Functional Roles of Human Kallikrein-related Peptidases*
Identifieur interne : 000548 ( Pmc/Curation ); précédent : 000547; suivant : 000549Functional Roles of Human Kallikrein-related Peptidases*
Auteurs : Georgia Sotiropoulou ; Georgios Pampalakis ; Eleftherios P. DiamandisSource :
- The Journal of Biological Chemistry [ 0021-9258 ] ; 2009.
Abstract
Kallikrein-related peptidases constitute a single family of 15 (chymo)trypsin-like proteases (KLK1–15) with pleiotropic physiological roles. Aberrant regulation of KLKs has been associated with diverse diseases such as hypertension, renal dysfunction, skin disorders, inflammation, neurodegeneration, and cancer. Recent studies suggested that coordinated activation and regulation of KLK activity are achieved via a complex network of interactions referred to as the “KLK activome.” However, it remains to be validated whether these hypothetical KLK activation cascade pathways are operative
Url:
DOI: 10.1074/jbc.R109.027946
PubMed: 19819870
PubMed Central: 2785139
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000548
Links to Exploration step
PMC:2785139Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Functional Roles of Human Kallikrein-related Peptidases<xref ref-type="fn" rid="FN1">*</xref>
</title>
<author><name sortKey="Sotiropoulou, Georgia" sort="Sotiropoulou, Georgia" uniqKey="Sotiropoulou G" first="Georgia" last="Sotiropoulou">Georgia Sotiropoulou</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pampalakis, Georgios" sort="Pampalakis, Georgios" uniqKey="Pampalakis G" first="Georgios" last="Pampalakis">Georgios Pampalakis</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Diamandis, Eleftherios P" sort="Diamandis, Eleftherios P" uniqKey="Diamandis E" first="Eleftherios P." last="Diamandis">Eleftherios P. Diamandis</name>
<affiliation><nlm:aff id="aff2"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff4"></nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">19819870</idno>
<idno type="pmc">2785139</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785139</idno>
<idno type="RBID">PMC:2785139</idno>
<idno type="doi">10.1074/jbc.R109.027946</idno>
<date when="2009">2009</date>
<idno type="wicri:Area/Pmc/Corpus">000548</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000548</idno>
<idno type="wicri:Area/Pmc/Curation">000548</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000548</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Functional Roles of Human Kallikrein-related Peptidases<xref ref-type="fn" rid="FN1">*</xref>
</title>
<author><name sortKey="Sotiropoulou, Georgia" sort="Sotiropoulou, Georgia" uniqKey="Sotiropoulou G" first="Georgia" last="Sotiropoulou">Georgia Sotiropoulou</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pampalakis, Georgios" sort="Pampalakis, Georgios" uniqKey="Pampalakis G" first="Georgios" last="Pampalakis">Georgios Pampalakis</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Diamandis, Eleftherios P" sort="Diamandis, Eleftherios P" uniqKey="Diamandis E" first="Eleftherios P." last="Diamandis">Eleftherios P. Diamandis</name>
<affiliation><nlm:aff id="aff2"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff4"></nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of Biological Chemistry</title>
<idno type="ISSN">0021-9258</idno>
<idno type="eISSN">1083-351X</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Kallikrein-related peptidases constitute a single family of 15 (chymo)trypsin-like proteases (KLK1–15) with pleiotropic physiological roles. Aberrant regulation of KLKs has been associated with diverse diseases such as hypertension, renal dysfunction, skin disorders, inflammation, neurodegeneration, and cancer. Recent studies suggested that coordinated activation and regulation of KLK activity are achieved via a complex network of interactions referred to as the “KLK activome.” However, it remains to be validated whether these hypothetical KLK activation cascade pathways are operative <italic>in vivo</italic>
. In addition, KLKs have emerged as versatile signaling molecules. In summary, KLKs represent attractive biomarkers for clinical applications and potential therapeutic targets for common human pathologies.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Biol Chem</journal-id>
<journal-id journal-id-type="hwp">jbc</journal-id>
<journal-id journal-id-type="pmc">jbc</journal-id>
<journal-id journal-id-type="publisher-id">JBC</journal-id>
<journal-title-group><journal-title>The Journal of Biological Chemistry</journal-title>
</journal-title-group>
<issn pub-type="ppub">0021-9258</issn>
<issn pub-type="epub">1083-351X</issn>
<publisher><publisher-name>American Society for Biochemistry and Molecular Biology</publisher-name>
<publisher-loc>9650 Rockville Pike, Bethesda, MD 20814, U.S.A.</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">19819870</article-id>
<article-id pub-id-type="pmc">2785139</article-id>
<article-id pub-id-type="publisher-id">R109.027946</article-id>
<article-id pub-id-type="doi">10.1074/jbc.R109.027946</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Thematic Minireview Series</subject>
</subj-group>
</article-categories>
<title-group><article-title>Functional Roles of Human Kallikrein-related Peptidases<xref ref-type="fn" rid="FN1">*</xref>
</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Sotiropoulou</surname>
<given-names>Georgia</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>‡</sup>
</xref>
<xref ref-type="corresp" rid="cor1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pampalakis</surname>
<given-names>Georgios</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>‡</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Diamandis</surname>
<given-names>Eleftherios P.</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>§</sup>
</xref>
<xref ref-type="aff" rid="aff3"><sup>¶</sup>
</xref>
<xref ref-type="aff" rid="aff4"><sup>‖</sup>
</xref>
</contrib>
<aff id="aff1">From the<label>‡</label>
Department of Pharmacy, University of Patras, Rion, 26500 Rion-Patras, Greece,</aff>
<aff id="aff2">the<label>§</label>
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada,</aff>
<aff id="aff3">the<label>¶</label>
Department of Clinical Biochemistry, University Health Network, Toronto, Ontario M5G 2C4, Canada and</aff>
<aff id="aff4">the<label>‖</label>
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A1, Canada</aff>
</contrib-group>
<author-notes><corresp id="cor1"><label>1</label>
To whom correspondence should be addressed. E-mail: <email>gdsotiro@upatras.gr</email>
.</corresp>
</author-notes>
<pub-date pub-type="ppub"><day>27</day>
<month>11</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="epub"><day>9</day>
<month>10</month>
<year>2009</year>
</pub-date>
<volume>284</volume>
<issue>48</issue>
<fpage>32989</fpage>
<lpage>32994</lpage>
<permissions><copyright-statement>© 2009 by The American Society for Biochemistry and Molecular Biology, Inc.</copyright-statement>
</permissions>
<self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zbc04809032989.pdf"></self-uri>
<abstract><p>Kallikrein-related peptidases constitute a single family of 15 (chymo)trypsin-like proteases (KLK1–15) with pleiotropic physiological roles. Aberrant regulation of KLKs has been associated with diverse diseases such as hypertension, renal dysfunction, skin disorders, inflammation, neurodegeneration, and cancer. Recent studies suggested that coordinated activation and regulation of KLK activity are achieved via a complex network of interactions referred to as the “KLK activome.” However, it remains to be validated whether these hypothetical KLK activation cascade pathways are operative <italic>in vivo</italic>
. In addition, KLKs have emerged as versatile signaling molecules. In summary, KLKs represent attractive biomarkers for clinical applications and potential therapeutic targets for common human pathologies.</p>
</abstract>
</article-meta>
</front>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000548 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000548 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Canada |area= ParkinsonCanadaV1 |flux= Pmc |étape= Curation |type= RBID |clé= PMC:2785139 |texte= Functional Roles of Human Kallikrein-related Peptidases* }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:19819870" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonCanadaV1
This area was generated with Dilib version V0.6.29. |