Using a Virtual Cortical Module Implementing a Neural Field Model to Modulate Brain Rhythms in Parkinson's Disease
Identifieur interne : 000988 ( Pmc/Curation ); précédent : 000987; suivant : 000989Using a Virtual Cortical Module Implementing a Neural Field Model to Modulate Brain Rhythms in Parkinson's Disease
Auteurs : Julien Modolo [Canada] ; Basabdatta Bhattacharya [Royaume-Uni] ; Roderick Edwards [Canada] ; Julien Campagnaud [France] ; Alexandre Legros [Canada] ; Anne Beuter [France]Source :
- Frontiers in Neuroscience [ 1662-4548 ] ; 2010.
Abstract
We propose a new method for selective modulation of cortical rhythms based on neural field theory, in which the activity of a cortical area is extensively monitored using a two-dimensional microelectrode array. The example of Parkinson's disease illustrates the proposed method, in which a neural field model is assumed to accurately describe experimentally recorded activity. In addition, we propose a new closed-loop stimulation signal that is both space- and time- dependent. This method is especially designed to specifically modulate a targeted brain rhythm, without interfering with other rhythms. A new class of neuroprosthetic devices is also proposed, in which the multielectrode array is seen as an artificial neural network interacting with biological tissue. Such a bio-inspired approach may provide a solution to optimize interactions between the stimulation device and the cortex aiming to attenuate or augment specific cortical rhythms. The next step will be to validate this new approach experimentally in patients with Parkinson's disease.
Url:
DOI: 10.3389/fnins.2010.00045
PubMed: 20730081
PubMed Central: 2920509
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000988
Links to Exploration step
PMC:2920509Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Using a Virtual Cortical Module Implementing a Neural Field Model to Modulate Brain Rhythms in Parkinson's Disease</title>
<author><name sortKey="Modolo, Julien" sort="Modolo, Julien" uniqKey="Modolo J" first="Julien" last="Modolo">Julien Modolo</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Medical Biophysics, Lawson Health Research Institute, University of Western Ontario</institution>
<country>London, ON, Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea></wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bhattacharya, Basabdatta" sort="Bhattacharya, Basabdatta" uniqKey="Bhattacharya B" first="Basabdatta" last="Bhattacharya">Basabdatta Bhattacharya</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Intelligent Systems Research Centre, University of Ulster</institution>
<country>Londonderry, United Kingdom</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea></wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Edwards, Roderick" sort="Edwards, Roderick" uniqKey="Edwards R" first="Roderick" last="Edwards">Roderick Edwards</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Mathematics and Statistics, University of Victoria</institution>
<country>Victoria, BC, Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea></wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Campagnaud, Julien" sort="Campagnaud, Julien" uniqKey="Campagnaud J" first="Julien" last="Campagnaud">Julien Campagnaud</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Bordeaux Polytechnic Institute, University of Bordeaux</institution>
<country>Bordeaux, France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea></wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Legros, Alexandre" sort="Legros, Alexandre" uniqKey="Legros A" first="Alexandre" last="Legros">Alexandre Legros</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Medical Biophysics, Lawson Health Research Institute, University of Western Ontario</institution>
<country>London, ON, Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea></wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Beuter, Anne" sort="Beuter, Anne" uniqKey="Beuter A" first="Anne" last="Beuter">Anne Beuter</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Bordeaux Polytechnic Institute, University of Bordeaux</institution>
<country>Bordeaux, France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea></wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">20730081</idno>
<idno type="pmc">2920509</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920509</idno>
<idno type="RBID">PMC:2920509</idno>
<idno type="doi">10.3389/fnins.2010.00045</idno>
<date when="2010">2010</date>
<idno type="wicri:Area/Pmc/Corpus">000988</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000988</idno>
<idno type="wicri:Area/Pmc/Curation">000988</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000988</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Using a Virtual Cortical Module Implementing a Neural Field Model to Modulate Brain Rhythms in Parkinson's Disease</title>
<author><name sortKey="Modolo, Julien" sort="Modolo, Julien" uniqKey="Modolo J" first="Julien" last="Modolo">Julien Modolo</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Medical Biophysics, Lawson Health Research Institute, University of Western Ontario</institution>
<country>London, ON, Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea></wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bhattacharya, Basabdatta" sort="Bhattacharya, Basabdatta" uniqKey="Bhattacharya B" first="Basabdatta" last="Bhattacharya">Basabdatta Bhattacharya</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Intelligent Systems Research Centre, University of Ulster</institution>
<country>Londonderry, United Kingdom</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea></wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Edwards, Roderick" sort="Edwards, Roderick" uniqKey="Edwards R" first="Roderick" last="Edwards">Roderick Edwards</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Mathematics and Statistics, University of Victoria</institution>
<country>Victoria, BC, Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea></wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Campagnaud, Julien" sort="Campagnaud, Julien" uniqKey="Campagnaud J" first="Julien" last="Campagnaud">Julien Campagnaud</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Bordeaux Polytechnic Institute, University of Bordeaux</institution>
<country>Bordeaux, France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea></wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Legros, Alexandre" sort="Legros, Alexandre" uniqKey="Legros A" first="Alexandre" last="Legros">Alexandre Legros</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Medical Biophysics, Lawson Health Research Institute, University of Western Ontario</institution>
<country>London, ON, Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea></wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Beuter, Anne" sort="Beuter, Anne" uniqKey="Beuter A" first="Anne" last="Beuter">Anne Beuter</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Bordeaux Polytechnic Institute, University of Bordeaux</institution>
<country>Bordeaux, France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea></wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Frontiers in Neuroscience</title>
<idno type="ISSN">1662-4548</idno>
<idno type="eISSN">1662-453X</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>We propose a new method for selective modulation of cortical rhythms based on neural field theory, in which the activity of a cortical area is extensively monitored using a two-dimensional microelectrode array. The example of Parkinson's disease illustrates the proposed method, in which a neural field model is assumed to accurately describe experimentally recorded activity. In addition, we propose a new closed-loop stimulation signal that is both space- and time- dependent. This method is especially designed to specifically modulate a targeted brain rhythm, without interfering with other rhythms. A new class of neuroprosthetic devices is also proposed, in which the multielectrode array is seen as an artificial neural network interacting with biological tissue. Such a bio-inspired approach may provide a solution to optimize interactions between the stimulation device and the cortex aiming to attenuate or augment specific cortical rhythms. The next step will be to validate this new approach experimentally in patients with Parkinson's disease.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Amari, S" uniqKey="Amari S">S. Amari</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Atay, F M" uniqKey="Atay F">F. M. Atay</name>
</author>
<author><name sortKey="Hutt, A" uniqKey="Hutt A">A. Hutt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Birdno, M J" uniqKey="Birdno M">M. J. Birdno</name>
</author>
<author><name sortKey="Kuncel, A M" uniqKey="Kuncel A">A. M. Kuncel</name>
</author>
<author><name sortKey="Dorval, A D" uniqKey="Dorval A">A. D. Dorval</name>
</author>
<author><name sortKey="Turner, D A" uniqKey="Turner D">D. A. Turner</name>
</author>
<author><name sortKey="Grill, W M" uniqKey="Grill W">W. M. Grill</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bressloff, P C" uniqKey="Bressloff P">P. C. Bressloff</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Caetano, G" uniqKey="Caetano G">G. Caetano</name>
</author>
<author><name sortKey="Jousmaki, V" uniqKey="Jousmaki V">V. Jousmaki</name>
</author>
<author><name sortKey="Hari, R" uniqKey="Hari R">R. Hari</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Canavero, S" uniqKey="Canavero S">S. Canavero</name>
</author>
<author><name sortKey="Paolotti, R" uniqKey="Paolotti R">R. Paolotti</name>
</author>
<author><name sortKey="Bonicalzi, V" uniqKey="Bonicalzi V">V. Bonicalzi</name>
</author>
<author><name sortKey="Castellano, G" uniqKey="Castellano G">G. Castellano</name>
</author>
<author><name sortKey="Greco Crasto, S" uniqKey="Greco Crasto S">S. Greco-Crasto</name>
</author>
<author><name sortKey="Rizzo, L" uniqKey="Rizzo L">L. Rizzo</name>
</author>
<author><name sortKey="Davini, O" uniqKey="Davini O">O. Davini</name>
</author>
<author><name sortKey="Zenga, F" uniqKey="Zenga F">F. Zenga</name>
</author>
<author><name sortKey="Ragazzi, P" uniqKey="Ragazzi P">P. Ragazzi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Crone, N E" uniqKey="Crone N">N. E. Crone</name>
</author>
<author><name sortKey="Boatman, D" uniqKey="Boatman D">D. Boatman</name>
</author>
<author><name sortKey="Gordon, B" uniqKey="Gordon B">B. Gordon</name>
</author>
<author><name sortKey="Hao, L" uniqKey="Hao L">L. Hao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Elble, R J" uniqKey="Elble R">R. J. Elble</name>
</author>
<author><name sortKey="Koller, W C" uniqKey="Koller W">W. C. Koller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ermentrout, G B" uniqKey="Ermentrout G">G. B. Ermentrout</name>
</author>
<author><name sortKey="Cowan, J D" uniqKey="Cowan J">J. D. Cowan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ermolaeva, V Y" uniqKey="Ermolaeva V">V. Y. Ermolaeva</name>
</author>
<author><name sortKey="Borgest, A N" uniqKey="Borgest A">A. N. Borgest</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Feng, X J" uniqKey="Feng X">X. J. Feng</name>
</author>
<author><name sortKey="Greenwald, B" uniqKey="Greenwald B">B. Greenwald</name>
</author>
<author><name sortKey="Rabitz, H" uniqKey="Rabitz H">H. Rabitz</name>
</author>
<author><name sortKey="Shea Brown, E" uniqKey="Shea Brown E">E. Shea-Brown</name>
</author>
<author><name sortKey="Kosut, R" uniqKey="Kosut R">R. Kosut</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gredal, O" uniqKey="Gredal O">O. Gredal</name>
</author>
<author><name sortKey="Pakkenberg, H" uniqKey="Pakkenberg H">H. Pakkenberg</name>
</author>
<author><name sortKey="Karlsborg, M" uniqKey="Karlsborg M">M. Karlsborg</name>
</author>
<author><name sortKey="Pakkenberg, B" uniqKey="Pakkenberg B">B. Pakkenberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Guehl, D" uniqKey="Guehl D">D. Guehl</name>
</author>
<author><name sortKey="Edwards, R" uniqKey="Edwards R">R. Edwards</name>
</author>
<author><name sortKey="Cuny, E" uniqKey="Cuny E">E. Cuny</name>
</author>
<author><name sortKey="Burbaud, P" uniqKey="Burbaud P">P. Burbaud</name>
</author>
<author><name sortKey="Rougier, A" uniqKey="Rougier A">A. Rougier</name>
</author>
<author><name sortKey="Modolo, J" uniqKey="Modolo J">J. Modolo</name>
</author>
<author><name sortKey="Beuter, A" uniqKey="Beuter A">A. Beuter</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hari, R" uniqKey="Hari R">R. Hari</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hari, R" uniqKey="Hari R">R. Hari</name>
</author>
<author><name sortKey="Salmelin, R" uniqKey="Salmelin R">R. Salmelin</name>
</author>
<author><name sortKey="Makela, J P" uniqKey="Makela J">J. P. Makela</name>
</author>
<author><name sortKey="Salenius, S" uniqKey="Salenius S">S. Salenius</name>
</author>
<author><name sortKey="Helle, M" uniqKey="Helle M">M. Helle</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hatospoulos, N G" uniqKey="Hatospoulos N">N. G. Hatospoulos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Horton, J C" uniqKey="Horton J">J. C. Horton</name>
</author>
<author><name sortKey="Adams, D L" uniqKey="Adams D">D. L. Adams</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="House, P A" uniqKey="House P">P. A. House</name>
</author>
<author><name sortKey="Macdonald, J D" uniqKey="Macdonald J">J. D. MacDonald</name>
</author>
<author><name sortKey="Tresco, P A" uniqKey="Tresco P">P. A. Tresco</name>
</author>
<author><name sortKey="Normann, R A" uniqKey="Normann R">R. A. Normann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huang, X" uniqKey="Huang X">X. Huang</name>
</author>
<author><name sortKey="Troy, W C" uniqKey="Troy W">W. C. Troy</name>
</author>
<author><name sortKey="Yang, Q" uniqKey="Yang Q">Q. Yang</name>
</author>
<author><name sortKey="Ma, H" uniqKey="Ma H">H. Ma</name>
</author>
<author><name sortKey="Laing, C R" uniqKey="Laing C">C. R. Laing</name>
</author>
<author><name sortKey="Schiff, S J" uniqKey="Schiff S">S. J. Schiff</name>
</author>
<author><name sortKey="Wu, J Y" uniqKey="Wu J">J. Y. Wu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kellis, S S" uniqKey="Kellis S">S. S. Kellis</name>
</author>
<author><name sortKey="House, P A" uniqKey="House P">P. A. House</name>
</author>
<author><name sortKey="Thomson, K E" uniqKey="Thomson K">K. E. Thomson</name>
</author>
<author><name sortKey="Brown, R" uniqKey="Brown R">R. Brown</name>
</author>
<author><name sortKey="Greger, B" uniqKey="Greger B">B. Greger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mcintyre, C C" uniqKey="Mcintyre C">C. C. McIntyre</name>
</author>
<author><name sortKey="Savasta, M" uniqKey="Savasta M">M. Savasta</name>
</author>
<author><name sortKey="Kerkerian Le Goff, L" uniqKey="Kerkerian Le Goff L">L. Kerkerian-Le Goff</name>
</author>
<author><name sortKey="Vitek, J L" uniqKey="Vitek J">J. L. Vitek</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Miller, K J" uniqKey="Miller K">K. J. Miller</name>
</author>
<author><name sortKey="Leuthardt, E C" uniqKey="Leuthardt E">E. C. Leuthardt</name>
</author>
<author><name sortKey="Schalk, G" uniqKey="Schalk G">G. Schalk</name>
</author>
<author><name sortKey="Rao, R P N" uniqKey="Rao R">R. P. N. Rao</name>
</author>
<author><name sortKey="Anderson, N R" uniqKey="Anderson N">N. R. Anderson</name>
</author>
<author><name sortKey="Moran, D W" uniqKey="Moran D">D. W. Moran</name>
</author>
<author><name sortKey="Miller, J W" uniqKey="Miller J">J. W. Miller</name>
</author>
<author><name sortKey="Ojemann, J G" uniqKey="Ojemann J">J. G. Ojemann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Modolo, J" uniqKey="Modolo J">J. Modolo</name>
</author>
<author><name sortKey="Beuter, A" uniqKey="Beuter A">A. Beuter</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Modolo, J" uniqKey="Modolo J">J. Modolo</name>
</author>
<author><name sortKey="Campagnaud, J" uniqKey="Campagnaud J">J. Campagnaud</name>
</author>
<author><name sortKey="Beuter, A" uniqKey="Beuter A">A. Beuter</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Modolo, J" uniqKey="Modolo J">J. Modolo</name>
</author>
<author><name sortKey="Edwards, R" uniqKey="Edwards R">R. Edwards</name>
</author>
<author><name sortKey="Campagnaud, J" uniqKey="Campagnaud J">J. Campagnaud</name>
</author>
<author><name sortKey="Bhattacharya, B" uniqKey="Bhattacharya B">B. Bhattacharya</name>
</author>
<author><name sortKey="Beuter, A" uniqKey="Beuter A">A. Beuter</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pagni, C A" uniqKey="Pagni C">C. A. Pagni</name>
</author>
<author><name sortKey="Zeme, S" uniqKey="Zeme S">S. Zeme</name>
</author>
<author><name sortKey="Zenga, F" uniqKey="Zenga F">F. Zenga</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pereira, E A C" uniqKey="Pereira E">E. A. C. Pereira</name>
</author>
<author><name sortKey="Green, A L" uniqKey="Green A">A. L. Green</name>
</author>
<author><name sortKey="Nandi, N" uniqKey="Nandi N">N. Nandi</name>
</author>
<author><name sortKey="Aziz, T Z" uniqKey="Aziz T">T. Z. Aziz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pineda, J A" uniqKey="Pineda J">J. A. Pineda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Popovych, O V" uniqKey="Popovych O">O. V. Popovych</name>
</author>
<author><name sortKey="Hauptmann, C" uniqKey="Hauptmann C">C. Hauptmann</name>
</author>
<author><name sortKey="Tass, P A" uniqKey="Tass P">P. A. Tass</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Priori, A" uniqKey="Priori A">A. Priori</name>
</author>
<author><name sortKey="Lefaucheur, J P" uniqKey="Lefaucheur J">J. P. Lefaucheur</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ranck, J B" uniqKey="Ranck J">J. B. Ranck</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rodriguez Oroz, M C" uniqKey="Rodriguez Oroz M">M. C. Rodriguez-Oroz</name>
</author>
<author><name sortKey="Rodriguez, M" uniqKey="Rodriguez M">M. Rodriguez</name>
</author>
<author><name sortKey="Guridi, J" uniqKey="Guridi J">J. Guridi</name>
</author>
<author><name sortKey="Mewes, K" uniqKey="Mewes K">K. Mewes</name>
</author>
<author><name sortKey="Chockmann, V" uniqKey="Chockmann V">V. Chockmann</name>
</author>
<author><name sortKey="Vitek, J" uniqKey="Vitek J">J. Vitek</name>
</author>
<author><name sortKey="Delong, M R" uniqKey="Delong M">M. R. DeLong</name>
</author>
<author><name sortKey="Obeso, J A" uniqKey="Obeso J">J. A. Obeso</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rosenblum, M G" uniqKey="Rosenblum M">M. G. Rosenblum</name>
</author>
<author><name sortKey="Pikovsky, A S" uniqKey="Pikovsky A">A. S. Pikovsky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rubin, J E" uniqKey="Rubin J">J. E. Rubin</name>
</author>
<author><name sortKey="Terman, D" uniqKey="Terman D">D. Terman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rubino, D" uniqKey="Rubino D">D. Rubino</name>
</author>
<author><name sortKey="Robbins, K A" uniqKey="Robbins K">K. A. Robbins</name>
</author>
<author><name sortKey="Hatsopoulos, N G" uniqKey="Hatsopoulos N">N. G. Hatsopoulos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Saighi, S" uniqKey="Saighi S">S. Saighi</name>
</author>
<author><name sortKey="Tomas, J" uniqKey="Tomas J">J. Tomas</name>
</author>
<author><name sortKey="Bornat, Y" uniqKey="Bornat Y">Y. Bornat</name>
</author>
<author><name sortKey="Renaud, S" uniqKey="Renaud S">S. Renaud</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Santaniello, S" uniqKey="Santaniello S">S. Santaniello</name>
</author>
<author><name sortKey="Fiengo, G" uniqKey="Fiengo G">G. Fiengo</name>
</author>
<author><name sortKey="Glielmo, L" uniqKey="Glielmo L">L. Glielmo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schnitzler, A" uniqKey="Schnitzler A">A. Schnitzler</name>
</author>
<author><name sortKey="Timmermann, L" uniqKey="Timmermann L">L. Timmermann</name>
</author>
<author><name sortKey="Gross, J" uniqKey="Gross J">J. Gross</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tass, P A" uniqKey="Tass P">P. A. Tass</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tass, P A" uniqKey="Tass P">P. A. Tass</name>
</author>
<author><name sortKey="Majtanik, M" uniqKey="Majtanik M">M. Majtanik</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Timmermann, L" uniqKey="Timmermann L">L. Timmermann</name>
</author>
<author><name sortKey="Fink, G R" uniqKey="Fink G">G. R. Fink</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Timmermann, L" uniqKey="Timmermann L">L. Timmermann</name>
</author>
<author><name sortKey="Florin, E" uniqKey="Florin E">E. Florin</name>
</author>
<author><name sortKey="Reck, C" uniqKey="Reck C">C. Reck</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Timmermann, L" uniqKey="Timmermann L">L. Timmermann</name>
</author>
<author><name sortKey="Gross, J" uniqKey="Gross J">J. Gross</name>
</author>
<author><name sortKey="Dirks, M" uniqKey="Dirks M">M. Dirks</name>
</author>
<author><name sortKey="Volkmann, J" uniqKey="Volkmann J">J. Volkmann</name>
</author>
<author><name sortKey="Freund, H J" uniqKey="Freund H">H. J. Freund</name>
</author>
<author><name sortKey="Schnitzler, A" uniqKey="Schnitzler A">A. Schnitzler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wilson, H R" uniqKey="Wilson H">H. R. Wilson</name>
</author>
<author><name sortKey="Cowan, J D" uniqKey="Cowan J">J. D. Cowan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zou, Q" uniqKey="Zou Q">Q. Zou</name>
</author>
<author><name sortKey="Bornat, Y" uniqKey="Bornat Y">Y. Bornat</name>
</author>
<author><name sortKey="Saighi, S" uniqKey="Saighi S">S. Saighi</name>
</author>
<author><name sortKey="Thomas, J" uniqKey="Thomas J">J. Thomas</name>
</author>
<author><name sortKey="Renaud, S" uniqKey="Renaud S">S. Renaud</name>
</author>
<author><name sortKey="Destexhe, A" uniqKey="Destexhe A">A. Destexhe</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Neurosci</journal-id>
<journal-id journal-id-type="publisher-id">Front. Neurosci.</journal-id>
<journal-title-group><journal-title>Frontiers in Neuroscience</journal-title>
</journal-title-group>
<issn pub-type="ppub">1662-4548</issn>
<issn pub-type="epub">1662-453X</issn>
<publisher><publisher-name>Frontiers Research Foundation</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">20730081</article-id>
<article-id pub-id-type="pmc">2920509</article-id>
<article-id pub-id-type="doi">10.3389/fnins.2010.00045</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Neuroscience</subject>
<subj-group><subject>Original Research</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Using a Virtual Cortical Module Implementing a Neural Field Model to Modulate Brain Rhythms in Parkinson's Disease</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Modolo</surname>
<given-names>Julien</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="author-notes" rid="fn001">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bhattacharya</surname>
<given-names>Basabdatta</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Edwards</surname>
<given-names>Roderick</given-names>
</name>
<xref ref-type="aff" rid="aff4"><sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Campagnaud</surname>
<given-names>Julien</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Legros</surname>
<given-names>Alexandre</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Beuter</surname>
<given-names>Anne</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
</contrib-group>
<aff id="aff1"><sup>1</sup>
<institution>Department of Medical Biophysics, Lawson Health Research Institute, University of Western Ontario</institution>
<country>London, ON, Canada</country>
</aff>
<aff id="aff2"><sup>2</sup>
<institution>Bordeaux Polytechnic Institute, University of Bordeaux</institution>
<country>Bordeaux, France</country>
</aff>
<aff id="aff3"><sup>3</sup>
<institution>Intelligent Systems Research Centre, University of Ulster</institution>
<country>Londonderry, United Kingdom</country>
</aff>
<aff id="aff4"><sup>4</sup>
<institution>Department of Mathematics and Statistics, University of Victoria</institution>
<country>Victoria, BC, Canada</country>
</aff>
<author-notes><fn fn-type="edited-by"><p>Edited by: Nicholas Hatsopoulos, University of Chicago, USA</p>
</fn>
<fn fn-type="edited-by"><p>Reviewed by: David Mogul, Illinois Institute of Technology, USA; Spencer Kellis, The University of Utah, USA</p>
</fn>
<corresp id="fn001">*Correspondence: Julien Modolo, Lawson Health Research Institute, St. Joseph's Health Care, 268, Grosvenor Street, Room E4-143, London, ON N6A 4V2, Canada. e-mail: <email>jmodolo@lawsonimaging.ca</email>
</corresp>
</author-notes>
<pub-date pub-type="epreprint"><day>02</day>
<month>3</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="epub"><day>28</day>
<month>6</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="collection"><year>2010</year>
</pub-date>
<volume>4</volume>
<elocation-id>45</elocation-id>
<history><date date-type="received"><day>22</day>
<month>12</month>
<year>2009</year>
</date>
<date date-type="accepted"><day>08</day>
<month>6</month>
<year>2010</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2010 Modolo, Bhattacharya, Edwards, Campagnaud, Legros, and Beuter.</copyright-statement>
<copyright-year>2010</copyright-year>
<license license-type="open-access" xlink:href="http://www.frontiersin.org/licenseagreement"><license-p>This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.</license-p>
</license>
</permissions>
<abstract><p>We propose a new method for selective modulation of cortical rhythms based on neural field theory, in which the activity of a cortical area is extensively monitored using a two-dimensional microelectrode array. The example of Parkinson's disease illustrates the proposed method, in which a neural field model is assumed to accurately describe experimentally recorded activity. In addition, we propose a new closed-loop stimulation signal that is both space- and time- dependent. This method is especially designed to specifically modulate a targeted brain rhythm, without interfering with other rhythms. A new class of neuroprosthetic devices is also proposed, in which the multielectrode array is seen as an artificial neural network interacting with biological tissue. Such a bio-inspired approach may provide a solution to optimize interactions between the stimulation device and the cortex aiming to attenuate or augment specific cortical rhythms. The next step will be to validate this new approach experimentally in patients with Parkinson's disease.</p>
</abstract>
<kwd-group><kwd>brain stimulation</kwd>
<kwd>dysrhythmia</kwd>
<kwd>neural field model</kwd>
<kwd>Parkinson's disease</kwd>
<kwd>neuroprosthetic devices</kwd>
</kwd-group>
<counts><fig-count count="6"></fig-count>
<table-count count="0"></table-count>
<equation-count count="8"></equation-count>
<ref-count count="45"></ref-count>
<page-count count="11"></page-count>
<word-count count="8784"></word-count>
</counts>
</article-meta>
</front>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000988 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000988 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Canada |area= ParkinsonCanadaV1 |flux= Pmc |étape= Curation |type= RBID |clé= PMC:2920509 |texte= Using a Virtual Cortical Module Implementing a Neural Field Model to Modulate Brain Rhythms in Parkinson's Disease }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:20730081" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonCanadaV1
This area was generated with Dilib version V0.6.29. |