Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases
Identifieur interne : 000360 ( Pmc/Curation ); précédent : 000359; suivant : 000361Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases
Auteurs : Rita Guerreiro [Royaume-Uni] ; Valentina Escott-Price [Royaume-Uni] ; Lee Darwent [Royaume-Uni] ; Laura Parkkinen [Royaume-Uni] ; Olaf Ansorge [Royaume-Uni] ; Dena G. Hernandez [États-Unis, Allemagne] ; Michael A. Nalls [États-Unis] ; Lorraine Clark [États-Unis] ; Lawrence Honig [États-Unis] ; Karen Marder [États-Unis] ; Wiesje Van Der Flier [Pays-Bas] ; Henne Holstege [Pays-Bas] ; Eva Louwersheimer [Pays-Bas] ; Afina Lemstra [Pays-Bas] ; Philip Scheltens [Pays-Bas] ; Ekaterina Rogaeva [Canada] ; Peter St George-Hyslop [Canada, Royaume-Uni] ; Elisabet Londos [Suède] ; Henrik Zetterberg [Suède, Royaume-Uni] ; Sara Ortega-Cubero [Espagne] ; Pau Pastor [Espagne] ; Tanis J. Ferman [États-Unis] ; Neill R. Graff-Radford [États-Unis] ; Owen A. Ross [États-Unis] ; Imelda Barber [Royaume-Uni] ; Anne Braae [Royaume-Uni] ; Kristelle Brown [Royaume-Uni] ; Kevin Morgan [Royaume-Uni] ; Walter Maetzler [Allemagne] ; Daniela Berg [Allemagne] ; Claire Troakes [Royaume-Uni] ; Safa Al-Sarraj [Royaume-Uni] ; Tammaryn Lashley [Royaume-Uni] ; Yaroslau Compta [Royaume-Uni, Espagne] ; Tamas Revesz [Royaume-Uni] ; Andrew Lees [Royaume-Uni] ; Nigel J. Cairns [États-Unis] ; Glenda M. Halliday [Australie] ; David Mann [Royaume-Uni] ; Stuart Pickering-Brown [Royaume-Uni] ; John Powell [Royaume-Uni] ; Katie Lunnon [Royaume-Uni] ; Michelle K. Lupton [Royaume-Uni] ; Dennis Dickson [États-Unis] ; John Hardy [Royaume-Uni] ; Andrew Singleton [États-Unis] ; Jose Bras [Royaume-Uni]Source :
- Neurobiology of Aging [ 0197-4580 ] ; 2016.
Abstract
The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the
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DOI: 10.1016/j.neurobiolaging.2015.10.028
PubMed: 26643944
PubMed Central: 4759606
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases</title><author><name sortKey="Guerreiro, Rita" sort="Guerreiro, Rita" uniqKey="Guerreiro R" first="Rita" last="Guerreiro">Rita Guerreiro</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Molecular Neuroscience, Institute of Neurology, UCL, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Molecular Neuroscience, Institute of Neurology, UCL, London</wicri:regionArea></affiliation></author><author><name sortKey="Escott Price, Valentina" sort="Escott Price, Valentina" uniqKey="Escott Price V" first="Valentina" last="Escott-Price">Valentina Escott-Price</name><affiliation wicri:level="1"><nlm:aff id="aff2">MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff</wicri:regionArea></affiliation></author><author><name sortKey="Darwent, Lee" sort="Darwent, Lee" uniqKey="Darwent L" first="Lee" last="Darwent">Lee Darwent</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Molecular Neuroscience, Institute of Neurology, UCL, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Molecular Neuroscience, Institute of Neurology, UCL, London</wicri:regionArea></affiliation></author><author><name sortKey="Parkkinen, Laura" sort="Parkkinen, Laura" uniqKey="Parkkinen L" first="Laura" last="Parkkinen">Laura Parkkinen</name><affiliation wicri:level="1"><nlm:aff id="aff3">Nuffield Department of Clinical Neurosciences, Oxford Parkinson's Disease Centre, University of Oxford, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Nuffield Department of Clinical Neurosciences, Oxford Parkinson's Disease Centre, University of Oxford, Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Ansorge, Olaf" sort="Ansorge, Olaf" uniqKey="Ansorge O" first="Olaf" last="Ansorge">Olaf Ansorge</name><affiliation wicri:level="1"><nlm:aff id="aff3">Nuffield Department of Clinical Neurosciences, Oxford Parkinson's Disease Centre, University of Oxford, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Nuffield Department of Clinical Neurosciences, Oxford Parkinson's Disease Centre, University of Oxford, Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Hernandez, Dena G" sort="Hernandez, Dena G" uniqKey="Hernandez D" first="Dena G." last="Hernandez">Dena G. Hernandez</name><affiliation wicri:level="1"><nlm:aff id="aff4">Laboratory of Neurogenetics, National Institutes on Aging, NIH, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neurogenetics, National Institutes on Aging, NIH, Bethesda, MD</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5">German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Neurodegenerative Diseases (DZNE), Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A." last="Nalls">Michael A. Nalls</name><affiliation wicri:level="1"><nlm:aff id="aff4">Laboratory of Neurogenetics, National Institutes on Aging, NIH, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neurogenetics, National Institutes on Aging, NIH, Bethesda, MD</wicri:regionArea></affiliation></author><author><name sortKey="Clark, Lorraine" sort="Clark, Lorraine" uniqKey="Clark L" first="Lorraine" last="Clark">Lorraine Clark</name><affiliation wicri:level="1"><nlm:aff id="aff6">Taub Institute for Alzheimer Disease and the Aging Brain, Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Taub Institute for Alzheimer Disease and the Aging Brain, Columbia University, New York, NY</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7">Department of Pathology and Cell Biology, Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Cell Biology, Columbia University, New York, NY</wicri:regionArea></affiliation></author><author><name sortKey="Honig, Lawrence" sort="Honig, Lawrence" uniqKey="Honig L" first="Lawrence" last="Honig">Lawrence Honig</name><affiliation wicri:level="1"><nlm:aff id="aff6">Taub Institute for Alzheimer Disease and the Aging Brain, Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Taub Institute for Alzheimer Disease and the Aging Brain, Columbia University, New York, NY</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7">Department of Pathology and Cell Biology, Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Cell Biology, Columbia University, New York, NY</wicri:regionArea></affiliation></author><author><name sortKey="Marder, Karen" sort="Marder, Karen" uniqKey="Marder K" first="Karen" last="Marder">Karen Marder</name><affiliation wicri:level="1"><nlm:aff id="aff6">Taub Institute for Alzheimer Disease and the Aging Brain, Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Taub Institute for Alzheimer Disease and the Aging Brain, Columbia University, New York, NY</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff8">Department