Curation of the Mammalian Palmitoylome Indicates a Pivotal Role for Palmitoylation in Diseases and Disorders of the Nervous System and Cancers
Identifieur interne : 000148 ( Pmc/Curation ); précédent : 000147; suivant : 000149Curation of the Mammalian Palmitoylome Indicates a Pivotal Role for Palmitoylation in Diseases and Disorders of the Nervous System and Cancers
Auteurs : Shaun S. Sanders [Canada] ; Dale D. O. Martin [Canada] ; Stefanie L. Butland [Canada] ; Mathieu Lavallée-Adam [États-Unis] ; Diego Calzolari [États-Unis] ; Chris Kay [Canada] ; John R. Yates [États-Unis] ; Michael R. Hayden [Canada]Source :
- PLoS Computational Biology [ 1553-734X ] ; 2015.
Abstract
Palmitoylation involves the reversible posttranslational addition of palmitate to cysteines and promotes membrane binding and subcellular localization. Recent advancements in the detection and identification of palmitoylated proteins have led to multiple palmitoylation proteomics studies but these datasets are contained within large supplemental tables, making downstream analysis and data mining time-consuming and difficult. Consequently, we curated the data from 15 palmitoylation proteomics studies into one compendium containing 1,838 genes encoding palmitoylated proteins; representing approximately 10% of the genome. Enrichment analysis revealed highly significant enrichments for Gene Ontology biological processes, pathway maps, and process networks related to the nervous system. Strikingly, 41% of synaptic genes encode a palmitoylated protein in the compendium. The top disease associations included cancers and diseases and disorders of the nervous system, with Schizophrenia, HD, and pancreatic ductal carcinoma among the top five, suggesting that aberrant palmitoylation may play a pivotal role in the balance of cell death and survival. This compendium provides a much-needed resource for cell biologists and the palmitoylation field, providing new perspectives for cancer and neurodegeneration.
Url:
DOI: 10.1371/journal.pcbi.1004405
PubMed: 26275289
PubMed Central: 4537140
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000148
Links to Exploration step
PMC:4537140Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Curation of the Mammalian Palmitoylome Indicates a Pivotal Role for Palmitoylation in Diseases and Disorders of the Nervous System and Cancers</title><author><name sortKey="Sanders, Shaun S" sort="Sanders, Shaun S" uniqKey="Sanders S" first="Shaun S." last="Sanders">Shaun S. Sanders</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, Child & Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, Child & Family Research Institute, University of British Columbia, Vancouver, British Columbia</wicri:regionArea></affiliation></author><author><name sortKey="Martin, Dale D O" sort="Martin, Dale D O" uniqKey="Martin D" first="Dale D. O." last="Martin">Dale D. O. Martin</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, Child & Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, Child & Family Research Institute, University of British Columbia, Vancouver, British Columbia</wicri:regionArea></affiliation></author><author><name sortKey="Butland, Stefanie L" sort="Butland, Stefanie L" uniqKey="Butland S" first="Stefanie L." last="Butland">Stefanie L. Butland</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, Child & Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, Child & Family Research Institute, University of British Columbia, Vancouver, British Columbia</wicri:regionArea></affiliation></author><author><name sortKey="Lavallee Adam, Mathieu" sort="Lavallee Adam, Mathieu" uniqKey="Lavallee Adam M" first="Mathieu" last="Lavallée-Adam">Mathieu Lavallée-Adam</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California</wicri:regionArea></affiliation></author><author><name sortKey="Calzolari, Diego" sort="Calzolari, Diego" uniqKey="Calzolari D" first="Diego" last="Calzolari">Diego Calzolari</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California</wicri:regionArea></affiliation></author><author><name sortKey="Kay, Chris" sort="Kay, Chris" uniqKey="Kay C" first="Chris" last="Kay">Chris Kay</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, Child & Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, Child & Family Research Institute, University of British Columbia, Vancouver, British Columbia</wicri:regionArea></affiliation></author><author><name sortKey="Yates, John R" sort="Yates, John R" uniqKey="Yates J" first="John R." last="Yates">John R. Yates</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California</wicri:regionArea></affiliation></author><author><name sortKey="Hayden, Michael R" sort="Hayden, Michael R" uniqKey="Hayden M" first="Michael R." last="Hayden">Michael R. Hayden</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, Child & Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, Child & Family Research Institute, University of British Columbia, Vancouver, British Columbia</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26275289</idno><idno type="pmc">4537140</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537140</idno><idno type="RBID">PMC:4537140</idno><idno type="doi">10.1371/journal.pcbi.1004405</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000148</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000148</idno><idno type="wicri:Area/Pmc/Curation">000148</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000148</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Curation of the Mammalian Palmitoylome Indicates a Pivotal Role for Palmitoylation in Diseases and Disorders of the Nervous System and Cancers</title><author><name sortKey="Sanders, Shaun S" sort="Sanders, Shaun S" uniqKey="Sanders S" first="Shaun S." last="Sanders">Shaun S. Sanders</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, Child & Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, Child & Family Research Institute, University of British Columbia, Vancouver, British Columbia</wicri:regionArea></affiliation></author><author><name sortKey="Martin, Dale D O" sort="Martin, Dale D O" uniqKey="Martin D" first="Dale D. O." last="Martin">Dale D. O. Martin</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, Child & Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, Child & Family Research Institute, University of British Columbia, Vancouver, British Columbia</wicri:regionArea></affiliation></author><author><name sortKey="Butland, Stefanie L" sort="Butland, Stefanie L" uniqKey="Butland S" first="Stefanie L." last="Butland">Stefanie L. Butland</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, Child & Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, Child & Family Research Institute, University of British Columbia, Vancouver, British Columbia</wicri:regionArea></affiliation></author><author><name sortKey="Lavallee Adam, Mathieu" sort="Lavallee Adam, Mathieu" uniqKey="Lavallee Adam M" first="Mathieu" last="Lavallée-Adam">Mathieu Lavallée-Adam</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California</wicri:regionArea></affiliation></author><author><name sortKey="Calzolari, Diego" sort="Calzolari, Diego" uniqKey="Calzolari D" first="Diego" last="Calzolari">Diego Calzolari</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California</wicri:regionArea></affiliation></author><author><name sortKey="Kay, Chris" sort="Kay, Chris" uniqKey="Kay C" first="Chris" last="Kay">Chris Kay</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, Child & Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, Child & Family Research Institute, University of British Columbia, Vancouver, British Columbia</wicri:regionArea></affiliation></author><author><name sortKey="Yates, John R" sort="Yates, John R" uniqKey="Yates J" first="John R." last="Yates">John R. Yates</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California</wicri:regionArea></affiliation></author><author><name sortKey="Hayden, Michael R" sort="Hayden, Michael R" uniqKey="Hayden M" first="Michael R." last="Hayden">Michael R. Hayden</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, Child & Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, Child & Family Research Institute, University of British Columbia, Vancouver, British Columbia</wicri:regionArea></affiliation></author></analytic><series><title level="j">PLoS Computational Biology</title><idno type="ISSN">1553-734X</idno><idno type="eISSN">1553-7358</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Palmitoylation involves the reversible posttranslational addition of palmitate to cysteines and promotes membrane binding and subcellular localization. Recent advancements in the detection and identification of palmitoylated proteins have led to multiple palmitoylation proteomics studies but these datasets are contained within large supplemental tables, making downstream analysis and data mining time-consuming and difficult. Consequently, we curated the data from 15 palmitoylation proteomics studies into one compendium containing 1,838 genes encoding palmitoylated proteins; representing approximately 10% of the genome. Enrichment analysis revealed highly significant enrichments for Gene Ontology biological processes, pathway maps, and process networks related to the nervous system. Strikingly, 41% of synaptic genes encode a palmitoylated protein in the compendium. The top disease associations included cancers and diseases and disorders of the nervous system, with Schizophrenia, HD, and pancreatic ductal carcinoma among the top five, suggesting that aberrant palmitoylation may play a pivotal role in the balance of cell death and survival. This compendium provides a much-needed resource for cell biologists and the palmitoylation field, providing new perspectives for cancer and neurodegeneration.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Hallak, H" uniqKey="Hallak H">H Hallak</name></author><author><name sortKey="Muszbek, L" uniqKey="Muszbek L">L Muszbek</name></author><author><name sortKey="Laposata, M" uniqKey="Laposata M">M Laposata</name></author><author><name sortKey="Belmonte, E" uniqKey="Belmonte E">E Belmonte</name></author><author><name sortKey="Brass, Lf" uniqKey="Brass L">LF Brass</name></author><author><name sortKey="Manning, Dr" uniqKey="Manning D">DR Manning</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smotrys, Je" uniqKey="Smotrys J">JE Smotrys</name></author><author><name sortKey="Linder, Me" uniqKey="Linder M">ME Linder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Salaun, C" uniqKey="Salaun C">C Salaun</name></author><author><name sortKey="Greaves, J" uniqKey="Greaves J">J Greaves</name></author><author><name sortKey="Chamberlain, Lh" uniqKey="Chamberlain L">LH Chamberlain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kostiuk, Ma" uniqKey="Kostiuk M">MA Kostiuk</name></author><author><name sortKey="Keller, Bo" uniqKey="Keller B">BO Keller</name></author><author><name sortKey="Berthiaume, Lg" uniqKey="Berthiaume L">LG Berthiaume</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ohno, Y" uniqKey="Ohno Y">Y Ohno</name></author><author><name sortKey="Kihara, A" uniqKey="Kihara A">A Kihara</name></author><author><name sortKey="Sano, T" uniqKey="Sano T">T Sano</name></author><author><name sortKey="Igarashi, Y" uniqKey="Igarashi Y">Y Igarashi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roth, Af" uniqKey="Roth A">AF Roth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lobo, S" uniqKey="Lobo S">S Lobo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, K" uniqKey="Huang K">K Huang</name></author><author><name sortKey="Yanai, A" uniqKey="Yanai A">A Yanai</name></author><author><name sortKey="Kang, R" uniqKey="Kang R">R Kang</name></author><author><name sortKey="Arstikaitis, P" uniqKey="Arstikaitis P">P Arstikaitis</name></author><author><name sortKey="Singaraja, Rr" uniqKey="Singaraja R">RR Singaraja</name></author><author><name sortKey="Metzler, M" uniqKey="Metzler M">M Metzler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tomatis, Vm" uniqKey="Tomatis V">VM Tomatis</name></author><author><name sortKey="Trenchi, A" uniqKey="Trenchi A">A Trenchi</name></author><author><name sortKey="Gomez, Ga" uniqKey="Gomez G">GA Gomez</name></author><author><name sortKey="Daniotti, Jl" uniqKey="Daniotti J">JL Daniotti</name></author><author><name sortKey="Uversky, Vn" uniqKey="Uversky V">VN Uversky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zeidman, R" uniqKey="Zeidman R">R Zeidman</name></author><author><name sortKey="Jackson, Cs" uniqKey="Jackson C">CS Jackson</name></author><author><name sortKey="Magee, Ai" uniqKey="Magee A">AI Magee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mansilla, F" uniqKey="Mansilla F">F Mansilla</name></author><author><name sortKey="Birkenkamp Demtroder, K" uniqKey="Birkenkamp Demtroder K">K Birkenkamp-Demtroder</name></author><author><name sortKey="Kruh Ffer, M" uniqKey="Kruh Ffer M">M Kruhøffer</name></author><author><name sortKey="S Rensen, Fb" uniqKey="S Rensen F">FB Sørensen</name></author><author><name sortKey="Andersen, Cl" uniqKey="Andersen C">CL Andersen</name></author><author><name sortKey="Laiho, P" uniqKey="Laiho P">P Laiho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oyama, T" uniqKey="Oyama T">T Oyama</name></author><author><name sortKey="Miyoshi, Y" uniqKey="Miyoshi Y">Y Miyoshi</name></author><author><name sortKey="Koyama, K" uniqKey="Koyama K">K Koyama</name></author><author><name sortKey="Nakagawa, H" uniqKey="Nakagawa H">H Nakagawa</name></author><author><name sortKey="Yamori, T" uniqKey="Yamori T">T Yamori</name></author><author><name sortKey="Ito, T" uniqKey="Ito T">T Ito</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamamoto, Y" uniqKey="Yamamoto Y">Y Yamamoto</name></author><author><name sortKey="Chochi, Y" uniqKey="Chochi Y">Y Chochi</name></author><author><name sortKey="Matsuyama, H" uniqKey="Matsuyama H">H Matsuyama</name></author><author><name sortKey="Eguchi, S" uniqKey="Eguchi S">S Eguchi</name></author><author><name sortKey="Kawauchi, S" uniqKey="Kawauchi S">S Kawauchi</name></author><author><name sortKey="Furuya, T" uniqKey="Furuya T">T Furuya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author><author><name sortKey="Planey, Sl" uniqKey="Planey S">SL Planey</name></author><author><name sortKey="Ceballos, C" uniqKey="Ceballos C">C Ceballos</name></author><author><name sortKey="Stevens, Sm" uniqKey="Stevens S">SM Stevens</name></author><author><name sortKey="Keay, Sk" uniqKey="Keay S">SK Keay</name></author><author><name sortKey="Zacharias, Da" uniqKey="Zacharias D">DA Zacharias</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Berchtold, La" uniqKey="Berchtold L">LA Berchtold</name></author><author><name sortKey="St Rling, Zm" uniqKey="St Rling Z">ZM Størling</name></author><author><name sortKey="Ortis, F" uniqKey="Ortis F">F Ortis</name></author><author><name sortKey="Lage, K" uniqKey="Lage K">K Lage</name></author><author><name sortKey="Bang Berthelsen, C" uniqKey="Bang Berthelsen C">C Bang-Berthelsen</name></author><author><name sortKey="Bergholdt, R" uniqKey="Bergholdt R">R Bergholdt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ren, W" uniqKey="Ren W">W Ren</name></author><author><name sortKey="Sun, Y" uniqKey="Sun Y">Y Sun</name></author><author><name sortKey="Du, K" uniqKey="Du K">K Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, H" uniqKey="Liu H">H Liu</name></author><author><name sortKey="Heath, Sc" uniqKey="Heath S">SC Heath</name></author><author><name sortKey="Sobin, C" uniqKey="Sobin C">C Sobin</name></author><author><name sortKey="Roos, Jl" uniqKey="Roos J">JL Roos</name></author><author><name sortKey="Galke, Bl" uniqKey="Galke B">BL Galke</name></author><author><name sortKey="Blundell, Ml" uniqKey="Blundell M">ML Blundell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mukai, J" uniqKey="Mukai J">J Mukai</name></author><author><name sortKey="Liu, H" uniqKey="Liu H">H Liu</name></author><author><name sortKey="Burt, Ra" uniqKey="Burt R">RA Burt</name></author><author><name sortKey="Swor, De" uniqKey="Swor D">DE Swor</name></author><author><name sortKey="Lai W, S" uniqKey="Lai W S">S Lai W-</name></author><author><name sortKey="Karayiorgou, M" uniqKey="Karayiorgou M">M Karayiorgou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mukai, J" uniqKey="Mukai J">J Mukai</name></author><author><name sortKey="Dhilla, A" uniqKey="Dhilla A">A Dhilla</name></author><author><name sortKey="Drew, Lj" uniqKey="Drew L">LJ Drew</name></author><author><name sortKey="Stark, Kl" uniqKey="Stark K">KL Stark</name></author><author><name sortKey="Cao, L" uniqKey="Cao L">L Cao</name></author><author><name sortKey="Macdermott, Ab" uniqKey="Macdermott A">AB MacDermott</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mansouri, Mr" uniqKey="Mansouri M">MR Mansouri</name></author><author><name sortKey="Marklund, L" uniqKey="Marklund L">L Marklund</name></author><author><name sortKey="Gustavsson, P" uniqKey="Gustavsson P">P Gustavsson</name></author><author><name sortKey="Davey, E" uniqKey="Davey E">E Davey</name></author><author><name sortKey="Carlsson, B" uniqKey="Carlsson B">B Carlsson</name></author><author><name sortKey="Larsson, C" uniqKey="Larsson C">C Larsson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raymond, Fl" uniqKey="Raymond F">FL Raymond</name></author><author><name sortKey="Tarpey, Ps" uniqKey="Tarpey P">PS Tarpey</name></author><author><name sortKey="Edkins, S" uniqKey="Edkins S">S Edkins</name></author><author><name sortKey="Tofts, C" uniqKey="Tofts C">C Tofts</name></author><author><name sortKey="O Eara, S" uniqKey="O Eara S">S O’Meara</name></author><author><name sortKey="Teague, J" uniqKey="Teague J">J Teague</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mizumaru, C" uniqKey="Mizumaru C">C Mizumaru</name></author><author><name sortKey="Saito, Y" uniqKey="Saito Y">Y Saito</name></author><author><name sortKey="Ishikawa, T" uniqKey="Ishikawa T">T Ishikawa</name></author><author><name sortKey="Yoshida, T" uniqKey="Yoshida T">T Yoshida</name></author><author><name sortKey="Yamamoto, T" uniqKey="Yamamoto T">T Yamamoto</name></author><author><name sortKey="Nakaya, T" uniqKey="Nakaya T">T Nakaya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meckler, X" uniqKey="Meckler X">X Meckler</name></author><author><name sortKey="Roseman, J" uniqKey="Roseman J">J Roseman</name></author><author><name sortKey="Das, P" uniqKey="Das P">P Das</name></author><author><name sortKey="Cheng, H" uniqKey="Cheng H">H Cheng</name></author><author><name sortKey="Pei, S" uniqKey="Pei S">S Pei</name></author><author><name sortKey="Keat, M" uniqKey="Keat M">M Keat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bhattacharyya, R" uniqKey="Bhattacharyya R">R Bhattacharyya</name></author><author><name sortKey="Barren, C" uniqKey="Barren C">C Barren</name></author><author><name sortKey="Kovacs, Dm" uniqKey="Kovacs D">DM Kovacs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yanai, A" uniqKey="Yanai A">A Yanai</name></author><author><name sortKey="Huang, K" uniqKey="Huang K">K Huang</name></author><author><name sortKey="Kang, R" uniqKey="Kang R">R Kang</name></author><author><name sortKey="Singaraja, Rr" uniqKey="Singaraja R">RR Singaraja</name></author><author><name sortKey="Arstikaitis, P" uniqKey="Arstikaitis P">P Arstikaitis</name></author><author><name sortKey="Gan, L" uniqKey="Gan L">L Gan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marin, Ep" uniqKey="Marin E">EP Marin</name></author><author><name sortKey="Derakhshan, B" uniqKey="Derakhshan B">B Derakhshan</name></author><author><name sortKey="Lam, Tt" uniqKey="Lam T">TT Lam</name></author><author><name sortKey="Davalos, A" uniqKey="Davalos A">A Davalos</name></author><author><name sortKey="Sessa, Wc" uniqKey="Sessa W">WC Sessa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Antinone, Se" uniqKey="Antinone S">SE Antinone</name></author><author><name sortKey="Ghadge, Gd" uniqKey="Ghadge G">GD Ghadge</name></author><author><name sortKey="Lam, Tt" uniqKey="Lam T">TT Lam</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Roos, Rp" uniqKey="Roos R">RP Roos</name></author><author><name sortKey="Green, Wn" uniqKey="Green W">WN Green</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Young, Fb" uniqKey="Young F">FB Young</name></author><author><name sortKey="Butland, Sl" uniqKey="Butland S">SL Butland</name></author><author><name sortKey="Sanders, Ss" uniqKey="Sanders S">SS Sanders</name></author><author><name sortKey="Sutton, Lm" uniqKey="Sutton L">LM Sutton</name></author><author><name sortKey="Hayden, Mr" uniqKey="Hayden M">MR Hayden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wan, J" uniqKey="Wan J">J Wan</name></author><author><name sortKey="Roth, Af" uniqKey="Roth A">AF Roth</name></author><author><name sortKey="Bailey, Ao" uniqKey="Bailey A">AO Bailey</name></author><author><name sortKey="Davis, Ng" uniqKey="Davis N">NG Davis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drisdel, Rc" uniqKey="Drisdel R">RC Drisdel</name></author><author><name sortKey="Green, Wn" uniqKey="Green W">WN Green</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Forrester, Mt" uniqKey="Forrester M">MT Forrester</name></author><author><name sortKey="Hess, Dt" uniqKey="Hess D">DT Hess</name></author><author><name sortKey="Thompson, Jw" uniqKey="Thompson J">JW Thompson</name></author><author><name sortKey="Hultman, R" uniqKey="Hultman R">R Hultman</name></author><author><name sortKey="Moseley, Ma" uniqKey="Moseley M">MA Moseley</name></author><author><name sortKey="Stamler, Js" uniqKey="Stamler J">JS Stamler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martin, Br" uniqKey="Martin B">BR Martin</name></author><author><name sortKey="Cravatt, Bf" uniqKey="Cravatt B">BF Cravatt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yap, Mc" uniqKey="Yap M">MC Yap</name></author><author><name sortKey="Kostiuk, Ma" uniqKey="Kostiuk M">MA Kostiuk</name></author><author><name sortKey="Martin, Ddo" uniqKey="Martin D">DDO Martin</name></author><author><name sortKey="Perinpanayagam, Ma" uniqKey="Perinpanayagam M">MA Perinpanayagam</name></author><author><name sortKey="Hak, Pg" uniqKey="Hak P">PG Hak</name></author><author><name sortKey="Siddam, A" uniqKey="Siddam A">A Siddam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wei, X" uniqKey="Wei X">X Wei</name></author><author><name sortKey="Song, H" uniqKey="Song H">H Song</name></author><author><name sortKey="Semenkovich, Cf" uniqKey="Semenkovich C">CF Semenkovich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ivaldi, C" uniqKey="Ivaldi C">C Ivaldi</name></author><author><name sortKey="Martin, Br" uniqKey="Martin B">BR Martin</name></author><author><name sortKey="Kieffer Jaquinod, S" uniqKey="Kieffer Jaquinod S">S Kieffer-Jaquinod</name></author><author><name sortKey="Chapel, A" uniqKey="Chapel A">A Chapel</name></author><author><name sortKey="Levade, T" uniqKey="Levade T">T Levade</name></author><author><name sortKey="Garin, J" uniqKey="Garin J">J Garin</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Wilson, Jp" uniqKey="Wilson J">JP Wilson</name></author><author><name sortKey="Raghavan, As" uniqKey="Raghavan A">AS Raghavan</name></author><author><name sortKey="Yang, Y Y" uniqKey="Yang Y">Y-Y Yang</name></author><author><name sortKey="Charron, G" uniqKey="Charron G">G Charron</name></author><author><name sortKey="Hang, Hc" uniqKey="Hang H">HC Hang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, W" uniqKey="Yang W">W Yang</name></author><author><name sortKey="Di Vizio, D" uniqKey="Di Vizio D">D Di Vizio</name></author><author><name sortKey="Kirchner, M" uniqKey="Kirchner M">M Kirchner</name></author><author><name sortKey="Steen, H" uniqKey="Steen H">H Steen</name></author><author><name sortKey="Freeman, Mr" uniqKey="Freeman M">MR Freeman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wan, J" uniqKey="Wan J">J Wan</name></author><author><name sortKey="Savas, Jn" uniqKey="Savas J">JN Savas</name></author><author><name sortKey="Roth, Af" uniqKey="Roth A">AF Roth</name></author><author><name sortKey="Sanders, Ss" uniqKey="Sanders S">SS Sanders</name></author><author><name sortKey="Singaraja, Rr" uniqKey="Singaraja R">RR Singaraja</name></author><author><name sortKey="Hayden, Mr" uniqKey="Hayden M">MR Hayden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martin, Br" uniqKey="Martin B">BR Martin</name></author><author><name sortKey="Wang, C" uniqKey="Wang C">C Wang</name></author><author><name sortKey="Adibekian, A" uniqKey="Adibekian A">A Adibekian</name></author><author><name sortKey="Tully, Se" uniqKey="Tully S">SE Tully</name></author><author><name sortKey="Cravatt, Bf" uniqKey="Cravatt B">BF Cravatt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Martin, Br" uniqKey="Martin B">BR Martin</name></author><author><name sortKey="Cravatt, Bf" uniqKey="Cravatt B">BF Cravatt</name></author><author><name sortKey="Hofmann, Sl" uniqKey="Hofmann S">SL Hofmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Merrick, Ba" uniqKey="Merrick B">BA Merrick</name></author><author><name sortKey="Dhungana, S" uniqKey="Dhungana S">S Dhungana</name></author><author><name sortKey="Williams, Jg" uniqKey="Williams J">JG Williams</name></author><author><name sortKey="Aloor, Jj" uniqKey="Aloor J">JJ Aloor</name></author><author><name sortKey="Peddada, S" uniqKey="Peddada S">S Peddada</name></author><author><name sortKey="Tomer, Kb" uniqKey="Tomer K">KB Tomer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yount, Js" uniqKey="Yount J">JS Yount</name></author><author><name sortKey="Moltedo, B" uniqKey="Moltedo B">B Moltedo</name></author><author><name sortKey="Yang Y, Y" uniqKey="Yang Y Y">Y Yang Y-</name></author><author><name sortKey="Charron, G" uniqKey="Charron G">G Charron</name></author><author><name sortKey="Moran, Tm" uniqKey="Moran T">TM Moran</name></author><author><name sortKey="L Pez, Cb" uniqKey="L Pez C">CB López</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kang, R" uniqKey="Kang R">R Kang</name></author><author><name sortKey="Wan, J" uniqKey="Wan J">J Wan</name></author><author><name sortKey="Arstikaitis, P" uniqKey="Arstikaitis P">P Arstikaitis</name></author><author><name sortKey="Takahashi, H" uniqKey="Takahashi H">H Takahashi</name></author><author><name sortKey="Huang, K" uniqKey="Huang K">K Huang</name></author><author><name sortKey="Bailey, Ao" uniqKey="Bailey A">AO Bailey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suzuki, R" uniqKey="Suzuki R">R Suzuki</name></author><author><name sortKey="Shimodaira, H" uniqKey="Shimodaira H">H Shimodaira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ashburner, M" uniqKey="Ashburner M">M Ashburner</name></author><author><name sortKey="Ball, Ca" uniqKey="Ball C">CA Ball</name></author><author><name sortKey="Blake, Ja" uniqKey="Blake J">JA Blake</name></author><author><name sortKey="Botstein, D" uniqKey="Botstein D">D Botstein</name></author><author><name sortKey="Butler, H" uniqKey="Butler H">H Butler</name></author><author><name sortKey="Cherry, Jm" uniqKey="Cherry J">JM Cherry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Apweiler, R" uniqKey="Apweiler R">R Apweiler</name></author><author><name sortKey="Bairoch, A" uniqKey="Bairoch A">A Bairoch</name></author><author><name sortKey="Wu, Ch" uniqKey="Wu C">CH Wu</name></author><author><name sortKey="Barker, Wc" uniqKey="Barker W">WC Barker</name></author><author><name sortKey="Boeckmann, B" uniqKey="Boeckmann B">B Boeckmann</name></author><author><name sortKey="Ferro, S" uniqKey="Ferro S">S Ferro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eichborn Von, J" uniqKey="Eichborn Von J">J Eichborn von</name></author><author><name sortKey="Dunkel, M" uniqKey="Dunkel M">M Dunkel</name></author><author><name sortKey="Gohlke, Bo" uniqKey="Gohlke B">BO Gohlke</name></author><author><name sortKey="Preissner, Sc" uniqKey="Preissner S">SC Preissner</name></author><author><name sortKey="Hoffmann, Mf" uniqKey="Hoffmann M">MF Hoffmann</name></author><author><name sortKey="Bauer, Jmj" uniqKey="Bauer J">JMJ Bauer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rothstein, Jd" uniqKey="Rothstein J">JD Rothstein</name></author><author><name sortKey="Lomen Hoerth, C" uniqKey="Lomen Hoerth C">C Lomen-Hoerth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morita, M" uniqKey="Morita M">M Morita</name></author><author><name sortKey="Aoki, M" uniqKey="Aoki M">M Aoki</name></author><author><name sortKey="Abe, K" uniqKey="Abe K">K Abe</name></author><author><name sortKey="Hasegawa, T" uniqKey="Hasegawa T">T Hasegawa</name></author><author><name sortKey="Sakuma, R" uniqKey="Sakuma R">R Sakuma</name></author><author><name sortKey="Onodera, Y" uniqKey="Onodera Y">Y Onodera</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Malnar, M" uniqKey="Malnar M">M Malnar</name></author><author><name sortKey="Hecimovic, S" uniqKey="Hecimovic S">S Hecimovic</name></author><author><name sortKey="Mattsson, N" uniqKey="Mattsson N">N Mattsson</name></author><author><name sortKey="Zetterberg, H" uniqKey="Zetterberg H">H Zetterberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, Wd" uniqKey="Park W">WD Park</name></author><author><name sortKey="O Brien, Jf" uniqKey="O Brien J">JF O'Brien</name></author><author><name sortKey="Lundquist, Pa" uniqKey="Lundquist P">PA Lundquist</name></author><author><name sortKey="Kraft, Dl" uniqKey="Kraft D">DL Kraft</name></author><author><name sortKey="Vockley, Cw" uniqKey="Vockley C">CW Vockley</name></author><author><name sortKey="Karnes, Ps" uniqKey="Karnes P">PS Karnes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Linder, Me" uniqKey="Linder M">ME Linder</name></author><author><name sortKey="Deschenes, Rj" uniqKey="Deschenes R">RJ Deschenes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gu, W" uniqKey="Gu W">W Gu</name></author><author><name sortKey="Brodtkorb, E" uniqKey="Brodtkorb E">E Brodtkorb</name></author><author><name sortKey="Steinlein, Ok" uniqKey="Steinlein O">OK Steinlein</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name></author><author><name sortKey="Hedberg, C" uniqKey="Hedberg C">C Hedberg</name></author><author><name sortKey="Dekker, Fj" uniqKey="Dekker F">FJ Dekker</name></author><author><name sortKey="Li, Q" uniqKey="Li Q">Q Li</name></author><author><name sortKey="Haigis, Km" uniqKey="Haigis K">KM Haigis</name></author><author><name sortKey="Hwang, E" uniqKey="Hwang E">E Hwang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Singaraja, Rr" uniqKey="Singaraja R">RR Singaraja</name></author><author><name sortKey="Huang, K" uniqKey="Huang K">K Huang</name></author><author><name sortKey="Sanders, Ss" uniqKey="Sanders S">SS Sanders</name></author><author><name sortKey="Milnerwood, Aj" uniqKey="Milnerwood A">AJ Milnerwood</name></author><author><name sortKey="Hines, R" uniqKey="Hines R">R Hines</name></author><author><name sortKey="Lerch, Jp" uniqKey="Lerch J">JP Lerch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jennings, Bc" uniqKey="Jennings B">BC Jennings</name></author><author><name sortKey="Linder, Me" uniqKey="Linder M">ME Linder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dasgupta, S" uniqKey="Dasgupta S">S Dasgupta</name></author><author><name sortKey="Bhattacharya, S" uniqKey="Bhattacharya S">S Bhattacharya</name></author><author><name sortKey="Maitra, S" uniqKey="Maitra S">S Maitra</name></author><author><name sortKey="Pal, D" uniqKey="Pal D">D Pal</name></author><author><name sortKey="Majumdar, Ss" uniqKey="Majumdar S">SS Majumdar</name></author><author><name sortKey="Datta, A" uniqKey="Datta A">A Datta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qin, H" uniqKey="Qin H">H Qin</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="Ye, F" uniqKey="Ye F">F Ye</name></author><author><name sortKey="Zhong, L" uniqKey="Zhong L">L Zhong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, X" uniqKey="Yang X">X Yang</name></author><author><name sortKey="Kovalenko, Ov" uniqKey="Kovalenko O">OV Kovalenko</name></author><author><name sortKey="Tang, W" uniqKey="Tang W">W Tang</name></author><author><name sortKey="Claas, C" uniqKey="Claas C">C Claas</name></author><author><name sortKey="Stipp, Cs" uniqKey="Stipp C">CS Stipp</name></author><author><name sortKey="Hemler, Me" uniqKey="Hemler M">ME Hemler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martin, Ddo" uniqKey="Martin D">DDO Martin</name></author><author><name sortKey="Beauchamp, E" uniqKey="Beauchamp E">E Beauchamp</name></author><author><name sortKey="Berthiaume, Lg" uniqKey="Berthiaume L">LG Berthiaume</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fukata, Y" uniqKey="Fukata Y">Y Fukata</name></author><author><name sortKey="Fukata, M" uniqKey="Fukata M">M Fukata</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="S Rensen, Sa" uniqKey="S Rensen S">SA Sørensen</name></author><author><name sortKey="Fenger, K" uniqKey="Fenger K">K Fenger</name></author><author><name sortKey="Olsen, Jh" uniqKey="Olsen J">JH Olsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ji, J" uniqKey="Ji J">J Ji</name></author><author><name sortKey="Sundquist, K" uniqKey="Sundquist K">K Sundquist</name></author><author><name sortKey="Sundquist, J" uniqKey="Sundquist J">J Sundquist</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Driver, Ja" uniqKey="Driver J">JA Driver</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, K" uniqKey="Huang K">K Huang</name></author><author><name sortKey="Sanders, Ss" uniqKey="Sanders S">SS Sanders</name></author><author><name sortKey="Kang, R" uniqKey="Kang R">R Kang</name></author><author><name sortKey="Carroll, Jb" uniqKey="Carroll J">JB Carroll</name></author><author><name sortKey="Sutton, L" uniqKey="Sutton L">L Sutton</name></author><author><name sortKey="Wan, J" uniqKey="Wan J">J Wan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ducker, Ce" uniqKey="Ducker C">CE Ducker</name></author><author><name sortKey="Stettler, Em" uniqKey="Stettler E">EM Stettler</name></author><author><name sortKey="French, Kj" uniqKey="French K">KJ French</name></author><author><name sortKey="Upson, Jj" uniqKey="Upson J">JJ Upson</name></author><author><name sortKey="Smith, Cd" uniqKey="Smith C">CD Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hashmi, S" uniqKey="Hashmi S">S Hashmi</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Suman, Ds" uniqKey="Suman D">DS Suman</name></author><author><name sortKey="Parhar, Rs" uniqKey="Parhar R">RS Parhar</name></author><author><name sortKey="Collison, K" uniqKey="Collison K">K Collison</name></author><author><name sortKey="Conca, W" uniqKey="Conca W">W Conca</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Flavin, R" uniqKey="Flavin R">R Flavin</name></author><author><name sortKey="Zadra, G" uniqKey="Zadra G">G Zadra</name></author><author><name sortKey="Loda, M" uniqKey="Loda M">M Loda</name></author><author><name sortKey="Ladanyi, M" uniqKey="Ladanyi M">M Ladanyi</name></author><author><name sortKey="Hogendoorn, Pc" uniqKey="Hogendoorn P">PC Hogendoorn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Di Sebastiano, K" uniqKey="Di Sebastiano K">K Di Sebastiano</name></author><author><name sortKey="Mourtzakis, M" uniqKey="Mourtzakis M">M Mourtzakis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Amminger, Gp" uniqKey="Amminger G">GP Amminger</name></author><author><name sortKey="Mcgorry, Pd" uniqKey="Mcgorry P">PD McGorry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ren, W" uniqKey="Ren W">W Ren</name></author><author><name sortKey="Jhala, Us" uniqKey="Jhala U">US Jhala</name></author><author><name sortKey="Du, K" uniqKey="Du K">K Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pruitt, Kd" uniqKey="Pruitt K">KD Pruitt</name></author><author><name sortKey="Tatusova, T" uniqKey="Tatusova T">T Tatusova</name></author><author><name sortKey="Maglott, Dr" uniqKey="Maglott D">DR Maglott</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yount, Js" uniqKey="Yount J">JS Yount</name></author><author><name sortKey="Charron, G" uniqKey="Charron G">G Charron</name></author><author><name sortKey="Hang, Hc" uniqKey="Hang H">HC Hang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maglott, D" uniqKey="Maglott D">D Maglott</name></author><author><name sortKey="Ostell, J" uniqKey="Ostell J">J Ostell</name></author><author><name sortKey="Pruitt, Kd" uniqKey="Pruitt K">KD Pruitt</name></author><author><name sortKey="Tatusova, T" uniqKey="Tatusova T">T Tatusova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wilhelm, M" uniqKey="Wilhelm M">M Wilhelm</name></author><author><name sortKey="Schlegl, J" uniqKey="Schlegl J">J Schlegl</name></author><author><name sortKey="Hahne, H" uniqKey="Hahne H">H Hahne</name></author><author><name sortKey="Moghaddas, Gholami A" uniqKey="Moghaddas G">Gholami A Moghaddas</name></author><author><name sortKey="Lieberenz, M" uniqKey="Lieberenz M">M Lieberenz</name></author><author><name sortKey="Savitski, Mm" uniqKey="Savitski M">MM Savitski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim M, S" uniqKey="Kim M S">S Kim M-</name></author><author><name sortKey="Pinto, Sm" uniqKey="Pinto S">SM Pinto</name></author><author><name sortKey="Getnet, D" uniqKey="Getnet D">D Getnet</name></author><author><name sortKey="Nirujogi, Rs" uniqKey="Nirujogi R">RS Nirujogi</name></author><author><name sortKey="Manda, Ss" uniqKey="Manda S">SS Manda</name></author><author><name sortKey="Chaerkady, R" uniqKey="Chaerkady R">R Chaerkady</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kelly, Gl" uniqKey="Kelly G">GL Kelly</name></author><author><name sortKey="Stylianou, J" uniqKey="Stylianou J">J Stylianou</name></author><author><name sortKey="Rasaiyaah, J" uniqKey="Rasaiyaah J">J Rasaiyaah</name></author><author><name sortKey="Wei, W" uniqKey="Wei W">W Wei</name></author><author><name sortKey="Thomas, W" uniqKey="Thomas W">W Thomas</name></author><author><name sortKey="Croom Carter, D" uniqKey="Croom Carter D">D Croom-Carter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kossenkov, Av" uniqKey="Kossenkov A">AV Kossenkov</name></author><author><name sortKey="Vachani, A" uniqKey="Vachani A">A Vachani</name></author><author><name sortKey="Chang, C" uniqKey="Chang C">C Chang</name></author><author><name sortKey="Nichols, C" uniqKey="Nichols C">C Nichols</name></author><author><name sortKey="Billouin, S" uniqKey="Billouin S">S Billouin</name></author><author><name sortKey="Horng, W" uniqKey="Horng W">W Horng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Narita, K" uniqKey="Narita K">K Narita</name></author><author><name sortKey="Kozuka Hata, H" uniqKey="Kozuka Hata H">H Kozuka-Hata</name></author><author><name sortKey="Nonami, Y" uniqKey="Nonami Y">Y Nonami</name></author><author><name sortKey="Ao Kondo, H" uniqKey="Ao Kondo H">H Ao-Kondo</name></author><author><name sortKey="Suzuki, T" uniqKey="Suzuki T">T Suzuki</name></author><author><name sortKey="Nakamura, H" uniqKey="Nakamura H">H Nakamura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hamosh, A" uniqKey="Hamosh A">A Hamosh</name></author><author><name sortKey="Scott, Af" uniqKey="Scott A">AF Scott</name></author><author><name sortKey="Amberger, Js" uniqKey="Amberger J">JS Amberger</name></author><author><name sortKey="Bocchini, Ca" uniqKey="Bocchini C">CA Bocchini</name></author><author><name sortKey="Mckusick, Va" uniqKey="Mckusick V">VA McKusick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ren, J" uniqKey="Ren J">J Ren</name></author><author><name sortKey="Wen, L" uniqKey="Wen L">L Wen</name></author><author><name sortKey="Gao, X" uniqKey="Gao X">X Gao</name></author><author><name sortKey="Jin, C" uniqKey="Jin C">C Jin</name></author><author><name sortKey="Xue, Y" uniqKey="Xue Y">Y Xue</name></author><author><name sortKey="Yao, X" uniqKey="Yao X">X Yao</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS Comput Biol</journal-id><journal-id journal-id-type="iso-abbrev">PLoS Comput. Biol</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">ploscomp</journal-id><journal-title-group><journal-title>PLoS Computational Biology</journal-title></journal-title-group><issn pub-type="ppub">1553-734X</issn><issn pub-type="epub">1553-7358</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, CA USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26275289</article-id><article-id pub-id-type="pmc">4537140</article-id><article-id pub-id-type="doi">10.1371/journal.pcbi.1004405</article-id><article-id pub-id-type="publisher-id">PCOMPBIOL-D-15-00645</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Curation of the Mammalian Palmitoylome Indicates a Pivotal Role for Palmitoylation in Diseases and Disorders of the Nervous System and Cancers</article-title><alt-title alt-title-type="running-head">A Mammalian Palmitoylation Compendium</alt-title></title-group><contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Sanders</surname><given-names>Shaun S.</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Martin</surname><given-names>Dale D. O.</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref><xref rid="cor001" ref-type="corresp">*</xref></contrib><contrib contrib-type="author"><name><surname>Butland</surname><given-names>Stefanie L.</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lavallée-Adam</surname><given-names>Mathieu</given-names></name><xref ref-type="aff" rid="aff002"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Calzolari</surname><given-names>Diego</given-names></name><xref ref-type="aff" rid="aff002"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kay</surname><given-names>Chris</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Yates</surname><given-names>John R.</given-names><suffix>III</suffix></name><xref ref-type="aff" rid="aff002"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hayden</surname><given-names>Michael R.</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref></contrib></contrib-group><aff id="aff001"><label>1</label><addr-line>Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, Child & Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada</addr-line></aff><aff id="aff002"><label>2</label><addr-line>Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California, United States of America</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Ben-Tal</surname><given-names>Nir</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>Tel Aviv University, ISRAEL</addr-line></aff><author-notes><fn fn-type="conflict" id="coi001"><p>The authors have declared that no competing interests exist.</p></fn><fn fn-type="con" id="contrib001"><p>Conceived and designed the experiments: SSS DDOM SLB MLA DC CK JRY MRH. Performed the experiments: SSS DDOM SLB MLA DC CK. Analyzed the data: SSS DDOM SLB MLA CK. Wrote the paper: SSS DDOM SLB MLA DC CK JRY MRH.</p></fn><corresp id="cor001">* E-mail: <email>dalem@cmmt.ubc.ca</email></corresp></author-notes><pub-date pub-type="epub"><day>14</day><month>8</month><year>2015</year></pub-date><pub-date pub-type="collection"><month>8</month><year>2015</year></pub-date><volume>11</volume><issue>8</issue><elocation-id>e1004405</elocation-id><history><date date-type="received"><day>20</day><month>4</month><year>2015</year></date><date date-type="accepted"><day>16</day><month>6</month><year>2015</year></date></history><permissions><copyright-statement>© 2015 Sanders et al</copyright-statement><copyright-year>2015</copyright-year><copyright-holder>Sanders et al</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.</license-p></license></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="pcbi.1004405.pdf"></self-uri><abstract><p>Palmitoylation involves the reversible posttranslational addition of palmitate to cysteines and promotes membrane binding and subcellular localization. Recent advancements in the detection and identification of palmitoylated proteins have led to multiple palmitoylation proteomics studies but these datasets are contained within large supplemental tables, making downstream analysis and data mining time-consuming and difficult. Consequently, we curated the data from 15 palmitoylation proteomics studies into one compendium containing 1,838 genes encoding palmitoylated proteins; representing approximately 10% of the genome. Enrichment analysis revealed highly significant enrichments for Gene Ontology biological processes, pathway maps, and process networks related to the nervous system. Strikingly, 41% of synaptic genes encode a palmitoylated protein in the compendium. The top disease associations included cancers and diseases and disorders of the nervous system, with Schizophrenia, HD, and pancreatic ductal carcinoma among the top five, suggesting that aberrant palmitoylation may play a pivotal role in the balance of cell death and survival. This compendium provides a much-needed resource for cell biologists and the palmitoylation field, providing new perspectives for cancer and neurodegeneration.</p></abstract><abstract abstract-type="summary"><title>Author Summary</title><p>Protein localization is essential for mediating protein function within the cellular context. Mislocalization of proteins can offset cellular balance, influencing whether a cell lives or dies. Many proteins are directed to cellular membranes through the addition of fats, or lipidation. In particular, palmitoylation involves the reversible addition of the fatty acid palmitate to cysteines. Its reversibility makes it a unique form of lipidation allowing its dynamic regulation. Recent advancements in fast, sensitive, non-radioactive methods to detect palmitoylation have led to an explosion in the identification of palmitoylated proteins through proteomics studies. However, the data is hidden in large supplemental tables in various formats. Thus, we curated a list of palmitoylated proteins revealing that approximately 10 percent of the human genome encodes for a proteoform that is palmitoylated. Computational analysis confirmed that palmitoylation is involved in protein localization and indicated a new role in metabolism. Importantly, we found that palmitoylation was enriched at neuronal synapses and in disorders of the nervous system, including Schizophrenia and Huntington disease. Interestingly, palmitoylation was equally enriched in cancers. Consequently, we suggest that palmitoylation plays a critical role in cell fate and our compendium provides a plethora of targets for neurodegeneration and cancer.</p></abstract><funding-group><funding-statement>This work was supported by the CHDI Foundation, Inc. (<ext-link ext-link-type="uri" xlink:href="http://chdifoundation.org">chdifoundation.org</ext-link> operating grant to MRH) and the Canadian Institutes of Health Research (CIHR operating grant to MRH GPG-102165; <ext-link ext-link-type="uri" xlink:href="http://www.cihr-irsc.gc.ca">www.cihr-irsc.gc.ca</ext-link>). Funding for JRY has been provided by National Institutes of Health (NIH) grants P41 GM103533, R01 MH067880, R01 MH100175 and UCLA/NHLBI Proteomics Centers (HHSN268201000035C). MLA holds a postdoctoral fellowship from Fonds de Recherche du Québec – Nature et Technologies. DDOM holds CIHR, Michael Smith Foundation for Health Research, and Bluma Tischler postdoctoral fellowships. CK holds a CIHR Doctoral award. MRH is a University Killam Professor and the Canada Research Chair in Human Genetics and Molecular Medicine. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement></funding-group><counts><fig-count count="5"></fig-count><table-count count="2"></table-count><page-count count="20"></page-count></counts><custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name><meta-value>All relevant data are within the paper and its Supporting Information files.</meta-value></custom-meta></custom-meta-group></article-meta><notes><title>Data Availability</title><p>All relevant data are within the paper and its Supporting Information files.</p></notes></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000148 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000148 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Pmc
|étape= Curation
|type= RBID
|clé= PMC:4537140
|texte= Curation of the Mammalian Palmitoylome Indicates a Pivotal Role for Palmitoylation in Diseases and Disorders of the Nervous System and Cancers
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:26275289" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |