Poor Gait Performance and Prediction of Dementia: Results From a Meta-Analysis
Identifieur interne : 000735 ( Pmc/Curation ); précédent : 000734; suivant : 000736Poor Gait Performance and Prediction of Dementia: Results From a Meta-Analysis
Auteurs : Olivier Beauchet [Canada] ; Cédric Annweiler [France] ; Michele L. Callisaya [Australie] ; Anne-Marie De Cock [Belgique] ; Jorunn L. Helbostad [Norvège] ; Reto W. Kressig [Suisse] ; Velandai Srikanth [Australie] ; Jean-Paul Steinmetz [Luxembourg (pays)] ; Helena M. Blumen [États-Unis] ; Joe Verghese [États-Unis] ; Gilles Allali [États-Unis, Suisse]Source :
- Journal of the American Medical Directors Association [ 1525-8610 ] ; 2016.
Abstract
Poor gait performance predicts risk of developing dementia. No structured critical evaluation has been conducted to study this association yet. The aim of this meta-analysis was to systematically examine the association of poor gait performance with incidence of dementia.
An English and French Medline search was conducted in June 2015, with no limit of date, using the medical subject headings terms “Gait” OR “Gait Disorders, Neurologic” OR “Gait Apraxia” OR “Gait Ataxia” AND “Dementia” OR “Frontotemporal Dementia” OR “Dementia, Multi-Infarct” OR “Dementia, Vascular” OR “Alzheimer Disease” OR “Lewy Body Disease” OR “Frontotemporal Dementia With Motor Neuron Disease” (Supplementary Concept). Poor gait performance was defined by standardized tests of walking, and dementia was diagnosed according to international consensus criteria. Four etiologies of dementia were identified: any dementia, Alzheimer disease (AD), vascular dementia (VaD), and non-AD (ie, pooling VaD, mixed dementias, and other dementias). Fixed effects meta-analyses were performed on the estimates in order to generate summary values.
Of the 796 identified abstracts, 12 (1.5%) were included in this systematic review and meta-analysis. Poor gait performance predicted dementia [pooled hazard ratio (HR) combined with relative risk and odds ratio = 1.53 with
This meta-analysis provides evidence that poor gait performance predicts dementia. This association depends on the type of dementia; poor gait performance is a stronger predictor of non-AD dementias than AD.
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DOI: 10.1016/j.jamda.2015.12.092
PubMed: 26852960
PubMed Central: 5319598
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Blumen</name><affiliation wicri:level="2"><nlm:aff id="A11">Division of Cognitive and Motor Aging, Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Division of Cognitive and Motor Aging, Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx</wicri:cityArea></affiliation></author><author><name sortKey="Verghese, Joe" sort="Verghese, Joe" uniqKey="Verghese J" first="Joe" last="Verghese">Joe Verghese</name><affiliation wicri:level="2"><nlm:aff id="A11">Division of Cognitive and Motor Aging, Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Division of Cognitive and Motor Aging, Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx</wicri:cityArea></affiliation></author><author><name sortKey="Allali, Gilles" sort="Allali, Gilles" uniqKey="Allali G" first="Gilles" last="Allali">Gilles Allali</name><affiliation wicri:level="2"><nlm:aff id="A11">Division of Cognitive and Motor Aging, Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Division of Cognitive and Motor Aging, Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A12">Department of Neurology, Geneva University Hospital and University of Geneva, Geneva, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Neurology, Geneva University Hospital and University of Geneva, Geneva</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26852960</idno><idno type="pmc">5319598</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319598</idno><idno type="RBID">PMC:5319598</idno><idno type="doi">10.1016/j.jamda.2015.12.092</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000735</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000735</idno><idno type="wicri:Area/Pmc/Curation">000735</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000735</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Poor Gait Performance and Prediction of Dementia: Results From a Meta-Analysis</title><author><name sortKey="Beauchet, Olivier" sort="Beauchet, Olivier" uniqKey="Beauchet O" first="Olivier" last="Beauchet">Olivier Beauchet</name><affiliation wicri:level="1"><nlm:aff id="A1">Division of Geriatric Medicine, Department of Medicine, Sir Mortimer B. Davis, Jewish General Hospital and Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Geriatric Medicine, Department of Medicine, Sir Mortimer B. Davis, Jewish General Hospital and Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Dr. Joseph Kaufmann Chair in Geriatric Medicine, Faculty of Medicine, McGill University, Montreal, Quebec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Dr. Joseph Kaufmann Chair in Geriatric Medicine, Faculty of Medicine, McGill University, Montreal, Quebec</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Center of Excellence on Aging and Chronic Diseases of McGill Integrated University Health Network, Quebec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Center of Excellence on Aging and Chronic Diseases of McGill Integrated University Health Network, Quebec</wicri:regionArea></affiliation></author><author><name sortKey="Annweiler, Cedric" sort="Annweiler, Cedric" uniqKey="Annweiler C" first="Cédric" last="Annweiler">Cédric Annweiler</name><affiliation wicri:level="1"><nlm:aff id="A4">Division of Geriatrics, Department of Neuroscience, Angers University Hospital, Angers, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Division of Geriatrics, Department of Neuroscience, Angers University Hospital, Angers</wicri:regionArea></affiliation></author><author><name sortKey="Callisaya, Michele L" sort="Callisaya, Michele L" uniqKey="Callisaya M" first="Michele L." last="Callisaya">Michele L. Callisaya</name><affiliation wicri:level="1"><nlm:aff id="A5">Menzies Institute of Medical Research, University of Tasmania, Hobart, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Menzies Institute of Medical Research, University of Tasmania, Hobart</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="De Cock, Anne Marie" sort="De Cock, Anne Marie" uniqKey="De Cock A" first="Anne-Marie" last="De Cock">Anne-Marie De Cock</name><affiliation wicri:level="1"><nlm:aff id="A7">Department of Geriatrics and Department of Primary and Interdisciplinary Care (ELIZA), University of Antwerp and AZ St Maarten Mechelen, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Geriatrics and Department of Primary and Interdisciplinary Care (ELIZA), University of Antwerp and AZ St Maarten Mechelen, Antwerp</wicri:regionArea></affiliation></author><author><name sortKey="Helbostad, Jorunn L" sort="Helbostad, Jorunn L" uniqKey="Helbostad J" first="Jorunn L." last="Helbostad">Jorunn L. Helbostad</name><affiliation wicri:level="1"><nlm:aff id="A8">Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim</wicri:regionArea></affiliation></author><author><name sortKey="Kressig, Reto W" sort="Kressig, Reto W" uniqKey="Kressig R" first="Reto W." last="Kressig">Reto W. Kressig</name><affiliation wicri:level="1"><nlm:aff id="A9">Department University Center for Medicine of Aging, Felix Platter Hospital and University of Basel, Basel, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department University Center for Medicine of Aging, Felix Platter Hospital and University of Basel, Basel</wicri:regionArea></affiliation></author><author><name sortKey="Srikanth, Velandai" sort="Srikanth, Velandai" uniqKey="Srikanth V" first="Velandai" last="Srikanth">Velandai Srikanth</name><affiliation wicri:level="1"><nlm:aff id="A6">Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Steinmetz, Jean Paul" sort="Steinmetz, Jean Paul" uniqKey="Steinmetz J" first="Jean-Paul" last="Steinmetz">Jean-Paul Steinmetz</name><affiliation wicri:level="1"><nlm:aff id="A10">Center for Memory and Mobility (CeM<sup>2</sup>), Luxembourg City, Luxembourg</nlm:aff><country xml:lang="fr">Luxembourg (pays)</country><wicri:regionArea>), Luxembourg City</wicri:regionArea></affiliation></author><author><name sortKey="Blumen, Helena M" sort="Blumen, Helena M" uniqKey="Blumen H" first="Helena M." last="Blumen">Helena M. Blumen</name><affiliation wicri:level="2"><nlm:aff id="A11">Division of Cognitive and Motor Aging, Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Division of Cognitive and Motor Aging, Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx</wicri:cityArea></affiliation></author><author><name sortKey="Verghese, Joe" sort="Verghese, Joe" uniqKey="Verghese J" first="Joe" last="Verghese">Joe Verghese</name><affiliation wicri:level="2"><nlm:aff id="A11">Division of Cognitive and Motor Aging, Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Division of Cognitive and Motor Aging, Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx</wicri:cityArea></affiliation></author><author><name sortKey="Allali, Gilles" sort="Allali, Gilles" uniqKey="Allali G" first="Gilles" last="Allali">Gilles Allali</name><affiliation wicri:level="2"><nlm:aff id="A11">Division of Cognitive and Motor Aging, Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Division of Cognitive and Motor Aging, Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A12">Department of Neurology, Geneva University Hospital and University of Geneva, Geneva, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Neurology, Geneva University Hospital and University of Geneva, Geneva</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of the American Medical Directors Association</title><idno type="ISSN">1525-8610</idno><idno type="eISSN">1538-9375</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Poor gait performance predicts risk of developing dementia. No structured critical evaluation has been conducted to study this association yet. The aim of this meta-analysis was to systematically examine the association of poor gait performance with incidence of dementia.</p></sec><sec id="S2"><title>Methods</title><p id="P2">An English and French Medline search was conducted in June 2015, with no limit of date, using the medical subject headings terms “Gait” OR “Gait Disorders, Neurologic” OR “Gait Apraxia” OR “Gait Ataxia” AND “Dementia” OR “Frontotemporal Dementia” OR “Dementia, Multi-Infarct” OR “Dementia, Vascular” OR “Alzheimer Disease” OR “Lewy Body Disease” OR “Frontotemporal Dementia With Motor Neuron Disease” (Supplementary Concept). Poor gait performance was defined by standardized tests of walking, and dementia was diagnosed according to international consensus criteria. Four etiologies of dementia were identified: any dementia, Alzheimer disease (AD), vascular dementia (VaD), and non-AD (ie, pooling VaD, mixed dementias, and other dementias). Fixed effects meta-analyses were performed on the estimates in order to generate summary values.</p></sec><sec id="S3"><title>Results</title><p id="P3">Of the 796 identified abstracts, 12 (1.5%) were included in this systematic review and meta-analysis. Poor gait performance predicted dementia [pooled hazard ratio (HR) combined with relative risk and odds ratio = 1.53 with <italic>P</italic> < .001 for any dementia, pooled HR = 1.79 with <italic>P</italic> < .001 for VaD, HR = 1.89 with <italic>P</italic> value < .001 for non-AD]. Findings were weaker for predicting AD (HR = 1.03 with <italic>P</italic> value = .004).</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">This meta-analysis provides evidence that poor gait performance predicts dementia. This association depends on the type of dementia; poor gait performance is a stronger predictor of non-AD dementias than AD.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">100893243</journal-id><journal-id journal-id-type="pubmed-jr-id">30377</journal-id><journal-id journal-id-type="nlm-ta">J Am Med Dir Assoc</journal-id><journal-id journal-id-type="iso-abbrev">J Am Med Dir Assoc</journal-id><journal-title-group><journal-title>Journal of the American Medical Directors Association</journal-title></journal-title-group><issn pub-type="ppub">1525-8610</issn><issn pub-type="epub">1538-9375</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26852960</article-id><article-id pub-id-type="pmc">5319598</article-id><article-id pub-id-type="doi">10.1016/j.jamda.2015.12.092</article-id><article-id pub-id-type="manuscript">NIHMS843740</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Poor Gait Performance and Prediction of Dementia: Results From a Meta-Analysis</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Beauchet</surname><given-names>Olivier</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A2">b</xref><xref ref-type="aff" rid="A3">c</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Annweiler</surname><given-names>Cédric</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A4">d</xref></contrib><contrib contrib-type="author"><name><surname>Callisaya</surname><given-names>Michele L.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A5">e</xref><xref ref-type="aff" rid="A6">f</xref></contrib><contrib contrib-type="author"><name><surname>De Cock</surname><given-names>Anne-Marie</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A7">g</xref></contrib><contrib contrib-type="author"><name><surname>Helbostad</surname><given-names>Jorunn L.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A8">h</xref></contrib><contrib contrib-type="author"><name><surname>Kressig</surname><given-names>Reto W.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A9">i</xref></contrib><contrib contrib-type="author"><name><surname>Srikanth</surname><given-names>Velandai</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A6">f</xref></contrib><contrib contrib-type="author"><name><surname>Steinmetz</surname><given-names>Jean-Paul</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A10">j</xref></contrib><contrib contrib-type="author"><name><surname>Blumen</surname><given-names>Helena M.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A11">k</xref></contrib><contrib contrib-type="author"><name><surname>Verghese</surname><given-names>Joe</given-names></name><degrees>MD, MBBS</degrees><xref ref-type="aff" rid="A11">k</xref></contrib><contrib contrib-type="author"><name><surname>Allali</surname><given-names>Gilles</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A11">k</xref><xref ref-type="aff" rid="A12">l</xref></contrib></contrib-group><aff id="A1"><label>a</label>Division of Geriatric Medicine, Department of Medicine, Sir Mortimer B. Davis, Jewish General Hospital and Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada</aff><aff id="A2"><label>b</label>Dr. Joseph Kaufmann Chair in Geriatric Medicine, Faculty of Medicine, McGill University, Montreal, Quebec, Canada</aff><aff id="A3"><label>c</label>Center of Excellence on Aging and Chronic Diseases of McGill Integrated University Health Network, Quebec, Canada</aff><aff id="A4"><label>d</label>Division of Geriatrics, Department of Neuroscience, Angers University Hospital, Angers, France</aff><aff id="A5"><label>e</label>Menzies Institute of Medical Research, University of Tasmania, Hobart, Australia</aff><aff id="A6"><label>f</label>Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Victoria, Australia</aff><aff id="A7"><label>g</label>Department of Geriatrics and Department of Primary and Interdisciplinary Care (ELIZA), University of Antwerp and AZ St Maarten Mechelen, Antwerp, Belgium</aff><aff id="A8"><label>h</label>Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway</aff><aff id="A9"><label>i</label>Department University Center for Medicine of Aging, Felix Platter Hospital and University of Basel, Basel, Switzerland</aff><aff id="A10"><label>j</label>Center for Memory and Mobility (CeM<sup>2</sup>), Luxembourg City, Luxembourg</aff><aff id="A11"><label>k</label>Division of Cognitive and Motor Aging, Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY</aff><aff id="A12"><label>l</label>Department of Neurology, Geneva University Hospital and University of Geneva, Geneva, Switzerland</aff><author-notes><corresp id="cor1"><label>*</label>Address correspondence to Olivier Beauchet, MD, PhD, Division of Geriatric Medicine, Department of Medicine, Sir Mortimer B. Davis, Jewish General Hospital, McGill University, 3755 chemin de la Côte-Sainte-Catherine, Montréal, QC H3T 1E2, Canada. <email>olivier.beauchet@mcgill.ca</email> (O. Beauchet)</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>20</day><month>1</month><year>2017</year></pub-date><pub-date pub-type="epub"><day>04</day><month>2</month><year>2016</year></pub-date><pub-date pub-type="ppub"><day>01</day><month>6</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>21</day><month>2</month><year>2017</year></pub-date><volume>17</volume><issue>6</issue><fpage>482</fpage><lpage>490</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.jamda.2015.12.092</pmc-comment>
<abstract><sec id="S1"><title>Background</title><p id="P1">Poor gait performance predicts risk of developing dementia. No structured critical evaluation has been conducted to study this association yet. The aim of this meta-analysis was to systematically examine the association of poor gait performance with incidence of dementia.</p></sec><sec id="S2"><title>Methods</title><p id="P2">An English and French Medline search was conducted in June 2015, with no limit of date, using the medical subject headings terms “Gait” OR “Gait Disorders, Neurologic” OR “Gait Apraxia” OR “Gait Ataxia” AND “Dementia” OR “Frontotemporal Dementia” OR “Dementia, Multi-Infarct” OR “Dementia, Vascular” OR “Alzheimer Disease” OR “Lewy Body Disease” OR “Frontotemporal Dementia With Motor Neuron Disease” (Supplementary Concept). Poor gait performance was defined by standardized tests of walking, and dementia was diagnosed according to international consensus criteria. Four etiologies of dementia were identified: any dementia, Alzheimer disease (AD), vascular dementia (VaD), and non-AD (ie, pooling VaD, mixed dementias, and other dementias). Fixed effects meta-analyses were performed on the estimates in order to generate summary values.</p></sec><sec id="S3"><title>Results</title><p id="P3">Of the 796 identified abstracts, 12 (1.5%) were included in this systematic review and meta-analysis. Poor gait performance predicted dementia [pooled hazard ratio (HR) combined with relative risk and odds ratio = 1.53 with <italic>P</italic> < .001 for any dementia, pooled HR = 1.79 with <italic>P</italic> < .001 for VaD, HR = 1.89 with <italic>P</italic> value < .001 for non-AD]. Findings were weaker for predicting AD (HR = 1.03 with <italic>P</italic> value = .004).</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">This meta-analysis provides evidence that poor gait performance predicts dementia. This association depends on the type of dementia; poor gait performance is a stronger predictor of non-AD dementias than AD.</p></sec></abstract><kwd-group><kwd>Epidemiology</kwd><kwd>gait disorders/ataxia</kwd><kwd>motor control</kwd><kwd>dementia</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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