysis revealed that rs113986870, one of the GWS SNPs near rs2732703, is significantly associated with four
<italic>KANSL1</italic>
probes that target transcription of the first translated exon and an untranslated exon in hippocampus (P≤1.3x10
<sup>−8</sup>
), frontal cortex (P≤1.3x10
<sup>−9</sup>
), and temporal cortex (P≤1.2x10
<sup>−11</sup>
). Rs113986870 is also strongly associated with a
<italic>MAPT</italic>
probe that targets transcription of alternatively spliced exon 3 in frontal cortex (P=9.2x10
<sup>−6</sup>
) and temporal cortex (P=2.6x10
<sup>−6</sup>
). Our
<italic>APOE</italic>
-stratified GWAS is the first to show GWS association for AD with SNPs in the chromosome 17q21.31 region. Replication of this finding in independent samples is needed to verify that SNPs in this region have significantly stronger effects on AD risk in persons lacking
<italic>APOE</italic>
ε4 compared to persons carrying this allele, and if this is found to hold, further examination of this region and studies aimed at deciphering the mechanism(s) are warranted.</p>
</div>
</front>
<back>
<div1 type="bibliography">
<listBibl>
<biblStruct>
<analytic>
<author>
<name sortKey="Gatz, M" uniqKey="Gatz M">M Gatz</name>
</author>
<author>
<name sortKey="Reynolds, Ca" uniqKey="Reynolds C">CA Reynolds</name>
</author>
<author>
<name sortKey="Fratiglioni, L" uniqKey="Fratiglioni L">L Fratiglioni</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Farrer, La" uniqKey="Farrer L">LA Farrer</name>
</author>
<author>
<name sortKey="Cupples, La" uniqKey="Cupples L">LA Cupples</name>
</author>
<author>
<name sortKey="Haines, Jl" uniqKey="Haines J">JL Haines</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Sherva, R" uniqKey="Sherva R">R Sherva</name>
</author>
<author>
<name sortKey="Farrer, La" uniqKey="Farrer L">LA Farrer</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Lambert, J C" uniqKey="Lambert J">J-C Lambert</name>
</author>
<author>
<name sortKey="Ibrahim Verbaas, Ca" uniqKey="Ibrahim Verbaas C">CA Ibrahim-Verbaas</name>
</author>
<author>
<name sortKey="Harold, D" uniqKey="Harold D">D Harold</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Jun, G" uniqKey="Jun G">G Jun</name>
</author>
<author>
<name sortKey="Vardarajan, Bn" uniqKey="Vardarajan B">BN Vardarajan</name>
</author>
<author>
<name sortKey="Buros, J" uniqKey="Buros J">J Buros</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Trabzuni, D1" uniqKey="Trabzuni D">D1 Trabzuni</name>
</author>
<author>
<name sortKey="Ryten, M" uniqKey="Ryten M">M Ryten</name>
</author>
<author>
<name sortKey="Walker, R" uniqKey="Walker R">R Walker</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Steinberg, Km" uniqKey="Steinberg K">KM Steinberg</name>
</author>
<author>
<name sortKey="Antonacci, F" uniqKey="Antonacci F">F Antonacci</name>
</author>
<author>
<name sortKey="Sudmant, Ph" uniqKey="Sudmant P">PH Sudmant</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Boettger, Lm" uniqKey="Boettger L">LM Boettger</name>
</author>
<author>
<name sortKey="Handsaker, Re" uniqKey="Handsaker R">RE Handsaker</name>
</author>
<author>
<name sortKey="Zody, Mc" uniqKey="Zody M">MC Zody</name>
</author>
<author>
<name sortKey="Mccarroll, Sa" uniqKey="Mccarroll S">SA McCarroll</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Li, X" uniqKey="Li X">X Li</name>
</author>
<author>
<name sortKey="Wu, L" uniqKey="Wu L">L Wu</name>
</author>
<author>
<name sortKey="Corsa, Ca" uniqKey="Corsa C">CA Corsa</name>
</author>
<author>
<name sortKey="Kunkel, S" uniqKey="Kunkel S">S Kunkel</name>
</author>
<author>
<name sortKey="Dou, Y" uniqKey="Dou Y">Y Dou</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Koolen, Da" uniqKey="Koolen D">DA Koolen</name>
</author>
<author>
<name sortKey="Kramer, Jm" uniqKey="Kramer J">JM Kramer</name>
</author>
<author>
<name sortKey="Neveling, K" uniqKey="Neveling K">K Neveling</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Zollino, M" uniqKey="Zollino M">M Zollino</name>
</author>
<author>
<name sortKey="Orteschi, D" uniqKey="Orteschi D">D Orteschi</name>
</author>
<author>
<name sortKey="Murdolo, M" uniqKey="Murdolo M">M Murdolo</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Giannuzzi, G" uniqKey="Giannuzzi G">G Giannuzzi</name>
</author>
<author>
<name sortKey="Siswara, P" uniqKey="Siswara P">P Siswara</name>
</author>
<author>
<name sortKey="Malig, M" uniqKey="Malig M">M Malig</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Trabzuni, D" uniqKey="Trabzuni D">D Trabzuni</name>
</author>
<author>
<name sortKey="Wray, S" uniqKey="Wray S">S Wray</name>
</author>
<author>
<name sortKey="Vandrovcova, J" uniqKey="Vandrovcova J">J Vandrovcova</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Caffrey, Tm" uniqKey="Caffrey T">TM Caffrey</name>
</author>
<author>
<name sortKey="Joachim, C" uniqKey="Joachim C">C Joachim</name>
</author>
<author>
<name sortKey="Wade Martins, R" uniqKey="Wade Martins R">R Wade-Martins</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Sim N Sanchez, J" uniqKey="Sim N Sanchez J">J Simón-Sánchez</name>
</author>
<author>
<name sortKey="Schulte, C" uniqKey="Schulte C">C Schulte</name>
</author>
<author>
<name sortKey="Bras, Jm" uniqKey="Bras J">JM Bras</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Hoglinger, Gu" uniqKey="Hoglinger G">GU Höglinger</name>
</author>
<author>
<name sortKey="Melhem, Nm" uniqKey="Melhem N">NM Melhem</name>
</author>
<author>
<name sortKey="Dickson, Dw" uniqKey="Dickson D">DW Dickson</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Ferrari, R" uniqKey="Ferrari R">R Ferrari</name>
</author>
<author>
<name sortKey="Hardy, J" uniqKey="Hardy J">J Hardy</name>
</author>
<author>
<name sortKey="Momeni, P" uniqKey="Momeni P">P Momeni</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Coppola, G" uniqKey="Coppola G">G Coppola</name>
</author>
<author>
<name sortKey="Chinnathambi, S" uniqKey="Chinnathambi S">S Chinnathambi</name>
</author>
<author>
<name sortKey="Lee, Jj" uniqKey="Lee J">JJ Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Lee, Se" uniqKey="Lee S">SE Lee</name>
</author>
<author>
<name sortKey="Tartaglia, Mc" uniqKey="Tartaglia M">MC Tartaglia</name>
</author>
<author>
<name sortKey="Yener, G" uniqKey="Yener G">G Yener</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Ikram, Ma" uniqKey="Ikram M">MA Ikram</name>
</author>
<author>
<name sortKey="Fornage, M" uniqKey="Fornage M">M Fornage</name>
</author>
<author>
<name sortKey="Smith, Av" uniqKey="Smith A">AV Smith</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Verpillat, P" uniqKey="Verpillat P">P Verpillat</name>
</author>
<author>
<name sortKey="Camuzat, A" uniqKey="Camuzat A">A Camuzat</name>
</author>
<author>
<name sortKey="Hannequin, D" uniqKey="Hannequin D">D Hannequin</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Zabetian, Cp" uniqKey="Zabetian C">CP Zabetian</name>
</author>
<author>
<name sortKey="Hutter, Cm" uniqKey="Hutter C">CM Hutter</name>
</author>
<author>
<name sortKey="Factor, Sa" uniqKey="Factor S">SA Factor</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Pittman, Am" uniqKey="Pittman A">AM Pittman</name>
</author>
<author>
<name sortKey="Myers, Aj" uniqKey="Myers A">AJ Myers</name>
</author>
<author>
<name sortKey="Abou Sleiman, P" uniqKey="Abou Sleiman P">P Abou-Sleiman</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Knopman, Ds1" uniqKey="Knopman D">DS1 Knopman</name>
</author>
<author>
<name sortKey="Petersen, Rc" uniqKey="Petersen R">RC Petersen</name>
</author>
<author>
<name sortKey="Edland, Sd" uniqKey="Edland S">SD Edland</name>
</author>
<author>
<name sortKey="Cha, Rh" uniqKey="Cha R">RH Cha</name>
</author>
<author>
<name sortKey="Rocca, Wa" uniqKey="Rocca W">WA Rocca</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Beecham, Gw" uniqKey="Beecham G">GW Beecham</name>
</author>
<author>
<name sortKey="Hamilton, K" uniqKey="Hamilton K">K Hamilton</name>
</author>
<author>
<name sortKey="Naj, A" uniqKey="Naj A">A Naj</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Myers, Aj" uniqKey="Myers A">AJ Myers</name>
</author>
<author>
<name sortKey="Kaleem, M" uniqKey="Kaleem M">M Kaleem</name>
</author>
<author>
<name sortKey="Marlowe, L" uniqKey="Marlowe L">L Marlowe</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Abraham, R" uniqKey="Abraham R">R Abraham</name>
</author>
<author>
<name sortKey="Sims, R" uniqKey="Sims R">R Sims</name>
</author>
<author>
<name sortKey="Carroll, L" uniqKey="Carroll L">L Carroll</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Creese, B" uniqKey="Creese B">B Creese</name>
