Dopaminergic Neurotransmission in the Human Brain: New Lessons from Perturbation and Imaging
Identifieur interne : 000887 ( Pmc/Curation ); précédent : 000886; suivant : 000888Dopaminergic Neurotransmission in the Human Brain: New Lessons from Perturbation and Imaging
Auteurs : Ji Hyun Ko [Canada] ; Antonio P. Strafella [Canada]Source :
- The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry [ 1073-8584 ] ; 2011.
Abstract
Dopamine plays an important role in several brain functions and is involved in the pathogenesis of several psychiatric and neurological disorders. Neuroimaging techniques such as positron emission tomography allow us to quantify dopaminergic activity in the living human brain. Combining these with brain stimulation techniques offers us the unique opportunity to tackle questions regarding region-specific neurochemical activity. Such studies may aid clinicians and scientists to disentangle neural circuitries within the human brain and thereby help them to understand the underlying mechanisms of a given function in relation to brain diseases. Furthermore, it may also aid the development of alternative treatment approaches for various neurological and psychiatric conditions.
Url:
DOI: 10.1177/1073858411401413
PubMed: 21536838
PubMed Central: 3479149
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Strafella</name><affiliation wicri:level="1"><nlm:aff id="A1">PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Division of Brain, Imaging and Behaviour–Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Brain, Imaging and Behaviour–Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Ontario</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Movement Disorder Unit, Toronto Western Hospital, UHN, University of Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Movement Disorder Unit, Toronto Western Hospital, UHN, University of Toronto, Ontario</wicri:regionArea></affiliation></author></analytic><series><title level="j">The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry</title><idno type="ISSN">1073-8584</idno><idno type="eISSN">1089-4098</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Dopamine plays an important role in several brain functions and is involved in the pathogenesis of several psychiatric and neurological disorders. Neuroimaging techniques such as positron emission tomography allow us to quantify dopaminergic activity in the living human brain. Combining these with brain stimulation techniques offers us the unique opportunity to tackle questions regarding region-specific neurochemical activity. Such studies may aid clinicians and scientists to disentangle neural circuitries within the human brain and thereby help them to understand the underlying mechanisms of a given function in relation to brain diseases. Furthermore, it may also aid the development of alternative treatment approaches for various neurological and psychiatric conditions.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9504819</journal-id><journal-id journal-id-type="pubmed-jr-id">22458</journal-id><journal-id journal-id-type="nlm-ta">Neuroscientist</journal-id><journal-id journal-id-type="iso-abbrev">Neuroscientist</journal-id><journal-title-group><journal-title>The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry</journal-title></journal-title-group><issn pub-type="ppub">1073-8584</issn><issn pub-type="epub">1089-4098</issn></journal-meta><article-meta><article-id pub-id-type="pmid">21536838</article-id><article-id pub-id-type="pmc">3479149</article-id><article-id pub-id-type="doi">10.1177/1073858411401413</article-id><article-id pub-id-type="manuscript">CAMS2366</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Dopaminergic Neurotransmission in the Human Brain: New Lessons from Perturbation and Imaging</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Ko</surname><given-names>Ji Hyun</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Strafella</surname><given-names>Antonio P.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib></contrib-group><aff id="A1"><label>1</label>PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada</aff><aff id="A2"><label>2</label>Division of Brain, Imaging and Behaviour–Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Ontario, Canada</aff><aff id="A3"><label>3</label>Movement Disorder Unit, Toronto Western Hospital, UHN, University of Toronto, Ontario, Canada</aff><author-notes><corresp id="FN1">Corresponding Author: Antonio P. Strafella, Toronto Western Hospital & Research Institute, PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada M5T 2S8, <email>antonio.strafella@uhnres.utoronto.ca</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>7</day><month>9</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>02</day><month>5</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>4</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>23</day><month>10</month><year>2012</year></pub-date><volume>18</volume><issue>2</issue><fpage>149</fpage><lpage>168</lpage><permissions><copyright-statement>© The Author(s) 2012</copyright-statement><copyright-year>2012</copyright-year></permissions><abstract><p id="P1">Dopamine plays an important role in several brain functions and is involved in the pathogenesis of several psychiatric and neurological disorders. Neuroimaging techniques such as positron emission tomography allow us to quantify dopaminergic activity in the living human brain. Combining these with brain stimulation techniques offers us the unique opportunity to tackle questions regarding region-specific neurochemical activity. Such studies may aid clinicians and scientists to disentangle neural circuitries within the human brain and thereby help them to understand the underlying mechanisms of a given function in relation to brain diseases. Furthermore, it may also aid the development of alternative treatment approaches for various neurological and psychiatric conditions.</p></abstract><kwd-group><kwd>brain imaging</kwd><kwd>dopamine</kwd><kwd>positron emission tomography</kwd><kwd>prefrontal cortex</kwd><kwd>transcranial magnetic stimulation</kwd></kwd-group><funding-group><award-group><funding-source country="Canada">Canadian Institutes of Health Research : </funding-source><award-id>64423 || </award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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