Methylomic changes in individuals with psychosis, prenatally exposed to endocrine disrupting compounds: Lessons from diethylstilbestrol
Identifieur interne : 000A79 ( Pmc/Curation ); précédent : 000A78; suivant : 000A80Methylomic changes in individuals with psychosis, prenatally exposed to endocrine disrupting compounds: Lessons from diethylstilbestrol
Auteurs : Fabrice Rivollier [France] ; Boris Chaumette [France] ; Narjes Bendjemaa [France] ; Mélanie Chayet [France] ; Bruno Millet [France] ; Nematollah Jaafari [France] ; Amina Barhdadi [Canada] ; Louis-Philippe Lemieux Perreault [Canada] ; Sylvie Provost [Canada] ; Marie-Pierre Dubé [Canada] ; Raphaël Gaillard [France] ; Marie-Odile Krebs [France] ; Oussama Kebir [France]Source :
- PLoS ONE [ 1932-6203 ] ; 2017.
Abstract
In the Western world, between 1940 and 1970, more than 2 million people were exposed
From 247 individuals born from mothers exposed to DES, we selected 69 siblings from 30 families. In each family, at least one sibling was exposed in utero to DES. We performed a methylome-wide association study using HumanMethylation450 DNA Analysis BeadChip® in peripheral blood. We analyzed methylation changes at individual CpGs or regions in exposed (n = 37) versus unexposed individuals (n = 32). We also compared exposed individuals with (n = 7) and without psychosis (n = 30).
There were more individuals with schizophrenia in the DES-exposed group. We found no significant differences between exposed and unexposed individuals with respect to differentially methylated CpGs or regions. The largest difference was in a region near the promoter of an ADAMTS proteoglycanase gene (
Url:
DOI: 10.1371/journal.pone.0174783
PubMed: 28406917
PubMed Central: 5390994
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000A79
Links to Exploration step
PMC:5390994Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Methylomic changes in individuals with psychosis, prenatally exposed to endocrine disrupting compounds: Lessons from diethylstilbestrol</title><author><name sortKey="Rivollier, Fabrice" sort="Rivollier, Fabrice" uniqKey="Rivollier F" first="Fabrice" last="Rivollier">Fabrice Rivollier</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Université Paris Descartes, Université Paris Sorbonne Paris Cité, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Descartes, Université Paris Sorbonne Paris Cité, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>INSERM, Laboratoire de Physiopathologie des Maladies Psychiatriques, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Laboratoire de Physiopathologie des Maladies Psychiatriques, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>CNRS, GDR3557-Institut de Psychiatrie, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, GDR3557-Institut de Psychiatrie, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Faculté de Médecine Paris Descartes, Centre Hospitalier Sainte-Anne, Service Hospitalo-Universitaire, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Faculté de Médecine Paris Descartes, Centre Hospitalier Sainte-Anne, Service Hospitalo-Universitaire, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Chaumette, Boris" sort="Chaumette, Boris" uniqKey="Chaumette B" first="Boris" last="Chaumette">Boris Chaumette</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Université Paris Descartes, Université Paris Sorbonne Paris Cité, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Descartes, Université Paris Sorbonne Paris Cité, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>INSERM, Laboratoire de Physiopathologie des Maladies Psychiatriques, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Laboratoire de Physiopathologie des Maladies Psychiatriques, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>CNRS, GDR3557-Institut de Psychiatrie, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, GDR3557-Institut de Psychiatrie, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Faculté de Médecine Paris Descartes, Centre Hospitalier Sainte-Anne, Service Hospitalo-Universitaire, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Faculté de Médecine Paris Descartes, Centre Hospitalier Sainte-Anne, Service Hospitalo-Universitaire, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Bendjemaa, Narjes" sort="Bendjemaa, Narjes" uniqKey="Bendjemaa N" first="Narjes" last="Bendjemaa">Narjes Bendjemaa</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Université Paris Descartes, Université Paris Sorbonne Paris Cité, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Descartes, Université Paris Sorbonne Paris Cité, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>INSERM, Laboratoire de Physiopathologie des Maladies Psychiatriques, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Laboratoire de Physiopathologie des Maladies Psychiatriques, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>CNRS, GDR3557-Institut de Psychiatrie, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, GDR3557-Institut de Psychiatrie, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Faculté de Médecine Paris Descartes, Centre Hospitalier Sainte-Anne, Service Hospitalo-Universitaire, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Faculté de Médecine Paris Descartes, Centre Hospitalier Sainte-Anne, Service Hospitalo-Universitaire, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Chayet, Melanie" sort="Chayet, Melanie" uniqKey="Chayet M" first="Mélanie" last="Chayet">Mélanie Chayet</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Faculté de Médecine Paris Descartes, Centre Hospitalier Sainte-Anne, Service Hospitalo-Universitaire, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Faculté de Médecine Paris Descartes, Centre Hospitalier Sainte-Anne, Service Hospitalo-Universitaire, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Millet, Bruno" sort="Millet, Bruno" uniqKey="Millet B" first="Bruno" last="Millet">Bruno Millet</name><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Department of Adults Psychiatry, ICM-A-IHU, UPMC UMR S 975, Inserm U 1127, CNRS UMR 7225, GH Pitié-Salpêtrière, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Adults Psychiatry, ICM-A-IHU, UPMC UMR S 975, Inserm U 1127, CNRS UMR 7225, GH Pitié-Salpêtrière, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Jaafari, Nematollah" sort="Jaafari, Nematollah" uniqKey="Jaafari N" first="Nematollah" last="Jaafari">Nematollah Jaafari</name><affiliation wicri:level="1"><nlm:aff id="aff006"><addr-line>Unité de Recherche Clinique en Psychiatrie Pierre Deniker, Centre Hospitalier Henri Laborit, INSERM CIC-P 1402, INSERM U 1084 Laboratoire Expérimental et Clinique en Neurosciences, Univ Poitiers, CHU Poitiers, Groupement De Recherche CNRS 3557, Poitiers, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité de Recherche Clinique en Psychiatrie Pierre Deniker, Centre Hospitalier Henri Laborit, INSERM CIC-P 1402, INSERM U 1084 Laboratoire Expérimental et Clinique en Neurosciences, Univ Poitiers, CHU Poitiers, Groupement De Recherche CNRS 3557, Poitiers</wicri:regionArea></affiliation></author><author><name sortKey="Barhdadi, Amina" sort="Barhdadi, Amina" uniqKey="Barhdadi A" first="Amina" last="Barhdadi">Amina Barhdadi</name><affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Université de Montréal, Beaulieu-Saucier Pharmacogenomics Center, Montréal Heart Institute, Montréal, QC, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Université de Montréal, Beaulieu-Saucier Pharmacogenomics Center, Montréal Heart Institute, Montréal, QC</wicri:regionArea></affiliation></author><author><name sortKey="Lemieux Perreault, Louis Philippe" sort="Lemieux Perreault, Louis Philippe" uniqKey="Lemieux Perreault L" first="Louis-Philippe" last="Lemieux