Rab5-family guanine nucleotide exchange factors bind retromer and promote its recruitment to endosomes
Identifieur interne : 000A32 ( Pmc/Curation ); précédent : 000A31; suivant : 000A33Rab5-family guanine nucleotide exchange factors bind retromer and promote its recruitment to endosomes
Auteurs : Bjorn D. M. Bean [Canada] ; Michael Davey [Canada] ; Jamie Snider [Canada] ; Matthew Jessulat [Canada] ; Viktor Deineko [Canada] ; Matthew Tinney [Canada] ; Igor Stagljar [Canada] ; Mohan Babu [Canada] ; Elizabeth Conibear [Canada]Source :
- Molecular Biology of the Cell [ 1059-1524 ] ; 2015.
Abstract
The retromer complex regulates vesicle transport at endosomes. Different members of the VPS9 domain–containing Rab5-family guanine nucleotide exchange factors interact with the yeast retromer complex and mediate its endosomal localization.
Url:
DOI: 10.1091/mbc.E14-08-1281
PubMed: 25609093
PubMed Central: 4357511
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xml:lang="fr">Canada</country><wicri:regionArea>Department of Biochemistry and Department of Molecular Genetics, University of Toronto, Toronto, ON M5S1A8</wicri:regionArea></affiliation></author><author><name sortKey="Babu, Mohan" sort="Babu, Mohan" uniqKey="Babu M" first="Mohan" last="Babu">Mohan Babu</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Biochemistry, Research and Innovation Centre, University of Regina, Regina, SK S4S 0A2, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Biochemistry, Research and Innovation Centre, University of Regina, Regina, SK S4S 0A2</wicri:regionArea></affiliation></author><author><name sortKey="Conibear, Elizabeth" sort="Conibear, Elizabeth" uniqKey="Conibear E" first="Elizabeth" last="Conibear">Elizabeth Conibear</name><affiliation wicri:level="1"><nlm:aff id="aff1">Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC V5Z 4H4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC V5Z 4H4</wicri:regionArea></affiliation></author></analytic><series><title level="j">Molecular Biology of the Cell</title><idno type="ISSN">1059-1524</idno><idno type="eISSN">1939-4586</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The retromer complex regulates vesicle transport at endosomes. Different members of the VPS9 domain–containing Rab5-family guanine nucleotide exchange factors interact with the yeast retromer complex and mediate its endosomal localization.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Attar, N" uniqKey="Attar N">N Attar</name></author><author><name sortKey="Cullen, Pj" uniqKey="Cullen P">PJ Cullen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Babu, M" uniqKey="Babu M">M Babu</name></author><author><name sortKey="Vlasblom, J" uniqKey="Vlasblom J">J Vlasblom</name></author><author><name sortKey="Pu, S" uniqKey="Pu S">S Pu</name></author><author><name sortKey="Guo, X" uniqKey="Guo X">X Guo</name></author><author><name sortKey="Graham, C" uniqKey="Graham C">C Graham</name></author><author><name sortKey="Bean, Bdm" uniqKey="Bean B">BDM Bean</name></author><author><name sortKey="Burston, He" uniqKey="Burston H">HE Burston</name></author><author><name 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Mol Biol Cell</journal-id><journal-id journal-id-type="iso-abbrev">Mol. Biol. Cell</journal-id><journal-id journal-id-type="hwp">molbiolcell</journal-id><journal-id journal-id-type="pmc">mbc</journal-id><journal-id journal-id-type="publisher-id">Mol. Bio. Cell</journal-id><journal-title-group><journal-title>Molecular Biology of the Cell</journal-title></journal-title-group><issn pub-type="ppub">1059-1524</issn><issn pub-type="epub">1939-4586</issn><publisher><publisher-name>The American Society for Cell Biology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25609093</article-id><article-id pub-id-type="pmc">4357511</article-id><article-id pub-id-type="publisher-id">E14-08-1281</article-id><article-id pub-id-type="doi">10.1091/mbc.E14-08-1281</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject><subj-group><subject>Membrane Trafficking</subject></subj-group></subj-group></article-categories><title-group><article-title>Rab5-family guanine nucleotide exchange factors bind retromer and promote its recruitment to endosomes</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Bean</surname><given-names>Bjorn D. M.