of Neurology, Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Columbia University, New York, NY</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Flier, Wiesje" sort="Van Der Flier, Wiesje" uniqKey="Van Der Flier W" first="Wiesje" last="Van Der Flier">Wiesje Van Der Flier</name><affiliation wicri:level="1"><nlm:aff id="aff9">Department Of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department Of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Holstege, Henne" sort="Holstege, Henne" uniqKey="Holstege H" first="Henne" last="Holstege">Henne Holstege</name><affiliation wicri:level="1"><nlm:aff id="aff9">Department Of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department Of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Louwersheimer, Eva" sort="Louwersheimer, Eva" uniqKey="Louwersheimer E" first="Eva" last="Louwersheimer">Eva Louwersheimer</name><affiliation wicri:level="1"><nlm:aff id="aff9">Department Of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department Of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Lemstra, Afina" sort="Lemstra, Afina" uniqKey="Lemstra A" first="Afina" last="Lemstra">Afina Lemstra</name><affiliation wicri:level="1"><nlm:aff id="aff9">Department Of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department Of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Scheltens, Philip" sort="Scheltens, Philip" uniqKey="Scheltens P" first="Philip" last="Scheltens">Philip Scheltens</name><affiliation wicri:level="1"><nlm:aff id="aff9">Department Of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department Of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Rogaeva, Ekaterina" sort="Rogaeva, Ekaterina" uniqKey="Rogaeva E" first="Ekaterina" last="Rogaeva">Ekaterina Rogaeva</name><affiliation wicri:level="1"><nlm:aff id="aff10">Department of Medicine, Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="St George Hyslop, Peter" sort="St George Hyslop, Peter" uniqKey="St George Hyslop P" first="Peter" last="St George-Hyslop">Peter St George-Hyslop</name><affiliation wicri:level="1"><nlm:aff id="aff10">Department of Medicine, Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff11">Cambridge Institute for Medical Research, and Cambridge National Institute of Health Research Biomedical Research Unit in Dementia, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cambridge Institute for Medical Research, and Cambridge National Institute of Health Research Biomedical Research Unit in Dementia, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Londos, Elisabet" sort="Londos, Elisabet" uniqKey="Londos E" first="Elisabet" last="Londos">Elisabet Londos</name><affiliation wicri:level="1"><nlm:aff id="aff12">Clinical Memory Research Unit, Institute of Clinical Sciences Malmö, Lund University, Lund, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Clinical Memory Research Unit, Institute of Clinical Sciences Malmö, Lund University, Lund</wicri:regionArea></affiliation></author><author><name sortKey="Zetterberg, Henrik" sort="Zetterberg, Henrik" uniqKey="Zetterberg H" first="Henrik" last="Zetterberg">Henrik Zetterberg</name><affiliation wicri:level="1"><nlm:aff id="aff13">Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Molecular Neuroscience, Institute of Neurology, UCL, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Molecular Neuroscience, Institute of Neurology, UCL, London</wicri:regionArea></affiliation></author><author><name sortKey="Ortega Cubero, Sara" sort="Ortega Cubero, Sara" uniqKey="Ortega Cubero S" first="Sara" last="Ortega-Cubero">Sara Ortega-Cubero</name><affiliation wicri:level="1"><nlm:aff id="aff14">Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, (CIMA), University of Navarra, Pamplona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, (CIMA), University of Navarra, Pamplona</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff15">CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Pastor, Pau" sort="Pastor, Pau" uniqKey="Pastor P" first="Pau" last="Pastor">Pau Pastor</name><affiliation wicri:level="1"><nlm:aff id="aff14">Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, (CIMA), University of Navarra, Pamplona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, (CIMA), University of Navarra, Pamplona</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff15">CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff16">Memory and Movement Disorders Units, Department of Neurology, University Hospital Mutua de Terrassa, University of Barcelona School of Medicine, Terrassa, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Memory and Movement Disorders Units, Department of Neurology, University Hospital Mutua de Terrassa, University of Barcelona School of Medicine, Terrassa, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Ferman, Tanis J" sort="Ferman, Tanis J" uniqKey="Ferman T" first="Tanis J." last="Ferman">Tanis J. Ferman</name><affiliation wicri:level="1"><nlm:aff id="aff17">Departments of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL</wicri:regionArea></affiliation></author><author><name sortKey="Graff Radford, Neill R" sort="Graff Radford, Neill R" uniqKey="Graff Radford N" first="Neill R." last="Graff-Radford">Neill R. Graff-Radford</name><affiliation wicri:level="1"><nlm:aff id="aff18">Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea></affiliation></author><author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name><affiliation wicri:level="1"><nlm:aff id="aff19">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea></affiliation></author><author><name sortKey="Barber, Imelda" sort="Barber, Imelda" uniqKey="Barber I" first="Imelda" last="Barber">Imelda Barber</name><affiliation wicri:level="1"><nlm:aff id="aff20">Translation Cell Sciences—Human Genetics, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Translation Cell Sciences—Human Genetics, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham</wicri:regionArea></affiliation></author><author><name sortKey="Braae, Anne" sort="Braae, Anne" uniqKey="Braae A" first="Anne" last="Braae">Anne Braae</name><affiliation wicri:level="1"><nlm:aff id="aff20">Translation Cell Sciences—Human Genetics, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Translation Cell Sciences—Human Genetics, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham</wicri:regionArea></affiliation></author><author><name sortKey="Brown, Kristelle" sort="Brown, Kristelle" uniqKey="Brown K" first="Kristelle" last="Brown">Kristelle Brown</name><affiliation wicri:level="1"><nlm:aff id="aff20">Translation Cell Sciences—Human Genetics, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Translation Cell Sciences—Human Genetics, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham</wicri:regionArea></affiliation></author><author><name sortKey="Morgan, Kevin" sort="Morgan, Kevin" uniqKey="Morgan K" first="Kevin" last="Morgan">Kevin Morgan</name><affiliation wicri:level="1"><nlm:aff id="aff20">Translation Cell Sciences—Human Genetics, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Translation Cell Sciences—Human Genetics, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham</wicri:regionArea></affiliation></author><author><name sortKey="Maetzler, Walter" sort="Maetzler, Walter" uniqKey="Maetzler W" first="Walter" last="Maetzler">Walter Maetzler</name><affiliation wicri:level="1"><nlm:aff id="aff21">Hertie Institute for Clinical Brain Research, Department of Neurodegeneration, Center of Neurology, University of Tuebingen, and DZNE, German Center for Neurodegenerative Diseases, Tuebingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Hertie Institute for Clinical Brain Research, Department of Neurodegeneration, Center of Neurology, University of Tuebingen, and DZNE, German Center for Neurodegenerative Diseases, Tuebingen</wicri:regionArea></affiliation></author><author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name><affiliation wicri:level="1"><nlm:aff id="aff21">Hertie Institute for Clinical Brain Research, Department of Neurodegeneration, Center of Neurology, University of Tuebingen, and DZNE, German Center for Neurodegenerative Diseases, Tuebingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Hertie Institute for Clinical Brain Research, Department of Neurodegeneration, Center of Neurology, University of Tuebingen, and DZNE, German Center for Neurodegenerative Diseases, Tuebingen</wicri:regionArea></affiliation></author><author><name sortKey="Troakes, Claire" sort="Troakes, Claire" uniqKey="Troakes C" first="Claire" last="Troakes">Claire Troakes</name><affiliation wicri:level="1"><nlm:aff id="aff22">MRC London Neurodegenerative Diseases Brain Bank, Institute of Psychiatry, Department of Clinical Neuroscience, King's College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC London Neurodegenerative Diseases Brain Bank, Institute of Psychiatry, Department of Clinical Neuroscience, King's College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Al Sarraj, Safa" sort="Al Sarraj, Safa" uniqKey="Al Sarraj S" first="Safa" last="Al-Sarraj">Safa Al-Sarraj</name><affiliation wicri:level="1"><nlm:aff id="aff22">MRC London Neurodegenerative Diseases Brain Bank, Institute of Psychiatry, Department of Clinical Neuroscience, King's College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC London Neurodegenerative Diseases Brain Bank, Institute of Psychiatry, Department of Clinical Neuroscience, King's College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Lashley, Tammaryn" sort="Lashley, Tammaryn" uniqKey="Lashley T" first="Tammaryn" last="Lashley">Tammaryn Lashley</name><affiliation wicri:level="1"><nlm:aff id="aff23">Queen Square Brain Bank, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Queen Square Brain Bank, Department of Molecular Neuroscience, UCL Institute of Neurology, London</wicri:regionArea></affiliation></author><author><name sortKey="Compta, Yaroslau" sort="Compta, Yaroslau" uniqKey="Compta Y" first="Yaroslau" last="Compta">Yaroslau Compta</name><affiliation wicri:level="1"><nlm:aff id="aff23">Queen Square Brain Bank, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Queen Square Brain Bank, Department of Molecular Neuroscience, UCL Institute of Neurology, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff24">Parkinson's Disease & Movement Disorders Unit, Neurology Service, Clinical Neuroscience Institute (ICN), Hospital Clínic/University of Barcelona/IDIBAPS, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Parkinson's Disease & Movement Disorders Unit, Neurology Service, Clinical Neuroscience Institute (ICN), Hospital Clínic/University of Barcelona/IDIBAPS, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Revesz, Tamas" sort="Revesz, Tamas" uniqKey="Revesz T" first="Tamas" last="Revesz">Tamas Revesz</name><affiliation wicri:level="1"><nlm:aff id="aff23">Queen Square Brain Bank, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Queen Square Brain Bank, Department of Molecular Neuroscience, UCL Institute of Neurology, London</wicri:regionArea></affiliation></author><author><name sortKey="Lees, Andrew" sort="Lees, Andrew" uniqKey="Lees A" first="Andrew" last="Lees">Andrew Lees</name><affiliation wicri:level="1"><nlm:aff id="aff23">Queen Square Brain Bank, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Queen Square Brain Bank, Department of Molecular Neuroscience, UCL Institute of Neurology, London</wicri:regionArea></affiliation></author><author><name sortKey="Cairns, Nigel J" sort="Cairns, Nigel J" uniqKey="Cairns N" first="Nigel J." last="Cairns">Nigel J. Cairns</name><affiliation wicri:level="1"><nlm:aff id="aff25">Department of Neurology, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, Saint Louis, MO, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, Saint Louis, MO</wicri:regionArea></affiliation></author><author><name sortKey="Halliday, Glenda M" sort="Halliday, Glenda M" uniqKey="Halliday G" first="Glenda M." last="Halliday">Glenda M. Halliday</name><affiliation wicri:level="1"><nlm:aff id="aff26">Neuroscience Research Australia, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Neuroscience Research Australia, Sydney</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff27">School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney</wicri:regionArea></affiliation></author><author><name sortKey="Mann, David" sort="Mann, David" uniqKey="Mann D" first="David" last="Mann">David Mann</name><affiliation wicri:level="1"><nlm:aff id="aff28">Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Manchester</wicri:regionArea></affiliation></author><author><name sortKey="Pickering Brown, Stuart" sort="Pickering Brown, Stuart" uniqKey="Pickering Brown S" first="Stuart" last="Pickering-Brown">Stuart Pickering-Brown</name><affiliation wicri:level="1"><nlm:aff id="aff28">Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Manchester</wicri:regionArea></affiliation></author><author><name sortKey="Powell, John" sort="Powell, John" uniqKey="Powell J" first="John" last="Powell">John Powell</name><affiliation wicri:level="1"><nlm:aff