Long-Term Potentiation Promotes Proliferation/Survival and Neuronal Differentiation of Neural Stem/Progenitor Cells
Identifieur interne : 000A99 ( Pmc/Curation ); précédent : 000A98; suivant : 000B00Long-Term Potentiation Promotes Proliferation/Survival and Neuronal Differentiation of Neural Stem/Progenitor Cells
Auteurs : Taesup Cho [Canada] ; Jae K. Ryu [Canada] ; Changiz Taghibiglou [Canada] ; Yuan Ge [Canada] ; Allen W. Chan [Canada] ; Lidong Liu [Canada] ; Jie Lu [Canada] ; James G. Mclarnon [Canada] ; Yu Tian Wang [Canada, République populaire de Chine]Source :
- PLoS ONE [ 1932-6203 ] ; 2013.
Abstract
Neural stem cell (NSC) replacement therapy is considered a promising cell replacement therapy for various neurodegenerative diseases. However, the low rate of NSC survival and neurogenesis currently limits its clinical potential. Here, we examined if hippocampal long-term potentiation (LTP), one of the most well characterized forms of synaptic plasticity, promotes neurogenesis by facilitating proliferation/survival and neuronal differentiation of NSCs. We found that the induction of hippocampal LTP significantly facilitates proliferation/survival and neuronal differentiation of both endogenous neural progenitor cells (NPCs) and exogenously transplanted NSCs in the hippocampus in rats. These effects were eliminated by preventing LTP induction by pharmacological blockade of the N-methyl-D-aspartate glutamate receptor (NMDAR) via systemic application of the receptor antagonist, 3-[(R)-2-carboxypiperazin-4-yl]-propyl-1-phosphonic acid (CPP). Moreover, using a NPC-neuron co-culture system, we were able to demonstrate that the LTP-promoted NPC neurogenesis is at least in part mediated by a LTP-increased neuronal release of brain-derived neurotrophic factor (BDNF) and its consequent activation of tropomysosin receptor kinase B (TrkB) receptors on NSCs. Our results indicate that LTP promotes the neurogenesis of both endogenous and exogenously transplanted NSCs in the brain. The study suggests that pre-conditioning of the host brain receiving area with a LTP-inducing deep brain stimulation protocol prior to NSC transplantation may increase the likelihood of success of using NSC transplantation as an effective cell therapy for various neurodegenerative diseases.
Url:
DOI: 10.1371/journal.pone.0076860
PubMed: 24146937
PubMed Central: 3798289
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Ryu</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver</wicri:regionArea></affiliation></author><author><name sortKey="Taghibiglou, Changiz" sort="Taghibiglou, Changiz" uniqKey="Taghibiglou C" first="Changiz" last="Taghibiglou">Changiz Taghibiglou</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Brain Research Centre and Department of Medicine, University of British Columbia, Vancouver, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Brain Research Centre and Department of Medicine, University of British Columbia, Vancouver</wicri:regionArea></affiliation></author><author><name sortKey="Ge, Yuan" sort="Ge, Yuan" uniqKey="Ge Y" first="Yuan" last="Ge">Yuan Ge</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Brain Research Centre and Department of Medicine, University of British Columbia, Vancouver, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Brain Research Centre and Department of Medicine, University of British Columbia, Vancouver</wicri:regionArea></affiliation></author><author><name sortKey="Chan, Allen W" sort="Chan, Allen W" uniqKey="Chan A" first="Allen W." last="Chan">Allen W. 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Mclarnon</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Yu Tian" sort="Wang, Yu Tian" uniqKey="Wang Y" first="Yu Tian" last="Wang">Yu Tian Wang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Brain Research Centre and Department of Medicine, University of British Columbia, Vancouver, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Brain Research Centre and Department of Medicine, University of British Columbia, Vancouver</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Translational Medicine Research Center, China Medical University Hospital and Graduate Institute of Immunology, China Medical University, Taichung, Taiwan, Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Translational Medicine Research Center, China Medical University Hospital and Graduate Institute of Immunology, China Medical University, Taichung, Taiwan</wicri:regionArea></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Neural stem cell (NSC) replacement therapy is considered a promising cell replacement therapy for various neurodegenerative diseases. However, the low rate of NSC survival and neurogenesis currently limits its clinical potential. Here, we examined if hippocampal long-term potentiation (LTP), one of the most well characterized forms of synaptic plasticity, promotes neurogenesis by facilitating proliferation/survival and neuronal differentiation of NSCs. We found that the induction of hippocampal LTP significantly facilitates proliferation/survival and neuronal differentiation of both endogenous neural progenitor cells (NPCs) and exogenously transplanted NSCs in the hippocampus in rats. These effects were eliminated by preventing LTP induction by pharmacological blockade of the N-methyl-D-aspartate glutamate receptor (NMDAR) via systemic application of the receptor antagonist, 3-[(R)-2-carboxypiperazin-4-yl]-propyl-1-phosphonic acid (CPP). Moreover, using a NPC-neuron co-culture system, we were able to demonstrate that the LTP-promoted NPC neurogenesis is at least in part mediated by a LTP-increased neuronal release of brain-derived neurotrophic factor (BDNF) and its consequent activation of tropomysosin receptor kinase B (TrkB) receptors on NSCs. Our results indicate that LTP promotes the neurogenesis of both endogenous and exogenously transplanted NSCs in the brain. The study suggests that pre-conditioning of the host brain receiving area with a LTP-inducing deep brain stimulation protocol prior to NSC transplantation may increase the likelihood of success of using NSC transplantation as an effective cell therapy for various neurodegenerative diseases.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ogawa, Y" uniqKey="Ogawa Y">Y Ogawa</name></author><author><name sortKey="Sawamoto, K" uniqKey="Sawamoto K">K Sawamoto</name></author><author><name sortKey="Miyata, T" uniqKey="Miyata T">T Miyata</name></author><author><name sortKey="Miyao, S" uniqKey="Miyao S">S Miyao</name></author><author><name sortKey="Watanabe, M" uniqKey="Watanabe M">M Watanabe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brustle, O" uniqKey="Brustle O">O Brustle</name></author><author><name sortKey="Mckay, Rd" uniqKey="Mckay R">RD 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<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24146937</article-id><article-id pub-id-type="pmc">3798289</article-id><article-id pub-id-type="publisher-id">PONE-D-13-19862</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0076860</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Long-Term Potentiation Promotes Proliferation/Survival and Neuronal Differentiation of Neural Stem/Progenitor Cells</article-title><alt-title alt-title-type="running-head">LTP Promotes Neurogenesis</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Cho</surname><given-names>Taesup</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ryu</surname><given-names>Jae K.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Taghibiglou</surname><given-names>Changiz</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ge</surname><given-names>Yuan</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chan</surname><given-names>Allen W.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Lidong</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lu</surname><given-names>Jie</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>McLarnon</surname><given-names>James G.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Yu Tian</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>Brain Research Centre and Department of Medicine, University of British Columbia, Vancouver, Canada</addr-line></aff><aff id="aff2"><label>2</label><addr-line>Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada</addr-line></aff><aff id="aff3"><label>3</label><addr-line>Translational Medicine Research Center, China Medical University Hospital and Graduate Institute of Immunology, China Medical University, Taichung, Taiwan, Republic of China</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Hu</surname><given-names>Wenhui</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>Temple University School of Medicine, United States of America</addr-line></aff><author-notes><corresp id="cor1">* E-mail: <email>ytwang@brain.ubc.ca</email></corresp><fn fn-type="conflict"><p><bold>Competing Interests: </bold>The authors have declared that no competing interests exist.</p></fn><fn fn-type="con"><p>Conceived and designed the experiments: TC YTW. Performed the experiments: TC JKR CT YG JL. Analyzed the data: TC JKR CT AWC LL. Contributed reagents/materials/analysis tools: LL JL. Wrote the paper: TC JKR AWC JGM YTW. Performed NSC transplantation: JKR. Performed surface biotinylation experiments: CT. Performed ELISA assay: YG. Analyzed data and aided in manuscript preparation: AWC LL. Prepared virus vectors: JL.</p></fn></author-notes><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>17</day><month>10</month><year>2013</year></pub-date><volume>8</volume><issue>10</issue><elocation-id>e76860</elocation-id><history><date date-type="received"><day>14</day><month>5</month><year>2013</year></date><date date-type="accepted"><day>28</day><month>8</month><year>2013</year></date></history><permissions><copyright-year>2013</copyright-year><copyright-holder>Cho et al</copyright-holder><license><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><abstract><p>Neural stem cell (NSC) replacement therapy is considered a promising cell replacement therapy for various neurodegenerative diseases. However, the low rate of NSC survival and neurogenesis currently limits its clinical potential. Here, we examined if hippocampal long-term potentiation (LTP), one of the most well characterized forms of synaptic plasticity, promotes neurogenesis by facilitating proliferation/survival and neuronal differentiation of NSCs. We found that the induction of hippocampal LTP significantly facilitates proliferation/survival and neuronal differentiation of both endogenous neural progenitor cells (NPCs) and exogenously transplanted NSCs in the hippocampus in rats. These effects were eliminated by preventing LTP induction by pharmacological blockade of the N-methyl-D-aspartate glutamate receptor (NMDAR) via systemic application of the receptor antagonist, 3-[(R)-2-carboxypiperazin-4-yl]-propyl-1-phosphonic acid (CPP). Moreover, using a NPC-neuron co-culture system, we were able to demonstrate that the LTP-promoted NPC neurogenesis is at least in part mediated by a LTP-increased neuronal release of brain-derived neurotrophic factor (BDNF) and its consequent activation of tropomysosin receptor kinase B (TrkB) receptors on NSCs. Our results indicate that LTP promotes the neurogenesis of both endogenous and exogenously transplanted NSCs in the brain. The study suggests that pre-conditioning of the host brain receiving area with a LTP-inducing deep brain stimulation protocol prior to NSC transplantation may increase the likelihood of success of using NSC transplantation as an effective cell therapy for various neurodegenerative diseases.</p></abstract><funding-group><funding-statement>This work was supported in part by the Canadian Institutes of Health Research (CIHR), Howard Hughes Medical Institute and Taiwan Department of Health Clinical Trial and Research Center of Excellence (DOH100-TD-B-111-004). YTW is the holder of the Heart and Stroke Foundation of British Columbia and the Yukon (HSFBC & Y) Chair in Stroke Research. T.C was supported by a Doctoral Award from the HSFBC. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement></funding-group><counts><page-count count="15"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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