</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Davey</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Snider</surname><given-names>Jamie</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jessulat</surname><given-names>Matthew</given-names></name><xref ref-type="aff" rid="aff4"><sup>d</sup></xref></contrib><contrib contrib-type="author"><name><surname>Deineko</surname><given-names>Viktor</given-names></name><xref ref-type="aff" rid="aff4"><sup>d</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tinney</surname><given-names>Matthew</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Stagljar</surname><given-names>Igor</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Babu</surname><given-names>Mohan</given-names></name><xref ref-type="aff" rid="aff4"><sup>d</sup></xref></contrib><contrib contrib-type="author"><name><surname>Conibear</surname><given-names>Elizabeth</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="corresp" rid="cor1"><sup>1</sup></xref></contrib><aff id="aff1"><sup>a</sup>Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC V5Z 4H4, Canada</aff><aff id="aff2"><sup>b</sup>Donnelly Centre, University of Toronto, Toronto, ON M5S3E1, Canada</aff><aff id="aff3"><sup>c</sup>Department of Biochemistry and Department of Molecular Genetics, University of Toronto, Toronto, ON M5S1A8, Canada</aff><aff id="aff4"><sup>d</sup>Department of Biochemistry, Research and Innovation Centre, University of Regina, Regina, SK S4S 0A2, Canada</aff></contrib-group><contrib-group><contrib contrib-type="editor"><name><surname>Lemmon</surname><given-names>Sandra</given-names></name><role>Monitoring Editor</role></contrib><aff>University of Miami</aff></contrib-group><author-notes><corresp id="cor1">Address correspondence to: Elizabeth Conibear (<email>conibear@cmmt.ubc.ca</email>).</corresp></author-notes><pub-date pub-type="ppub"><day>15</day><month>3</month><year>2015</year></pub-date><volume>26</volume><issue>6</issue><fpage>1119</fpage><lpage>1128</lpage><history><date date-type="received"><day>19</day><month>8</month><year>2014</year></date><date date-type="rev-recd"><day>15</day><month>12</month><year>2014</year></date><date date-type="accepted"><day>13</day><month>1</month><year>2015</year></date></history><permissions><copyright-statement>© 2015 Bean <italic>et al.</italic> This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0">http://creativecommons.org/licenses/by-nc-sa/3.0</ext-link>).</copyright-statement><copyright-year>2015</copyright-year><license license-type="creative-commons"><license-p>“ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.</license-p></license></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="1119.pdf"></self-uri><abstract abstract-type="precis"><p>The retromer complex regulates vesicle transport at endosomes. Different members of the VPS9 domain–containing Rab5-family guanine nucleotide exchange factors interact with the yeast retromer complex and mediate its endosomal localization.</p></abstract><abstract><p>The retromer complex facilitates the sorting of integral membrane proteins from the endosome to the late Golgi. In mammalian cells, the efficient recruitment of retromer to endosomes requires the lipid phosphatidylinositol 3-phosphate (PI3P) as well as Rab5 and Rab7 GTPases. However, in yeast, the role of Rabs in recruiting retromer to endosomes is less clear. We identified novel physical interactions between retromer and the <italic>Saccharomyces cerevisiae</italic> VPS9-domain Rab5-family guanine nucleotide exchange factors (GEFs) Muk1 and Vps9. Furthermore, we identified a new yeast VPS9 domain-containing protein, <underline>V</underline>A<underline>R</underline>P-<underline>l</underline>ike 1 (Vrl1), which is related to the human VARP protein. All three VPS9 domain–containing proteins show localization to endosomes, and the presence of any one of them is necessary for the endosomal recruitment of retromer. We find that expression of an active VPS9-domain protein is required for correct localization of the phosphatidylinositol 3-kinase Vps34 and the production of endosomal PI3P. These results suggest that VPS9 GEFs promote retromer recruitment by establishing PI3P-enriched domains at the endosomal membrane. The interaction of retromer with distinct VPS9 GEFs could thus link GEF-dependent regulatory inputs to the temporal or spatial coordination of retromer assembly or function.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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