</author>
<author>
<name sortKey="Corbett, A" uniqKey="Corbett A">A Corbett</name>
</author>
<author>
<name sortKey="Jones, E" uniqKey="Jones E">E Jones</name>
</author>
<author>
<name sortKey="Fox, C" uniqKey="Fox C">C Fox</name>
</author>
<author>
<name sortKey="Ballard, C" uniqKey="Ballard C">C Ballard</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Allen, M" uniqKey="Allen M">M Allen</name>
</author>
<author>
<name sortKey="Kachadoorian, M" uniqKey="Kachadoorian M">M Kachadoorian</name>
</author>
<author>
<name sortKey="Quicksall, Z" uniqKey="Quicksall Z">Z Quicksall</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Zody, Mc" uniqKey="Zody M">MC Zody</name>
</author>
<author>
<name sortKey="Jiang, Z" uniqKey="Jiang Z">Z Jiang</name>
</author>
<author>
<name sortKey="Fung, Hc" uniqKey="Fung H">HC Fung</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Trabzuni, D" uniqKey="Trabzuni D">D Trabzuni</name>
</author>
<author>
<name sortKey="Wray, S" uniqKey="Wray S">S Wray</name>
</author>
<author>
<name sortKey="Vandrovcova, J" uniqKey="Vandrovcova J">J Vandrovcova</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Zhong, Q" uniqKey="Zhong Q">Q Zhong</name>
</author>
<author>
<name sortKey="Congdon, Ee" uniqKey="Congdon E">EE Congdon</name>
</author>
<author>
<name sortKey="Nagaraja, Hn" uniqKey="Nagaraja H">HN Nagaraja</name>
</author>
<author>
<name sortKey="Kuret, J" uniqKey="Kuret J">J Kuret</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Krstic, D" uniqKey="Krstic D">D Krstic</name>
</author>
<author>
<name sortKey="Knuesel, I" uniqKey="Knuesel I">I Knuesel</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Laws, Sm" uniqKey="Laws S">SM Laws</name>
</author>
<author>
<name sortKey="Friedrich, P" uniqKey="Friedrich P">P Friedrich</name>
</author>
<author>
<name sortKey="Diehl Schmid, J" uniqKey="Diehl Schmid J">J Diehl-Schmid</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Roks, G" uniqKey="Roks G">G Roks</name>
</author>
<author>
<name sortKey="Dermaut, B" uniqKey="Dermaut B">B Dermaut</name>
</author>
<author>
<name sortKey="Heutink, P" uniqKey="Heutink P">P Heutink</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Cousin, E" uniqKey="Cousin E">E Cousin</name>
</author>
<author>
<name sortKey="Mace, S" uniqKey="Mace S">S Macé</name>
</author>
<author>
<name sortKey="Rocher, C" uniqKey="Rocher C">C Rocher</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Tesseur, I" uniqKey="Tesseur I">I Tesseur</name>
</author>
<author>
<name sortKey="Van Dorpe, J" uniqKey="Van Dorpe J">J Van Dorpe</name>
</author>
<author>
<name sortKey="Spittaels, K" uniqKey="Spittaels K">K Spittaels</name>
</author>
<author>
<name sortKey="Van Den Haute, C" uniqKey="Van Den Haute C">C Van den Haute</name>
</author>
<author>
<name sortKey="Moechars, D" uniqKey="Moechars D">D Moechars</name>
</author>
<author>
<name sortKey="Van Leuven, F" uniqKey="Van Leuven F">F Van Leuven</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Cruchaga, C" uniqKey="Cruchaga C">C Cruchaga</name>
</author>
<author>
<name sortKey="Kauwe, Js" uniqKey="Kauwe J">JS Kauwe</name>
</author>
<author>
<name sortKey="Harari, O" uniqKey="Harari O">O Harari</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Morris, Gp" uniqKey="Morris G">GP Morris</name>
</author>
<author>
<name sortKey="Clark, Ia" uniqKey="Clark I">IA Clark</name>
</author>
<author>
<name sortKey="Vissel, B" uniqKey="Vissel B">B Vissel</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Zuccolo, J" uniqKey="Zuccolo J">J Zuccolo</name>
</author>
<author>
<name sortKey="Bau, J" uniqKey="Bau J">J Bau</name>
</author>
<author>
<name sortKey="Childs, Sj" uniqKey="Childs S">SJ Childs</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Karch, Cm" uniqKey="Karch C">CM Karch</name>
</author>
<author>
<name sortKey="Jeng, At" uniqKey="Jeng A">AT Jeng</name>
</author>
<author>
<name sortKey="Nowotny, P" uniqKey="Nowotny P">P Nowotny</name>
</author>
<author>
<name sortKey="Cady, J" uniqKey="Cady J">J Cady</name>
</author>
<author>
<name sortKey="Cruchaga, C" uniqKey="Cruchaga C">C Cruchaga</name>
</author>
<author>
<name sortKey="Goate, Am" uniqKey="Goate A">AM Goate</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Chen Plotkin, As" uniqKey="Chen Plotkin A">AS Chen-Plotkin</name>
</author>
<author>
<name sortKey="Unger, Tl" uniqKey="Unger T">TL Unger</name>
</author>
<author>
<name sortKey="Gallagher, Md" uniqKey="Gallagher M">MD Gallagher</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Lang, Cm" uniqKey="Lang C">CM Lang</name>
</author>
<author>
<name sortKey="Fellerer, K" uniqKey="Fellerer K">K Fellerer</name>
</author>
<author>
<name sortKey="Schwenk, Bm" uniqKey="Schwenk B">BM Schwenk</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Van Deerlin, Vm" uniqKey="Van Deerlin V">VM Van Deerlin</name>
</author>
<author>
<name sortKey="Sleiman, Pm" uniqKey="Sleiman P">PM Sleiman</name>
</author>
<author>
<name sortKey="Martinez Lage, M" uniqKey="Martinez Lage M">M Martinez-Lage</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Vass, R" uniqKey="Vass R">R Vass</name>
</author>
<author>
<name sortKey="Ashbridge, E" uniqKey="Ashbridge E">E Ashbridge</name>
</author>
<author>
<name sortKey="Geser, F" uniqKey="Geser F">F Geser</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Rutherford, Nj" uniqKey="Rutherford N">NJ Rutherford</name>
</author>
<author>
<name sortKey="Carrasquillo, Mm" uniqKey="Carrasquillo M">MM Carrasquillo</name>
</author>
<author>
<name sortKey="Li, M" uniqKey="Li M">M Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Cruchaga, C" uniqKey="Cruchaga C">C Cruchaga</name>
</author>
<author>
<name sortKey="Graff, C" uniqKey="Graff C">C Graff</name>
</author>
<author>
<name sortKey="Chiang, Hh" uniqKey="Chiang H">HH Chiang</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article">
<pmc-dir>properties open_access</pmc-dir>
<pmc-dir>properties manuscript</pmc-dir>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-journal-id">9607835</journal-id>
<journal-id journal-id-type="pubmed-jr-id">20545</journal-id>
<journal-id journal-id-type="nlm-ta">Mol Psychiatry</journal-id>
<journal-id journal-id-type="iso-abbrev">Mol. Psychiatry</journal-id>
<journal-title-group>
<journal-title>Molecular psychiatry</journal-title>
</journal-title-group>
<issn pub-type="ppub">1359-4184</issn>
<issn pub-type="epub">1476-5578</issn>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">25778476</article-id>
<article-id pub-id-type="pmc">4573764</article-id>
<article-id pub-id-type="doi">10.1038/mp.2015.23</article-id>
<article-id pub-id-type="manuscript">NIHMS654371</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Article</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>A NOVEL ALZHEIMER DISEASE LOCUS LOCATED NEAR THE GENE ENCODING TAU PROTEIN</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Jun</surname>
<given-names>Gyungah</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Ibrahim-Verbaas</surname>
<given-names>Carla A.</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Vronskaya</surname>
<given-names>Maria</given-names>
</name>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Lambert</surname>
<given-names>Jean-Charles</given-names>
</name>
<xref ref-type="aff" rid="A7">7</xref>
<xref ref-type="aff" rid="A8">8</xref>
<xref ref-type="aff" rid="A9">9</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Chung</surname>
<given-names>Jaeyoon</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Naj</surname>
<given-names>Adam C.</given-names>
</name>
<xref ref-type="aff" rid="A10">10</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Kunkle</surname>
<given-names>Brian W.</given-names>
</name>
<xref ref-type="aff" rid="A11">11</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Wang</surname>
<given-names>Li-San</given-names>
</name>
<xref ref-type="aff" rid="A10">10</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Bis</surname>
<given-names>Joshua C.</given-names>
</name>
<xref ref-type="aff" rid="A12">12</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Bellenguez</surname>
<given-names>Céline</given-names>
</name>
<xref ref-type="aff" rid="A7">7</xref>
<xref ref-type="aff" rid="A8">8</xref>
<xref ref-type="aff" rid="A9">9</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Harold</surname>
<given-names>Denise</given-names>
</name>
<xref ref-type="aff" rid="A13">13</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Lunetta</surname>
<given-names>Kathryn L.</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Destefano</surname>
<given-names>Anita L.</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Grenier-Boley</surname>
<given-names>Benjamin</given-names>
</name>
<xref ref-type="aff" rid="A7">7</xref>
<xref ref-type="aff" rid="A8">8</xref>
<xref ref-type="aff" rid="A9">9</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Sims</surname>
<given-names>Rebecca</given-names>
</name>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Beecham</surname>
<given-names>Gary W.</given-names>
</name>
<xref ref-type="aff" rid="A11">11</xref>
<xref ref-type="aff" rid="A14">14</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Smith</surname>
<given-names>Albert V.</given-names>
</name>
<xref ref-type="aff" rid="A15">15</xref>
<xref ref-type="aff" rid="A16">16</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Chouraki</surname>
<given-names>Vincent</given-names>
</name>
<xref ref-type="aff" rid="A17">17</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Hamilton-Nelson</surname>
<given-names>Kara L.</given-names>
</name>
<xref ref-type="aff" rid="A11">11</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Ikram</surname>
<given-names>M. Arfan</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
<xref ref-type="aff" rid="A18">18</xref>
<xref ref-type="aff" rid="A19">19</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Fievet</surname>
<given-names>Nathalie</given-names>
</name>
<xref ref-type="aff" rid="A7">7</xref>
<xref ref-type="aff" rid="A8">8</xref>
<xref ref-type="aff" rid="A9">9</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Denning</surname>
<given-names>Nicola</given-names>
</name>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Martin</surname>
<given-names>Eden R.</given-names>
</name>
<xref ref-type="aff" rid="A11">11</xref>
<xref ref-type="aff" rid="A14">14</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Schmidt</surname>
<given-names>Helena</given-names>
</name>
<xref ref-type="aff" rid="A20">20</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Kamatani</surname>
<given-names>Yochiro</given-names>
</name>
<xref ref-type="aff" rid="A21">21</xref>
<xref ref-type="aff" rid="A22">22</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Dunstan</surname>
<given-names>Melanie L</given-names>
</name>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Valladares</surname>
<given-names>Otto</given-names>
</name>
<xref ref-type="aff" rid="A10">10</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Laza</surname>
<given-names>Agustin Ruiz</given-names>
</name>
<xref ref-type="aff" rid="A23">23</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Zelenika</surname>
<given-names>Diana</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Ramirez</surname>
<given-names>Alfredo</given-names>
</name>
<xref ref-type="aff" rid="A25">25</xref>
<xref ref-type="aff" rid="A26">26</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Foroud</surname>
<given-names>Tatiana M.</given-names>
</name>
<xref ref-type="aff" rid="A27">27</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Choi</surname>
<given-names>Seung-Hoan</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Boland</surname>
<given-names>Anne</given-names>
</name>
<xref ref-type="aff" rid="A24">24</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Becker</surname>
<given-names>Tim</given-names>
</name>
<xref ref-type="aff" rid="A28">28</xref>
<xref ref-type="aff" rid="A29">29</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Kukull</surname>
<given-names>Walter A.</given-names>
</name>
<xref ref-type="aff" rid="A30">30</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>van der Lee</surname>
<given-names>Sven J.</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Pasquier</surname>
<given-names>Florence</given-names>
</name>
<xref ref-type="aff" rid="A8">8</xref>
<xref ref-type="aff" rid="A31">31</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Cruchaga</surname>
<given-names>Carlos</given-names>
</name>
<xref ref-type="aff" rid="A32">32</xref>
<xref ref-type="aff" rid="A33">33</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Beekly</surname>
<given-names>Duane</given-names>
</name>
<xref ref-type="aff" rid="A34">34</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Fitzpatrick</surname>
<given-names>Annette L.</given-names>
</name>
<xref ref-type="aff" rid="A30">30</xref>
<xref ref-type="aff" rid="A35">35</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Hanon</surname>
<given-names>Oliver</given-names>
</name>
<xref ref-type="aff" rid="A36">36</xref>
<xref ref-type="aff" rid="A37">37</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Gill</surname>
<given-names>Michael</given-names>
</name>
<xref ref-type="aff" rid="A38">38</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Barber</surname>
<given-names>Robert</given-names>
</name>
<xref ref-type="aff" rid="A39">39</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Gudnason</surname>
<given-names>Vilmundur</given-names>
</name>
<xref ref-type="aff" rid="A15">15</xref>
<xref ref-type="aff" rid="A16">16</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Campion</surname>
<given-names>Dominique</given-names>
</name>
<xref ref-type="aff" rid="A40">40</xref>
<xref ref-type="aff" rid="A41">41</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Love</surname>
<given-names>Seth</given-names>
</name>
<xref ref-type="aff" rid="A42">42</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Bennett</surname>
<given-names>David A.</given-names>
</name>
<xref ref-type="aff" rid="A43">43</xref>
<xref ref-type="aff" rid="A44">44</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Amin</surname>
<given-names>Najaf</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Berr</surname>
<given-names>Claudine</given-names>
</name>
<xref ref-type="aff" rid="A45">45</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Tsolaki</surname>
<given-names>Magda</given-names>
</name>
<xref ref-type="aff" rid="A46">46</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Buxbaum</surname>
<given-names>Joseph D.</given-names>
</name>
<xref ref-type="aff" rid="A47">47</xref>
<xref ref-type="aff" rid="A48">48</xref>
<xref ref-type="aff" rid="A49">49</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Lopez</surname>
<given-names>Oscar L.</given-names>
</name>
<xref ref-type="aff" rid="A50">50</xref>
<xref ref-type="aff" rid="A51">51</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Deramecourt</surname>
<given-names>Vincent</given-names>
</name>
<xref ref-type="aff" rid="A8">8</xref>
<xref ref-type="aff" rid="A31">31</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Fox</surname>
<given-names>Nick C</given-names>
</name>
<xref ref-type="aff" rid="A52">52</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Cantwell</surname>
<given-names>Laura B.</given-names>
</name>
<xref ref-type="aff" rid="A10">10</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Tárraga</surname>
<given-names>Lluis</given-names>
</name>
<xref ref-type="aff" rid="A53">53</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Dufouil</surname>
<given-names>Carole</given-names>
</name>
<xref ref-type="aff" rid="A54">54</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Hardy</surname>
<given-names>John</given-names>
</name>
<xref ref-type="aff" rid="A55">55</xref>
<xref ref-type="aff" rid="A56">56</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Crane</surname>
<given-names>Paul K.</given-names>
</name>
<xref ref-type="aff" rid="A57">57</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Eiriksdottir</surname>
<given-names>Gudny</given-names>
</name>
<xref ref-type="aff" rid="A16">16</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Hannequin</surname>
<given-names>Didier</given-names>
</name>
<xref ref-type="aff" rid="A40">40</xref>
<xref ref-type="aff" rid="A54">54</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Clarke</surname>
<given-names>Robert</given-names>
</name>
<xref ref-type="aff" rid="A58">58</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Evans</surname>
<given-names>Denis</given-names>
</name>
<xref ref-type="aff" rid="A59">59</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Mosley</surname>
<given-names>Thomas H.</given-names>
<suffix>Jr.</suffix>
</name>
<xref ref-type="aff" rid="A60">60</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Letenneur</surname>
<given-names>Luc</given-names>
</name>
<xref ref-type="aff" rid="A54">54</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Brayne</surname>
<given-names>Carol</given-names>
</name>
<xref ref-type="aff" rid="A61">61</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Maier</surname>
<given-names>Wolfgang</given-names>
