NTS-polyplex: A potential nanocarrier for neurotrophic therapy of Parkinson’s disease
Identifieur interne : 000749 ( Pmc/Curation ); précédent : 000748; suivant : 000750NTS-polyplex: A potential nanocarrier for neurotrophic therapy of Parkinson’s disease
Auteurs : Daniel Martinez-Fong [Mexique] ; Michael J. Bannon [États-Unis] ; Louis-Eric Trudeau ; Juan A. Gonzalez-Barrios [Mexique] ; Martha L. Arango-Rodriguez [Chili] ; Nancy G. Hernandez-Chan [Mexique] ; David Reyes-Corona [Mexique] ; Juan Armendáriz-Borunda [Mexique] ; Ivan Navarro-Quiroga [États-Unis]Source :
- Nanomedicine : nanotechnology, biology, and medicine [ 1549-9634 ] ; 2012.
Abstract
Nanomedicine has focused on targeted neurotrophic gene delivery to the brain as a strategy to stop and reverse neurodegeneration in Parkinson’s disease. Because of improved transfection ability, synthetic nanocarriers have become candidates for neurotrophic therapy. Neurotensin (NTS)-polyplex is a “Trojan horse” synthetic nanocarrier system that enters dopaminergic neurons through NTS receptor internalization to deliver a genetic cargo. The success of preclinical studies with different neurotrophic genes supports the possibility of using NTS-polyplex in nanomedicine. In this review, we describe the mechanism of NTS-polyplex transfection. We discuss the concept that an effective neurotrophic therapy requires a simultaneous effect on the axon terminals and soma of the remaining dopaminergic neurons. We also discuss the future of this strategy for the treatment of Parkinson’s disease.
Url:
DOI: 10.1016/j.nano.2012.02.009
PubMed: 22406187
PubMed Central: 3394898
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000749
Links to Exploration step
PMC:3394898Curation
No country items
Louis-Eric Trudeau<affiliation><nlm:aff id="A4">Department of Pharmacology, Groupe de Recherchesur le SystèmeNerveux Central, Faculty of Medicine, Université de Montréal, 2900 Boulevard Édouard-Montpetit, Montréal, Québec, H4T 1J4 Canada</nlm:aff><wicri:noCountry code="subfield">H4T 1J4 Canada</wicri:noCountry></affiliation>Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">NTS-polyplex: A potential nanocarrier for neurotrophic therapy of Parkinson’s disease</title><author><name sortKey="Martinez Fong, Daniel" sort="Martinez Fong, Daniel" uniqKey="Martinez Fong D" first="Daniel" last="Martinez-Fong">Daniel Martinez-Fong</name><affiliation wicri:level="1"><nlm:aff id="A1">Departamento de Fisiología, Biofísica y Neurociencias, CINVESTAV-I.P.N., Apartado postal 14-740, México D.F., 07000 México</nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Fisiología, Biofísica y Neurociencias, CINVESTAV-I.P.N., Apartado postal 14-740, México D.F.</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Doctorado en Nanociencias y Nanotecnología, CINVESTAV-I.P.N., Apartado postal 14-740, México D.F., 07000 México</nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Doctorado en Nanociencias y Nanotecnología, CINVESTAV-I.P.N., Apartado postal 14-740, México D.F.</wicri:regionArea></affiliation></author><author><name sortKey="Bannon, Michael J" sort="Bannon, Michael J" uniqKey="Bannon M" first="Michael J." last="Bannon">Michael J. Bannon</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Pharmacology, Wayne State University School of Medicine, 540 E Canfield Ave, 3355 Scott Hall, Detroit, MI 48201 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Department of Pharmacology, Wayne State University School of Medicine, 540 E Canfield Ave, 3355 Scott Hall, Detroit</wicri:cityArea></affiliation></author><author><name sortKey="Trudeau, Louis Eric" sort="Trudeau, Louis Eric" uniqKey="Trudeau L" first="Louis-Eric" last="Trudeau">Louis-Eric Trudeau</name><affiliation><nlm:aff id="A4">Department of Pharmacology, Groupe de Recherchesur le SystèmeNerveux Central, Faculty of Medicine, Université de Montréal, 2900 Boulevard