Contribution of Insula in Parkinson’s Disease: A Quantitative Meta-Analysis Study
Identifieur interne : 000878 ( Pmc/Curation ); précédent : 000877; suivant : 000879Contribution of Insula in Parkinson’s Disease: A Quantitative Meta-Analysis Study
Auteurs : Marion Criaud [Canada, France] ; Leigh Christopher [Canada] ; Philippe Boulinguez [France] ; Benedicte Ballanger [France] ; Anthony E. Lang [Canada] ; Sang S. Cho [Canada] ; Sylvain Houle [Canada] ; Antonio P. Strafella [Canada]Source :
- Human brain mapping [ 1065-9471 ] ; 2016.
Abstract
The insula region is known to be an integrating hub interacting with multiple brain networks involved in cognitive, affective, sensory, and autonomic processes. There is growing evidence suggesting that this region may have an important role in Parkinson’s disease (PD). Thus, to investigate the functional organization of the insular cortex and its potential role in parkinsonian features, we used a coordinate-based quantitative meta-analysis approach, the activation likelihood estimation. A total of 132 insular foci were selected from 96 published experiments comprising the five functional categories: cognition, affective/behavioral symptoms, bodily awareness/autonomic function, sensorimotor function, and nonspecific resting functional changes associated with the disease. We found a significant convergence of activation maxima related to PD in different insular regions including anterior and posterior regions bilaterally. This study provides evidence of an important functional distribution of different domains within the insular cortex in PD, particularly in relation to nonmotor aspects, with an influence of medication effect.
Url:
DOI: 10.1002/hbm.23109
PubMed: 26800238
PubMed Central: 4874784
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<front><div type="abstract" xml:lang="en"><p id="P1">The insula region is known to be an integrating hub interacting with multiple brain networks involved in cognitive, affective, sensory, and autonomic processes. There is growing evidence suggesting that this region may have an important role in Parkinson’s disease (PD). Thus, to investigate the functional organization of the insular cortex and its potential role in parkinsonian features, we used a coordinate-based quantitative meta-analysis approach, the activation likelihood estimation. A total of 132 insular foci were selected from 96 published experiments comprising the five functional categories: cognition, affective/behavioral symptoms, bodily awareness/autonomic function, sensorimotor function, and nonspecific resting functional changes associated with the disease. We found a significant convergence of activation maxima related to PD in different insular regions including anterior and posterior regions bilaterally. This study provides evidence of an important functional distribution of different domains within the insular cortex in PD, particularly in relation to nonmotor aspects, with an influence of medication effect.</p>
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<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Houle</surname>
<given-names>Sylvain</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Strafella</surname>
<given-names>Antonio P.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A3">3</xref>
<xref rid="FN1" ref-type="author-notes">*</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Morton and Gloria Shulman Movement Disorder Unit & E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Ontario, Canada</aff>
<aff id="A2"><label>2</label>
Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada</aff>
<aff id="A3"><label>3</label>
Division of Brain, Imaging and Behaviour – Systems Neuroscience, Krembil Research Institute, UHN, University of Toronto, Ontario, Canada</aff>
<aff id="A4"><label>4</label>
Université Lyon 1, Villeurbanne, France</aff>
<aff id="A5"><label>5</label>
Centre De Neuroscience Cognitive, CNRS, UMR5229, Bron, France</aff>
<aff id="A6"><label>6</label>
Université De Lyon, Lyon, F-69622, France</aff>
<author-notes><corresp id="FN1"><label>*</label>
Correspondence to: Antonio P. Strafella, MD, PhD, FRCPC; Toronto Western Hospital and Institute, UHN & Research Imaging Centre, CAMH, University of Toronto, Toronto, Ontario, Canada. <email>antonio.strafella@uhn.ca</email>
and <email>antonio.strafella@camhpet.ca</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>16</day>
<month>5</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub"><day>22</day>
<month>1</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="ppub"><month>4</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>5</month>
<year>2017</year>
</pub-date>
<volume>37</volume>
<issue>4</issue>
<fpage>1375</fpage>
<lpage>1392</lpage>
<pmc-comment>elocation-id from pubmed: 10.1002/hbm.23109</pmc-comment>
<abstract><p id="P1">The insula region is known to be an integrating hub interacting with multiple brain networks involved in cognitive, affective, sensory, and autonomic processes. There is growing evidence suggesting that this region may have an important role in Parkinson’s disease (PD). Thus, to investigate the functional organization of the insular cortex and its potential role in parkinsonian features, we used a coordinate-based quantitative meta-analysis approach, the activation likelihood estimation. A total of 132 insular foci were selected from 96 published experiments comprising the five functional categories: cognition, affective/behavioral symptoms, bodily awareness/autonomic function, sensorimotor function, and nonspecific resting functional changes associated with the disease. We found a significant convergence of activation maxima related to PD in different insular regions including anterior and posterior regions bilaterally. This study provides evidence of an important functional distribution of different domains within the insular cortex in PD, particularly in relation to nonmotor aspects, with an influence of medication effect.</p>
</abstract>
<kwd-group><kwd>Parkinson’s disease</kwd>
<kwd>insula</kwd>
<kwd>nonmotor symptoms</kwd>
<kwd>dopamine</kwd>
<kwd>cognition</kwd>
<kwd>behavior</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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