ParkinsonCanadaV1, Pmc, Curation, bibRecord, 000279

Modeling Neurodegeneration in Zebrafish

Identifieur interne : 000279 ( Pmc/Curation ); précédent : 000278; suivant : 000280

Modeling Neurodegeneration in Zebrafish

Auteurs : Yanwei Xi ; Sandra Noble ; Marc Ekker

Source :

Current Neurology and Neuroscience Reports [ 1528-4042 ] ; 2011.

RBID : PMC:3075402

Abstract

The zebrafish, Danio rerio, has been established as an excellent vertebrate model for the study of developmental biology and gene function. It also has proven to be a valuable model to study human diseases. Here, we reviewed recent publications using zebrafish to study the pathology of human neurodegenerative diseases including Parkinson’s, Huntington’s, and Alzheimer’s. These studies indicate that zebrafish genes and their human homologues have conserved functions with respect to the etiology of neurodegenerative diseases. The characteristics of the zebrafish and the experimental approaches to which it is amenable make this species a useful complement to other animal models for the study of pathologic mechanisms of neurodegenerative diseases and for the screening of compounds with therapeutic potential.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075402

DOI: 10.1007/s11910-011-0182-2
PubMed: 21271309
PubMed Central: 3075402

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Yanwei Xi

<affiliation><nlm:aff id="Aff1">Department of Biology, Center for Advanced Research in Environmental Genomics, University of Ottawa, 30 Marie Curie, Ottawa, Ontario K1N 6N5 Canada</nlm:aff>
<wicri:noCountry code="subfield">Ontario K1N 6N5 Canada</wicri:noCountry>
</affiliation>

Sandra Noble

<affiliation><nlm:aff id="Aff1">Department of Biology, Center for Advanced Research in Environmental Genomics, University of Ottawa, 30 Marie Curie, Ottawa, Ontario K1N 6N5 Canada</nlm:aff>
<wicri:noCountry code="subfield">Ontario K1N 6N5 Canada</wicri:noCountry>
</affiliation>

Marc Ekker

<affiliation><nlm:aff id="Aff1">Department of Biology, Center for Advanced Research in Environmental Genomics, University of Ottawa, 30 Marie Curie, Ottawa, Ontario K1N 6N5 Canada</nlm:aff>
<wicri:noCountry code="subfield">Ontario K1N 6N5 Canada</wicri:noCountry>
</affiliation>

Le document en format XML

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<wicri:noCountry code="subfield">Ontario K1N 6N5 Canada</wicri:noCountry>
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<front><div type="abstract" xml:lang="en"><p>The zebrafish, <italic>Danio rerio</italic>
, has been established as an excellent vertebrate model for the study of developmental biology and gene function. It also has proven to be a valuable model to study human diseases. Here, we reviewed recent publications using zebrafish to study the pathology of human neurodegenerative diseases including Parkinson’s, Huntington’s, and Alzheimer’s. These studies indicate that zebrafish genes and their human homologues have conserved functions with respect to the etiology of neurodegenerative diseases. The characteristics of the zebrafish and the experimental approaches to which it is amenable make this species a useful complement to other animal models for the study of pathologic mechanisms of neurodegenerative diseases and for the screening of compounds with therapeutic potential.</p>
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<contrib-group><contrib contrib-type="author"><name><surname>Xi</surname>
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<aff id="Aff1">Department of Biology, Center for Advanced Research in Environmental Genomics, University of Ottawa, 30 Marie Curie, Ottawa, Ontario K1N 6N5 Canada</aff>
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<pub-date pub-type="epub"><day>27</day>
<month>1</month>
<year>2011</year>
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<pub-date pub-type="pmc-release"><day>27</day>
<month>1</month>
<year>2011</year>
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<pub-date pub-type="ppub"><month>6</month>
<year>2011</year>
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<volume>11</volume>
<issue>3</issue>
<fpage>274</fpage>
<lpage>282</lpage>
<permissions><copyright-statement>© The Author(s) 2011</copyright-statement>
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<abstract id="Abs1"><p>The zebrafish, <italic>Danio rerio</italic>
, has been established as an excellent vertebrate model for the study of developmental biology and gene function. It also has proven to be a valuable model to study human diseases. Here, we reviewed recent publications using zebrafish to study the pathology of human neurodegenerative diseases including Parkinson’s, Huntington’s, and Alzheimer’s. These studies indicate that zebrafish genes and their human homologues have conserved functions with respect to the etiology of neurodegenerative diseases. The characteristics of the zebrafish and the experimental approaches to which it is amenable make this species a useful complement to other animal models for the study of pathologic mechanisms of neurodegenerative diseases and for the screening of compounds with therapeutic potential.</p>
</abstract>
<kwd-group><title>Keywords</title>
<kwd>Zebrafish</kwd>
<kwd>Neurodegenerative diseases</kwd>
<kwd>Parkinson’s disease</kwd>
<kwd>Huntington’s disease</kwd>
<kwd>Alzheimer’s disease</kwd>
<kwd>Dopaminergic neuron</kwd>
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<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
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Modeling Neurodegeneration in Zebrafish

Modeling Neurodegeneration in Zebrafish

Source :

Abstract

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