Perreault">Louis-Philippe Lemieux Perreault</name><affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Université de Montréal, Beaulieu-Saucier Pharmacogenomics Center, Montréal Heart Institute, Montréal, QC, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Université de Montréal, Beaulieu-Saucier Pharmacogenomics Center, Montréal Heart Institute, Montréal, QC</wicri:regionArea></affiliation></author><author><name sortKey="Provost, Sylvie" sort="Provost, Sylvie" uniqKey="Provost S" first="Sylvie" last="Provost">Sylvie Provost</name><affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Université de Montréal, Beaulieu-Saucier Pharmacogenomics Center, Montréal Heart Institute, Montréal, QC, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Université de Montréal, Beaulieu-Saucier Pharmacogenomics Center, Montréal Heart Institute, Montréal, QC</wicri:regionArea></affiliation></author><author><name sortKey="Dube, Marie Pierre" sort="Dube, Marie Pierre" uniqKey="Dube M" first="Marie-Pierre" last="Dubé">Marie-Pierre Dubé</name><affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Université de Montréal, Beaulieu-Saucier Pharmacogenomics Center, Montréal Heart Institute, Montréal, QC, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Université de Montréal, Beaulieu-Saucier Pharmacogenomics Center, Montréal Heart Institute, Montréal, QC</wicri:regionArea></affiliation></author><author><name sortKey="Gaillard, Raphael" sort="Gaillard, Raphael" uniqKey="Gaillard R" first="Raphaël" last="Gaillard">Raphaël Gaillard</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Université Paris Descartes, Université Paris Sorbonne Paris Cité, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Descartes, Université Paris Sorbonne Paris Cité, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>INSERM, Laboratoire de Physiopathologie des Maladies Psychiatriques, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Laboratoire de Physiopathologie des Maladies Psychiatriques, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>CNRS, GDR3557-Institut de Psychiatrie, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, GDR3557-Institut de Psychiatrie, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Faculté de Médecine Paris Descartes, Centre Hospitalier Sainte-Anne, Service Hospitalo-Universitaire, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Faculté de Médecine Paris Descartes, Centre Hospitalier Sainte-Anne, Service Hospitalo-Universitaire, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Krebs, Marie Odile" sort="Krebs, Marie Odile" uniqKey="Krebs M" first="Marie-Odile" last="Krebs">Marie-Odile Krebs</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Université Paris Descartes, Université Paris Sorbonne Paris Cité, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Descartes, Université Paris Sorbonne Paris Cité, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>INSERM, Laboratoire de Physiopathologie des Maladies Psychiatriques, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Laboratoire de Physiopathologie des Maladies Psychiatriques, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>CNRS, GDR3557-Institut de Psychiatrie, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, GDR3557-Institut de Psychiatrie, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Faculté de Médecine Paris Descartes, Centre Hospitalier Sainte-Anne, Service Hospitalo-Universitaire, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Faculté de Médecine Paris Descartes, Centre Hospitalier Sainte-Anne, Service Hospitalo-Universitaire, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Kebir, Oussama" sort="Kebir, Oussama" uniqKey="Kebir O" first="Oussama" last="Kebir">Oussama Kebir</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Université Paris Descartes, Université Paris Sorbonne Paris Cité, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Descartes, Université Paris Sorbonne Paris Cité, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>INSERM, Laboratoire de Physiopathologie des Maladies Psychiatriques, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Laboratoire de Physiopathologie des Maladies Psychiatriques, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>CNRS, GDR3557-Institut de Psychiatrie, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, GDR3557-Institut de Psychiatrie, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Faculté de Médecine Paris Descartes, Centre Hospitalier Sainte-Anne, Service Hospitalo-Universitaire, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Faculté de Médecine Paris Descartes, Centre Hospitalier Sainte-Anne, Service Hospitalo-Universitaire, Paris</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28406917</idno><idno type="pmc">5390994</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390994</idno><idno type="RBID">PMC:5390994</idno><idno type="doi">10.1371/journal.pone.0174783</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000A79</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A79</idno><idno type="wicri:Area/Pmc/Curation">000A79</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A79</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Methylomic changes in individuals with psychosis, prenatally exposed to endocrine disrupting compounds: Lessons from diethylstilbestrol</title><author><name sortKey="Rivollier, Fabrice" sort="Rivollier, Fabrice" uniqKey="Rivollier F" first="Fabrice" last="Rivollier">Fabrice Rivollier</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Université Paris Descartes, Université Paris Sorbonne Paris Cité, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Descartes, Université Paris Sorbonne Paris Cité, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>INSERM, Laboratoire de Physiopathologie des Maladies Psychiatriques, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Laboratoire de Physiopathologie des Maladies Psychiatriques, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>CNRS, GDR3557-Institut de Psychiatrie, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, GDR3557-Institut de Psychiatrie, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Faculté de Médecine Paris Descartes, Centre Hospitalier Sainte-Anne, Service Hospitalo-Universitaire, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Faculté de Médecine Paris Descartes, Centre Hospitalier Sainte-Anne, Service Hospitalo-Universitaire, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Chaumette, Boris" sort="Chaumette, Boris" uniqKey="Chaumette B" first="Boris" last="Chaumette">Boris Chaumette</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Université Paris Descartes, Université Paris Sorbonne Paris Cité, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Descartes, Université Paris Sorbonne Paris Cité, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>INSERM, Laboratoire de Physiopathologie des Maladies Psychiatriques, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Laboratoire de Physiopathologie des Maladies Psychiatriques, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>CNRS, GDR3557-Institut de Psychiatrie, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, GDR3557-Institut de Psychiatrie, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Faculté de Médecine Paris Descartes, Centre Hospitalier Sainte-Anne, Service Hospitalo-Universitaire, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Faculté de Médecine Paris Descartes, Centre Hospitalier Sainte-Anne, Service Hospitalo-Universitaire, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Bendjemaa, Narjes" sort="Bendjemaa, Narjes" uniqKey="Bendjemaa N" first="Narjes" last="Bendjemaa">Narjes Bendjemaa</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Université