Dopaminergic Neurotransmission in the Human Brain: New Lessons from Perturbation and Imaging
Identifieur interne : 000887 ( Pmc/Curation ); précédent : 000886; suivant : 000888Dopaminergic Neurotransmission in the Human Brain: New Lessons from Perturbation and Imaging
Auteurs : Ji Hyun Ko [Canada] ; Antonio P. Strafella [Canada]Source :
- The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry [ 1073-8584 ] ; 2011.
Abstract
Dopamine plays an important role in several brain functions and is involved in the pathogenesis of several psychiatric and neurological disorders. Neuroimaging techniques such as positron emission tomography allow us to quantify dopaminergic activity in the living human brain. Combining these with brain stimulation techniques offers us the unique opportunity to tackle questions regarding region-specific neurochemical activity. Such studies may aid clinicians and scientists to disentangle neural circuitries within the human brain and thereby help them to understand the underlying mechanisms of a given function in relation to brain diseases. Furthermore, it may also aid the development of alternative treatment approaches for various neurological and psychiatric conditions.
Url:
DOI: 10.1177/1073858411401413
PubMed: 21536838
PubMed Central: 3479149
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PMC:3479149Le document en format XML
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<front><div type="abstract" xml:lang="en"><p id="P1">Dopamine plays an important role in several brain functions and is involved in the pathogenesis of several psychiatric and neurological disorders. Neuroimaging techniques such as positron emission tomography allow us to quantify dopaminergic activity in the living human brain. Combining these with brain stimulation techniques offers us the unique opportunity to tackle questions regarding region-specific neurochemical activity. Such studies may aid clinicians and scientists to disentangle neural circuitries within the human brain and thereby help them to understand the underlying mechanisms of a given function in relation to brain diseases. Furthermore, it may also aid the development of alternative treatment approaches for various neurological and psychiatric conditions.</p>
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PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada</aff>
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Division of Brain, Imaging and Behaviour–Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Ontario, Canada</aff>
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Movement Disorder Unit, Toronto Western Hospital, UHN, University of Toronto, Ontario, Canada</aff>
<author-notes><corresp id="FN1">Corresponding Author: Antonio P. Strafella, Toronto Western Hospital & Research Institute, PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada M5T 2S8, <email>antonio.strafella@uhnres.utoronto.ca</email>
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<permissions><copyright-statement>© The Author(s) 2012</copyright-statement>
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<abstract><p id="P1">Dopamine plays an important role in several brain functions and is involved in the pathogenesis of several psychiatric and neurological disorders. Neuroimaging techniques such as positron emission tomography allow us to quantify dopaminergic activity in the living human brain. Combining these with brain stimulation techniques offers us the unique opportunity to tackle questions regarding region-specific neurochemical activity. Such studies may aid clinicians and scientists to disentangle neural circuitries within the human brain and thereby help them to understand the underlying mechanisms of a given function in relation to brain diseases. Furthermore, it may also aid the development of alternative treatment approaches for various neurological and psychiatric conditions.</p>
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