Functional MRI of visual responses in the awake, behaving marmoset
Identifieur interne : 000866 ( Pmc/Curation ); précédent : 000865; suivant : 000867Functional MRI of visual responses in the awake, behaving marmoset
Auteurs : Chia-Chun Hung ; Cecil C. Yen ; Jennifer L. Ciuchta ; Daniel Papoti ; Nicholas A. Bock [Canada] ; David A. Leopold [États-Unis] ; Afonso C. SilvaSource :
- NeuroImage [ 1053-8119 ] ; 2015.
Abstract
The visual brain is composed of interconnected subcortical and cortical structures that receive and process image information originating in the retina. The visual system of nonhuman primates, in particular macaques, has been studied in great detail in order to elucidate principles of human sensation and perception. The common marmoset (
Url:
DOI: 10.1016/j.neuroimage.2015.06.090
PubMed: 26149609
PubMed Central: 4589494
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<front><div type="abstract" xml:lang="en"><p id="P2">The visual brain is composed of interconnected subcortical and cortical structures that receive and process image information originating in the retina. The visual system of nonhuman primates, in particular macaques, has been studied in great detail in order to elucidate principles of human sensation and perception. The common marmoset (<italic>Callithrix jacchus</italic>
) is a small New World monkey of growing interest as a primate model for neuroscience. Marmosets have advantages over macaques because of their small size, lissencephalic cortex, and growing potential for viral and genetic manipulations. Previous anatomical studies and electrophysiological recordings in anesthetized marmosets have shown that this species’ cortical visual hierarchy closely resembles that of other primates, including humans. Until now, however, there have been no attempts to systematically study visual responses throughout the marmoset brain using fMRI. Here we show that awake marmosets readily learn to carry out a simple visual task inside the bore of an MRI scanner during functional mapping experiments. Functional scanning at 500μm in-plane resolution in a 30 cm horizontal bore at 7T revealed robust positive blood oxygenation level-dependent (BOLD) fMRI responses to visual stimuli throughout visual cortex and associated subcortical areas. Nonvisual sensory areas showed negative contrasts to visual stimuli compared to the fixation dot only baseline. Structured images of objects and faces led to stronger responses than scrambled control images at stages beyond early visual cortex. Our study establishes functional MRI mapping of visual responses in awake, behaving marmosets is straightforward and valuable for assessing the functional organization of the primate brain at high resolution.</p>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9215515</journal-id>
<journal-id journal-id-type="pubmed-jr-id">20498</journal-id>
<journal-id journal-id-type="nlm-ta">Neuroimage</journal-id>
<journal-id journal-id-type="iso-abbrev">Neuroimage</journal-id>
<journal-title-group><journal-title>NeuroImage</journal-title>
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<issn pub-type="ppub">1053-8119</issn>
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<article-id pub-id-type="manuscript">NIHMS711899</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
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<title-group><article-title>Functional MRI of visual responses in the awake, behaving marmoset</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Hung</surname>
<given-names>Chia-Chun</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yen</surname>
<given-names>Cecil C.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ciuchta</surname>
<given-names>Jennifer L.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Papoti</surname>
<given-names>Daniel</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bock</surname>
<given-names>Nicholas A.</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Leopold</surname>
<given-names>David A.</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Silva</surname>
<given-names>Afonso C.</given-names>
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<xref ref-type="aff" rid="A1">1</xref>
<xref rid="FN1" ref-type="author-notes">*</xref>
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<aff id="A1"><label>1</label>
Cerebral Microcirculation Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892</aff>
<aff id="A2"><label>2</label>
Section on Cognitive Neurophysiology and Imaging, Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, MD, 20892</aff>
<aff id="A3"><label>3</label>
Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario, L8S 4K1, Canada</aff>
<aff id="A4"><label>4</label>
Neurophysiology Imaging Facility, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Eye Institute, Bethesda, MD 20892</aff>
<author-notes><corresp id="FN1">Corresponding Author: Afonso C. Silva, Ph.D., Chief, Cerebral Microcirculation Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 49 Convent Drive MSC 1065, Building 49 Room 3A72, Bethesda MD 20892-1065 USA, Tel: +1-301-402-9703, Fax: +1-301-480-8670, <email>SilvaA@ninds.nih.gov</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>31</day>
<month>7</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub"><day>03</day>
<month>7</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="ppub"><day>15</day>
<month>10</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>15</day>
<month>10</month>
<year>2016</year>
</pub-date>
<volume>120</volume>
<fpage>1</fpage>
<lpage>11</lpage>
<pmc-comment>elocation-id from pubmed: 10.1016/j.neuroimage.2015.06.090</pmc-comment>
<abstract id="Abs1"><p id="P2">The visual brain is composed of interconnected subcortical and cortical structures that receive and process image information originating in the retina. The visual system of nonhuman primates, in particular macaques, has been studied in great detail in order to elucidate principles of human sensation and perception. The common marmoset (<italic>Callithrix jacchus</italic>
) is a small New World monkey of growing interest as a primate model for neuroscience. Marmosets have advantages over macaques because of their small size, lissencephalic cortex, and growing potential for viral and genetic manipulations. Previous anatomical studies and electrophysiological recordings in anesthetized marmosets have shown that this species’ cortical visual hierarchy closely resembles that of other primates, including humans. Until now, however, there have been no attempts to systematically study visual responses throughout the marmoset brain using fMRI. Here we show that awake marmosets readily learn to carry out a simple visual task inside the bore of an MRI scanner during functional mapping experiments. Functional scanning at 500μm in-plane resolution in a 30 cm horizontal bore at 7T revealed robust positive blood oxygenation level-dependent (BOLD) fMRI responses to visual stimuli throughout visual cortex and associated subcortical areas. Nonvisual sensory areas showed negative contrasts to visual stimuli compared to the fixation dot only baseline. Structured images of objects and faces led to stronger responses than scrambled control images at stages beyond early visual cortex. Our study establishes functional MRI mapping of visual responses in awake, behaving marmosets is straightforward and valuable for assessing the functional organization of the primate brain at high resolution.</p>
</abstract>
<abstract abstract-type="graphical" id="Abs2"><title>Graphical Abstract</title>
<p id="P3"><graphic xlink:href="nihms711899u1.jpg" position="anchor" orientation="portrait"></graphic>
</p>
</abstract>
<kwd-group><kwd>Marmoset</kwd>
<kwd>fMRI</kwd>
<kwd>vision</kwd>
<kwd>visual system</kwd>
<kwd>primate</kwd>
</kwd-group>
</article-meta>
</front>
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