Paris Descartes, Université Paris Sorbonne Paris Cité, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Descartes, Université Paris Sorbonne Paris Cité, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>INSERM, Laboratoire de Physiopathologie des Maladies Psychiatriques, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Laboratoire de Physiopathologie des Maladies Psychiatriques, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>CNRS, GDR3557-Institut de Psychiatrie, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, GDR3557-Institut de Psychiatrie, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Faculté de Médecine Paris Descartes, Centre Hospitalier Sainte-Anne, Service Hospitalo-Universitaire, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Faculté de Médecine Paris Descartes, Centre Hospitalier Sainte-Anne, Service Hospitalo-Universitaire, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Chayet, Melanie" sort="Chayet, Melanie" uniqKey="Chayet M" first="Mélanie" last="Chayet">Mélanie Chayet</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Faculté de Médecine Paris Descartes, Centre Hospitalier Sainte-Anne, Service Hospitalo-Universitaire, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Faculté de Médecine Paris Descartes, Centre Hospitalier Sainte-Anne, Service Hospitalo-Universitaire, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Millet, Bruno" sort="Millet, Bruno" uniqKey="Millet B" first="Bruno" last="Millet">Bruno Millet</name><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Department of Adults Psychiatry, ICM-A-IHU, UPMC UMR S 975, Inserm U 1127, CNRS UMR 7225, GH Pitié-Salpêtrière, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Adults Psychiatry, ICM-A-IHU, UPMC UMR S 975, Inserm U 1127, CNRS UMR 7225, GH Pitié-Salpêtrière, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Jaafari, Nematollah" sort="Jaafari, Nematollah" uniqKey="Jaafari N" first="Nematollah" last="Jaafari">Nematollah Jaafari</name><affiliation wicri:level="1"><nlm:aff id="aff006"><addr-line>Unité de Recherche Clinique en Psychiatrie Pierre Deniker, Centre Hospitalier Henri Laborit, INSERM CIC-P 1402, INSERM U 1084 Laboratoire Expérimental et Clinique en Neurosciences, Univ Poitiers, CHU Poitiers, Groupement De Recherche CNRS 3557, Poitiers, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité de Recherche Clinique en Psychiatrie Pierre Deniker, Centre Hospitalier Henri Laborit, INSERM CIC-P 1402, INSERM U 1084 Laboratoire Expérimental et Clinique en Neurosciences, Univ Poitiers, CHU Poitiers, Groupement De Recherche CNRS 3557, Poitiers</wicri:regionArea></affiliation></author><author><name sortKey="Barhdadi, Amina" sort="Barhdadi, Amina" uniqKey="Barhdadi A" first="Amina" last="Barhdadi">Amina Barhdadi</name><affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Université de Montréal, Beaulieu-Saucier Pharmacogenomics Center, Montréal Heart Institute, Montréal, QC, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Université de Montréal, Beaulieu-Saucier Pharmacogenomics Center, Montréal Heart Institute, Montréal, QC</wicri:regionArea></affiliation></author><author><name sortKey="Lemieux Perreault, Louis Philippe" sort="Lemieux Perreault, Louis Philippe" uniqKey="Lemieux Perreault L" first="Louis-Philippe" last="Lemieux Perreault">Louis-Philippe Lemieux Perreault</name><affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Université de Montréal, Beaulieu-Saucier Pharmacogenomics Center, Montréal Heart Institute, Montréal, QC, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Université de Montréal, Beaulieu-Saucier Pharmacogenomics Center, Montréal Heart Institute, Montréal, QC</wicri:regionArea></affiliation></author><author><name sortKey="Provost, Sylvie" sort="Provost, Sylvie" uniqKey="Provost S" first="Sylvie" last="Provost">Sylvie Provost</name><affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Université de Montréal, Beaulieu-Saucier Pharmacogenomics Center, Montréal Heart Institute, Montréal, QC, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Université de Montréal, Beaulieu-Saucier Pharmacogenomics Center, Montréal Heart Institute, Montréal, QC</wicri:regionArea></affiliation></author><author><name sortKey="Dube, Marie Pierre" sort="Dube, Marie Pierre" uniqKey="Dube M" first="Marie-Pierre" last="Dubé">Marie-Pierre Dubé</name><affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Université de Montréal, Beaulieu-Saucier Pharmacogenomics Center, Montréal Heart Institute, Montréal, QC, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Université de Montréal, Beaulieu-Saucier Pharmacogenomics Center, Montréal Heart Institute, Montréal, QC</wicri:regionArea></affiliation></author><author><name sortKey="Gaillard, Raphael" sort="Gaillard, Raphael" uniqKey="Gaillard R" first="Raphaël" last="Gaillard">Raphaël Gaillard</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Université Paris Descartes, Université Paris Sorbonne Paris Cité, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Descartes, Université Paris Sorbonne Paris Cité, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>INSERM, Laboratoire de Physiopathologie des Maladies Psychiatriques, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Laboratoire de Physiopathologie des Maladies Psychiatriques, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>CNRS, GDR3557-Institut de Psychiatrie, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, GDR3557-Institut de Psychiatrie, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Faculté de Médecine Paris Descartes, Centre Hospitalier Sainte-Anne, Service Hospitalo-Universitaire, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Faculté de Médecine Paris Descartes, Centre Hospitalier Sainte-Anne, Service Hospitalo-Universitaire, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Krebs, Marie Odile" sort="Krebs, Marie Odile" uniqKey="Krebs M" first="Marie-Odile" last="Krebs">Marie-Odile Krebs</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Université Paris Descartes, Université Paris Sorbonne Paris Cité, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Descartes, Université Paris Sorbonne Paris Cité, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>INSERM, Laboratoire de Physiopathologie des Maladies Psychiatriques, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Laboratoire de Physiopathologie des Maladies Psychiatriques, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>CNRS, GDR3557-Institut de Psychiatrie, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, GDR3557-Institut de Psychiatrie, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Faculté de Médecine Paris Descartes, Centre Hospitalier Sainte-Anne, Service Hospitalo-Universitaire, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Faculté de Médecine Paris Descartes, Centre Hospitalier Sainte-Anne, Service Hospitalo-Universitaire, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Kebir, Oussama" sort="Kebir, Oussama" uniqKey="Kebir O" first="Oussama" last="Kebir">Oussama Kebir</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Université Paris Descartes, Université Paris Sorbonne Paris Cité, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Descartes, Université Paris Sorbonne Paris Cité, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>INSERM, Laboratoire de Physiopathologie des Maladies Psychiatriques, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Laboratoire de Physiopathologie des Maladies Psychiatriques, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>CNRS, GDR3557-Institut de Psychiatrie, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, GDR3557-Institut de Psychiatrie, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Faculté de Médecine Paris Descartes, Centre Hospitalier Sainte-Anne, Service Hospitalo-Universitaire, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Faculté de Médecine Paris Descartes, Centre Hospitalier Sainte-Anne, Service Hospitalo-Universitaire, Paris</wicri:regionArea></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Background</title><p>In the Western world, between 1940 and 1970, more than 2 million people were exposed <italic>in utero</italic> to diethylstilbestrol (DES). In exposed individuals, and in their descendants, adverse outcomes have been linked to such exposure, including cancers, genital malformations, and less consistently, psychiatric disorders. We aimed to explore whether prenatal DES exposure would be associated with DNA methylation changes, and whether these epigenetic modifications would be associated with increased risk of psychosis.</p></sec><sec id="sec002"><title>Methods</title><p>From 247 individuals born from mothers exposed to DES, we selected 69 siblings from 30 families. In each family, at least one sibling was exposed in utero to DES. We performed a methylome-wide association study using HumanMethylation450 DNA Analysis BeadChip® in peripheral blood. We analyzed methylation changes at individual CpGs or regions in exposed (n = 37) versus unexposed individuals (n = 32). We also compared exposed individuals with (n = 7) and without psychosis (n = 30).</p></sec><sec id="sec003"><title>Results</title><p>There were more individuals with schizophrenia in the DES-exposed group. We found no significant differences between exposed and unexposed individuals with respect to differentially methylated CpGs or regions. The largest difference was in a region near the promoter of an ADAMTS proteoglycanase gene (<italic>ADAMTS9</italic>). Compared to exposed individuals without psychosis, exposed individuals with psychosis had differential methylation in the region encompassing the gene encoding the zinc finger protein 57 (<italic>ZFP57</italic>).</p></sec><sec id="sec004"><title>Conclusions</title><p><italic>In utero</italic> exposure to DES was not associated with methylation changes at specific CpG or regions. In exposed individuals, however, psychosis was associated with specific methylomic modifications that could impact neurodevelopment and neuroplasticity.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Smith, Ow" uniqKey="Smith O">OW Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Herbst, Al" uniqKey="Herbst A">AL Herbst</name></author><author><name sortKey="Scully, Re" uniqKey="Scully R">RE Scully</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoover, Rn" uniqKey="Hoover R">RN Hoover</name></author><author><name sortKey="Hyer, M" uniqKey="Hyer M">M Hyer</name></author><author><name sortKey="Pfeiffer, Rm" uniqKey="Pfeiffer R">RM Pfeiffer</name></author><author><name sortKey="Adam, E" uniqKey="Adam E">E Adam</name></author><author><name sortKey="Bond, B" uniqKey="Bond B">B Bond</name></author><author><name sortKey="Cheville, Al" uniqKey="Cheville A">AL Cheville</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Whitehead, Ed" uniqKey="Whitehead E">ED Whitehead</name></author><author><name sortKey="Leiter, E" uniqKey="Leiter E">E Leiter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brouwers, Mm" uniqKey="Brouwers M">MM Brouwers</name></author><author><name sortKey="Feitz, Wfj" uniqKey="Feitz W">WFJ Feitz</name></author><author><name sortKey="Roelofs, L A J" uniqKey="Roelofs L">L a. J Roelofs</name></author><author><name sortKey="Kiemeney, L A Lm" uniqKey="Kiemeney L">L a. LM Kiemeney</name></author><author><name sortKey="De Gier, Rpe" uniqKey="De Gier R">RPE de Gier</name></author><author><name sortKey="Roeleveld, N" uniqKey="Roeleveld N">N Roeleveld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klip, H" uniqKey="Klip H">H Klip</name></author><author><name sortKey="Verloop, J" uniqKey="Verloop J">J Verloop</name></author><author><name sortKey="Van Gool, Jd" uniqKey="Van Gool J">JD van Gool</name></author><author><name sortKey="Koster, Meta" uniqKey="Koster M">META Koster</name></author><author><name sortKey="Burger, Cw" uniqKey="Burger C">CW Burger</name></author><author><name sortKey="Van Leeuwen, Fe" uniqKey="Van Leeuwen F">FE van Leeuwen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tournaire, M" uniqKey="Tournaire M">M Tournaire</name></author><author><name sortKey="Epelboin, S" uniqKey="Epelboin S">S Epelboin</name></author><author><name sortKey="Devouche, E" uniqKey="Devouche E">E Devouche</name></author><author><name sortKey="Viot, G" uniqKey="Viot G">G Viot</name></author><author><name sortKey="Le Bidois, J" uniqKey="Le Bidois J">J Le Bidois</name></author><author><name sortKey="Cabau, A" uniqKey="Cabau A">A Cabau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kebir, O" uniqKey="Kebir O">O Kebir</name></author><author><name sortKey="Krebs, M O" uniqKey="Krebs M">M-O Krebs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Hamilton, Kj" uniqKey="Hamilton K">KJ Hamilton</name></author><author><name sortKey="Lai, Ay" uniqKey="Lai A">AY Lai</name></author><author><name sortKey="Burns, Ka" uniqKey="Burns K">KA Burns</name></author><author><name sortKey="Li, L" uniqKey="Li L">L Li</name></author><author><name sortKey="Wade, Pa" uniqKey="Wade P">PA Wade</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bromer, Jg" uniqKey="Bromer J">JG Bromer</name></author><author><name sortKey="Wu, J" uniqKey="Wu J">J Wu</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author><author><name sortKey="Taylor, Hs" uniqKey="Taylor H">HS Taylor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haddad, R" uniqKey="Haddad R">R Haddad</name></author><author><name sortKey="Kasneci, A" uniqKey="Kasneci A">A Kasneci</name></author><author><name sortKey="Mepham, K" uniqKey="Mepham K">K Mepham</name></author><author><name sortKey="Sebag, Ia" uniqKey="Sebag I">IA Sebag</name></author><author><name sortKey="Chalifour, Le" uniqKey="Chalifour L">LE Chalifour</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sato, K" uniqKey="Sato K">K Sato</name></author><author><name sortKey="Fukata, H" uniqKey="Fukata H">H Fukata</name></author><author><name sortKey="Kogo, Y" uniqKey="Kogo Y">Y Kogo</name></author><author><name sortKey="Ohgane, J" uniqKey="Ohgane J">J Ohgane</name></author><author><name sortKey="Shiota, K" uniqKey="Shiota K">K Shiota</name></author><author><name sortKey="Mori, C" uniqKey="Mori C">C Mori</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harlid, S" uniqKey="Harlid S">S Harlid</name></author><author><name sortKey="Xu, Z" uniqKey="Xu Z">Z Xu</name></author><author><name sortKey="Panduri, V" uniqKey="Panduri V">V Panduri</name></author><author><name sortKey="D Loisio, Aa" uniqKey="D Loisio A">AA D’Aloisio</name></author><author><name sortKey="Deroo, La" uniqKey="Deroo L">LA DeRoo</name></author><author><name sortKey="Sandler, Dp" uniqKey="Sandler D">DP Sandler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bimonte, Ha" uniqKey="Bimonte H">HA Bimonte</name></author><author><name sortKey="Denenberg, Vh" uniqKey="Denenberg V">VH Denenberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Castilhos, J" uniqKey="De Castilhos J">J de Castilhos</name></author><author><name sortKey="Hermel, Ees" uniqKey="Hermel E">EES Hermel</name></author><author><name sortKey="Rasia Filho, Aa" uniqKey="Rasia Filho A">AA Rasia-Filho</name></author><author><name sortKey="Achaval, M" uniqKey="Achaval M">M Achaval</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bridges, Rs" uniqKey="Bridges R">RS Bridges</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kubo, K" uniqKey="Kubo K">K Kubo</name></author><author><name sortKey="Arai, O" uniqKey="Arai O">O Arai</name></author><author><name sortKey="Omura, M" uniqKey="Omura M">M Omura</name></author><author><name sortKey="Watanabe, R" uniqKey="Watanabe R">R Watanabe</name></author><author><name sortKey="Ogata, R" uniqKey="Ogata R">R Ogata</name></author><author><name sortKey="Aou, S" uniqKey="Aou S">S Aou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hines, M" uniqKey="Hines M">M Hines</name></author><author><name sortKey="Alsum, P" uniqKey="Alsum P">P Alsum</name></author><author><name sortKey="Roy, M" uniqKey="Roy M">M Roy</name></author><author><name sortKey="Gorski, Ra" uniqKey="Gorski R">RA Gorski</name></author><author><name sortKey="Goy, Rw" uniqKey="Goy R">RW Goy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Palanza, P" uniqKey="Palanza P">P Palanza</name></author><author><name sortKey="Parmigiani, S" uniqKey="Parmigiani S">S Parmigiani</name></author><author><name sortKey="Liu, H" uniqKey="Liu H">H Liu</name></author><author><name sortKey="Vom Saal, Fs" uniqKey="Vom Saal F">FS vom Saal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Okada, N" uniqKey="Okada N">N Okada</name></author><author><name sortKey="Fukunaga, M" uniqKey="Fukunaga M">M Fukunaga</name></author><author><name sortKey="Yamashita, F" uniqKey="Yamashita F">F Yamashita</name></author><author><name sortKey="Koshiyama, D" uniqKey="Koshiyama D">D Koshiyama</name></author><author><name sortKey="Yamamori, H" uniqKey="Yamamori H">H Yamamori</name></author><author><name sortKey="Ohi, K" uniqKey="Ohi K">K Ohi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dempster, E" uniqKey="Dempster E">E Dempster</name></author><author><name sortKey="Viana, J" uniqKey="Viana J">J Viana</name></author><author><name sortKey="Pidsley, R" uniqKey="Pidsley R">R Pidsley</name></author><author><name sortKey="Mill, J" uniqKey="Mill J">J Mill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Labrie, V" uniqKey="Labrie V">V Labrie</name></author><author><name sortKey="Pai, S" uniqKey="Pai S">S Pai</name></author><author><name sortKey="Petronis, A" uniqKey="Petronis A">A Petronis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kebir, O" uniqKey="Kebir O">O Kebir</name></author><author><name sortKey="Chaumette, B" uniqKey="Chaumette B">B Chaumette</name></author><author><name sortKey="Rivollier, F" uniqKey="Rivollier F">F Rivollier</name></author><author><name sortKey="Miozzo, F" uniqKey="Miozzo F">F Miozzo</name></author><author><name sortKey="Lemieux Perreault, Lp" uniqKey="Lemieux Perreault L">LP Lemieux Perreault</name></author><author><name sortKey="Barhdadi, A" uniqKey="Barhdadi A">A Barhdadi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aberg, Ka" uniqKey="Aberg K">KA Aberg</name></author><author><name sortKey="Mcclay, Jl" uniqKey="Mcclay J">JL McClay</name></author><author><name sortKey="Nerella, S" uniqKey="Nerella S">S Nerella</name></author><author><name sortKey="Clark, S" uniqKey="Clark S">S Clark</name></author><author><name sortKey="Kumar, G" uniqKey="Kumar G">G Kumar</name></author><author><name sortKey="Chen, W" uniqKey="Chen W">W Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Slotkin, Ta" uniqKey="Slotkin T">TA Slotkin</name></author><author><name sortKey="Seidler, Fj" uniqKey="Seidler F">FJ Seidler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zuo, X" uniqKey="Zuo X">X Zuo</name></author><author><name sortKey="Sheng, J" uniqKey="Sheng J">J Sheng</name></author><author><name sortKey="Lau, H T" uniqKey="Lau H">H-T Lau</name></author><author><name sortKey="Mcdonald, Cm" uniqKey="Mcdonald C">CM McDonald</name></author><author><name sortKey="Andrade, M" uniqKey="Andrade M">M Andrade</name></author><author><name sortKey="Cullen, De" uniqKey="Cullen D">DE Cullen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Braun, Jm" uniqKey="Braun J">JM Braun</name></author><author><name sortKey="Yolton, K" uniqKey="Yolton K">K Yolton</name></author><author><name sortKey="Dietrich, Kn" uniqKey="Dietrich K">KN Dietrich</name></author><author><name sortKey="Hornung, R" uniqKey="Hornung R">R Hornung</name></author><author><name sortKey="Ye, X" uniqKey="Ye X">X Ye</name></author><author><name sortKey="Calafat, Am" uniqKey="Calafat A">AM Calafat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Winneke, G" uniqKey="Winneke G">G Winneke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ricceri, L" uniqKey="Ricceri L">L Ricceri</name></author><author><name sortKey="Venerosi, A" uniqKey="Venerosi A">A Venerosi</name></author><author><name sortKey="Capone, F" uniqKey="Capone F">F Capone</name></author><author><name sortKey="Cometa, Mf" uniqKey="Cometa M">MF Cometa</name></author><author><name sortKey="Lorenzini, P" uniqKey="Lorenzini P">P Lorenzini</name></author><author><name sortKey="Fortuna, S" uniqKey="Fortuna S">S Fortuna</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, X" uniqKey="Xu X">X Xu</name></author><author><name sortKey="Tian, D" uniqKey="Tian D">D Tian</name></author><author><name sortKey="Hong, X" uniqKey="Hong X">X Hong</name></author><author><name sortKey="Chen, L" uniqKey="Chen L">L Chen</name></author><author><name sortKey="Xie, L" uniqKey="Xie L">L Xie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, X" uniqKey="Xu X">X Xu</name></author><author><name sortKey="Dong, F" uniqKey="Dong F">F Dong</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Wang, R" uniqKey="Wang R">R Wang</name></author><author><name sortKey="Shen, X" uniqKey="Shen X">X Shen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wolfsberg, Tg" uniqKey="Wolfsberg T">TG Wolfsberg</name></author><author><name sortKey="Straight, Pd" uniqKey="Straight P">PD Straight</name></author><author><name sortKey="Gerena, Rl" uniqKey="Gerena R">RL Gerena</name></author><author><name sortKey="Huovila, Ap" uniqKey="Huovila A">AP Huovila</name></author><author><name sortKey="Primakoff, P" uniqKey="Primakoff P">P Primakoff</name></author><author><name sortKey="Myles, Dg" uniqKey="Myles D">DG Myles</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clark, Me" uniqKey="Clark M">ME Clark</name></author><author><name sortKey="Kelner, Gs" uniqKey="Kelner G">GS Kelner</name></author><author><name sortKey="Turbeville, La" uniqKey="Turbeville L">LA Turbeville</name></author><author><name sortKey="Boyer, A" uniqKey="Boyer A">A Boyer</name></author><author><name sortKey="Arden, Kc" uniqKey="Arden K">KC Arden</name></author><author><name sortKey="Maki, Ra" uniqKey="Maki R">RA Maki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shindo, T" uniqKey="Shindo T">T Shindo</name></author><author><name sortKey="Kurihara, H" uniqKey="Kurihara H">H Kurihara</name></author><author><name sortKey="Kuno, K" uniqKey="Kuno K">K Kuno</name></author><author><name sortKey="Yokoyama, H" uniqKey="Yokoyama H">H Yokoyama</name></author><author><name sortKey="Wada, T" uniqKey="Wada T">T Wada</name></author><author><name sortKey="Kurihara, Y" uniqKey="Kurihara Y">Y Kurihara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mittaz, L" uniqKey="Mittaz L">L Mittaz</name></author><author><name sortKey="Russell, Dl" uniqKey="Russell D">DL Russell</name></author><author><name sortKey="Wilson, T" uniqKey="Wilson T">T Wilson</name></author><author><name sortKey="Brasted, M" uniqKey="Brasted M">M Brasted</name></author><author><name sortKey="Tkalcevic, J" uniqKey="Tkalcevic J">J Tkalcevic</name></author><author><name sortKey="Salamonsen, La" uniqKey="Salamonsen L">LA Salamonsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, C" uniqKey="Zhang C">C Zhang</name></author><author><name sortKey="Shao, Y" uniqKey="Shao Y">Y Shao</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author><author><name sortKey="Wu, Q" uniqKey="Wu Q">Q Wu</name></author><author><name sortKey="Yang, H" uniqKey="Yang H">H Yang</name></author><author><name sortKey="Zhong, Q" uniqKey="Zhong Q">Q Zhong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lemarchant, S" uniqKey="Lemarchant S">S Lemarchant</name></author><author><name sortKey="Pruvost, M" uniqKey="Pruvost M">M Pruvost</name></author><author><name sortKey="Montaner, J" uniqKey="Montaner J">J Montaner</name></author><author><name sortKey="Emery, E" uniqKey="Emery E">E Emery</name></author><author><name sortKey="Vivien, D" uniqKey="Vivien D">D Vivien</name></author><author><name sortKey="Kanninen, K" uniqKey="Kanninen K">K Kanninen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ogiue Ikeda, M" uniqKey="Ogiue Ikeda M">M Ogiue-Ikeda</name></author><author><name sortKey="Tanabe, N" uniqKey="Tanabe N">N Tanabe</name></author><author><name sortKey="Mukai, H" uniqKey="Mukai H">H Mukai</name></author><author><name sortKey="Hojo, Y" uniqKey="Hojo Y">Y Hojo</name></author><author><name sortKey="Murakami, G" uniqKey="Murakami G">G Murakami</name></author><author><name sortKey="Tsurugizawa, T" uniqKey="Tsurugizawa T">T Tsurugizawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kawato, S" uniqKey="Kawato S">S Kawato</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Okazaki, S" uniqKey="Okazaki S">S Okazaki</name></author><author><name sortKey="Tanase, S" uniqKey="Tanase S">S Tanase</name></author><author><name sortKey="Choudhury, Bk" uniqKey="Choudhury B">BK Choudhury</name></author><author><name sortKey="Setoyama, K" uniqKey="Setoyama K">K Setoyama</name></author><author><name sortKey="Miura, R" uniqKey="Miura R">R Miura</name></author><author><name sortKey="Ogawa, M" uniqKey="Ogawa M">M Ogawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, X" uniqKey="Li X">X Li</name></author><author><name sortKey="Ito, M" uniqKey="Ito M">M Ito</name></author><author><name sortKey="Zhou, F" uniqKey="Zhou F">F Zhou</name></author><author><name sortKey="Youngson, N" uniqKey="Youngson N">N Youngson</name></author><author><name sortKey="Zuo, X" uniqKey="Zuo X">X Zuo</name></author><author><name sortKey="Leder, P" uniqKey="Leder P">P Leder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Quenneville, S" uniqKey="Quenneville S">S Quenneville</name></author><author><name sortKey="Verde, G" uniqKey="Verde G">G Verde</name></author><author><name sortKey="Corsinotti, A" uniqKey="Corsinotti A">A Corsinotti</name></author><author><name sortKey="Kapopoulou, A" uniqKey="Kapopoulou A">A Kapopoulou</name></author><author><name sortKey="Jakobsson, J" uniqKey="Jakobsson J">J Jakobsson</name></author><author><name sortKey="Offner, S" uniqKey="Offner S">S Offner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Plant, K" uniqKey="Plant K">K Plant</name></author><author><name sortKey="Fairfax, Bp" uniqKey="Fairfax B">BP Fairfax</name></author><author><name sortKey="Makino, S" uniqKey="Makino S">S Makino</name></author><author><name sortKey="Vandiedonck, C" uniqKey="Vandiedonck C">C Vandiedonck</name></author><author><name sortKey="Radhakrishnan, J" uniqKey="Radhakrishnan J">J Radhakrishnan</name></author><author><name sortKey="Knight, Jc" uniqKey="Knight J">JC Knight</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Amarasekera, M" uniqKey="Amarasekera M">M Amarasekera</name></author><author><name sortKey="Martino, D" uniqKey="Martino D">D Martino</name></author><author><name sortKey="Ashley, S" uniqKey="Ashley S">S Ashley</name></author><author><name sortKey="Harb, H" uniqKey="Harb H">H Harb</name></author><author><name sortKey="Kesper, D" uniqKey="Kesper D">D Kesper</name></author><author><name sortKey="Strickland, D" uniqKey="Strickland D">D Strickland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ovsyannikova, Ig" uniqKey="Ovsyannikova I">IG Ovsyannikova</name></author><author><name sortKey="Salk, Hm" uniqKey="Salk H">HM Salk</name></author><author><name sortKey="Larrabee, Br" uniqKey="Larrabee B">BR Larrabee</name></author><author><name sortKey="Pankratz, Vs" uniqKey="Pankratz V">VS Pankratz</name></author><author><name sortKey="Poland, Ga" uniqKey="Poland G">GA Poland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cirillo, A" uniqKey="Cirillo A">A Cirillo</name></author><author><name sortKey="Di Salle, A" uniqKey="Di Salle A">A Di Salle</name></author><author><name sortKey="Petillo, O" uniqKey="Petillo O">O Petillo</name></author><author><name sortKey="Melone, Mab" uniqKey="Melone M">MAB Melone</name></author><author><name sortKey="Grimaldi, G" uniqKey="Grimaldi G">G Grimaldi</name></author><author><name sortKey="Bellotti, A" uniqKey="Bellotti A">A Bellotti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ladd Acosta, C" uniqKey="Ladd Acosta C">C Ladd-Acosta</name></author><author><name sortKey="Hansen, Kd" uniqKey="Hansen K">KD Hansen</name></author><author><name sortKey="Briem, E" uniqKey="Briem E">E Briem</name></author><author><name sortKey="Fallin, Md" uniqKey="Fallin M">MD Fallin</name></author><author><name sortKey="Kaufmann, We" uniqKey="Kaufmann W">WE Kaufmann</name></author><author><name sortKey="Feinberg, Ap" uniqKey="Feinberg A">AP Feinberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rapoport, J" uniqKey="Rapoport J">J Rapoport</name></author><author><name sortKey="Chavez, A" uniqKey="Chavez A">A Chavez</name></author><author><name sortKey="Greenstein, D" uniqKey="Greenstein D">D Greenstein</name></author><author><name sortKey="Addington, A" uniqKey="Addington A">A Addington</name></author><author><name sortKey="Gogtay, N" uniqKey="Gogtay N">N Gogtay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chisholm, K" uniqKey="Chisholm K">K Chisholm</name></author><author><name sortKey="Lin, A" uniqKey="Lin A">A Lin</name></author><author><name sortKey="Abu Akel, A" uniqKey="Abu Akel A">A Abu-Akel</name></author><author><name sortKey="Wood, Sj" uniqKey="Wood S">SJ Wood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aberg, Ka" uniqKey="Aberg K">KA Aberg</name></author><author><name sortKey="Xie, Ly" uniqKey="Xie L">LY Xie</name></author><author><name sortKey="Mcclay, Jl" uniqKey="Mcclay J">JL McClay</name></author><author><name sortKey="Nerella, S" uniqKey="Nerella S">S Nerella</name></author><author><name sortKey="Vunck, S" uniqKey="Vunck S">S Vunck</name></author><author><name sortKey="Snider, S" uniqKey="Snider S">S Snider</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Masliah, E" uniqKey="Masliah E">E Masliah</name></author><author><name sortKey="Dumaop, W" uniqKey="Dumaop W">W Dumaop</name></author><author><name sortKey="Galasko, D" uniqKey="Galasko D">D Galasko</name></author><author><name sortKey="Desplats, P" uniqKey="Desplats P">P Desplats</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kaminsky, Z" uniqKey="Kaminsky Z">Z Kaminsky</name></author><author><name sortKey="Tochigi, M" uniqKey="Tochigi M">M Tochigi</name></author><author><name sortKey="Jia, P" uniqKey="Jia P">P Jia</name></author><author><name sortKey="Pal, M" uniqKey="Pal M">M Pal</name></author><author><name sortKey="Mill, J" uniqKey="Mill J">J Mill</name></author><author><name sortKey="Kwan, A" uniqKey="Kwan A">A Kwan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dempster, El" uniqKey="Dempster E">EL Dempster</name></author><author><name sortKey="Pidsley, R" uniqKey="Pidsley R">R Pidsley</name></author><author><name sortKey="Schalkwyk, Lc" uniqKey="Schalkwyk L">LC Schalkwyk</name></author><author><name sortKey="Owens, S" uniqKey="Owens S">S Owens</name></author><author><name sortKey="Georgiades, A" uniqKey="Georgiades A">A Georgiades</name></author><author><name sortKey="Kane, F" uniqKey="Kane F">F Kane</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, CA USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28406917</article-id><article-id pub-id-type="pmc">5390994</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0174783</article-id><article-id pub-id-type="publisher-id">PONE-D-16-44532</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and life sciences</subject><subj-group><subject>Cell biology</subject><subj-group><subject>Chromosome biology</subject><subj-group><subject>Chromatin</subject><subj-group><subject>Chromatin modification</subject><subj-group><subject>DNA methylation</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and life sciences</subject><subj-group><subject>Genetics</subject><subj-group><subject>Epigenetics</subject><subj-group><subject>Chromatin</subject><subj-group><subject>Chromatin modification</subject><subj-group><subject>DNA methylation</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and life sciences</subject><subj-group><subject>Genetics</subject><subj-group><subject>Gene expression</subject><subj-group><subject>Chromatin</subject><subj-group><subject>Chromatin modification</subject><subj-group><subject>DNA methylation</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and life sciences</subject><subj-group><subject>Genetics</subject><subj-group><subject>DNA</subject><subj-group><subject>DNA modification</subject><subj-group><subject>DNA methylation</subject></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and life sciences</subject><subj-group><subject>Biochemistry</subject><subj-group><subject>Nucleic acids</subject><subj-group><subject>DNA</subject><subj-group><subject>DNA modification</subject><subj-group><subject>DNA methylation</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and life sciences</subject><subj-group><subject>Genetics</subject><subj-group><subject>Epigenetics</subject><subj-group><subject>DNA modification</subject><subj-group><subject>DNA methylation</subject></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and life sciences</subject><subj-group><subject>Genetics</subject><subj-group><subject>Gene expression</subject><subj-group><subject>DNA modification</subject><subj-group><subject>DNA methylation</subject></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Mental Health and Psychiatry</subject><subj-group><subject>Psychoses</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Research and Analysis Methods</subject><subj-group><subject>Specimen Preparation and Treatment</subject><subj-group><subject>Mechanical Treatment of Specimens</subject><subj-group><subject>Specimen Disruption</subject><subj-group><subject>Chemical Disruption</subject></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Anatomy</subject><subj-group><subject>Body Fluids</subject><subj-group><subject>Blood</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Anatomy</subject><subj-group><subject>Body Fluids</subject><subj-group><subject>Blood</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Physiology</subject><subj-group><subject>Body Fluids</subject><subj-group><subject>Blood</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Physiology</subject><subj-group><subject>Body Fluids</subject><subj-group><subject>Blood</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Health Care</subject><subj-group><subject>Health Care Policy</subject><subj-group><subject>Treatment Guidelines</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Genetics</subject><subj-group><subject>Epigenetics</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Mental Health and Psychiatry</subject><subj-group><subject>Schizophrenia</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Developmental Biology</subject><subj-group><subject>Morphogenesis</subject><subj-group><subject>Neurodevelopment</subject></subj-group></subj-group></subj-group></subj-group></article-categories><title-group><article-title>Methylomic changes in individuals with psychosis, prenatally exposed to endocrine disrupting compounds: Lessons from diethylstilbestrol</article-title><alt-title alt-title-type="running-head">Methylomic changes in individuals prenatally exposed to diethylstilbestrol</alt-title></title-group><contrib-group><contrib contrib-type="author"><contrib-id authenticated="true" contrib-id-type="orcid">http://orcid.org/0000-0001-5805-0770</contrib-id><name><surname>Rivollier</surname><given-names>Fabrice</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref><xref ref-type="aff" rid="aff002"><sup>2</sup></xref><xref ref-type="aff" rid="aff003"><sup>3</sup></xref><xref ref-type="aff" rid="aff004"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chaumette</surname><given-names>Boris</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref><xref ref-type="aff" rid="aff002"><sup>2</sup></xref><xref ref-type="aff" rid="aff003"><sup>3</sup></xref><xref ref-type="aff" rid="aff004"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bendjemaa</surname><given-names>Narjes</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref><xref ref-type="aff" rid="aff002"><sup>2</sup></xref><xref ref-type="aff" rid="aff003"><sup>3</sup></xref><xref ref-type="aff" rid="aff004"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chayet</surname><given-names>Mélanie</given-names></name><xref ref-type="aff" rid="aff004"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Millet</surname><given-names>Bruno</given-names></name><xref ref-type="aff" rid="aff005"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jaafari</surname><given-names>Nematollah</given-names></name><xref ref-type="aff" rid="aff006"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Barhdadi</surname><given-names>Amina</given-names></name><xref ref-type="aff" rid="aff007"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lemieux Perreault</surname><given-names>Louis-Philippe</given-names></name><xref ref-type="aff" rid="aff007"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Provost</surname><given-names>Sylvie</given-names></name><xref ref-type="aff" rid="aff007"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Dubé</surname><given-names>Marie-Pierre</given-names></name><xref ref-type="aff" rid="aff007"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gaillard</surname><given-names>Raphaël</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref><xref ref-type="aff" rid="aff002"><sup>2</sup></xref><xref ref-type="aff" rid="aff003"><sup>3</sup></xref><xref ref-type="aff" rid="aff004"><sup>4</sup></xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Krebs</surname><given-names>Marie-Odile</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref><xref ref-type="aff" rid="aff002"><sup>2</sup></xref><xref ref-type="aff" rid="aff003"><sup>3</sup></xref><xref ref-type="aff" rid="aff004"><sup>4</sup></xref><xref ref-type="corresp" rid="cor001">*</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Kebir</surname><given-names>Oussama</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref><xref ref-type="aff" rid="aff002"><sup>2</sup></xref><xref ref-type="aff" rid="aff003"><sup>3</sup></xref><xref ref-type="aff" rid="aff004"><sup>4</sup></xref></contrib></contrib-group><aff id="aff001"><label>1</label><addr-line>Université Paris Descartes, Université Paris Sorbonne Paris Cité, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris, France</addr-line></aff><aff id="aff002"><label>2</label><addr-line>INSERM, Laboratoire de Physiopathologie des Maladies Psychiatriques, Centre de Psychiatrie et Neurosciences, UMR S 894, Paris, France</addr-line></aff><aff id="aff003"><label>3</label><addr-line>CNRS, GDR3557-Institut de Psychiatrie, Paris, France</addr-line></aff><aff id="aff004"><label>4</label><addr-line>Faculté de Médecine Paris Descartes, Centre Hospitalier Sainte-Anne, Service Hospitalo-Universitaire, Paris, France</addr-line></aff><aff id="aff005"><label>5</label><addr-line>Department of Adults Psychiatry, ICM-A-IHU, UPMC UMR S 975, Inserm U 1127, CNRS UMR 7225, GH Pitié-Salpêtrière, Paris, France</addr-line></aff><aff id="aff006"><label>6</label><addr-line>Unité de Recherche Clinique en Psychiatrie Pierre Deniker, Centre Hospitalier Henri Laborit, INSERM CIC-P 1402, INSERM U 1084 Laboratoire Expérimental et Clinique en Neurosciences, Univ Poitiers, CHU Poitiers, Groupement De Recherche CNRS 3557, Poitiers, France</addr-line></aff><aff id="aff007"><label>7</label><addr-line>Université de Montréal, Beaulieu-Saucier Pharmacogenomics Center, Montréal Heart Institute, Montréal, QC, Canada</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Chaudhuri</surname><given-names>Gautam</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>Meharry Medical College, UNITED STATES</addr-line></aff><author-notes><fn fn-type="COI-statement" id="coi001"><p><bold>Competing Interests: </bold>The authors have declared that no competing interests exist.</p></fn><fn fn-type="con"><p><list list-type="simple"><list-item><p><bold>Conceptualization:</bold> MOK OK.</p></list-item><list-item><p><bold>Data curation:</bold> FR BC MC NB BM NJ SP OK.</p></list-item><list-item><p><bold>Formal analysis:</bold> FR BC.</p></list-item><list-item><p><bold>Funding acquisition:</bold> BM NJ RG MOK OK.</p></list-item><list-item><p><bold>Investigation:</bold> FR MC NB BM NJ OK.</p></list-item><list-item><p><bold>Methodology:</bold> MC NB AB MPD MOK OK.</p></list-item><list-item><p><bold>Project administration:</bold> MOK.</p></list-item><list-item><p><bold>Resources:</bold> BM NJ RG MOK.</p></list-item><list-item><p><bold>Software:</bold> BC SP LPLP.</p></list-item><list-item><p><bold>Supervision:</bold> MPD MOK OK.</p></list-item><list-item><p><bold>Validation:</bold> MOK OK.</p></list-item><list-item><p><bold>Visualization:</bold> FR BC AB.</p></list-item><list-item><p><bold>Writing – original draft:</bold> FR BC MOK OK.</p></list-item><list-item><p><bold>Writing – review & editing:</bold> FR MOK OK.</p></list-item></list></p></fn><corresp id="cor001">* E-mail: <email>marie-odile.krebs@inserm.fr</email></corresp></author-notes><pub-date pub-type="epub"><day>13</day><month>4</month><year>2017</year></pub-date><pub-date pub-type="collection"><year>2017</year></pub-date><volume>12</volume><issue>4</issue><elocation-id>e0174783</elocation-id><history><date date-type="received"><day>9</day><month>11</month><year>2016</year></date><date date-type="accepted"><day>15</day><month>3</month><year>2017</year></date></history><permissions><copyright-statement>© 2017 Rivollier et al</copyright-statement><copyright-year>2017</copyright-year><copyright-holder>Rivollier et al</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="pone.0174783.pdf"></self-uri><abstract><sec id="sec001"><title>Background</title><p>In the Western world, between 1940 and 1970, more than 2 million people were exposed <italic>in utero</italic> to diethylstilbestrol (DES). In exposed individuals, and in their descendants, adverse outcomes have been linked to such exposure, including cancers, genital malformations, and less consistently, psychiatric disorders. We aimed to explore whether prenatal DES exposure would be associated with DNA methylation changes, and whether these epigenetic modifications would be associated with increased risk of psychosis.</p></sec><sec id="sec002"><title>Methods</title><p>From 247 individuals born from mothers exposed to DES, we selected 69 siblings from 30 families. In each family, at least one sibling was exposed in utero to DES. We performed a methylome-wide association study using HumanMethylation450 DNA Analysis BeadChip® in peripheral blood. We analyzed methylation changes at individual CpGs or regions in exposed (n = 37) versus unexposed individuals (n = 32). We also compared exposed individuals with (n = 7) and without psychosis (n = 30).</p></sec><sec id="sec003"><title>Results</title><p>There were more individuals with schizophrenia in the DES-exposed group. We found no significant differences between exposed and unexposed individuals with respect to differentially methylated CpGs or regions. The largest difference was in a region near the promoter of an ADAMTS proteoglycanase gene (<italic>ADAMTS9</italic>). Compared to exposed individuals without psychosis, exposed individuals with psychosis had differential methylation in the region encompassing the gene encoding the zinc finger protein 57 (<italic>ZFP57</italic>).</p></sec><sec id="sec004"><title>Conclusions</title><p><italic>In utero</italic> exposure to DES was not associated with methylation changes at specific CpG or regions. In exposed individuals, however, psychosis was associated with specific methylomic modifications that could impact neurodevelopment and neuroplasticity.</p></sec></abstract><funding-group><award-group id="award001"><funding-source><institution-wrap><institution-id institution-id-type="funder-id">http://dx.doi.org/10.13039/501100001665</institution-id><institution>Agence Nationale de la Recherche</institution></institution-wrap></funding-source><award-id>08-MNP-007</award-id></award-group><funding-statement>This work was supported by the French Governement Agence Nationale pour la Recherche grant (ANR, 08-MNP-007) and by a competitive grant from Ile-de-France, Partenariat institutions-citoyens pour la recherche et l'innovation (PICRI 2007). The Institut National de la Santé et de la Recherche Médicale (INSERM) promoted the study. Additional financial support was obtained from Université Paris Descartes (recurrent funding), Fondation Deniker and Fonds Québécois de Recherche sur la Société et la Culture-INSERM joint grant (Marie-Odile KREBS, Oussama KEBIR). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement></funding-group><counts><fig-count count="0"></fig-count><table-count count="3"></table-count><page-count count="12"></page-count></counts><custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name><meta-value>This work was supported by the French Governement Agence Nationale pour la Recherche grant (ANR, 08-MNP-007) and by a competitive grant from Ile-de-France, Partenariat institutions-citoyens pour la recherche et l'innovation (PICRI 2007). The Institut National de la Santé et de la Recherche Médicale (INSERM) promoted the study. Additional financial support was obtained from Université Paris Descartes (recurrent funding), Fondation Deniker and Fonds Québécois de Recherche sur la Société et la Culture-INSERM joint grant (Marie-Odile KREBS, Oussama KEBIR). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</meta-value></custom-meta></custom-meta-group></article-meta><notes><title>Data Availability</title><p>This work was supported by the French Governement Agence Nationale pour la Recherche grant (ANR, 08-MNP-007) and by a competitive grant from Ile-de-France, Partenariat institutions-citoyens pour la recherche et l'innovation (PICRI 2007). The Institut National de la Santé et de la Recherche Médicale (INSERM) promoted the study. Additional financial support was obtained from Université Paris Descartes (recurrent funding), Fondation Deniker and Fonds Québécois de Recherche sur la Société et la Culture-INSERM joint grant (Marie-Odile KREBS, Oussama KEBIR). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</p></notes></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A79 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000A79 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Pmc
|étape= Curation
|type= RBID
|clé= PMC:5390994
|texte= Methylomic changes in individuals with psychosis, prenatally exposed to endocrine disrupting compounds: Lessons from diethylstilbestrol
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:28406917" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |