Preliminary evidence for human globus pallidus pars interna neurons signaling reward and sensory stimuli
Identifieur interne : 000A57 ( Pmc/Curation ); précédent : 000A56; suivant : 000A58Preliminary evidence for human globus pallidus pars interna neurons signaling reward and sensory stimuli
Auteurs : Nicholas A. Howell [Canada] ; Ian A. Prescott [Canada] ; Andres M. Lozano [Canada] ; Mojgan Hodaie [Canada] ; Valerie Voon [Royaume-Uni] ; William D. Hutchison [Canada]Source :
- Neuroscience [ 0306-4522 ] ; 2016.
Abstract
Non-motor responses of human GPi neurons are described. Cells were identified that showed increased firing to reward-stimuli. Visual-sensory responses unrelated to reward also observed.
Url:
DOI: 10.1016/j.neuroscience.2016.04.020
PubMed: 27109924
PubMed Central: 4884665
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Hutchison</name><affiliation wicri:level="1"><nlm:aff id="af005">Institute of Medical Science, Faculty of Medicine, University of Toronto, 1 King’s College Circle, Toronto, Ontario M5S1A8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Institute of Medical Science, Faculty of Medicine, University of Toronto, 1 King’s College Circle, Toronto, Ontario M5S1A8</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af010">Division of Brain Imaging & Behaviour – Systems Neuroscience, Toronto Western Research Institute, University Health Network, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Brain Imaging & Behaviour – Systems Neuroscience, Toronto Western Research Institute, University Health Network, 399 Bathurst Street, Toronto, Ontario M5T 2S8</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af015">Department of Physiology, Faculty of Medicine, University of Toronto, 1 King’s College Circle, Toronto, Ontario M5S 1A8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Physiology, Faculty of Medicine, University of Toronto, 1 King’s College Circle, Toronto, Ontario M5S 1A8</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af020">Division of Neurosurgery, Department of Surgery, Krembil Neuroscience Center, University of Toronto, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurosurgery, Department of Surgery, Krembil Neuroscience Center, University of Toronto, 399 Bathurst Street, Toronto, Ontario M5T 2S8</wicri:regionArea></affiliation></author></analytic><series><title level="j">Neuroscience</title><idno type="ISSN">0306-4522</idno><idno type="eISSN">1873-7544</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple"><list-item id="o0005"><label>•</label><p>Non-motor responses of human GPi neurons are described.</p></list-item><list-item id="o0010"><label>•</label><p>Cells were identified that showed increased firing to reward-stimuli.</p></list-item><list-item id="o0015"><label>•</label><p>Visual-sensory responses unrelated to reward also observed.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Aarsland, D" uniqKey="Aarsland D">D. Aarsland</name></author><author><name sortKey="P Hlhagen, S" uniqKey="P Hlhagen S">S. Påhlhagen</name></author><author><name sortKey="Ballard, C G" uniqKey="Ballard C">C.G. Ballard</name></author><author><name sortKey="Ehrt, U" uniqKey="Ehrt U">U. Ehrt</name></author><author><name sortKey="Svenningsson, P" uniqKey="Svenningsson P">P. Svenningsson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Adam, R" uniqKey="Adam R">R. Adam</name></author><author><name sortKey="Leff, A" uniqKey="Leff A">A. Leff</name></author><author><name sortKey="Sinha, N" uniqKey="Sinha N">N. Sinha</name></author><author><name sortKey="Turner, C" uniqKey="Turner C">C. Turner</name></author><author><name sortKey="Bays, P" uniqKey="Bays P">P. Bays</name></author><author><name sortKey="Draganski, B" uniqKey="Draganski B">B. Draganski</name></author><author><name sortKey="Husain, M" uniqKey="Husain M">M. Husain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aldridge, J W" uniqKey="Aldridge J">J.W. Aldridge</name></author><author><name sortKey="Anderson, R J" uniqKey="Anderson R">R.J. Anderson</name></author><author><name sortKey="Murphy, J T" uniqKey="Murphy J">J.T. Murphy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alexander, G E" uniqKey="Alexander G">G.E. Alexander</name></author><author><name sortKey="Delong, M R" uniqKey="Delong M">M.R. DeLong</name></author><author><name sortKey="Strick, P L" uniqKey="Strick P">P.L. Strick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Apicella, P" uniqKey="Apicella P">P. Apicella</name></author><author><name sortKey="Scarnati, E" uniqKey="Scarnati E">E. Scarnati</name></author><author><name sortKey="Ljungberg, T" uniqKey="Ljungberg T">T. Ljungberg</name></author><author><name sortKey="Schultz, W" uniqKey="Schultz W">W. Schultz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arimura, N" uniqKey="Arimura N">N. Arimura</name></author><author><name sortKey="Nakayama, Y" uniqKey="Nakayama Y">Y. Nakayama</name></author><author><name sortKey="Yamagata, T" uniqKey="Yamagata T">T. Yamagata</name></author><author><name sortKey="Tanji, J" uniqKey="Tanji J">J. Tanji</name></author><author><name sortKey="Hoshi, E" uniqKey="Hoshi E">E. Hoshi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bechtereva, N P" uniqKey="Bechtereva N">N.P. Bechtereva</name></author><author><name sortKey="Kropotov, J D" uniqKey="Kropotov J">J.D. Kropotov</name></author><author><name sortKey="Etlinger, S C" uniqKey="Etlinger S">S.C. Etlinger</name></author><author><name sortKey="Ponomarev, V A" uniqKey="Ponomarev V">V.A. Ponomarev</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berridge, K C" uniqKey="Berridge K">K.C. Berridge</name></author><author><name sortKey="Robinson, T E" uniqKey="Robinson T">T.E. Robinson</name></author><author><name sortKey="Aldridge, J W" uniqKey="Aldridge J">J.W. Aldridge</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bhatia, K P" uniqKey="Bhatia K">K.P. Bhatia</name></author><author><name sortKey="Marsden, C D" uniqKey="Marsden C">C.D. Marsden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bischoff Grethe, A" uniqKey="Bischoff Grethe A">A. Bischoff-Grethe</name></author><author><name sortKey="Buxton, R B" uniqKey="Buxton R">R.B. Buxton</name></author><author><name sortKey="Paulus, M P" uniqKey="Paulus M">M.P. Paulus</name></author><author><name sortKey="Fleisher, A S" uniqKey="Fleisher A">A.S. Fleisher</name></author><author><name sortKey="Yang, T T" uniqKey="Yang T">T.T. Yang</name></author><author><name sortKey="Brown, G G" uniqKey="Brown G">G.G. Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bromberg Martin, E S" uniqKey="Bromberg Martin E">E.S. Bromberg-Martin</name></author><author><name sortKey="Matsumoto, M" uniqKey="Matsumoto M">M. Matsumoto</name></author><author><name sortKey="Hikosaka, O" uniqKey="Hikosaka O">O. Hikosaka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bromberg Martin, E S" uniqKey="Bromberg Martin E">E.S. Bromberg-Martin</name></author><author><name sortKey="Matsumoto, M" uniqKey="Matsumoto M">M. Matsumoto</name></author><author><name sortKey="Hong, S" uniqKey="Hong S">S. Hong</name></author><author><name sortKey="Hikosaka, O" uniqKey="Hikosaka O">O. Hikosaka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Delong, M R" uniqKey="Delong M">M.R. DeLong</name></author><author><name sortKey="Wichmann, T" uniqKey="Wichmann T">T. Wichmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eshel, N" uniqKey="Eshel N">N. Eshel</name></author><author><name sortKey="Roiser, J P" uniqKey="Roiser J">J.P. Roiser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gdowski, M J" uniqKey="Gdowski M">M.J. Gdowski</name></author><author><name sortKey="Miller, L E" uniqKey="Miller L">L.E. Miller</name></author><author><name sortKey="Parrish, T" uniqKey="Parrish T">T. Parrish</name></author><author><name sortKey="Nenonene, E K" uniqKey="Nenonene E">E.K. Nenonene</name></author><author><name sortKey="Houk, J C" uniqKey="Houk J">J.C. Houk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haber, S N" uniqKey="Haber S">S.N. Haber</name></author><author><name sortKey="Knutson, B" uniqKey="Knutson B">B. Knutson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haber, S N" uniqKey="Haber S">S.N. Haber</name></author><author><name sortKey="Lynd, E" uniqKey="Lynd E">E. Lynd</name></author><author><name sortKey="Klein, C" uniqKey="Klein C">C. Klein</name></author><author><name sortKey="Groenewegen, H J" uniqKey="Groenewegen H">H.J. Groenewegen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hong, S" uniqKey="Hong S">S. Hong</name></author><author><name sortKey="Hikosaka, O" uniqKey="Hikosaka O">O. Hikosaka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hong, S" uniqKey="Hong S">S. Hong</name></author><author><name sortKey="Jhou, T C" uniqKey="Jhou T">T.C. Jhou</name></author><author><name sortKey="Smith, M" uniqKey="Smith M">M. Smith</name></author><author><name sortKey="Saleem, K S" uniqKey="Saleem K">K.S. Saleem</name></author><author><name sortKey="Hikosaka, O" uniqKey="Hikosaka O">O. Hikosaka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoover, J E" uniqKey="Hoover J">J.E. Hoover</name></author><author><name sortKey="Strick, P L" uniqKey="Strick P">P.L. Strick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoshi, E" uniqKey="Hoshi E">E. Hoshi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hutchison, W D" uniqKey="Hutchison W">W.D. Hutchison</name></author><author><name sortKey="Lang, A E" uniqKey="Lang A">A.E. Lang</name></author><author><name sortKey="Dostrovsky, J O" uniqKey="Dostrovsky J">J.O. Dostrovsky</name></author><author><name sortKey="Lozano, A M" uniqKey="Lozano A">A.M. Lozano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hutchison, W D" uniqKey="Hutchison W">W.D. Hutchison</name></author><author><name sortKey="Lozano, A M" uniqKey="Lozano A">A.M. Lozano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ide, J S" uniqKey="Ide J">J.S. Ide</name></author><author><name sortKey="Li, C S R" uniqKey="Li C">C.-S.R. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jorge, R E" uniqKey="Jorge R">R.E. Jorge</name></author><author><name sortKey="Starkstein, S E" uniqKey="Starkstein S">S.E. Starkstein</name></author><author><name sortKey="Robinson, R G" uniqKey="Robinson R">R.G. Robinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Joshua, M" uniqKey="Joshua M">M. Joshua</name></author><author><name sortKey="Adler, A" uniqKey="Adler A">A. Adler</name></author><author><name sortKey="Rosin, B" uniqKey="Rosin B">B. Rosin</name></author><author><name sortKey="Vaadia, E" uniqKey="Vaadia E">E. Vaadia</name></author><author><name sortKey="Bergman, H" uniqKey="Bergman H">H. Bergman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, H F" uniqKey="Kim H">H.F. Kim</name></author><author><name sortKey="Hikosaka, O" uniqKey="Hikosaka O">O. Hikosaka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Knutson, B" uniqKey="Knutson B">B. Knutson</name></author><author><name sortKey="Westdorp, A" uniqKey="Westdorp A">A. Westdorp</name></author><author><name sortKey="Kaiser, E" uniqKey="Kaiser E">E. Kaiser</name></author><author><name sortKey="Hommer, D" uniqKey="Hommer D">D. Hommer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Levy, R" uniqKey="Levy R">R. Levy</name></author><author><name sortKey="Lozano, A M" uniqKey="Lozano A">A.M. Lozano</name></author><author><name sortKey="Hutchison, W D" uniqKey="Hutchison W">W.D. Hutchison</name></author><author><name sortKey="Dostrovsky, J O" uniqKey="Dostrovsky J">J.O. Dostrovsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lombardi, W J" uniqKey="Lombardi W">W.J. Lombardi</name></author><author><name sortKey="Gross, R E" uniqKey="Gross R">R.E. Gross</name></author><author><name sortKey="Trepanier, L L" uniqKey="Trepanier L">L.L. Trepanier</name></author><author><name sortKey="Lang, A E" uniqKey="Lang A">A.E. Lang</name></author><author><name sortKey="Lozano, A M" uniqKey="Lozano A">A.M. Lozano</name></author><author><name sortKey="Saint Cyr, J A" uniqKey="Saint Cyr J">J.A. Saint-Cyr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Middleton, F A" uniqKey="Middleton F">F.A. Middleton</name></author><author><name sortKey="Strick, P L" uniqKey="Strick P">P.L. Strick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Middleton, F A" uniqKey="Middleton F">F.A. Middleton</name></author><author><name sortKey="Strick, P L" uniqKey="Strick P">P.L. Strick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miller, J M" uniqKey="Miller J">J.M. Miller</name></author><author><name sortKey="Vorel, S R" uniqKey="Vorel S">S.R. Vorel</name></author><author><name sortKey="Tranguch, A J" uniqKey="Tranguch A">A.J. Tranguch</name></author><author><name sortKey="Kenny, E T" uniqKey="Kenny E">E.T. Kenny</name></author><author><name sortKey="Mazzoni, P" uniqKey="Mazzoni P">P. Mazzoni</name></author><author><name sortKey="Van Gorp, W G" uniqKey="Van Gorp W">W.G. van Gorp</name></author><author><name sortKey="Kleber, H D" uniqKey="Kleber H">H.D. Kleber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mirenowicz, J" uniqKey="Mirenowicz J">J. Mirenowicz</name></author><author><name sortKey="Schultz, W" uniqKey="Schultz W">W. Schultz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mushiake, H" uniqKey="Mushiake H">H. Mushiake</name></author><author><name sortKey="Strick, P L" uniqKey="Strick P">P.L. Strick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pagonabarraga, J" uniqKey="Pagonabarraga J">J. Pagonabarraga</name></author><author><name sortKey="Kulisevsky, J" uniqKey="Kulisevsky J">J. Kulisevsky</name></author><author><name sortKey="Strafella, A P" uniqKey="Strafella A">A.P. Strafella</name></author><author><name sortKey="Krack, P" uniqKey="Krack P">P. Krack</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parent, A" uniqKey="Parent A">A. Parent</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parent, A" uniqKey="Parent A">A. Parent</name></author><author><name sortKey="Hazrati, L N" uniqKey="Hazrati L">L.N. Hazrati</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parent, M" uniqKey="Parent M">M. Parent</name></author><author><name sortKey="Levesque, M" uniqKey="Levesque M">M. Lévesque</name></author><author><name sortKey="Parent, A" uniqKey="Parent A">A. Parent</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pasquereau, B" uniqKey="Pasquereau B">B. Pasquereau</name></author><author><name sortKey="Nadjar, A" uniqKey="Nadjar A">A. Nadjar</name></author><author><name sortKey="Arkadir, D" uniqKey="Arkadir D">D. Arkadir</name></author><author><name sortKey="Bezard, E" uniqKey="Bezard E">E. Bezard</name></author><author><name sortKey="Goillandeau, M" uniqKey="Goillandeau M">M. Goillandeau</name></author><author><name sortKey="Bioulac, B" uniqKey="Bioulac B">B. Bioulac</name></author><author><name sortKey="Gross, C E" uniqKey="Gross C">C.E. Gross</name></author><author><name sortKey="Boraud, T" uniqKey="Boraud T">T. Boraud</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prescott, I A" uniqKey="Prescott I">I.A. Prescott</name></author><author><name sortKey="Liu, L D" uniqKey="Liu L">L.D. Liu</name></author><author><name sortKey="Dostrovsky, J O" uniqKey="Dostrovsky J">J.O. Dostrovsky</name></author><author><name sortKey="Hodaie, M" uniqKey="Hodaie M">M. Hodaie</name></author><author><name sortKey="Lozano, A M" uniqKey="Lozano A">A.M. Lozano</name></author><author><name sortKey="Hutchison, W D" uniqKey="Hutchison W">W.D. Hutchison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reijnders, J S A M" uniqKey="Reijnders J">J.S.A.M. Reijnders</name></author><author><name sortKey="Ehrt, U" uniqKey="Ehrt U">U. Ehrt</name></author><author><name sortKey="Weber, W E J" uniqKey="Weber W">W.E.J. Weber</name></author><author><name sortKey="Aarsland, D" uniqKey="Aarsland D">D. Aarsland</name></author><author><name sortKey="Leentjens, A F G" uniqKey="Leentjens A">A.F.G. Leentjens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schroll, H" uniqKey="Schroll H">H. Schroll</name></author><author><name sortKey="Horn, A" uniqKey="Horn A">A. Horn</name></author><author><name sortKey="Groschel, C" uniqKey="Groschel C">C. Gröschel</name></author><author><name sortKey="Brucke, C" uniqKey="Brucke C">C. Brücke</name></author><author><name sortKey="Lutjens, G" uniqKey="Lutjens G">G. Lütjens</name></author><author><name sortKey="Schneider, G H" uniqKey="Schneider G">G.-H. Schneider</name></author><author><name sortKey="Krauss, J K" uniqKey="Krauss J">J.K. Krauss</name></author><author><name sortKey="Kuhn, A A" uniqKey="Kuhn A">A.A. Kühn</name></author><author><name sortKey="Hamker, F H" uniqKey="Hamker F">F.H. Hamker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schultz, W" uniqKey="Schultz W">W. Schultz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schultz, W" uniqKey="Schultz W">W. Schultz</name></author><author><name sortKey="Dayan, P" uniqKey="Dayan P">P. Dayan</name></author><author><name sortKey="Montague, P R" uniqKey="Montague P">P.R. Montague</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scott, R B" uniqKey="Scott R">R.B. Scott</name></author><author><name sortKey="Harrison, J" uniqKey="Harrison J">J. Harrison</name></author><author><name sortKey="Boulton, C" uniqKey="Boulton C">C. Boulton</name></author><author><name sortKey="Wilson, J" uniqKey="Wilson J">J. Wilson</name></author><author><name sortKey="Gregory, R" uniqKey="Gregory R">R. Gregory</name></author><author><name sortKey="Parkin, S" uniqKey="Parkin S">S. Parkin</name></author><author><name sortKey="Bain, P G" uniqKey="Bain P">P.G. Bain</name></author><author><name sortKey="Joint, C" uniqKey="Joint C">C. Joint</name></author><author><name sortKey="Stein, J" uniqKey="Stein J">J. Stein</name></author><author><name sortKey="Aziz, T Z" uniqKey="Aziz T">T.Z. Aziz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shin, S" uniqKey="Shin S">S. Shin</name></author><author><name sortKey="Sommer, M A" uniqKey="Sommer M">M.A. Sommer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Strub, R L" uniqKey="Strub R">R.L. Strub</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tachibana, Y" uniqKey="Tachibana Y">Y. Tachibana</name></author><author><name sortKey="Hikosaka, O" uniqKey="Hikosaka O">O. Hikosaka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Turner, R S" uniqKey="Turner R">R.S. Turner</name></author><author><name sortKey="Desmurget, M" uniqKey="Desmurget M">M. Desmurget</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vidailhet, M" uniqKey="Vidailhet M">M. Vidailhet</name></author><author><name sortKey="Vercueil, L" uniqKey="Vercueil L">L. Vercueil</name></author><author><name sortKey="Houeto, J L" uniqKey="Houeto J">J.-L. Houeto</name></author><author><name sortKey="Krystkowiak, P" uniqKey="Krystkowiak P">P. Krystkowiak</name></author><author><name sortKey="Benabid, A L" uniqKey="Benabid A">A.-L. Benabid</name></author><author><name sortKey="Cornu, P" uniqKey="Cornu P">P. Cornu</name></author><author><name sortKey="Lagrange, C" uniqKey="Lagrange C">C. Lagrange</name></author><author><name sortKey="Tezenas Du Montcel, S" uniqKey="Tezenas Du Montcel S">S. Tézenas du Montcel</name></author><author><name sortKey="Dormont, D" uniqKey="Dormont D">D. Dormont</name></author><author><name sortKey="Grand, S" uniqKey="Grand S">S. Grand</name></author><author><name sortKey="Blond, S" uniqKey="Blond S">S. Blond</name></author><author><name sortKey="Detante, O" uniqKey="Detante O">O. Detante</name></author><author><name sortKey="Pillon, B" uniqKey="Pillon B">B. Pillon</name></author><author><name sortKey="Ardouin, C" uniqKey="Ardouin C">C. Ardouin</name></author><author><name sortKey="Agid, Y" uniqKey="Agid Y">Y. Agid</name></author><author><name sortKey="Destee, A" uniqKey="Destee A">A. Destée</name></author><author><name sortKey="Pollak, P" uniqKey="Pollak P">P. Pollak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vijayaraghavan, L" uniqKey="Vijayaraghavan L">L. Vijayaraghavan</name></author><author><name sortKey="Krishnamoorthy, E S" uniqKey="Krishnamoorthy E">E.S. Krishnamoorthy</name></author><author><name sortKey="Brown, R G" uniqKey="Brown R">R.G. Brown</name></author><author><name sortKey="Trimble, M R" uniqKey="Trimble M">M.R. Trimble</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vijayaraghavan, L" uniqKey="Vijayaraghavan L">L. Vijayaraghavan</name></author><author><name sortKey="Vaidya, J G" uniqKey="Vaidya J">J.G. Vaidya</name></author><author><name sortKey="Humphreys, C T" uniqKey="Humphreys C">C.T. Humphreys</name></author><author><name sortKey="Beglinger, L J" uniqKey="Beglinger L">L.J. Beglinger</name></author><author><name sortKey="Paradiso, S" uniqKey="Paradiso S">S. Paradiso</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vitek, J L" uniqKey="Vitek J">J.L. Vitek</name></author><author><name sortKey="Bakay, R A" uniqKey="Bakay R">R.A. Bakay</name></author><author><name sortKey="Hashimoto, T" uniqKey="Hashimoto T">T. Hashimoto</name></author><author><name sortKey="Kaneoke, Y" uniqKey="Kaneoke Y">Y. Kaneoke</name></author><author><name sortKey="Mewes, K" uniqKey="Mewes K">K. Mewes</name></author><author><name sortKey="Zhang, J Y" uniqKey="Zhang J">J.Y. Zhang</name></author><author><name sortKey="Rye, D" uniqKey="Rye D">D. Rye</name></author><author><name sortKey="Starr, P" uniqKey="Starr P">P. Starr</name></author><author><name sortKey="Baron, M" uniqKey="Baron M">M. Baron</name></author><author><name sortKey="Turner, R" uniqKey="Turner R">R. Turner</name></author><author><name sortKey="Delong, M R" uniqKey="Delong M">M.R. DeLong</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Neuroscience</journal-id><journal-id journal-id-type="iso-abbrev">Neuroscience</journal-id><journal-title-group><journal-title>Neuroscience</journal-title></journal-title-group><issn pub-type="ppub">0306-4522</issn><issn pub-type="epub">1873-7544</issn><publisher><publisher-name>Elsevier Science</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27109924</article-id><article-id pub-id-type="pmc">4884665</article-id><article-id pub-id-type="publisher-id">S0306-4522(16)30085-9</article-id><article-id pub-id-type="doi">10.1016/j.neuroscience.2016.04.020</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Preliminary evidence for human globus pallidus pars interna neurons signaling reward and sensory stimuli</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Howell</surname><given-names>Nicholas A.</given-names></name><xref rid="af005" ref-type="aff">a</xref><xref rid="af010" ref-type="aff">b</xref></contrib><contrib contrib-type="author"><name><surname>Prescott</surname><given-names>Ian A.</given-names></name><xref rid="af010" ref-type="aff">b</xref><xref rid="af015" ref-type="aff">c</xref></contrib><contrib contrib-type="author"><name><surname>Lozano</surname><given-names>Andres M.</given-names></name><xref rid="af010" ref-type="aff">b</xref><xref rid="af020" ref-type="aff">d</xref></contrib><contrib contrib-type="author"><name><surname>Hodaie</surname><given-names>Mojgan</given-names></name><xref rid="af005" ref-type="aff">a</xref><xref rid="af010" ref-type="aff">b</xref><xref rid="af020" ref-type="aff">d</xref></contrib><contrib contrib-type="author"><name><surname>Voon</surname><given-names>Valerie</given-names></name><xref rid="af025" ref-type="aff">e</xref><xref rid="af030" ref-type="aff">f</xref><xref rid="af035" ref-type="aff">g</xref><xref rid="fn1" ref-type="fn">†</xref></contrib><contrib contrib-type="author"><name><surname>Hutchison</surname><given-names>William D.</given-names></name><email>whutch@uhnres.utoronto.ca</email><xref rid="af005" ref-type="aff">a</xref><xref rid="af010" ref-type="aff">b</xref><xref rid="af015" ref-type="aff">c</xref><xref rid="af020" ref-type="aff">d</xref><xref rid="cor1" ref-type="corresp">⁎</xref><xref rid="fn1" ref-type="fn">†</xref></contrib></contrib-group><aff id="af005"><label>a</label>Institute of Medical Science, Faculty of Medicine, University of Toronto, 1 King’s College Circle, Toronto, Ontario M5S1A8, Canada</aff><aff id="af010"><label>b</label>Division of Brain Imaging & Behaviour – Systems Neuroscience, Toronto Western Research Institute, University Health Network, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada</aff><aff id="af015"><label>c</label>Department of Physiology, Faculty of Medicine, University of Toronto, 1 King’s College Circle, Toronto, Ontario M5S 1A8, Canada</aff><aff id="af020"><label>d</label>Division of Neurosurgery, Department of Surgery, Krembil Neuroscience Center, University of Toronto, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada</aff><aff id="af025"><label>e</label>Department of Psychiatry, University of Cambridge, Herchel Smith Building for Brain & Mind Sciences, Cambridge CB2 0SZ, UK</aff><aff id="af030"><label>f</label>Behavioural and Clinical Neurosciences Institute, University of Cambridge, Sir William Hardy Building, Downing Street, Cambridge CB2 3EB, UK</aff><aff id="af035"><label>g</label>Cambridgeshire and Peterborough NHS Foundation Trust, Fulbourn Hospital, Cambridge CB21 5EF, UK</aff><author-notes><corresp id="cor1"><label>⁎</label>Correspondence to: W. D. Hutchison, Toronto Western Research Institute, 399 Bathurst Street, MP11-308, Toronto, Ontario M5T 2S8, Canada.Toronto Western Research Institute399 Bathurst StreetMP11-308TorontoOntarioM5T 2S8Canada <email>whutch@uhnres.utoronto.ca</email></corresp><fn id="fn1"><label>†</label><p id="np005">These authors contributed equally to the work.</p></fn></author-notes><pub-date pub-type="pmc-release"><day>22</day><month>7</month><year>2016</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><day>22</day><month>7</month><year>2016</year></pub-date><volume>328</volume><fpage>30</fpage><lpage>39</lpage><history><date date-type="accepted"><day>14</day><month>4</month><year>2016</year></date></history><permissions><copyright-statement>© 2016 The Author(s)</copyright-statement><copyright-year>2016</copyright-year><license license-type="CC BY" xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).</license-p></license></permissions><abstract abstract-type="author-highlights" id="ab005"><title>Highlights</title><p><list list-type="simple"><list-item id="o0005"><label>•</label><p>Non-motor responses of human GPi neurons are described.</p></list-item><list-item id="o0010"><label>•</label><p>Cells were identified that showed increased firing to reward-stimuli.</p></list-item><list-item id="o0015"><label>•</label><p>Visual-sensory responses unrelated to reward also observed.</p></list-item></list></p></abstract><abstract id="ab010"><p>The globus pallidus pars interna (GPi) is a component of the basal ganglia, a network of subcortical nuclei that process motor, associative, and limbic information. While non-human primate studies have suggested a role for the GPi in non-motor functions, there have been no single-unit studies of non-motor electrophysiological behavior of human GPi neurons. We therefore sought to extend these findings by collecting single-unit recordings from awake patients during functional stereotactic neurosurgery targeting the GPi for deep brain stimulation. To assess cellular responses to non-motor information, patients performed a reward task where virtual money could be won, lost, or neither, depending on their performance while cellular activity was monitored. Changes in the firing rates of isolated GPi neurons after the presentation of reward-related stimuli were compared between different reward contingencies (win, loss, null). We observed neurons that modulated their firing rate significantly to the presentation of reward-related stimuli. We furthermore found neurons that responded to visual-stimuli more broadly. This is the first single-unit evidence of human GPi neurons carrying non-motor information. These results are broadly consistent with previous findings in the animal literature and suggest non-motor information may be represented in the single-unit activity of human GPi neurons.</p></abstract><kwd-group id="kg005"><title>Abbreviations</title><kwd>BG, basal ganglia</kwd><kwd>CD, cervical dystonia</kwd><kwd>DBS, deep brain stimulation</kwd><kwd><sc>l</sc>-Dopa, levodopa</kwd><kwd>GPi, globus pallidus pars interna</kwd><kwd>PD, Parkinson disease</kwd></kwd-group><kwd-group id="kg010"><title>Key words</title><kwd>globus pallidus pars interna</kwd><kwd>reward</kwd><kwd>sensory</kwd><kwd>electrophysiology</kwd><kwd>basal ganglia</kwd><kwd>human neuroscience</kwd></kwd-group></article-meta></front><floats-group><fig id="f0005"><label>Fig. 1</label><caption><p>Schematic of the behavioral task. (A) In win trials, a black circle is used as a cue. After the cue is displayed for a variable time, a lightning bolt symbol appears prompting the patient to button press. A fixation point is then displayed, followed by a feedback screen. If the reaction time was small enough, $1 is awarded, indicated by a picture of a one dollar coin (Canadian Dollar). Otherwise, no money is gained or lost, no picture is displayed, and the words “GO FASTER!!” appear. In both cases the net amount of money won or lost is displayed on the screen. (B and C) The process for the no-win and loss trials is the same, except for the differences in cue and outcomes possible. In the case of no-win trials, the outcome screen contains only the patient’s net amount of money for the experiment up to that point. For loss trials, fast reaction times only display net money and slow reaction times additionally display an image of a crossed one-dollar coin with the words “GO FASTER!!” displayed above. (D) The respective duration of each stimulus for one trial. Triggers are created by the software program at the beginning of the cue, lightning bolt, and outcome screen presentations as well as at the time of the button press.</p></caption><graphic xlink:href="gr1"></graphic></fig><fig id="f0010"><label>Fig. 2</label><caption><p>Reward responses of globus pallidus pars interna neurons. Reward-responsive globus pallidus pars interna neuron. The neuron depicted, recorded at +8.0 mm above target, phasically increased its firing rate after presentation of lose (red circle) compared to win trial-onset cues (black circle) (<italic>χ</italic><sup>2</sup><sub>(2)</sub> = 7.97, <italic>p</italic> = 0.02; Win vs. Loss <italic>Z</italic> <italic>=</italic> 2.36, <italic>p</italic> = 0.02; Null vs. Loss <italic>Z</italic> = −2.67, <italic>p</italic> = 0.01; Win vs. Null <italic>p</italic> > 0.05). Top: averaged accelerometer trace. Bottom: averaged firing rate histograms centered on cue presentation. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)</p></caption><graphic xlink:href="gr2"></graphic></fig><fig id="f0015"><label>Fig. 3</label><caption><p>Visual-sensory responses of globus pallidus pars interna neurons. Visual sensory cues elicited responses on similar time scales in GPi cells, although each neuron responded preferentially for a particular type of visual stimulus. The neuron depicted in (A), recorded at +3.4 mm above target, responded significantly more for movement cues compared to trial outcome cues (<italic>χ</italic><sup>2</sup><sub>(3)</sub> = 66.97, <italic>p</italic> < 0.0001; Baseline vs. Onset Cue <italic>Z</italic> = −6.55, <italic>p</italic> < 0.0001; Baseline vs. Movement Cue <italic>Z</italic> = −7.53, <italic>p</italic> < 0.0001; Baseline vs. Outcome Cue <italic>Z</italic> = −4.83, <italic>p</italic> < 0.0001). Responses were often biphasic excitation-inhibitions (e.g. A), but in one instance a phasic excitation (B). The neuron in (B), +2.2 mm above target, indicated a response for onset versus outcome (<italic>χ</italic><sup>2</sup><sub>(3)</sub> = 16.89, <italic>p</italic> < 0.001; Baseline vs. Onset Cue <italic>Z</italic> = −3.68, <italic>p</italic> < 0.001; Baseline vs. Movement Cue <italic>Z</italic> = −2.95, <italic>p</italic> = 0.01, Baseline vs. Outcome Cue <italic>Z</italic> = −1.13, <italic>p</italic> > 0.05; Onset Cue vs. Outcome Cue <italic>Z</italic> = −2.54, <italic>p</italic> = 0.02). Top: averaged accelerometer traces. Bottom: averaged firing rate histograms centered on stimulus presentation.</p></caption><graphic xlink:href="gr3"></graphic></fig><fig id="f0020"><label>Fig. 4</label><caption><p>Anatomical localization of task-responsive globus pallidus pars interna neurons. Reconstructed locations of neurons indicating significant responses to reward (square) or visual-sensory (diamond) information. Globus pallidus pars interna (GPi), globus pallidus pars externa (GPe), optic tract (OT). Sagittal section 20.0 mm lateral from midline.</p></caption><graphic xlink:href="gr4"></graphic></fig></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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