id="aff29">Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Lunnon, Katie" sort="Lunnon, Katie" uniqKey="Lunnon K" first="Katie" last="Lunnon">Katie Lunnon</name><affiliation wicri:level="1"><nlm:aff id="aff30">Institute of Clinical and Biomedical Science, University of Exeter Medical School, University of Exeter, Exeter, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Clinical and Biomedical Science, University of Exeter Medical School, University of Exeter, Exeter</wicri:regionArea></affiliation></author><author><name sortKey="Lupton, Michelle K" sort="Lupton, Michelle K" uniqKey="Lupton M" first="Michelle K." last="Lupton">Michelle K. Lupton</name><affiliation wicri:level="1"><nlm:aff id="aff29">Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Dickson, Dennis" sort="Dickson, Dennis" uniqKey="Dickson D" first="Dennis" last="Dickson">Dennis Dickson</name><affiliation wicri:level="1"><nlm:aff id="aff19">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea></affiliation></author><author><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name><affiliation wicri:level="1"><nlm:aff id="aff31">Reta Lila Weston Research Laboratories, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Reta Lila Weston Research Laboratories, Department of Molecular Neuroscience, UCL Institute of Neurology, London</wicri:regionArea></affiliation></author><author><name sortKey="Singleton, Andrew" sort="Singleton, Andrew" uniqKey="Singleton A" first="Andrew" last="Singleton">Andrew Singleton</name><affiliation wicri:level="1"><nlm:aff id="aff4">Laboratory of Neurogenetics, National Institutes on Aging, NIH, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neurogenetics, National Institutes on Aging, NIH, Bethesda, MD</wicri:regionArea></affiliation></author><author><name sortKey="Bras, Jose" sort="Bras, Jose" uniqKey="Bras J" first="Jose" last="Bras">Jose Bras</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Molecular Neuroscience, Institute of Neurology, UCL, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Molecular Neuroscience, Institute of Neurology, UCL, London</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26643944</idno><idno type="pmc">4759606</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759606</idno><idno type="RBID">PMC:4759606</idno><idno type="doi">10.1016/j.neurobiolaging.2015.10.028</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000360</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000360</idno><idno type="wicri:Area/Pmc/Curation">000360</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000360</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases</title><author><name sortKey="Guerreiro, Rita" sort="Guerreiro, Rita" uniqKey="Guerreiro R" first="Rita" last="Guerreiro">Rita Guerreiro</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Molecular Neuroscience, Institute of Neurology, UCL, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Molecular Neuroscience, Institute of Neurology, UCL, London</wicri:regionArea></affiliation></author><author><name sortKey="Escott Price, Valentina" sort="Escott Price, Valentina" uniqKey="Escott Price V" first="Valentina" last="Escott-Price">Valentina Escott-Price</name><affiliation wicri:level="1"><nlm:aff id="aff2">MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff</wicri:regionArea></affiliation></author><author><name sortKey="Darwent, Lee" sort="Darwent, Lee" uniqKey="Darwent L" first="Lee" last="Darwent">Lee Darwent</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Molecular Neuroscience, Institute of Neurology, UCL, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Molecular Neuroscience, Institute of Neurology, UCL, London</wicri:regionArea></affiliation></author><author><name sortKey="Parkkinen, Laura" sort="Parkkinen, Laura" uniqKey="Parkkinen L" first="Laura" last="Parkkinen">Laura Parkkinen</name><affiliation wicri:level="1"><nlm:aff id="aff3">Nuffield Department of Clinical Neurosciences, Oxford Parkinson's Disease Centre, University of Oxford, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Nuffield Department of Clinical Neurosciences, Oxford Parkinson's Disease Centre, University of Oxford, Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Ansorge, Olaf" sort="Ansorge, Olaf" uniqKey="Ansorge O" first="Olaf" last="Ansorge">Olaf Ansorge</name><affiliation wicri:level="1"><nlm:aff id="aff3">Nuffield Department of Clinical Neurosciences, Oxford Parkinson's Disease Centre, University of Oxford, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Nuffield Department of Clinical Neurosciences, Oxford Parkinson's Disease Centre, University of Oxford, Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Hernandez, Dena G" sort="Hernandez, Dena G" uniqKey="Hernandez D" first="Dena G." last="Hernandez">Dena G. Hernandez</name><affiliation wicri:level="1"><nlm:aff id="aff4">Laboratory of Neurogenetics, National Institutes on Aging, NIH, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neurogenetics, National Institutes on Aging, NIH, Bethesda, MD</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5">German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Neurodegenerative Diseases (DZNE), Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A." last="Nalls">Michael A. Nalls</name><affiliation wicri:level="1"><nlm:aff id="aff4">Laboratory of Neurogenetics, National Institutes on Aging, NIH, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neurogenetics, National Institutes on Aging, NIH, Bethesda, MD</wicri:regionArea></affiliation></author><author><name sortKey="Clark, Lorraine" sort="Clark, Lorraine" uniqKey="Clark L" first="Lorraine" last="Clark">Lorraine Clark</name><affiliation wicri:level="1"><nlm:aff id="aff6">Taub Institute for Alzheimer Disease and the Aging Brain, Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Taub Institute for Alzheimer Disease and the Aging Brain, Columbia University, New York, NY</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7">Department of Pathology and Cell Biology, Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Cell Biology, Columbia University, New York, NY</wicri:regionArea></affiliation></author><author><name sortKey="Honig, Lawrence" sort="Honig, Lawrence" uniqKey="Honig L" first="Lawrence" last="Honig">Lawrence Honig</name><affiliation wicri:level="1"><nlm:aff id="aff6">Taub Institute for Alzheimer Disease and the Aging Brain, Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Taub Institute for Alzheimer Disease and the Aging Brain, Columbia University, New York, NY</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7">Department of Pathology and Cell Biology, Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Cell Biology, Columbia University, New York, NY</wicri:regionArea></affiliation></author><author><name sortKey="Marder, Karen" sort="Marder, Karen" uniqKey="Marder K" first="Karen" last="Marder">Karen Marder</name><affiliation wicri:level="1"><nlm:aff id="aff6">Taub Institute for Alzheimer Disease and the Aging Brain, Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Taub Institute for Alzheimer Disease and the Aging Brain, Columbia University, New York, NY</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff8">Department of Neurology, Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Columbia University, New York, NY</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Flier, Wiesje" sort="Van Der Flier, Wiesje" uniqKey="Van Der Flier W" first="Wiesje" last="Van Der Flier">Wiesje Van Der Flier</name><affiliation wicri:level="1"><nlm:aff id="aff9">Department Of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department Of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Holstege, Henne" sort="Holstege, Henne" uniqKey="Holstege H" first="Henne" last="Holstege">Henne Holstege</name><affiliation wicri:level="1"><nlm:aff id="aff9">Department Of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department Of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Louwersheimer, Eva" sort="Louwersheimer, Eva" uniqKey="Louwersheimer E" first="Eva" last="Louwersheimer">Eva Louwersheimer</name><affiliation wicri:level="1"><nlm:aff id="aff9">Department Of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department Of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Lemstra, Afina" sort="Lemstra, Afina" uniqKey="Lemstra A" first="Afina" last="Lemstra">Afina Lemstra</name><affiliation wicri:level="1"><nlm:aff id="aff9">Department Of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department Of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Scheltens, Philip" sort="Scheltens, Philip" uniqKey="Scheltens P" first="Philip" last="Scheltens">Philip Scheltens</name><affiliation wicri:level="1"><nlm:aff id="aff9">Department Of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department Of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Rogaeva, Ekaterina" sort="Rogaeva, Ekaterina" uniqKey="Rogaeva E" first="Ekaterina" last="Rogaeva">Ekaterina Rogaeva</name><affiliation wicri:level="1"><nlm:aff id="aff10">Department of Medicine, Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="St George Hyslop, Peter" sort="St George Hyslop, Peter" uniqKey="St George Hyslop P" first="Peter" last="St George-Hyslop">Peter St George-Hyslop</name><affiliation wicri:level="1"><nlm:aff id="aff10">Department of Medicine, Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff11">Cambridge Institute for Medical Research, and Cambridge National Institute of Health Research Biomedical Research Unit in Dementia, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cambridge Institute for Medical Research, and Cambridge National Institute of Health Research Biomedical Research Unit in Dementia, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Londos, Elisabet" sort="Londos, Elisabet" uniqKey="Londos E" first="Elisabet" last="Londos">Elisabet Londos</name><affiliation wicri:level="1"><nlm:aff id="aff12">Clinical Memory Research Unit, Institute of Clinical Sciences Malmö, Lund University, Lund, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Clinical Memory Research Unit, Institute of Clinical Sciences Malmö, Lund University, Lund</wicri:regionArea></affiliation></author><author><name sortKey="Zetterberg, Henrik" sort="Zetterberg, Henrik" uniqKey="Zetterberg H" first="Henrik" last="Zetterberg">Henrik Zetterberg</name><affiliation wicri:level="1"><nlm:aff id="aff13">Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Molecular Neuroscience, Institute of Neurology, UCL, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Molecular Neuroscience, Institute of Neurology, UCL, London</wicri:regionArea></affiliation></author><author><name sortKey="Ortega Cubero, Sara" sort="Ortega Cubero, Sara" uniqKey="Ortega Cubero S" first="Sara" last="Ortega-Cubero">Sara Ortega-Cubero</name><affiliation wicri:level="1"><nlm:aff id="aff14">Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, (CIMA), University of Navarra, Pamplona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, (CIMA), University of Navarra, Pamplona</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff15">CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Pastor, Pau" sort="Pastor, Pau" uniqKey="Pastor P" first="Pau" last="Pastor">Pau Pastor</name><affiliation wicri:level="1"><nlm:aff id="aff14">Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, (CIMA), University of Navarra, Pamplona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, (CIMA), University of Navarra, Pamplona</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff15">CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff16">Memory and Movement Disorders Units, Department of Neurology, University Hospital Mutua de Terrassa, University of Barcelona School of Medicine, Terrassa, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Memory and Movement Disorders Units, Department of Neurology, University Hospital Mutua de Terrassa, University of Barcelona School of Medicine, Terrassa, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Ferman, Tanis J" sort="Ferman, Tanis J" uniqKey="Ferman T" first="Tanis J." last="Ferman">Tanis J. Ferman</name><affiliation wicri:level="1"><nlm:aff id="aff17">Departments of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL</wicri:regionArea></affiliation></author><author><name sortKey="Graff Radford, Neill R" sort="Graff Radford, Neill R" uniqKey="Graff Radford N" first="Neill R." last="Graff-Radford">Neill R. Graff-Radford</name><affiliation wicri:level="1"><nlm:aff id="aff18">Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea></affiliation></author><author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name><affiliation wicri:level="1"><nlm:aff id="aff19">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea></affiliation></author><author><name sortKey="Barber, Imelda" sort="Barber, Imelda" uniqKey="Barber I" first="Imelda" last="Barber">Imelda Barber</name><affiliation wicri:level="1"><nlm:aff id="aff20">Translation Cell Sciences—Human Genetics, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Translation Cell Sciences—Human Genetics, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham</wicri:regionArea></affiliation></author><author><name sortKey="Braae, Anne" sort="Braae, Anne" uniqKey="Braae A" first="Anne" last="Braae">Anne Braae</name><affiliation wicri:level="1"><nlm:aff id="aff20">Translation Cell Sciences—Human Genetics, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Translation Cell Sciences—Human Genetics, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham</wicri:regionArea></affiliation></author><author><name sortKey="Brown, Kristelle" sort="Brown, Kristelle" uniqKey="Brown K" first="Kristelle" last="Brown">Kristelle Brown</name><affiliation wicri:level="1"><nlm:aff id="aff20">Translation Cell Sciences—Human Genetics, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Translation Cell Sciences—Human Genetics, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham</wicri:regionArea></affiliation></author><author><name sortKey="Morgan, Kevin" sort="Morgan, Kevin" uniqKey="Morgan K" first="Kevin" last="Morgan">Kevin Morgan</name><affiliation wicri:level="1"><nlm:aff id="aff20">Translation Cell Sciences—Human Genetics, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Translation Cell Sciences—Human Genetics, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham</wicri:regionArea></affiliation></author><author><name sortKey="Maetzler, Walter" sort="Maetzler, Walter" uniqKey="Maetzler W" first="Walter" last="Maetzler">Walter Maetzler</name><affiliation wicri:level="1"><nlm:aff id="aff21">Hertie Institute for Clinical Brain Research, Department of Neurodegeneration, Center of Neurology, University of Tuebingen, and DZNE, German Center for Neurodegenerative Diseases, Tuebingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Hertie Institute for Clinical Brain Research, Department of Neurodegeneration, Center of Neurology, University of Tuebingen, and DZNE, German Center for Neurodegenerative Diseases, Tuebingen</wicri:regionArea></affiliation></author><author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name><affiliation wicri:level="1"><nlm:aff id="aff21">Hertie Institute for Clinical Brain Research, Department of Neurodegeneration, Center of Neurology, University of Tuebingen, and DZNE, German Center for Neurodegenerative Diseases, Tuebingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Hertie Institute for Clinical Brain Research, Department of Neurodegeneration, Center of Neurology, University of Tuebingen, and DZNE, German Center for Neurodegenerative Diseases, Tuebingen</wicri:regionArea></affiliation></author><author><name sortKey="Troakes, Claire" sort="Troakes, Claire" uniqKey="Troakes C" first="Claire" last="Troakes">Claire Troakes</name><affiliation wicri:level="1"><nlm:aff id="aff22">MRC London Neurodegenerative Diseases Brain Bank, Institute of Psychiatry, Department of Clinical Neuroscience, King's College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC London Neurodegenerative Diseases Brain Bank, Institute of Psychiatry, Department of Clinical Neuroscience, King's College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Al Sarraj, Safa" sort="Al Sarraj, Safa" uniqKey="Al Sarraj S" first="Safa" last="Al-Sarraj">Safa Al-Sarraj</name><affiliation wicri:level="1"><nlm:aff id="aff22">MRC London Neurodegenerative Diseases Brain Bank, Institute of Psychiatry, Department of Clinical Neuroscience, King's College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC London Neurodegenerative Diseases Brain Bank, Institute of Psychiatry, Department of Clinical Neuroscience, King's College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Lashley, Tammaryn" sort="Lashley, Tammaryn" uniqKey="Lashley T" first="Tammaryn" last="Lashley">Tammaryn Lashley</name><affiliation wicri:level="1"><nlm:aff id="aff23">Queen Square Brain Bank, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Queen Square Brain Bank, Department of Molecular Neuroscience, UCL Institute of Neurology, London</wicri:regionArea></affiliation></author><author><name sortKey="Compta, Yaroslau" sort="Compta, Yaroslau" uniqKey="Compta Y" first="Yaroslau" last="Compta">Yaroslau Compta</name><affiliation wicri:level="1"><nlm:aff id="aff23">Queen Square Brain Bank, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Queen Square Brain Bank, Department of Molecular Neuroscience, UCL Institute of Neurology, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff24">Parkinson's Disease & Movement Disorders Unit, Neurology Service, Clinical Neuroscience Institute (ICN), Hospital Clínic/University of Barcelona/IDIBAPS, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Parkinson's Disease & Movement Disorders Unit, Neurology Service, Clinical Neuroscience Institute (ICN), Hospital Clínic/University of Barcelona/IDIBAPS, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Revesz, Tamas" sort="Revesz, Tamas" uniqKey="Revesz T" first="Tamas" last="Revesz">Tamas Revesz</name><affiliation wicri:level="1"><nlm:aff id="aff23">Queen Square Brain Bank, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Queen Square Brain Bank, Department of Molecular Neuroscience, UCL Institute of Neurology, London</wicri:regionArea></affiliation></author><author><name sortKey="Lees, Andrew" sort="Lees, Andrew" uniqKey="Lees A" first="Andrew" last="Lees">Andrew Lees</name><affiliation wicri:level="1"><nlm:aff id="aff23">Queen Square Brain Bank, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Queen Square Brain Bank, Department of Molecular Neuroscience, UCL Institute of Neurology, London</wicri:regionArea></affiliation></author><author><name sortKey="Cairns, Nigel J" sort="Cairns, Nigel J" uniqKey="Cairns N" first="Nigel J." last="Cairns">Nigel J. Cairns</name><affiliation wicri:level="1"><nlm:aff id="aff25">Department of Neurology, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, Saint Louis, MO, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, Saint Louis, MO</wicri:regionArea></affiliation></author><author><name sortKey="Halliday, Glenda M" sort="Halliday, Glenda M" uniqKey="Halliday G" first="Glenda M." last="Halliday">Glenda M. Halliday</name><affiliation wicri:level="1"><nlm:aff id="aff26">Neuroscience Research Australia, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Neuroscience Research Australia, Sydney</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff27">School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney</wicri:regionArea></affiliation></author><author><name sortKey="Mann, David" sort="Mann, David" uniqKey="Mann D" first="David" last="Mann">David Mann</name><affiliation wicri:level="1"><nlm:aff id="aff28">Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Manchester</wicri:regionArea></affiliation></author><author><name sortKey="Pickering Brown, Stuart" sort="Pickering Brown, Stuart" uniqKey="Pickering Brown S" first="Stuart" last="Pickering-Brown">Stuart Pickering-Brown</name><affiliation wicri:level="1"><nlm:aff id="aff28">Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Manchester</wicri:regionArea></affiliation></author><author><name sortKey="Powell, John" sort="Powell, John" uniqKey="Powell J" first="John" last="Powell">John Powell</name><affiliation wicri:level="1"><nlm:aff id="aff29">Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Lunnon, Katie" sort="Lunnon, Katie" uniqKey="Lunnon K" first="Katie" last="Lunnon">Katie Lunnon</name><affiliation wicri:level="1"><nlm:aff id="aff30">Institute of Clinical and Biomedical Science, University of Exeter Medical School, University of Exeter, Exeter, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Clinical and Biomedical Science, University of Exeter Medical School, University of Exeter, Exeter</wicri:regionArea></affiliation></author><author><name sortKey="Lupton, Michelle K" sort="Lupton, Michelle K" uniqKey="Lupton M" first="Michelle K." last="Lupton">Michelle K. Lupton</name><affiliation wicri:level="1"><nlm:aff id="aff29">Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Dickson, Dennis" sort="Dickson, Dennis" uniqKey="Dickson D" first="Dennis" last="Dickson">Dennis Dickson</name><affiliation wicri:level="1"><nlm:aff id="aff19">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea></affiliation></author><author><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name><affiliation wicri:level="1"><nlm:aff id="aff31">Reta Lila Weston Research Laboratories, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Reta Lila Weston Research Laboratories, Department of Molecular Neuroscience, UCL Institute of Neurology, London</wicri:regionArea></affiliation></author><author><name sortKey="Singleton, Andrew" sort="Singleton, Andrew" uniqKey="Singleton A" first="Andrew" last="Singleton">Andrew Singleton</name><affiliation wicri:level="1"><nlm:aff id="aff4">Laboratory of Neurogenetics, National Institutes on Aging, NIH, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neurogenetics, National Institutes on Aging, NIH, Bethesda, MD</wicri:regionArea></affiliation></author><author><name sortKey="Bras, Jose" sort="Bras, Jose" uniqKey="Bras J" first="Jose" last="Bras">Jose Bras</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Molecular Neuroscience, Institute of Neurology, UCL, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Molecular Neuroscience, Institute of Neurology, UCL, London</wicri:regionArea></affiliation></author></analytic><series><title level="j">Neurobiology of Aging</title><idno type="ISSN">0197-4580</idno><idno type="eISSN">1558-1497</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the <italic>APOE</italic> locus, DLB is equally correlated to AD and PD.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bras, J" uniqKey="Bras J">J. Bras</name></author><author><name sortKey="Guerreiro, R" uniqKey="Guerreiro R">R. Guerreiro</name></author><author><name sortKey="Darwent, L" uniqKey="Darwent L">L. Darwent</name></author><author><name sortKey="Parkkinen, L" uniqKey="Parkkinen L">L. Parkkinen</name></author><author><name sortKey="Ansorge, O" uniqKey="Ansorge O">O. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Neurobiol Aging</journal-id><journal-id journal-id-type="iso-abbrev">Neurobiol. 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contrib-type="author"><name><surname>Lees</surname><given-names>Andrew</given-names></name><xref rid="aff23" ref-type="aff">w</xref></contrib><contrib contrib-type="author"><name><surname>Cairns</surname><given-names>Nigel J.</given-names></name><xref rid="aff25" ref-type="aff">y</xref></contrib><contrib contrib-type="author"><name><surname>Halliday</surname><given-names>Glenda M.</given-names></name><xref rid="aff26" ref-type="aff">z</xref><xref rid="aff27" ref-type="aff">aa</xref></contrib><contrib contrib-type="author"><name><surname>Mann</surname><given-names>David</given-names></name><xref rid="aff28" ref-type="aff">bb</xref></contrib><contrib contrib-type="author"><name><surname>Pickering-Brown</surname><given-names>Stuart</given-names></name><xref rid="aff28" ref-type="aff">bb</xref></contrib><contrib contrib-type="author"><name><surname>Powell</surname><given-names>John</given-names></name><xref rid="aff29" ref-type="aff">cc</xref></contrib><contrib contrib-type="author"><name><surname>Lunnon</surname><given-names>Katie</given-names></name><xref rid="aff30" ref-type="aff">dd</xref></contrib><contrib contrib-type="author"><name><surname>Lupton</surname><given-names>Michelle K.</given-names></name><xref rid="aff29" ref-type="aff">cc</xref></contrib><contrib contrib-type="author"><collab>International Parkinson's Disease Genomics Consortium (IPDGC)</collab><xref rid="fn1" ref-type="fn">1</xref></contrib><contrib contrib-type="author"><name><surname>Dickson</surname><given-names>Dennis</given-names></name><xref rid="aff19" ref-type="aff">s</xref></contrib><contrib contrib-type="author"><name><surname>Hardy</surname><given-names>John</given-names></name><xref rid="aff31" ref-type="aff">ee</xref></contrib><contrib contrib-type="author"><name><surname>Singleton</surname><given-names>Andrew</given-names></name><xref rid="aff4" ref-type="aff">d</xref></contrib><contrib contrib-type="author"><name><surname>Bras</surname><given-names>Jose</given-names></name><email>j.bras@ucl.ac.uk</email><xref rid="aff1" ref-type="aff">a</xref><xref rid="cor1" ref-type="corresp">∗</xref></contrib></contrib-group><aff id="aff1"><label>a</label>Department of Molecular Neuroscience, Institute of Neurology, UCL, London, UK</aff><aff id="aff2"><label>b</label>MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, UK</aff><aff id="aff3"><label>c</label>Nuffield Department of Clinical Neurosciences, Oxford Parkinson's Disease Centre, University of Oxford, Oxford, UK</aff><aff id="aff4"><label>d</label>Laboratory of Neurogenetics, National Institutes on Aging, NIH, Bethesda, MD, USA</aff><aff id="aff5"><label>e</label>German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany</aff><aff id="aff6"><label>f</label>Taub Institute for Alzheimer Disease and the Aging Brain, Columbia University, New York, NY, USA</aff><aff id="aff7"><label>g</label>Department of Pathology and Cell Biology, Columbia University, New York, NY, USA</aff><aff id="aff8"><label>h</label>Department of Neurology, Columbia University, New York, NY, USA</aff><aff id="aff9"><label>i</label>Department Of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands</aff><aff id="aff10"><label>j</label>Department of Medicine, Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada</aff><aff id="aff11"><label>k</label>Cambridge Institute for Medical Research, and Cambridge National Institute of Health Research Biomedical Research Unit in Dementia, University of Cambridge, Cambridge, UK</aff><aff id="aff12"><label>l</label>Clinical Memory Research Unit, Institute of Clinical Sciences Malmö, Lund University, Lund, Sweden</aff><aff id="aff13"><label>m</label>Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden</aff><aff id="aff14"><label>n</label>Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, (CIMA), University of Navarra, Pamplona, Spain</aff><aff id="aff15"><label>o</label>CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain</aff><aff id="aff16"><label>p</label>Memory and Movement Disorders Units, Department of Neurology, University Hospital Mutua de Terrassa, University of Barcelona School of Medicine, Terrassa, Barcelona, Spain</aff><aff id="aff17"><label>q</label>Departments of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL, USA</aff><aff id="aff18"><label>r</label>Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</aff><aff id="aff19"><label>s</label>Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</aff><aff id="aff20"><label>t</label>Translation Cell Sciences—Human Genetics, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UK</aff><aff id="aff21"><label>u</label>Hertie Institute for Clinical Brain Research, Department of Neurodegeneration, Center of Neurology, University of Tuebingen, and DZNE, German Center for Neurodegenerative Diseases, Tuebingen, Germany</aff><aff id="aff22"><label>v</label>MRC London Neurodegenerative Diseases Brain Bank, Institute of Psychiatry, Department of Clinical Neuroscience, King's College London, London, UK</aff><aff id="aff23"><label>w</label>Queen Square Brain Bank, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK</aff><aff id="aff24"><label>x</label>Parkinson's Disease & Movement Disorders Unit, Neurology Service, Clinical Neuroscience Institute (ICN), Hospital Clínic/University of Barcelona/IDIBAPS, Barcelona, Spain</aff><aff id="aff25"><label>y</label>Department of Neurology, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, Saint Louis, MO, USA</aff><aff id="aff26"><label>z</label>Neuroscience Research Australia, Sydney, Australia</aff><aff id="aff27"><label>aa</label>School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia</aff><aff id="aff28"><label>bb</label>Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK</aff><aff id="aff29"><label>cc</label>Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK</aff><aff id="aff30"><label>dd</label>Institute of Clinical and Biomedical Science, University of Exeter Medical School, University of Exeter, Exeter, UK</aff><aff id="aff31"><label>ee</label>Reta Lila Weston Research Laboratories, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK</aff><author-notes><corresp id="cor1"><label>∗</label>Corresponding author at: Department of Molecular Neuroscience, Institute of Neurology, University College of London, 8-11 Queen Square, DRC, Box 16, London, WC1N 3AR, UK. Tel.: +44 203 448 3936.Department of Molecular NeuroscienceInstitute of NeurologyUniversity College of London8-11 Queen SquareDRCBox 16LondonWC1N 3ARUK <email>j.bras@ucl.ac.uk</email></corresp><fn id="fn1"><label>1</label><p id="ntpara0010">A complete list of the IPDGC members is listed in the <xref rid="appsec1" ref-type="sec">Supplementary Material</xref>.</p></fn><fn id="fn2"><label>2</label><p id="ntpara0015">Equally contributing authors.</p></fn></author-notes><pub-date pub-type="pmc-release"><day>1</day><month>2</month><year>2016</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>2</month><year>2016</year></pub-date><volume>38</volume><fpage>214.e7</fpage><lpage>214.e10</lpage><history><date date-type="received"><day>13</day><month>10</month><year>2015</year></date><date date-type="rev-recd"><day>27</day><month>10</month><year>2015</year></date><date date-type="accepted"><day>28</day><month>10</month><year>2015</year></date></history><permissions><copyright-statement>© 2016 The Authors</copyright-statement><copyright-year>2016</copyright-year><license license-type="CC BY" xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).</license-p></license></permissions><abstract><p>The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the <italic>APOE</italic> locus, DLB is equally correlated to AD and PD.</p></abstract><kwd-group><title>Keywords</title><kwd>Dementia with Lewy bodies</kwd><kwd>Alzheimer's disease</kwd><kwd>Parkinson's disease</kwd><kwd>Genetic correlation</kwd></kwd-group></article-meta></front><floats-group><table-wrap id="tbl1" position="float"><label>Table 1</label><caption><p>Samples included in the study</p></caption><table frame="hsides" rules="groups"><thead><tr><th>Trait</th><th>Total cases</th><th>Pathologically confirmed cases</th></tr></thead><tbody><tr><td>DLB</td><td align="char">788</td><td align="char">667</td></tr><tr><td>AD</td><td align="char">959</td><td align="char">113</td></tr><tr><td>PD</td><td align="char">804</td><td align="char">0</td></tr></tbody></table><table-wrap-foot><fn><p>Key: AD, Alzheimer's disease; DLB, dementia with Lewy bodies; PD, Parkinson's disease.</p></fn></table-wrap-foot></table-wrap><table-wrap id="tbl2" position="float"><label>Table 2</label><caption><p>Genetic correlation scores between pairs of diseases</p></caption><table frame="hsides" rules="groups"><thead><tr><th>Trait1</th><th>Trait2</th><th>Genetic correlation</th><th>SE</th><th><italic>p</italic>-value</th></tr></thead><tbody><tr><td>AD</td><td>DLB</td><td align="char">0.578</td><td align="char">0.075</td><td align="char">1.1 × 10<sup>−12</sup></td></tr><tr><td>PD</td><td>DLB</td><td align="char">0.362</td><td align="char">0.107</td><td align="char">7.1 × 10<sup>−4</sup></td></tr><tr><td>AD</td><td>PD</td><td align="char">0.08</td><td align="char">0.101</td><td>0.39</td></tr><tr><td>AD</td><td>DLB_NO_APOE</td><td align="char">0.332</td><td align="char">0.106</td><td align="char">1.8 × 10<sup>−3</sup></td></tr></tbody></table><table-wrap-foot><fn><p>Key: AD, Alzheimer's disease; DLB, dementia with Lewy bodies; PD, Parkinson's disease; SE, standard error.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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