</name>
<xref ref-type="aff" rid="A25">25</xref>
<xref ref-type="aff" rid="A28">28</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>De Jager</surname>
<given-names>Philip</given-names>
</name>
<xref ref-type="aff" rid="A62">62</xref>
<xref ref-type="aff" rid="A5">5</xref>
<xref ref-type="aff" rid="A63">63</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Emilsson</surname>
<given-names>Valur</given-names>
</name>
<xref ref-type="aff" rid="A16">16</xref>
<xref ref-type="aff" rid="A64">64</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Dartigues</surname>
<given-names>Jean-François</given-names>
</name>
<xref ref-type="aff" rid="A54">54</xref>
<xref ref-type="aff" rid="A65">65</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Hampel</surname>
<given-names>Harald</given-names>
</name>
<xref ref-type="aff" rid="A66">66</xref>
<xref ref-type="aff" rid="A67">67</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Kamboh</surname>
<given-names>M. Ilyas</given-names>
</name>
<xref ref-type="aff" rid="A50">50</xref>
<xref ref-type="aff" rid="A68">68</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>de Bruijn</surname>
<given-names>Renee F.A.G.</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Tzourio</surname>
<given-names>Christophe</given-names>
</name>
<xref ref-type="aff" rid="A54">54</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Pastor</surname>
<given-names>Pau</given-names>
</name>
<xref ref-type="aff" rid="A69">69</xref>
<xref ref-type="aff" rid="A70">70</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Larson</surname>
<given-names>Eric B.</given-names>
</name>
<xref ref-type="aff" rid="A57">57</xref>
<xref ref-type="aff" rid="A71">71</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Rotter</surname>
<given-names>Jerome I.</given-names>
</name>
<xref ref-type="aff" rid="A72">72</xref>
<xref ref-type="aff" rid="A73">73</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>O’Donovan</surname>
<given-names>Michael C</given-names>
</name>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Montine</surname>
<given-names>Thomas J.</given-names>
</name>
<xref ref-type="aff" rid="A74">74</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Nalls</surname>
<given-names>Michael A.</given-names>
</name>
<xref ref-type="aff" rid="A75">75</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Mead</surname>
<given-names>Simon</given-names>
</name>
<xref ref-type="aff" rid="A55">55</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Reiman</surname>
<given-names>Eric M.</given-names>
</name>
<xref ref-type="aff" rid="A76">76</xref>
<xref ref-type="aff" rid="A77">77</xref>
<xref ref-type="aff" rid="A78">78</xref>
<xref ref-type="aff" rid="A79">79</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Jonsson</surname>
<given-names>Palmi V.</given-names>
</name>
<xref ref-type="aff" rid="A15">15</xref>
<xref ref-type="aff" rid="A80">80</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Holmes</surname>
<given-names>Clive</given-names>
</name>
<xref ref-type="aff" rid="A81">81</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>St George-Hyslop</surname>
<given-names>Peter H.</given-names>
</name>
<xref ref-type="aff" rid="A82">82</xref>
<xref ref-type="aff" rid="A83">83</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Boada</surname>
<given-names>Mercè</given-names>
</name>
<xref ref-type="aff" rid="A53">53</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Passmore</surname>
<given-names>Peter</given-names>
</name>
<xref ref-type="aff" rid="A84">84</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Wendland</surname>
<given-names>Jens R.</given-names>
</name>
<xref ref-type="aff" rid="A85">85</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Schmidt</surname>
<given-names>Reinhold</given-names>
</name>
<xref ref-type="aff" rid="A86">86</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Morgan</surname>
<given-names>Kevin</given-names>
</name>
<xref ref-type="aff" rid="A87">87</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Winslow</surname>
<given-names>Ashley R.</given-names>
</name>
<xref ref-type="aff" rid="A85">85</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Powell</surname>
<given-names>John F</given-names>
</name>
<xref ref-type="aff" rid="A88">88</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Carasquillo</surname>
<given-names>Minerva</given-names>
</name>
<xref ref-type="aff" rid="A89">89</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Younkin</surname>
<given-names>Steven G.</given-names>
</name>
<xref ref-type="aff" rid="A89">89</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Jakobsdóttir</surname>
<given-names>Jóhanna</given-names>
</name>
<xref ref-type="aff" rid="A16">16</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Kauwe</surname>
<given-names>John SK</given-names>
</name>
<xref ref-type="aff" rid="A90">90</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Wilhelmsen</surname>
<given-names>Kirk C.</given-names>
</name>
<xref ref-type="aff" rid="A91">91</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Rujescu</surname>
<given-names>Dan</given-names>
</name>
<xref ref-type="aff" rid="A92">92</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Nöthen</surname>
<given-names>Markus M</given-names>
</name>
<xref ref-type="aff" rid="A26">26</xref>
<xref ref-type="aff" rid="A93">93</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Hofman</surname>
<given-names>Albert</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
<xref ref-type="aff" rid="A19">19</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Jones</surname>
<given-names>Lesley</given-names>
</name>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author">
<collab>IGAP Consortium</collab>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Haines</surname>
<given-names>Jonathan L.</given-names>
</name>
<xref ref-type="aff" rid="A94">94</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Psaty</surname>
<given-names>Bruce M.</given-names>
</name>
<xref ref-type="aff" rid="A12">12</xref>
<xref ref-type="aff" rid="A30">30</xref>
<xref ref-type="aff" rid="A35">35</xref>
<xref ref-type="aff" rid="A71">71</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Van Broeckhoven</surname>
<given-names>Christine</given-names>
</name>
<xref ref-type="aff" rid="A95">95</xref>
<xref ref-type="aff" rid="A96">96</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Holmans</surname>
<given-names>Peter</given-names>
</name>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Launer</surname>
<given-names>Lenore J.</given-names>
</name>
<xref ref-type="aff" rid="A97">97</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Mayeux</surname>
<given-names>Richard</given-names>
</name>
<xref ref-type="aff" rid="A98">98</xref>
<xref ref-type="aff" rid="A99">99</xref>
<xref ref-type="aff" rid="A100">100</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Lathrop</surname>
<given-names>Mark</given-names>
</name>
<xref ref-type="aff" rid="A24">24</xref>
<xref ref-type="aff" rid="A101">101</xref>
<xref ref-type="aff" rid="A102">102</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Goate</surname>
<given-names>Alison M.</given-names>
</name>
<xref ref-type="aff" rid="A32">32</xref>
<xref ref-type="aff" rid="A33">33</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Escott-Price</surname>
<given-names>Valentina</given-names>
</name>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Seshadri</surname>
<given-names>Sudha</given-names>
</name>
<xref ref-type="aff" rid="A17">17</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Pericak-Vance</surname>
<given-names>Margaret A.</given-names>
</name>
<xref ref-type="aff" rid="A11">11</xref>
<xref ref-type="aff" rid="A14">14</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Amouyel</surname>
<given-names>Philippe</given-names>
</name>
<xref ref-type="aff" rid="A7">7</xref>
<xref ref-type="aff" rid="A8">8</xref>
<xref ref-type="aff" rid="A9">9</xref>
<xref ref-type="aff" rid="A103">103</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Williams</surname>
<given-names>Julie</given-names>
</name>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>van Duijn</surname>
<given-names>Cornelia M.</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Schellenberg</surname>
<given-names>Gerard D.</given-names>
</name>
<xref ref-type="aff" rid="A10">10</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Farrer</surname>
<given-names>Lindsay A.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A3">3</xref>
<xref ref-type="aff" rid="A17">17</xref>
<xref ref-type="aff" rid="A104">104</xref>
<xref rid="FN1" ref-type="author-notes">†</xref>
</contrib>
</contrib-group>
<aff id="A1">
<label>1</label>
Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA</aff>
<aff id="A2">
<label>2</label>
Department of Ophthalmology, Boston University School of Medicine, Boston, MA, USA</aff>
<aff id="A3">
<label>3</label>
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</aff>
<aff id="A4">
<label>4</label>
Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</aff>
<aff id="A5">
<label>5</label>
Department of Neurology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</aff>
<aff id="A6">
<label>6</label>
Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK</aff>
<aff id="A7">
<label>7</label>
Inserm U744, Lille, France</aff>
<aff id="A8">
<label>8</label>
Université Lille 2, Lille, France</aff>
<aff id="A9">
<label>9</label>
Institut Pasteur de Lille, Lille, France</aff>
<aff id="A10">
<label>10</label>
Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA</aff>
<aff id="A11">
<label>11</label>
The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA</aff>
<aff id="A12">
<label>12</label>
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA</aff>
<aff id="A13">
<label>13</label>
Trinity College, University of Dublin, Dublin, Ireland</aff>
<aff id="A14">
<label>14</label>
Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA</aff>
<aff id="A15">
<label>15</label>
University of Iceland, Faculty of Medicine, Reykjavik, Iceland</aff>
<aff id="A16">
<label>16</label>
Icelandic Heart Association, Kopavogur, Iceland</aff>
<aff id="A17">
<label>17</label>
Department of Neurology, Boston University School of Medicine, Boston, MA, USA</aff>
<aff id="A18">
<label>18</label>
Netherlands Consortium for Healthy Aging, Leiden, The Netherlands</aff>
<aff id="A19">
<label>19</label>
Department of Radiology, Erasmus University Medical Center, Erasmus, Rotterdam, The Netherlands</aff>
<aff id="A20">
<label>20</label>
Institute for Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria</aff>
<aff id="A21">
<label>21</label>
Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, Riken, Kanagawa, Japan</aff>
<aff id="A22">
<label>22</label>
Foundation Jean Dausset – CEPH, Paris, France</aff>
<aff id="A23">
<label>23</label>
Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain</aff>
<aff id="A24">
<label>24</label>
Centre National de Genotypage, Institut Genomique, Commissariat a l’energie Atomique, Evry, France</aff>
<aff id="A25">
<label>25</label>
Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany</aff>
<aff id="A26">
<label>26</label>
Institute of Human Genetics, University of Bonn, Bonn, Germany</aff>
<aff id="A27">
<label>27</label>
Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA</aff>
<aff id="A28">
<label>28</label>
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany</aff>
<aff id="A29">
<label>29</label>
Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany</aff>
<aff id="A30">
<label>30</label>
Department of Epidemiology, University of Washington, Seattle, WA, USA</aff>
<aff id="A31">
<label>31</label>
Centre National de Reference pour les Malades Alzheimer Jeunes (CNR-MAJ), Centre Hospitalier Régional Universitaire de Lille, Lille, France</aff>
<aff id="A32">
<label>32</label>
Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO, USA</aff>
<aff id="A33">
<label>33</label>
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA</aff>
<aff id="A34">
<label>34</label>
National Alzheimer’s Coordinating Center, University of Washington, Seattle, WA, USA</aff>
<aff id="A35">
<label>35</label>
Departments of Health Services, University of Washington, Seattle, WA, USA</aff>
<aff id="A36">
<label>36</label>
University Paris Descartes, Sorbonne Paris V, France</aff>
<aff id="A37">
<label>37</label>
Broca Hospital, Geriatrics Department, Paris, France</aff>
<aff id="A38">
<label>38</label>
Mercer’s Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland</aff>
<aff id="A39">
<label>39</label>
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA</aff>
<aff id="A40">
<label>40</label>
CNR-MAJ, Inserm U1079, Rouen, France</aff>
<aff id="A41">
<label>41</label>
University Hospital, 76031 Rouen, France</aff>
<aff id="A42">
<label>42</label>
University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol, UK</aff>
<aff id="A43">
<label>43</label>
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA</aff>
<aff id="A44">
<label>44</label>
Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</aff>
<aff id="A45">
<label>45</label>
Inserm U888, Hôpital La Colombière, Montpellier, France</aff>
<aff id="A46">
<label>46</label>
Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece</aff>
<aff id="A47">
<label>47</label>
Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA</aff>
<aff id="A48">
<label>48</label>
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA</aff>
<aff id="A49">
<label>49</label>
Departments of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY, USA</aff>
<aff id="A50">
<label>50</label>
University of Pittsburgh Alzheimer’s Disease Research Center, Pittsburgh, PA, USA</aff>
<aff id="A51">
<label>51</label>
Departments of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</aff>
<aff id="A52">
<label>52</label>
Dementia Research Centre, Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK</aff>
<aff id="A53">
<label>53</label>
Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain</aff>
<aff id="A54">
<label>54</label>
Inserm U897, Victor Segalen University, F-33076, Bordeaux, France</aff>
<aff id="A55">
<label>55</label>
Department of Molecular Neuroscience, Institute of Neurology, London, UK</aff>
<aff id="A56">
<label>56</label>
Reta Lilla Weston Laboratories, Institute of Neurology, London, UK</aff>
<aff id="A57">
<label>57</label>
Department of Medicine, University of Washington, Seattle, WA, USA</aff>
<aff id="A58">
<label>58</label>
Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of Oxford, Oxford, UK</aff>
<aff id="A59">
<label>59</label>
Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA</aff>
<aff id="A60">
<label>60</label>
Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, MS, USA</aff>
<aff id="A61">
<label>61</label>
Institute of Public Health, University of Cambridge, Cambridge, UK</aff>
<aff id="A62">
<label>62</label>
Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA</aff>
<aff id="A63">
<label>63</label>
Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA</aff>
<aff id="A64">
<label>64</label>
Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavik, Iceland</aff>
<aff id="A65">
<label>65</label>
Centre de Mémoire de Ressources et de Recherche de Bordeaux, CHU de Bordeaux, Bordeaux, France</aff>
<aff id="A66">
<label>66</label>
Department of Psychiatry, University of Frankfurt, Frankfurt am Main, Germany</aff>
<aff id="A67">
<label>67</label>
Department of Psychiatry, Ludwig Maximilians University, Munich, Germany</aff>
<aff id="A68">
<label>68</label>
Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA</aff>
<aff id="A69">
<label>69</label>
Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain</aff>
<aff id="A70">
<label>70</label>
CIBERNED, Instituto de Salud Carlos III, Madrid, Spain</aff>
<aff id="A71">
<label>71</label>
Group Health, Group Health Research Institute, Seattle, WA, USA</aff>
<aff id="A72">
<label>72</label>
Institute for Translational Genomics and Population Sciences. Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA</aff>
<aff id="A73">
<label>73</label>
Division of Genetic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA</aff>
<aff id="A74">
<label>74</label>
Department of Pathology, University of Washington, Seattle, WA, USA</aff>
<aff id="A75">
<label>75</label>
Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, MD, USA</aff>
<aff id="A76">
<label>76</label>
Arizona Alzheimer’s Consortium, Phoenix, AZ, USA</aff>
<aff id="A77">
<label>77</label>
Department of Psychiatry, University of Arizona, Phoenix, AZ, USA</aff>
<aff id="A78">
<label>78</label>
Banner Alzheimer’s Institute, Phoenix, AZ, USA</aff>
<aff id="A79">
<label>79</label>
Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona</aff>
<aff id="A80">
<label>80</label>
Department of Geriatrics, Landspitali National University Hospital, Reykjavik, Iceland</aff>
<aff id="A81">
<label>81</label>
Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK</aff>
<aff id="A82">
<label>82</label>
Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Canada</aff>
<aff id="A83">
<label>83</label>
Cambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK</aff>
<aff id="A84">
<label>84</label>
Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University, Belfast, UK</aff>
<aff id="A85">
<label>85</label>
PharmaTherapeutics Clinical Research, Pfizer Worldwide Research and Development, Cambridge, MA, USA</aff>
<aff id="A86">
<label>86</label>
Department of Neurology, Medical University of Graz, Graz, Austria</aff>
<aff id="A87">
<label>87</label>
Institute of Genetics, Queen’s Medical Centre, University of Nottingham, Nottingham, UK</aff>
<aff id="A88">
<label>88</label>
King’s College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, UK</aff>
<aff id="A89">
<label>89</label>
Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</aff>
<aff id="A90">
<label>90</label>
Department of Biology, Brigham Young University, Provo, Utah, USA</aff>
<aff id="A91">
<label>91</label>
Department of Genetics, University of North Carolina Chapel Hill, Chapel Hill, NC, USA</aff>
<aff id="A92">
<label>92</label>
Department of Psychiatry, Psychotherapy and Psychosomatics Martin-Luther-University Halle-Wittenberg, Julius-Kühn-Str. 706112 Halle Germany</aff>
<aff id="A93">
<label>93</label>
Institute of Human Genetics, Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany</aff>
<aff id="A94">
<label>94</label>
Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA</aff>
<aff id="A95">
<label>95</label>
Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</aff>
<aff id="A96">
<label>96</label>
Institute Born-Bunge, University of Antwerp, Antwerp, Belgium</aff>
<aff id="A97">
<label>97</label>
Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, MD, USA</aff>
<aff id="A98">
<label>98</label>
Taub Institute on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY, USA</aff>
<aff id="A99">
<label>99</label>
Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA</aff>
<aff id="A100">
<label>100</label>
Department of Neurology, Columbia University, New York, NY, USA</aff>
<aff id="A101">
<label>101</label>
McGill University and Génome Québec Innovation Centre, Montreal, Canada</aff>
<aff id="A102">
<label>102</label>
Fondation Jean Dausset- CEPH, Paris, France</aff>
<aff id="A103">
<label>103</label>
University Hospital, CHRU Lille, Lille, France</aff>
<aff id="A104">
<label>104</label>
Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA</aff>
<author-notes>
<corresp id="FN1">
<label>†</label>
Corresponding author: Lindsay A. Farrer, Ph.D., Biomedical Genetics E200, Boston University School of Medicine, 72 East Concord Street, Boston, MA. Phone: (617) 638-5393; FAX: (617) 638-4275;
<email>farrer@bu.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted">
<day>11</day>
<month>1</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub">
<day>17</day>
<month>3</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="ppub">
<month>1</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="pmc-release">
<day>18</day>
<month>5</month>
<year>2016</year>
</pub-date>
<volume>21</volume>
<issue>1</issue>
<fpage>108</fpage>
<lpage>117</lpage>
<pmc-comment>elocation-id from pubmed: 10.1038/mp.2015.23</pmc-comment>
<permissions>
<license xlink:href="http://www.nature.com/authors/editorial_policies/license.html#terms">
<license-p>Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:
<ext-link ext-link-type="uri" xlink:href="http://www.nature.com/authors/editorial_policies/license.html#terms">http://www.nature.com/authors/editorial_policies/license.html#terms</ext-link>
</license-p>
</license>
</permissions>
<abstract>
<p id="P1">
<italic>APOE</italic>
ε4, the most significant genetic risk factor for Alzheimer disease (AD), may mask effects of other loci. We re-analyzed genome-wide association study (GWAS) data from the International Genomics of Alzheimer’s Project (IGAP) Consortium in
<italic>APOE</italic>
ε4+ (10,352 cases and 9,207 controls) and
<italic>APOE</italic>
ε4− (7,184 cases and 26,968 controls) subgroups as well as in the total sample testing for interaction between a SNP and
<italic>APOE</italic>
ε4 status. Suggestive associations (P<1x10
<sup>−4</sup>
) in stage 1 were evaluated in an independent sample (stage 2) containing 4,203 subjects (
<italic>APOE</italic>
ε4+: 1,250 cases and 536 controls;
<italic>APOE</italic>
ε4-: 718 cases and 1,699 controls). Among
<italic>APOE</italic>
ε4− subjects, novel genome-wide significant (GWS) association was observed with 17 SNPs (all between
<italic>KANSL1</italic>
and
<italic>LRRC37A</italic>
on chromosome 17 near
<italic>MAPT</italic>
) in a meta-analysis of the stage 1 and stage 2 datasets (best SNP, rs2732703, P=5·8x10
<sup>−9</sup>
). Conditional analysis revealed that rs2732703 accounted for association signals in the entire 100 kilobase region that includes
<italic>MAPT</italic>
. Except for previously identified AD loci showing stronger association in
<italic>APOE</italic>
ε4+ subjects (
<italic>CR1</italic>
and
<italic>CLU</italic>
) or
<italic>APOE</italic>
ε4− subjects (
<italic>MS4A6A/MS4A4A/ MS4A6E</italic>
), no other SNPs were significantly associated with AD in a specific
<italic>APOE</italic>
genotype subgroup. In addition, the finding in the stage 1 sample that AD risk is significantly influenced by the interaction of
<italic>APOE</italic>
with rs1595014 in
<italic>TMEM106B</italic>
(P=1·6x10
<sup>−7</sup>
) is noteworthy because
<italic>TMEM106B</italic>
variants have previously been associated with risk of frontotemporal dementia. Expression quantitative trait locus analysis revealed that rs113986870, one of the GWS SNPs near rs2732703, is significantly associated with four
<italic>KANSL1</italic>
probes that target transcription of the first translated exon and an untranslated exon in hippocampus (P≤1.3x10
<sup>−8</sup>
), frontal cortex (P≤1.3x10
<sup>−9</sup>
), and temporal cortex (P≤1.2x10
<sup>−11</sup>
). Rs113986870 is also strongly associated with a
<italic>MAPT</italic>
probe that targets transcription of alternatively spliced exon 3 in frontal cortex (P=9.2x10
<sup>−6</sup>
) and temporal cortex (P=2.6x10
<sup>−6</sup>
). Our
<italic>APOE</italic>
-stratified GWAS is the first to show GWS association for AD with SNPs in the chromosome 17q21.31 region. Replication of this finding in independent samples is needed to verify that SNPs in this region have significantly stronger effects on AD risk in persons lacking
<italic>APOE</italic>
ε4 compared to persons carrying this allele, and if this is found to hold, further examination of this region and studies aimed at deciphering the mechanism(s) are warranted.</p>
</abstract>
</article-meta>
</front>
<floats-group>
<fig id="F1" orientation="portrait" position="float">
<label>Figure 1</label>
<caption>
<p>Association of AD with SNPs in chromosome 17q21.31 in the combined stage 1 and stage 2 samples.
<bold>(A)</bold>
Regional Manhattan plot in the
<italic>APOE</italic>
ε4+ (upper panel) and the
<italic>APOE</italic>
ε4− (lower panel) subgroups. SNPs with the lowest
<italic>P</italic>
-value are indicated with a purple diamond. Computed estimates of linkage disequilibrium (r
<sup>2</sup>
) of SNPs in this region with the most significant SNP are shown as red circles for r
<sup>2</sup>
≥ 0.8, orange circles for 0.6 ≤ r
<sup>2</sup>
< 0.8, green circles for 0.4 ≤ r
<sup>2</sup>
< 0.6, light blue circles for 0.2 ≤ r
<sup>2</sup>
< 0.4, and blue circles for r
<sup>2</sup>
< 0.2. Unannotated SNPs are shown as grey circles.
<bold>(B)</bold>
Forest plot of association results for rs2732703 in the Stage 1, Stage 2 and total samples among
<italic>APOE</italic>
ε4− subjects.</p>
</caption>
<graphic xlink:href="nihms654371f1"></graphic>
</fig>
<fig id="F2" orientation="portrait" position="float">
<label>Figure 2</label>
<caption>
<p>Genotype specific effect of the eQTL rs113986870 on expression of
<italic>KANSL1</italic>
.
<bold>(A)</bold>
Gene-level expression of
<italic>KANSL1</italic>
transcript t3760137. Transcript-level expression represents the average across all
<italic>KANSL1</italic>
exon probe sets.
<bold>(B)</bold>
Expression of exon probe 3760212. Probes 3760211, 3760212, and 3760213 measure expression of the first translated exon, are present in all three transcript variants, and were significantly associated with the eQTL. Expression profiles for probes 3760211 and 3760213 showed similar to those for probe 3760212 (
<xref rid="T3" ref-type="table">Table 3</xref>
). The distance from 3760212 to rs113986870 is 85,431 base pairs. Log2 scale of expression (Y-axis) is shown for 10 regions of cognitively normal human brains (X-axis) ordered by mean expression level. Rs113986870 genotype counts: AA=0, AG=56, and GG=76. Rs113986870 allele frequencies are 0.21 (A) and 0.79 (G).
<bold>CRBL =</bold>
cerebellum,
<bold>FCTX</bold>
= frontal cortex,
<bold>HIPP</bold>
= hippocampus,
<bold>MEDU</bold>
= medulla (specifically inferior olivary nucleus),
<bold>OCTX</bold>
= occipital cortex (specifically primary visual cortex),
<bold>PUTM</bold>
= putamen,
<bold>SNIG</bold>
= substantia nigra (SNIG),
<bold>THAL</bold>
= thalamus,
<bold>TCTX</bold>
= temporal cortex),
<bold>WHMT</bold>
= intralobular white matter.</p>
</caption>
<graphic xlink:href="nihms654371f2"></graphic>
</fig>
<table-wrap id="T1" position="float" orientation="landscape">
<label>Table 1</label>
<caption>
<p>Association results (P<10
<sup>−6</sup>
) in novel AD loci among APOE ε4− subjects in the combined stage 1 and stage 2 samples.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th valign="middle" rowspan="2" align="center" colspan="1">SNP</th>
<th valign="middle" rowspan="2" align="center" colspan="1">CH</th>
<th valign="middle" rowspan="2" align="center" colspan="1">Region or Closest Gene</th>
<th valign="middle" rowspan="2" align="center" colspan="1">MA</th>
<th valign="middle" rowspan="2" align="center" colspan="1">MAF</th>
<th colspan="2" valign="bottom" align="center" rowspan="1">Stage 1
<hr></hr>
</th>
<th colspan="2" valign="bottom" align="center" rowspan="1">Stage 2
<hr></hr>
</th>
<th colspan="2" valign="bottom" align="center" rowspan="1">Stages 1 + 2
<hr></hr>
</th>
</tr>
<tr>
<th valign="middle" align="center" rowspan="1" colspan="1">OR (95% CI)</th>
<th valign="middle" align="center" rowspan="1" colspan="1">P</th>
<th valign="middle" align="center" rowspan="1" colspan="1">OR (95% CI)</th>
<th valign="middle" align="center" rowspan="1" colspan="1">P</th>
<th valign="middle" align="center" rowspan="1" colspan="1">OR (95% CI)</th>
<th valign="middle" align="center" rowspan="1" colspan="1">P</th>
</tr>
</thead>
<tbody>
<tr>
<td align="center" valign="top" rowspan="1" colspan="1">rs16847609</td>
<td align="center" valign="top" rowspan="1" colspan="1">3</td>
<td align="center" valign="top" rowspan="1" colspan="1">SOX14/CLDN18</td>
<td align="center" valign="top" rowspan="1" colspan="1">A</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.09</td>
<td align="center" valign="top" rowspan="1" colspan="1">1.21 (1.12–1.29)</td>
<td align="center" valign="top" rowspan="1" colspan="1">2.3x10
<sup>−7</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">1.09 (0.87–1.37)</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.47</td>
<td align="center" valign="top" rowspan="1" colspan="1">1.19 (1.11–1.28)</td>
<td align="center" valign="top" rowspan="1" colspan="1">5.3x10
<sup>−7</sup>
</td>
</tr>
<tr>
<td align="center" valign="top" rowspan="1" colspan="1">rs382216</td>
<td align="center" valign="top" rowspan="1" colspan="1">5</td>
<td align="center" valign="top" rowspan="1" colspan="1">CDC42SE2-ACSL6</td>
<td align="center" valign="top" rowspan="1" colspan="1">T</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.36</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.88 (0.83–0.93)</td>
<td align="center" valign="top" rowspan="1" colspan="1">6.5x10
<sup>−6</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.78 (0.67–0.91)</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.002</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.87 (0.82–0.92)</td>
<td align="center" valign="top" rowspan="1" colspan="1">2.0x10
<sup>−7</sup>
</td>
</tr>
<tr>
<td align="center" valign="top" rowspan="1" colspan="1">rs11168036</td>
<td align="center" valign="top" rowspan="1" colspan="1">5</td>
<td align="center" valign="top" rowspan="1" colspan="1">PFDN1/HBEGF</td>
<td align="center" valign="top" rowspan="1" colspan="1">T</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.50</td>
<td align="center" valign="top" rowspan="1" colspan="1">1.14 (1.09–1.19)</td>
<td align="center" valign="top" rowspan="1" colspan="1">9.3x10
<sup>−9</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.97 (0.85–1.11)</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.64</td>
<td align="center" valign="top" rowspan="1" colspan="1">1.12 (1.07–1.17)</td>
<td align="center" valign="top" rowspan="1" colspan="1">3.2x10
<sup>−7</sup>
</td>
</tr>
<tr>
<td align="center" valign="top" rowspan="1" colspan="1">rs2732703</td>
<td align="center" valign="top" rowspan="1" colspan="1">17</td>
<td align="center" valign="top" rowspan="1" colspan="1">KANSL1/LRRC37A</td>
<td align="center" valign="top" rowspan="1" colspan="1">G</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.13</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.73 (0.65–0.83)</td>
<td align="center" valign="top" rowspan="1" colspan="1">6.4x10
<sup>−7</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.71 (0.58–0.88)</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.001</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.73 (0.65–0.81)</td>
<td align="center" valign="top" rowspan="1" colspan="1">5.8x10
<sup>−9</sup>
</td>
</tr>
<tr>
<td align="center" valign="top" rowspan="1" colspan="1">rs71380849</td>
<td align="center" valign="top" rowspan="1" colspan="1">17</td>
<td align="center" valign="top" rowspan="1" colspan="1">CDR2L</td>
<td align="center" valign="top" rowspan="1" colspan="1">A</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.06</td>
<td align="center" valign="top" rowspan="1" colspan="1">1.45 (1.24–1.70)</td>
<td align="center" valign="top" rowspan="1" colspan="1">3.8x10
<sup>−6</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">1.59 (1.01–2.50)</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.04</td>
<td align="center" valign="top" rowspan="1" colspan="1">1.47 (1.26–1.71)</td>
<td align="center" valign="top" rowspan="1" colspan="1">9.1x10
<sup>−7</sup>
</td>
</tr>
</tbody>
</table>
</table-wrap>
<table-wrap id="T2" position="float" orientation="landscape">
<label>Table 2</label>
<caption>
<p>Results (P<10
<sup>−6</sup>
) in previously known AD loci showing different pattern of association among APOE ε4+ and ε4− subjects in the combined datasets.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th valign="middle" rowspan="2" align="center" colspan="1">SNP</th>
<th valign="middle" rowspan="2" align="center" colspan="1">CH</th>
<th valign="middle" rowspan="2" align="center" colspan="1">Region or Closest Gene</th>
<th valign="middle" rowspan="2" align="center" colspan="1">MA</th>
<th valign="middle" rowspan="2" align="center" colspan="1">MAF</th>
<th colspan="2" valign="bottom" align="center" rowspan="1">
<italic>APOE</italic>
ε
<italic>4(+)</italic>
<hr></hr>
</th>
<th colspan="2" valign="bottom" align="center" rowspan="1">
<italic>APOE</italic>
ε
<italic>4(−)</italic>
<hr></hr>
</th>
</tr>
<tr>
<th valign="middle" align="center" rowspan="1" colspan="1">OR (95% CI)</th>
<th valign="middle" align="center" rowspan="1" colspan="1">P</th>
<th valign="middle" align="center" rowspan="1" colspan="1">OR (95% CI)</th>
<th valign="middle" align="center" rowspan="1" colspan="1">P</th>
</tr>
</thead>
<tbody>
<tr>
<td align="center" valign="top" rowspan="1" colspan="1">rs679515</td>
<td align="center" valign="top" rowspan="1" colspan="1">1</td>
<td align="center" valign="top" rowspan="1" colspan="1">CR1</td>
<td align="center" valign="top" rowspan="1" colspan="1">T</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.21</td>
<td align="center" valign="top" rowspan="1" colspan="1">1.22 (1.14 –1.30)</td>
<td align="center" valign="top" rowspan="1" colspan="1">3.6x10
<sup>−9</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">1.13 (1.07 – 1.19)</td>
<td align="center" valign="top" rowspan="1" colspan="1">1.6x10
<sup>−5</sup>
</td>
</tr>
<tr>
<td align="center" valign="top" rowspan="1" colspan="1">rs4663105</td>
<td align="center" valign="top" rowspan="1" colspan="1">2</td>
<td align="center" valign="top" rowspan="1" colspan="1">BIN1</td>
<td align="center" valign="top" rowspan="1" colspan="1">C</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.43</td>
<td align="center" valign="top" rowspan="1" colspan="1">1.19 (1.12 – 1.25)</td>
<td align="center" valign="top" rowspan="1" colspan="1">2.5x10
<sup>−9</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">1.19 (1.13 – 1.24)</td>
<td align="center" valign="top" rowspan="1" colspan="1">1.8x10
<sup>−12</sup>
</td>
</tr>
<tr>
<td align="center" valign="top" rowspan="1" colspan="1">rs9331896</td>
<td align="center" valign="top" rowspan="1" colspan="1">8</td>
<td align="center" valign="top" rowspan="1" colspan="1">CLU</td>
<td align="center" valign="top" rowspan="1" colspan="1">C</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.38</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.84 (0.80 – 0.89)</td>
<td align="center" valign="top" rowspan="1" colspan="1">2.8x10
<sup>−9</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.90 (0.86 – 0.94)</td>
<td align="center" valign="top" rowspan="1" colspan="1">9.6x10
<sup>−6</sup>
</td>
</tr>
<tr>
<td align="center" valign="top" rowspan="1" colspan="1">rs1582763</td>
<td align="center" valign="top" rowspan="1" colspan="1">11</td>
<td align="center" valign="top" rowspan="1" colspan="1">MS4 region</td>
<td align="center" valign="top" rowspan="1" colspan="1">A</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.37</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.92 (0.87 – 0.97)</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.003</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.87 (0.83 – 0.91)</td>
<td align="center" valign="top" rowspan="1" colspan="1">2.2x10
<sup>−9</sup>
</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="TFN1">
<p>CH = chromosome; MA = minor allele; MAF = minor allele frequency.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="T3" position="float" orientation="landscape">
<label>Table 3</label>
<caption>
<p>Exon probes covering the region between 43.5 and 45.0 Mb on chromosome 17 that reveal significant rs113986870 allelic expression differences averaged over of 10 brain areas</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th valign="bottom" align="center" rowspan="1" colspan="1">Gene</th>
<th valign="bottom" align="center" rowspan="1" colspan="1">ExprID</th>
<th valign="bottom" align="center" rowspan="1" colspan="1">Start</th>
<th valign="bottom" align="center" rowspan="1" colspan="1">End</th>
<th valign="bottom" align="center" rowspan="1" colspan="1">AVGALL</th>
<th valign="bottom" align="center" rowspan="1" colspan="1">FCTX</th>
<th valign="bottom" align="center" rowspan="1" colspan="1">HIPP</th>
<th valign="bottom" align="center" rowspan="1" colspan="1">TCTX</th>
</tr>
</thead>
<tbody>
<tr>
<td align="center" valign="top" rowspan="1" colspan="1">LRRC37A4P</td>
<td align="center" valign="top" rowspan="1" colspan="1">3759896</td>
<td align="center" valign="top" rowspan="1" colspan="1">43583231</td>
<td align="center" valign="top" rowspan="1" colspan="1">43583802</td>
<td align="center" valign="top" rowspan="1" colspan="1">1.4x10
<sup>−15</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">6.4x10
<sup>−4</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">4.0x10
<sup>−6</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">2.4x10
<sup>−5</sup>
</td>
</tr>
<tr>
<td align="center" valign="top" rowspan="1" colspan="1">LRRC37A4P</td>
<td align="center" valign="top" rowspan="1" colspan="1">3759898</td>
<td align="center" valign="top" rowspan="1" colspan="1">43584264</td>
<td align="center" valign="top" rowspan="1" colspan="1">43584884</td>
<td align="center" valign="top" rowspan="1" colspan="1">1.7x10
<sup>−20</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">8.0x10
<sup>−11</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">5.3x10
<sup>−10</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">3.6x10
<sup>−9</sup>
</td>
</tr>
<tr>
<td align="center" valign="top" rowspan="1" colspan="1">C17orf69</td>
<td align="center" valign="top" rowspan="1" colspan="1">3723594</td>
<td align="center" valign="top" rowspan="1" colspan="1">43716765</td>
<td align="center" valign="top" rowspan="1" colspan="1">43716853</td>
<td align="center" valign="top" rowspan="1" colspan="1">3.3x10
<sup>−13</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">2.0x10
<sup>−5</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">1.6x10
<sup>−7</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">8.3x10
<sup>−5</sup>
</td>
</tr>
<tr>
<td align="center" valign="top" rowspan="1" colspan="1">C17orf69</td>
<td align="center" valign="top" rowspan="1" colspan="1">3723604</td>
<td align="center" valign="top" rowspan="1" colspan="1">43723359</td>
<td align="center" valign="top" rowspan="1" colspan="1">43723556</td>
<td align="center" valign="top" rowspan="1" colspan="1">4.9x10
<sup>−10</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.004</td>
<td align="center" valign="top" rowspan="1" colspan="1">9.8x10
<sup>−4</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">1.3x10
<sup>−5</sup>
</td>
</tr>
<tr>
<td align="center" valign="top" rowspan="1" colspan="1">MAPT</td>
<td align="center" valign="top" rowspan="1" colspan="1">3723712</td>
<td align="center" valign="top" rowspan="1" colspan="1">44051752</td>
<td align="center" valign="top" rowspan="1" colspan="1">44051833</td>
<td align="center" valign="top" rowspan="1" colspan="1">3.6x10
<sup>−14</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">9.2x10
<sup>−6</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">7.6x10
<sup>−4</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">2.6x10
<sup>−6</sup>
</td>
</tr>
<tr>
<td align="center" valign="top" rowspan="1" colspan="1">KANSL1</td>
<td align="center" valign="top" rowspan="1" colspan="1">3760158</td>
<td align="center" valign="top" rowspan="1" colspan="1">44117069</td>
<td align="center" valign="top" rowspan="1" colspan="1">44117161</td>
<td align="center" valign="top" rowspan="1" colspan="1">9.8x10
<sup>−14</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">2.8x10
<sup>−5</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.008</td>
<td align="center" valign="top" rowspan="1" colspan="1">6.2x10
<sup>−5</sup>
</td>
</tr>
<tr>
<td align="center" valign="top" rowspan="1" colspan="1">KANSL1</td>
<td align="center" valign="top" rowspan="1" colspan="1">3760211</td>
<td align="center" valign="top" rowspan="1" colspan="1">44247654</td>
<td align="center" valign="top" rowspan="1" colspan="1">44247852</td>
<td align="center" valign="top" rowspan="1" colspan="1">4.0x10
<sup>−23</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">8.0x10
<sup>−13</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">3.0x10
<sup>−17</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">1.6x10
<sup>−15</sup>
</td>
</tr>
<tr>
<td align="center" valign="top" rowspan="1" colspan="1">KANSL1</td>
<td align="center" valign="top" rowspan="1" colspan="1">3760212</td>
<td align="center" valign="top" rowspan="1" colspan="1">44248224</td>
<td align="center" valign="top" rowspan="1" colspan="1">44248977</td>
<td align="center" valign="top" rowspan="1" colspan="1">1.4x10
<sup>−24</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">2.6x10
<sup>−18</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">7.8x10
<sup>−20</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">2.5x10
<sup>−21</sup>
</td>
</tr>
<tr>
<td align="center" valign="top" rowspan="1" colspan="1">KANSL1</td>
<td align="center" valign="top" rowspan="1" colspan="1">3760213</td>
<td align="center" valign="top" rowspan="1" colspan="1">44249529</td>
<td align="center" valign="top" rowspan="1" colspan="1">44249592</td>
<td align="center" valign="top" rowspan="1" colspan="1">7.7x10
<sup>−16</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">3.0x10
<sup>−11</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">1.1x10
<sup>−13</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">1.2x10
<sup>−11</sup>
</td>
</tr>
<tr>
<td align="center" valign="top" rowspan="1" colspan="1">KANSL1</td>
<td align="center" valign="top" rowspan="1" colspan="1">3760219</td>
<td align="center" valign="top" rowspan="1" colspan="1">44270189</td>
<td align="center" valign="top" rowspan="1" colspan="1">44270252</td>
<td align="center" valign="top" rowspan="1" colspan="1">4.3x10
<sup>−13</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">1.3x10
<sup>−9</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">1.3x10
<sup>−8</sup>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">1.3x10
<sup>−11</sup>
</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="TFN2">
<p>Map position is based on 1000 Genomes database release GRCh37/hg19 assembly, February 2009. Significance threshold after multiple testing determined as 0.05/292,000 exon probes = 1.7x10
<sup>−7</sup>
; ExprID: exon-specific probeset ID. AVEALL: average expression levels across 10 regions including cerebellum (CRBL), frontal cortex (FCTX), hippocampus (HIPP), medulla (specifically inferior olivary nucleus, MEDU), occipital cortex (specifically primary visual cortex, OCTX), putamen (PUTM), substantia nigra (SNIG), thalamus (THAL), temporal cortex (TCTX), and intralobular white matter (WHMT).</p>
</fn>
</table-wrap-foot>
</table-wrap>
</floats-group>
</pmc>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Pmc/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B59 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000B59 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Canada
   |area=    ParkinsonCanadaV1
   |flux=    Pmc
   |étape=   Curation
   |type=    RBID
   |clé=     PMC:4573764
   |texte=   A NOVEL ALZHEIMER DISEASE LOCUS LOCATED NEAR THE GENE ENCODING TAU PROTEIN
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i   -Sk "pubmed:25778476" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd   \
       | NlmPubMed2Wicri -a ParkinsonCanadaV1
Wicri

This area was generated with Dilib version V0.6.29.
Data generation: Thu May 4 22:20:19 2017. Site generation: Fri Dec 23 23:17:26 2022