Édouard-Montpetit, Montréal, Québec, H4T 1J4 Canada</nlm:aff><wicri:noCountry code="subfield">H4T 1J4 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Gonzalez Barrios, Juan A" sort="Gonzalez Barrios, Juan A" uniqKey="Gonzalez Barrios J" first="Juan A." last="Gonzalez-Barrios">Juan A. Gonzalez-Barrios</name><affiliation wicri:level="1"><nlm:aff id="A5">Laboratorio de MedicinaGenómica, Hospital Regional “1o. deOctubre”, Av. IPN No. 1669, México D. F., C.P. 07760, México</nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Laboratorio de MedicinaGenómica, Hospital Regional “1o. deOctubre”, Av. IPN No. 1669, México D. F., C.P. 07760</wicri:regionArea></affiliation></author><author><name sortKey="Arango Rodriguez, Martha L" sort="Arango Rodriguez, Martha L" uniqKey="Arango Rodriguez M" first="Martha L." last="Arango-Rodriguez">Martha L. Arango-Rodriguez</name><affiliation wicri:level="1"><nlm:aff id="A6">Instituto de Ciencias, Facultad de MedicinaClínicaAlemana Universidad del Desarrollo. Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Instituto de Ciencias, Facultad de MedicinaClínicaAlemana Universidad del Desarrollo. Santiago</wicri:regionArea></affiliation></author><author><name sortKey="Hernandez Chan, Nancy G" sort="Hernandez Chan, Nancy G" uniqKey="Hernandez Chan N" first="Nancy G." last="Hernandez-Chan">Nancy G. Hernandez-Chan</name><affiliation wicri:level="1"><nlm:aff id="A1">Departamento de Fisiología, Biofísica y Neurociencias, CINVESTAV-I.P.N., Apartado postal 14-740, México D.F., 07000 México</nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Fisiología, Biofísica y Neurociencias, CINVESTAV-I.P.N., Apartado postal 14-740, México D.F.</wicri:regionArea></affiliation></author><author><name sortKey="Reyes Corona, David" sort="Reyes Corona, David" uniqKey="Reyes Corona D" first="David" last="Reyes-Corona">David Reyes-Corona</name><affiliation wicri:level="1"><nlm:aff id="A1">Departamento de Fisiología, Biofísica y Neurociencias, CINVESTAV-I.P.N., Apartado postal 14-740, México D.F., 07000 México</nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Fisiología, Biofísica y Neurociencias, CINVESTAV-I.P.N., Apartado postal 14-740, México D.F.</wicri:regionArea></affiliation></author><author><name sortKey="Armendariz Borunda, Juan" sort="Armendariz Borunda, Juan" uniqKey="Armendariz Borunda J" first="Juan" last="Armendáriz-Borunda">Juan Armendáriz-Borunda</name><affiliation wicri:level="1"><nlm:aff id="A7">Institute for Molecular Biology and Gene Therapy, Department of Molecular Biology and Genomics, University of Guadalajara, Guadalajara, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Institute for Molecular Biology and Gene Therapy, Department of Molecular Biology and Genomics, University of Guadalajara, Guadalajara</wicri:regionArea></affiliation></author><author><name sortKey="Navarro Quiroga, Ivan" sort="Navarro Quiroga, Ivan" uniqKey="Navarro Quiroga I" first="Ivan" last="Navarro-Quiroga">Ivan Navarro-Quiroga</name><affiliation wicri:level="1"><nlm:aff id="A8">KAI-research 11300 Rockville pike, Rockville MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>KAI-research 11300 Rockville pike, Rockville MD</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22406187</idno><idno type="pmc">3394898</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394898</idno><idno type="RBID">PMC:3394898</idno><idno type="doi">10.1016/j.nano.2012.02.009</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000749</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000749</idno><idno type="wicri:Area/Pmc/Curation">000749</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000749</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">NTS-polyplex: A potential nanocarrier for neurotrophic therapy of Parkinson’s disease</title><author><name sortKey="Martinez Fong, Daniel" sort="Martinez Fong, Daniel" uniqKey="Martinez Fong D" first="Daniel" last="Martinez-Fong">Daniel Martinez-Fong</name><affiliation wicri:level="1"><nlm:aff id="A1">Departamento de Fisiología, Biofísica y Neurociencias, CINVESTAV-I.P.N., Apartado postal 14-740, México D.F., 07000 México</nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Fisiología, Biofísica y Neurociencias, CINVESTAV-I.P.N., Apartado postal 14-740, México D.F.</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Doctorado en Nanociencias y Nanotecnología, CINVESTAV-I.P.N., Apartado postal 14-740, México D.F., 07000 México</nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Doctorado en Nanociencias y Nanotecnología, CINVESTAV-I.P.N., Apartado postal 14-740, México D.F.</wicri:regionArea></affiliation></author><author><name sortKey="Bannon, Michael J" sort="Bannon, Michael J" uniqKey="Bannon M" first="Michael J." last="Bannon">Michael J. Bannon</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Pharmacology, Wayne State University School of Medicine, 540 E Canfield Ave, 3355 Scott Hall, Detroit, MI 48201 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Department of Pharmacology, Wayne State University School of Medicine, 540 E Canfield Ave, 3355 Scott Hall, Detroit</wicri:cityArea></affiliation></author><author><name sortKey="Trudeau, Louis Eric" sort="Trudeau, Louis Eric" uniqKey="Trudeau L" first="Louis-Eric" last="Trudeau">Louis-Eric Trudeau</name><affiliation><nlm:aff id="A4">Department of Pharmacology, Groupe de Recherchesur le SystèmeNerveux Central, Faculty of Medicine, Université de Montréal, 2900 Boulevard Édouard-Montpetit, Montréal, Québec, H4T 1J4 Canada</nlm:aff><wicri:noCountry code="subfield">H4T 1J4 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Gonzalez Barrios, Juan A" sort="Gonzalez Barrios, Juan A" uniqKey="Gonzalez Barrios J" first="Juan A." last="Gonzalez-Barrios">Juan A. Gonzalez-Barrios</name><affiliation wicri:level="1"><nlm:aff id="A5">Laboratorio de MedicinaGenómica, Hospital Regional “1o. deOctubre”, Av. IPN No. 1669, México D. F., C.P. 07760, México</nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Laboratorio de MedicinaGenómica, Hospital Regional “1o. deOctubre”, Av. IPN No. 1669, México D. F., C.P. 07760</wicri:regionArea></affiliation></author><author><name sortKey="Arango Rodriguez, Martha L" sort="Arango Rodriguez, Martha L" uniqKey="Arango Rodriguez M" first="Martha L." last="Arango-Rodriguez">Martha L. Arango-Rodriguez</name><affiliation wicri:level="1"><nlm:aff id="A6">Instituto de Ciencias, Facultad de MedicinaClínicaAlemana Universidad del Desarrollo. Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Instituto de Ciencias, Facultad de MedicinaClínicaAlemana Universidad del Desarrollo. Santiago</wicri:regionArea></affiliation></author><author><name sortKey="Hernandez Chan, Nancy G" sort="Hernandez Chan, Nancy G" uniqKey="Hernandez Chan N" first="Nancy G." last="Hernandez-Chan">Nancy G. Hernandez-Chan</name><affiliation wicri:level="1"><nlm:aff id="A1">Departamento de Fisiología, Biofísica y Neurociencias, CINVESTAV-I.P.N., Apartado postal 14-740, México D.F., 07000 México</nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Fisiología, Biofísica y Neurociencias, CINVESTAV-I.P.N., Apartado postal 14-740, México D.F.</wicri:regionArea></affiliation></author><author><name sortKey="Reyes Corona, David" sort="Reyes Corona, David" uniqKey="Reyes Corona D" first="David" last="Reyes-Corona">David Reyes-Corona</name><affiliation wicri:level="1"><nlm:aff id="A1">Departamento de Fisiología, Biofísica y Neurociencias, CINVESTAV-I.P.N., Apartado postal 14-740, México D.F., 07000 México</nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Fisiología, Biofísica y Neurociencias, CINVESTAV-I.P.N., Apartado postal 14-740, México D.F.</wicri:regionArea></affiliation></author><author><name sortKey="Armendariz Borunda, Juan" sort="Armendariz Borunda, Juan" uniqKey="Armendariz Borunda J" first="Juan" last="Armendáriz-Borunda">Juan Armendáriz-Borunda</name><affiliation wicri:level="1"><nlm:aff id="A7">Institute for Molecular Biology and Gene Therapy, Department of Molecular Biology and Genomics, University of Guadalajara, Guadalajara, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Institute for Molecular Biology and Gene Therapy, Department of Molecular Biology and Genomics, University of Guadalajara, Guadalajara</wicri:regionArea></affiliation></author><author><name sortKey="Navarro Quiroga, Ivan" sort="Navarro Quiroga, Ivan" uniqKey="Navarro Quiroga I" first="Ivan" last="Navarro-Quiroga">Ivan Navarro-Quiroga</name><affiliation wicri:level="1"><nlm:aff id="A8">KAI-research 11300 Rockville pike, Rockville MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>KAI-research 11300 Rockville pike, Rockville MD</wicri:regionArea></affiliation></author></analytic><series><title level="j">Nanomedicine : nanotechnology, biology, and medicine</title><idno type="ISSN">1549-9634</idno><idno type="eISSN">1549-9642</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">Nanomedicine has focused on targeted neurotrophic gene delivery to the brain as a strategy to stop and reverse neurodegeneration in Parkinson’s disease. Because of improved transfection ability, synthetic nanocarriers have become candidates for neurotrophic therapy. Neurotensin (NTS)-polyplex is a “Trojan horse” synthetic nanocarrier system that enters dopaminergic neurons through NTS receptor internalization to deliver a genetic cargo. The success of preclinical studies with different neurotrophic genes supports the possibility of using NTS-polyplex in nanomedicine. In this review, we describe the mechanism of NTS-polyplex transfection. We discuss the concept that an effective neurotrophic therapy requires a simultaneous effect on the axon terminals and soma of the remaining dopaminergic neurons. We also discuss the future of this strategy for the treatment of Parkinson’s disease.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101233142</journal-id><journal-id journal-id-type="pubmed-jr-id">32817</journal-id><journal-id journal-id-type="nlm-ta">Nanomedicine</journal-id><journal-id journal-id-type="iso-abbrev">Nanomedicine</journal-id><journal-title-group><journal-title>Nanomedicine : nanotechnology, biology, and medicine</journal-title></journal-title-group><issn pub-type="ppub">1549-9634</issn><issn pub-type="epub">1549-9642</issn></journal-meta><article-meta><article-id pub-id-type="pmid">22406187</article-id><article-id pub-id-type="pmc">3394898</article-id><article-id pub-id-type="doi">10.1016/j.nano.2012.02.009</article-id><article-id pub-id-type="manuscript">NIHMS362679</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>NTS-polyplex: A potential nanocarrier for neurotrophic therapy of Parkinson’s disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Martinez-Fong</surname><given-names>Daniel</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A2">b</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Bannon</surname><given-names>Michael J.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Trudeau</surname><given-names>Louis-Eric</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A4">d</xref></contrib><contrib contrib-type="author"><name><surname>Gonzalez-Barrios</surname><given-names>Juan A.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A5">e</xref></contrib><contrib contrib-type="author"><name><surname>Arango-Rodriguez</surname><given-names>Martha L.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A6">f</xref></contrib><contrib contrib-type="author"><name><surname>Hernandez-Chan</surname><given-names>Nancy G.</given-names></name><degrees>MSc</degrees><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Reyes-Corona</surname><given-names>David</given-names></name><degrees>MSc</degrees><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Armendáriz-Borunda</surname><given-names>Juan</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A7">g</xref></contrib><contrib contrib-type="author"><name><surname>Navarro-Quiroga</surname><given-names>Ivan</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A8">h</xref></contrib></contrib-group><aff id="A1"><label>a</label>Departamento de Fisiología, Biofísica y Neurociencias, CINVESTAV-I.P.N., Apartado postal 14-740, México D.F., 07000 México</aff><aff id="A2"><label>b</label>Doctorado en Nanociencias y Nanotecnología, CINVESTAV-I.P.N., Apartado postal 14-740, México D.F., 07000 México</aff><aff id="A3"><label>c</label>Department of Pharmacology, Wayne State University School of Medicine, 540 E Canfield Ave, 3355 Scott Hall, Detroit, MI 48201 USA</aff><aff id="A4"><label>d</label>Department of Pharmacology, Groupe de Recherchesur le SystèmeNerveux Central, Faculty of Medicine, Université de Montréal, 2900 Boulevard Édouard-Montpetit, Montréal, Québec, H4T 1J4 Canada</aff><aff id="A5"><label>e</label>Laboratorio de MedicinaGenómica, Hospital Regional “1o. deOctubre”, Av. IPN No. 1669, México D. F., C.P. 07760, México</aff><aff id="A6"><label>f</label>Instituto de Ciencias, Facultad de MedicinaClínicaAlemana Universidad del Desarrollo. Santiago, Chile</aff><aff id="A7"><label>g</label>Institute for Molecular Biology and Gene Therapy, Department of Molecular Biology and Genomics, University of Guadalajara, Guadalajara, Mexico</aff><aff id="A8"><label>h</label>KAI-research 11300 Rockville pike, Rockville MD, USA</aff><author-notes><corresp id="FN1"><label>*</label>Corresponding author: Dr. Daniel Martinez-Fong; Departamento de Fisiología, Biofísica y Neurociencias; CINVESTAV, Apartado postal 14-740, México D.F., 07000 México. Tel. +52(55)5747-3959. Fax: +52(55)5747-3754. <email>dmartine@fisio.cinvestav.mx</email>; <email>martinez.fong@gmail.com</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>20</day><month>3</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>07</day><month>3</month><year>2012</year></pub-date><pub-date pub-type="ppub"><month>10</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>10</month><year>2013</year></pub-date><volume>8</volume><issue>7</issue><fpage>1052</fpage><lpage>1069</lpage><permissions><copyright-statement>© 2012 Elsevier Inc. All rights reserved.</copyright-statement><copyright-year>2012</copyright-year></permissions><abstract><p id="P2">Nanomedicine has focused on targeted neurotrophic gene delivery to the brain as a strategy to stop and reverse neurodegeneration in Parkinson’s disease. Because of improved transfection ability, synthetic nanocarriers have become candidates for neurotrophic therapy. Neurotensin (NTS)-polyplex is a “Trojan horse” synthetic nanocarrier system that enters dopaminergic neurons through NTS receptor internalization to deliver a genetic cargo. The success of preclinical studies with different neurotrophic genes supports the possibility of using NTS-polyplex in nanomedicine. In this review, we describe the mechanism of NTS-polyplex transfection. We discuss the concept that an effective neurotrophic therapy requires a simultaneous effect on the axon terminals and soma of the remaining dopaminergic neurons. We also discuss the future of this strategy for the treatment of Parkinson’s disease.</p></abstract><kwd-group><kwd>Neurorestoration</kwd><kwd>neuroprotection</kwd><kwd>neurodegeneration</kwd><kwd>regeneration</kwd><kwd>survival</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000749 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000749 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Pmc
|étape= Curation
|type= RBID
|clé= PMC:3394898
|texte= NTS-polyplex: A potential nanocarrier for neurotrophic therapy of Parkinson’s disease
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:22406187" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |