A Four-Year Longitudinal Study on Restless Legs Syndrome in Parkinson Disease
Identifieur interne : 000131 ( Pmc/Curation ); précédent : 000130; suivant : 000132A Four-Year Longitudinal Study on Restless Legs Syndrome in Parkinson Disease
Auteurs : Marcello Moccia [Italie] ; Roberto Erro [Royaume-Uni, Italie] ; Marina Picillo [Italie, Canada] ; Gabriella Santangelo [Italie] ; Emanuele Spina [Italie] ; Roberto Allocca [Italie] ; Katia Longo [Italie] ; Marianna Amboni [Italie] ; Raffaele Palladino [Royaume-Uni, Italie] ; Roberta Assante [Italie] ; Sabina Pappatà [Italie] ; Maria Teresa Pellecchia [Italie] ; Paolo Barone [Italie] ; Carmine Vitale [Italie]Source :
- Sleep [ 0161-8105 ] ; 2016.
Abstract
Restless legs syndrome (RLS) prevalence estimates range from 0% to 52% in Parkinson disease (PD), but the causal relationship between the two disorders is still debated. The present study aims to evaluate RLS prevalence in de novo PD subjects, its incidence during the first 4 years from diagnosis, and possible relationships with clinical, laboratory, and neuroradiological data.
One hundred nine newly diagnosed, drug-naïve PD subjects were evaluated at the time of PD diagnosis, and after 2- and 4-years. RLS diagnosis was performed with the RLS Diagnostic Index at each visit. Motor features, additional non-motor symptoms (NMS), and concomitant dopaminergic and nondopaminergic treatments were also gathered. Moreover, at baseline, 65 subjects were randomly selected to undergo a FP-CIT SPECT to study dopamine transporter availability.
RLS prevalence rose from 4.6% at baseline evaluation to 6.5% after 2 years and to 16.3% after 4 years (P = 0.007). A multinomial logistic stepwise regression model selected NMS Questionnaire items more likely to be associated with RLS at diagnosis (insomnia, OR = 15.555; P = 0.040) and with occurrence of RLS during follow-up (dizziness, OR = 1.153; P = 0.022; and daytime sleepiness; OR = 9.557; P = 0.001), as compared to patients without RLS. Older age was more likely associated to increased RLS occurrence during follow-up in a random effect logistic regression model (OR = 1.187; P = 0.036). A multinomial logistic stepwise model found increased dopaminergic transporter availability of affected caudate and putamen to be more likely associated with RLS presence at diagnosis (n = 5; OR = 75.711; P = 0.077), and RLS occurrence during follow-up (n = 16; OR = 12.004; P = 0.059), respectively, as compared to patients without RLS (n = 88).
RLS is present since PD diagnosis, and increases in prevalence during the course of PD. PD subjects with RLS have higher age at PD onset, more preserved dopaminergic pathways, and worse sleep and cardiovascular disturbances.
Moccia M, Erro R, Picillo M, Santangelo G, Spina E, Allocca R, Longo K, Amboni M, Palladino R, Assante R, Pappatà S, Pellecchia MT, Barone P, Vitale C. A four-year longitudinal study on restless legs syndrome in Parkinson disease.
Url:
DOI: 10.5665/sleep.5452
PubMed: 26564123
PubMed Central: 4712388
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<author><name sortKey="Spina, Emanuele" sort="Spina, Emanuele" uniqKey="Spina E" first="Emanuele" last="Spina">Emanuele Spina</name>
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<author><name sortKey="Allocca, Roberto" sort="Allocca, Roberto" uniqKey="Allocca R" first="Roberto" last="Allocca">Roberto Allocca</name>
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<author><name sortKey="Longo, Katia" sort="Longo, Katia" uniqKey="Longo K" first="Katia" last="Longo">Katia Longo</name>
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<author><name sortKey="Amboni, Marianna" sort="Amboni, Marianna" uniqKey="Amboni M" first="Marianna" last="Amboni">Marianna Amboni</name>
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<author><name sortKey="Palladino, Raffaele" sort="Palladino, Raffaele" uniqKey="Palladino R" first="Raffaele" last="Palladino">Raffaele Palladino</name>
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<country xml:lang="fr">Royaume-Uni</country>
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<author><name sortKey="Assante, Roberta" sort="Assante, Roberta" uniqKey="Assante R" first="Roberta" last="Assante">Roberta Assante</name>
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<author><name sortKey="Pappata, Sabina" sort="Pappata, Sabina" uniqKey="Pappata S" first="Sabina" last="Pappatà">Sabina Pappatà</name>
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<author><name sortKey="Pellecchia, Maria Teresa" sort="Pellecchia, Maria Teresa" uniqKey="Pellecchia M" first="Maria Teresa" last="Pellecchia">Maria Teresa Pellecchia</name>
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<wicri:regionArea>Center for Neurodegenerative Diseases (CEMAND), Neuroscience Section, Department of Medicine, University of Salerno, Salerno</wicri:regionArea>
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<author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name>
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<country xml:lang="fr">Italie</country>
<wicri:regionArea>Center for Neurodegenerative Diseases (CEMAND), Neuroscience Section, Department of Medicine, University of Salerno, Salerno</wicri:regionArea>
</affiliation>
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<author><name sortKey="Vitale, Carmine" sort="Vitale, Carmine" uniqKey="Vitale C" first="Carmine" last="Vitale">Carmine Vitale</name>
<affiliation wicri:level="1"><nlm:aff id="aff7">IDC Hermitage-Capodimonte, Naples, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>IDC Hermitage-Capodimonte, Naples</wicri:regionArea>
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<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Motor Sciences, University Parthenope, Naples</wicri:regionArea>
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<series><title level="j">Sleep</title>
<idno type="ISSN">0161-8105</idno>
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<imprint><date when="2016">2016</date>
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<front><div type="abstract" xml:lang="en"><sec><title>Study Objectives:</title>
<p>Restless legs syndrome (RLS) prevalence estimates range from 0% to 52% in Parkinson disease (PD), but the causal relationship between the two disorders is still debated. The present study aims to evaluate RLS prevalence in de novo PD subjects, its incidence during the first 4 years from diagnosis, and possible relationships with clinical, laboratory, and neuroradiological data.</p>
</sec>
<sec><title>Methods:</title>
<p>One hundred nine newly diagnosed, drug-naïve PD subjects were evaluated at the time of PD diagnosis, and after 2- and 4-years. RLS diagnosis was performed with the RLS Diagnostic Index at each visit. Motor features, additional non-motor symptoms (NMS), and concomitant dopaminergic and nondopaminergic treatments were also gathered. Moreover, at baseline, 65 subjects were randomly selected to undergo a FP-CIT SPECT to study dopamine transporter availability.</p>
</sec>
<sec><title>Results:</title>
<p>RLS prevalence rose from 4.6% at baseline evaluation to 6.5% after 2 years and to 16.3% after 4 years (P = 0.007). A multinomial logistic stepwise regression model selected NMS Questionnaire items more likely to be associated with RLS at diagnosis (insomnia, OR = 15.555; P = 0.040) and with occurrence of RLS during follow-up (dizziness, OR = 1.153; P = 0.022; and daytime sleepiness; OR = 9.557; P = 0.001), as compared to patients without RLS. Older age was more likely associated to increased RLS occurrence during follow-up in a random effect logistic regression model (OR = 1.187; P = 0.036). A multinomial logistic stepwise model found increased dopaminergic transporter availability of affected caudate and putamen to be more likely associated with RLS presence at diagnosis (n = 5; OR = 75.711; P = 0.077), and RLS occurrence during follow-up (n = 16; OR = 12.004; P = 0.059), respectively, as compared to patients without RLS (n = 88).</p>
</sec>
<sec><title>Conclusions:</title>
<p>RLS is present since PD diagnosis, and increases in prevalence during the course of PD. PD subjects with RLS have higher age at PD onset, more preserved dopaminergic pathways, and worse sleep and cardiovascular disturbances.</p>
</sec>
<sec><title>Citation:</title>
<p>Moccia M, Erro R, Picillo M, Santangelo G, Spina E, Allocca R, Longo K, Amboni M, Palladino R, Assante R, Pappatà S, Pellecchia MT, Barone P, Vitale C. A four-year longitudinal study on restless legs syndrome in Parkinson disease. <italic>SLEEP</italic>
2016;39(2):405–412.</p>
</sec>
</div>
</front>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Sleep</journal-id>
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<issn pub-type="ppub">0161-8105</issn>
<issn pub-type="epub">1550-9109</issn>
<publisher><publisher-name>Associated Professional Sleep Societies, LLC</publisher-name>
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<article-meta><article-id pub-id-type="pmid">26564123</article-id>
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<article-categories><subj-group subj-group-type="heading"><subject>Neurological Disorders</subject>
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<title-group><article-title>A Four-Year Longitudinal Study on Restless Legs Syndrome in Parkinson Disease</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Moccia</surname>
<given-names>Marcello</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Erro</surname>
<given-names>Roberto</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Picillo</surname>
<given-names>Marina</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="aff4"><sup>4</sup>
</xref>
<xref ref-type="aff" rid="aff5"><sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Santangelo</surname>
<given-names>Gabriella</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="aff6"><sup>6</sup>
</xref>
<xref ref-type="aff" rid="aff7"><sup>7</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Spina</surname>
<given-names>Emanuele</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Allocca</surname>
<given-names>Roberto</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Longo</surname>
<given-names>Katia</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="aff7"><sup>7</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Amboni</surname>
<given-names>Marianna</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="aff7"><sup>7</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Palladino</surname>
<given-names>Raffaele</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="aff8"><sup>8</sup>
</xref>
<xref ref-type="aff" rid="aff9"><sup>9</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Assante</surname>
<given-names>Roberta</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="aff10"><sup>10</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pappatà</surname>
<given-names>Sabina</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="aff11"><sup>11</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pellecchia</surname>
<given-names>Maria Teresa</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="aff4"><sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Barone</surname>
<given-names>Paolo</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="aff4"><sup>4</sup>
</xref>
<xref ref-type="corresp" rid="cor1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vitale</surname>
<given-names>Carmine</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="aff7"><sup>7</sup>
</xref>
<xref ref-type="aff" rid="aff12"><sup>12</sup>
</xref>
</contrib>
<aff id="aff1"><label>1</label>
Department of Neurosciences, Reproductive Sciences and Odontostomatology, Federico II University, Naples, Italy</aff>
<aff id="aff2"><label>2</label>
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, UK</aff>
<aff id="aff3"><label>3</label>
Department of Neurological and Movement Sciences, University of Verona, Policlinico Borgo Roma, Verona, Italy</aff>
<aff id="aff4"><label>4</label>
Center for Neurodegenerative Diseases (CEMAND), Neuroscience Section, Department of Medicine, University of Salerno, Salerno, Italy</aff>
<aff id="aff5"><label>5</label>
Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease, Division of Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada</aff>
<aff id="aff6"><label>6</label>
Department of Psychology, Neuropsychology Laboratory, Second University of Naples, Caserta, Italy</aff>
<aff id="aff7"><label>7</label>
IDC Hermitage-Capodimonte, Naples, Italy</aff>
<aff id="aff8"><label>8</label>
Department of Primary Care and Public Health, Imperial College, London, UK</aff>
<aff id="aff9"><label>9</label>
Department of Public Health, Federico II University, Naples, Italy</aff>
<aff id="aff10"><label>10</label>
Department of Advanced Biomedical Sciences, University Federico II, Naples, Italy</aff>
<aff id="aff11"><label>11</label>
Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy</aff>
<aff id="aff12"><label>12</label>
Department of Motor Sciences, University Parthenope, Naples, Italy</aff>
</contrib-group>
<author-notes><corresp id="cor1">Address correspondence to: Prof. Paolo Barone, <addr-line>Center for Neurodegenerative Disease–CEMAND, Neuroscience Section, Department of Medicine, University of Salerno, Via S. Allende, 84081 Baronissi (SA), Italy</addr-line>
<phone>0039089672328</phone>
<email>pbarone@unisa.it</email>
</corresp>
</author-notes>
<pub-date pub-type="epub"><day>1</day>
<month>2</month>
<year>2016</year>
</pub-date>
<volume>39</volume>
<issue>2</issue>
<fpage>405</fpage>
<lpage>412</lpage>
<history><date date-type="received"><month>3</month>
<year>2015</year>
</date>
<date date-type="rev-recd"><month>7</month>
<year>2015</year>
</date>
<date date-type="accepted"><month>8</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-statement>© 2016 Associated Professional Sleep Societies, LLC.</copyright-statement>
<copyright-year>2016</copyright-year>
</permissions>
<abstract><sec><title>Study Objectives:</title>
<p>Restless legs syndrome (RLS) prevalence estimates range from 0% to 52% in Parkinson disease (PD), but the causal relationship between the two disorders is still debated. The present study aims to evaluate RLS prevalence in de novo PD subjects, its incidence during the first 4 years from diagnosis, and possible relationships with clinical, laboratory, and neuroradiological data.</p>
</sec>
<sec><title>Methods:</title>
<p>One hundred nine newly diagnosed, drug-naïve PD subjects were evaluated at the time of PD diagnosis, and after 2- and 4-years. RLS diagnosis was performed with the RLS Diagnostic Index at each visit. Motor features, additional non-motor symptoms (NMS), and concomitant dopaminergic and nondopaminergic treatments were also gathered. Moreover, at baseline, 65 subjects were randomly selected to undergo a FP-CIT SPECT to study dopamine transporter availability.</p>
</sec>
<sec><title>Results:</title>
<p>RLS prevalence rose from 4.6% at baseline evaluation to 6.5% after 2 years and to 16.3% after 4 years (P = 0.007). A multinomial logistic stepwise regression model selected NMS Questionnaire items more likely to be associated with RLS at diagnosis (insomnia, OR = 15.555; P = 0.040) and with occurrence of RLS during follow-up (dizziness, OR = 1.153; P = 0.022; and daytime sleepiness; OR = 9.557; P = 0.001), as compared to patients without RLS. Older age was more likely associated to increased RLS occurrence during follow-up in a random effect logistic regression model (OR = 1.187; P = 0.036). A multinomial logistic stepwise model found increased dopaminergic transporter availability of affected caudate and putamen to be more likely associated with RLS presence at diagnosis (n = 5; OR = 75.711; P = 0.077), and RLS occurrence during follow-up (n = 16; OR = 12.004; P = 0.059), respectively, as compared to patients without RLS (n = 88).</p>
</sec>
<sec><title>Conclusions:</title>
<p>RLS is present since PD diagnosis, and increases in prevalence during the course of PD. PD subjects with RLS have higher age at PD onset, more preserved dopaminergic pathways, and worse sleep and cardiovascular disturbances.</p>
</sec>
<sec><title>Citation:</title>
<p>Moccia M, Erro R, Picillo M, Santangelo G, Spina E, Allocca R, Longo K, Amboni M, Palladino R, Assante R, Pappatà S, Pellecchia MT, Barone P, Vitale C. A four-year longitudinal study on restless legs syndrome in Parkinson disease. <italic>SLEEP</italic>
2016;39(2):405–412.</p>
</sec>
</abstract>
<kwd-group><kwd>Parkinson</kwd>
<kwd>restless</kwd>
<kwd>RLS</kwd>
<kwd>sleep</kwd>
<kwd>progression</kwd>
<kwd>DAT</kwd>
<kwd>SPECT</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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