GBA mutations are associated with Rapid Eye Movement Sleep Behavior Disorder
Identifieur interne : 000052 ( Pmc/Curation ); précédent : 000051; suivant : 000053GBA mutations are associated with Rapid Eye Movement Sleep Behavior Disorder
Auteurs : Ziv Gan-Or [Canada] ; Anat Mirelman [Israël] ; Ronald B. Postuma [Canada] ; Isabelle Arnulf [France] ; Anat Bar-Shira [Israël] ; Yves Dauvilliers [France] ; Alex Desautels [Canada] ; Jean-François Gagnon [Canada] ; Claire S. Leblond [Canada] ; Birgit Frauscher [Autriche] ; Roy N. Alcalay [États-Unis] ; Rachel Saunders-Pullman [États-Unis] ; Susan B. Bressman [États-Unis] ; Karen Marder [États-Unis] ; Christelle Monaca [France] ; Birgit Högl [Autriche] ; Avi Orr-Urtreger [Israël] ; Patrick A. Dion [Canada] ; Jacques Y. Montplaisir [Canada] ; Nir Giladi [Israël] ; Guy A. Rouleau [Canada]Source :
- Annals of Clinical and Translational Neurology [ 2328-9503 ] ; 2015.
Abstract
Rapid eye movement sleep behavior disorder and
Url:
DOI: 10.1002/acn3.228
PubMed: 26401515
PubMed Central: 4574811
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Postuma</name><affiliation wicri:level="1"><nlm:aff id="au4"><institution>Department of Neurology, Montreal General Hospital</institution><addr-line>Montréal, Quebec, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montréal, Quebec</wicri:regionArea></affiliation></author><author><name sortKey="Arnulf, Isabelle" sort="Arnulf, Isabelle" uniqKey="Arnulf I" first="Isabelle" last="Arnulf">Isabelle Arnulf</name><affiliation wicri:level="1"><nlm:aff id="au5"><institution>Sleep Disorders Unit, Pitié Salpêtrière Hospital, Brain and Spine Institute and Sorbonne Universities, UPMC Paris 6 University</institution><addr-line>Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris</wicri:regionArea></affiliation></author><author><name sortKey="Bar Shira, Anat" sort="Bar Shira, Anat" uniqKey="Bar Shira A" first="Anat" last="Bar-Shira">Anat Bar-Shira</name><affiliation wicri:level="1"><nlm:aff id="au6"><institution>The Genetic Institute, Tel-Aviv Sourasky Medical Center</institution><addr-line>Tel-Aviv, Israel</addr-line></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Dauvilliers, Yves" sort="Dauvilliers, Yves" uniqKey="Dauvilliers Y" first="Yves" last="Dauvilliers">Yves Dauvilliers</name><affiliation wicri:level="1"><nlm:aff id="au7"><institution>Sleep Unit, National Reference Network for Narcolepsy, Department of Neurology, Hôpital-Gui-de Chauliac, CHU Montpellier</institution><addr-line>Montpellier, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Montpellier</wicri:regionArea></affiliation></author><author><name sortKey="Desautels, Alex" sort="Desautels, Alex" uniqKey="Desautels A" first="Alex" last="Desautels">Alex Desautels</name><affiliation wicri:level="1"><nlm:aff id="au8"><institution>Centre d’Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal</institution><addr-line>Montréal, Quebec, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montréal, Quebec</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au9"><institution>Department of Neurosciences, Université de Montréal</institution><addr-line>Montréal, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montréal</wicri:regionArea></affiliation></author><author><name sortKey="Gagnon, Jean Francois" sort="Gagnon, Jean Francois" uniqKey="Gagnon J" first="Jean-François" last="Gagnon">Jean-François Gagnon</name><affiliation wicri:level="1"><nlm:aff id="au8"><institution>Centre d’Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal</institution><addr-line>Montréal, Quebec, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montréal, Quebec</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au10"><institution>Département de psychologie, Université du Québec à Montréal</institution><addr-line>Montréal, Quebec, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montréal, Quebec</wicri:regionArea></affiliation></author><author><name sortKey="Leblond, Claire S" sort="Leblond, Claire S" uniqKey="Leblond C" first="Claire S" last="Leblond">Claire S. Leblond</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Montreal Neurological Institute, McGill University</institution><addr-line>Montréal, Quebec, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montréal, Quebec</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Human Genetics, McGill University</institution><addr-line>Montréal, Quebec, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montréal, Quebec</wicri:regionArea></affiliation></author><author><name sortKey="Frauscher, Birgit" sort="Frauscher, Birgit" uniqKey="Frauscher B" first="Birgit" last="Frauscher">Birgit Frauscher</name><affiliation wicri:level="1"><nlm:aff id="au11"><institution>Sleep Disorders Clinic, Department of Neurology, Innsbruck Medical University</institution><addr-line>Innsbruck, Austria</addr-line></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Innsbruck</wicri:regionArea></affiliation></author><author><name sortKey="Alcalay, Roy N" sort="Alcalay, Roy N" uniqKey="Alcalay R" first="Roy N" last="Alcalay">Roy N. Alcalay</name><affiliation wicri:level="2"><nlm:aff id="au12"><institution>Department of Neurology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University</institution><addr-line>New York, New York</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>New York</wicri:cityArea></affiliation></author><author><name sortKey="Saunders Pullman, Rachel" sort="Saunders Pullman, Rachel" uniqKey="Saunders Pullman R" first="Rachel" last="Saunders-Pullman">Rachel Saunders-Pullman</name><affiliation wicri:level="2"><nlm:aff id="au13"><institution>Department of Neurology, Icahn School of Medicine at Mount Sinai</institution><addr-line>New York, New York</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>New York</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="au14"><institution>Department of Neurology, Albert Einstein College of Medicine Bronx</institution><addr-line>New York, New York</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>New York</wicri:cityArea></affiliation></author><author><name sortKey="Bressman, Susan B" sort="Bressman, Susan B" uniqKey="Bressman S" first="Susan B" last="Bressman">Susan B. Bressman</name><affiliation wicri:level="2"><nlm:aff id="au15"><institution>Department of Neurology, Beth Israel Medical Center</institution><addr-line>New York, New York</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>New York</wicri:cityArea></affiliation></author><author><name sortKey="Marder, Karen" sort="Marder, Karen" uniqKey="Marder K" first="Karen" last="Marder">Karen Marder</name><affiliation wicri:level="2"><nlm:aff id="au16"><institution>Columbia Presbyterian Medical Center, Columbia University</institution><addr-line>New York, New York</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>New York</wicri:cityArea></affiliation></author><author><name sortKey="Monaca, Christelle" sort="Monaca, Christelle" uniqKey="Monaca C" first="Christelle" last="Monaca">Christelle Monaca</name><affiliation wicri:level="1"><nlm:aff id="au17"><institution>Department of clinical neurophysiology and sleep center, University Lille north of France, CHU Lille</institution><addr-line>Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Lille</wicri:regionArea></affiliation></author><author><name sortKey="Hogl, Birgit" sort="Hogl, Birgit" uniqKey="Hogl B" first="Birgit" last="Högl">Birgit Högl</name><affiliation wicri:level="1"><nlm:aff id="au11"><institution>Sleep Disorders Clinic, Department of Neurology, Innsbruck Medical University</institution><addr-line>Innsbruck, Austria</addr-line></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Innsbruck</wicri:regionArea></affiliation></author><author><name sortKey="Orr Urtreger, Avi" sort="Orr Urtreger, Avi" uniqKey="Orr Urtreger A" first="Avi" last="Orr-Urtreger">Avi Orr-Urtreger</name><affiliation wicri:level="1"><nlm:aff id="au6"><institution>The Genetic Institute, Tel-Aviv Sourasky Medical Center</institution><addr-line>Tel-Aviv, Israel</addr-line></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au18"><institution>The Sackler Faculty of Medicine, Tel-Aviv University</institution><addr-line>Tel-Aviv, Israel</addr-line></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Dion, Patrick A" sort="Dion, Patrick A" uniqKey="Dion P" first="Patrick A" last="Dion">Patrick A. Dion</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Montreal Neurological Institute, McGill University</institution><addr-line>Montréal, Quebec, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montréal, Quebec</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Human Genetics, McGill University</institution><addr-line>Montréal, Quebec, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montréal, Quebec</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au19"><institution>Department of Neurology and Neurosurgery, McGill University</institution><addr-line>Montréal, Quebec, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montréal, Quebec</wicri:regionArea></affiliation></author><author><name sortKey="Montplaisir, Jacques Y" sort="Montplaisir, Jacques Y" uniqKey="Montplaisir J" first="Jacques Y" last="Montplaisir">Jacques Y. Montplaisir</name><affiliation wicri:level="1"><nlm:aff id="au8"><institution>Centre d’Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal</institution><addr-line>Montréal, Quebec, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montréal, Quebec</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au20"><institution>Department of Psychiatry, Université de Montréal</institution><addr-line>Montréal, Quebec, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montréal, Quebec</wicri:regionArea></affiliation></author><author><name sortKey="Giladi, Nir" sort="Giladi, Nir" uniqKey="Giladi N" first="Nir" last="Giladi">Nir Giladi</name><affiliation wicri:level="1"><nlm:aff id="au3"><institution>Department of Neurology, Tel-Aviv Sourasky Medical Center</institution><addr-line>Tel-Aviv, Israel</addr-line></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au18"><institution>The Sackler Faculty of Medicine, Tel-Aviv University</institution><addr-line>Tel-Aviv, Israel</addr-line></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Rouleau, Guy A" sort="Rouleau, Guy A" uniqKey="Rouleau G" first="Guy A" last="Rouleau">Guy A. Rouleau</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Montreal Neurological Institute, McGill University</institution><addr-line>Montréal, Quebec, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montréal, Quebec</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Human Genetics, McGill University</institution><addr-line>Montréal, Quebec, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montréal, Quebec</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au19"><institution>Department of Neurology and Neurosurgery, McGill University</institution><addr-line>Montréal, Quebec, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montréal, Quebec</wicri:regionArea></affiliation></author></analytic><series><title level="j">Annals of Clinical and Translational Neurology</title><idno type="ISSN">2328-9503</idno><idno type="eISSN">2328-9503</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Rapid eye movement sleep behavior disorder and <italic>GBA</italic> mutations are both associated with Parkinson's disease. The <italic>GBA</italic> gene was sequenced in idiopathic rapid eye movement sleep behavior disorder patients (<italic>n</italic> = 265), and compared to controls (<italic>n</italic> = 2240). Rapid eye movement sleep behavior disorder questionnaire was performed in an independent Parkinson's disease cohort (<italic>n</italic> = 120). <italic>GBA</italic> mutations carriers had an OR of 6.24 (10.2% in patients vs. 1.8% in controls, <italic>P </italic><<italic> </italic>0.0001) for rapid eye movement sleep behavior disorder, and among Parkinson's disease patients, the OR for mutation carriers to have probable rapid eye movement sleep behavior disorder was 3.13 (<italic>P </italic>=<italic> </italic>0.039). These results demonstrate that rapid eye movement sleep behavior disorder is associated with <italic>GBA</italic> mutations, and that combining genetic and prodromal data may assist in identifying individuals susceptible to Parkinson's disease.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Sidransky, E" uniqKey="Sidransky E">E Sidransky</name></author><author><name sortKey="Nalls, Ma" uniqKey="Nalls M">MA Nalls</name></author><author><name sortKey="Aasly, Jo" uniqKey="Aasly J">JO Aasly</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mata, If" uniqKey="Mata I">IF Mata</name></author><author><name sortKey="Samii, A" uniqKey="Samii A">A Samii</name></author><author><name sortKey="Schneer, Sh" uniqKey="Schneer S">SH Schneer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsuang, D" uniqKey="Tsuang D">D Tsuang</name></author><author><name sortKey="Leverenz, Jb" 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Ann Clin Transl Neurol</journal-id><journal-id journal-id-type="iso-abbrev">Ann Clin Transl Neurol</journal-id><journal-id journal-id-type="publisher-id">acn3</journal-id><journal-title-group><journal-title>Annals of Clinical and Translational Neurology</journal-title></journal-title-group><issn pub-type="ppub">2328-9503</issn><issn pub-type="epub">2328-9503</issn><publisher><publisher-name>John Wiley & Sons, Ltd</publisher-name><publisher-loc>Chichester, UK</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26401515</article-id><article-id pub-id-type="pmc">4574811</article-id><article-id pub-id-type="doi">10.1002/acn3.228</article-id><article-categories><subj-group subj-group-type="heading"><subject>Brief Communication</subject></subj-group></article-categories><title-group><article-title>GBA mutations are associated with Rapid Eye Movement Sleep Behavior Disorder</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Gan-Or</surname><given-names>Ziv</given-names></name><xref ref-type="aff" rid="au1">1</xref><xref ref-type="aff" rid="au2">2</xref></contrib><contrib contrib-type="author"><name><surname>Mirelman</surname><given-names>Anat</given-names></name><xref ref-type="aff" rid="au3">3</xref></contrib><contrib contrib-type="author"><name><surname>Postuma</surname><given-names>Ronald B</given-names></name><xref ref-type="aff" rid="au4">4</xref></contrib><contrib contrib-type="author"><name><surname>Arnulf</surname><given-names>Isabelle</given-names></name><xref ref-type="aff" rid="au5">5</xref></contrib><contrib contrib-type="author"><name><surname>Bar-Shira</surname><given-names>Anat</given-names></name><xref ref-type="aff" rid="au6">6</xref></contrib><contrib contrib-type="author"><name><surname>Dauvilliers</surname><given-names>Yves</given-names></name><xref ref-type="aff" rid="au7">7</xref></contrib><contrib contrib-type="author"><name><surname>Desautels</surname><given-names>Alex</given-names></name><xref ref-type="aff" rid="au8">8</xref><xref ref-type="aff" rid="au9">9</xref></contrib><contrib contrib-type="author"><name><surname>Gagnon</surname><given-names>Jean-François</given-names></name><xref ref-type="aff" rid="au8">8</xref><xref ref-type="aff" rid="au10">10</xref></contrib><contrib contrib-type="author"><name><surname>Leblond</surname><given-names>Claire S</given-names></name><xref ref-type="aff" rid="au1">1</xref><xref ref-type="aff" rid="au2">2</xref></contrib><contrib contrib-type="author"><name><surname>Frauscher</surname><given-names>Birgit</given-names></name><xref ref-type="aff" rid="au11">11</xref></contrib><contrib contrib-type="author"><name><surname>Alcalay</surname><given-names>Roy N</given-names></name><xref ref-type="aff" rid="au12">12</xref></contrib><contrib contrib-type="author"><name><surname>Saunders-Pullman</surname><given-names>Rachel</given-names></name><xref ref-type="aff" rid="au13">13</xref><xref ref-type="aff" rid="au14">14</xref></contrib><contrib contrib-type="author"><name><surname>Bressman</surname><given-names>Susan B</given-names></name><xref ref-type="aff" rid="au15">15</xref></contrib><contrib contrib-type="author"><name><surname>Marder</surname><given-names>Karen</given-names></name><xref ref-type="aff" rid="au16">16</xref></contrib><contrib contrib-type="author"><name><surname>Monaca</surname><given-names>Christelle</given-names></name><xref ref-type="aff" rid="au17">17</xref></contrib><contrib contrib-type="author"><name><surname>Högl</surname><given-names>Birgit</given-names></name><xref ref-type="aff" rid="au11">11</xref></contrib><contrib contrib-type="author"><name><surname>Orr-Urtreger</surname><given-names>Avi</given-names></name><xref ref-type="aff" rid="au6">6</xref><xref ref-type="aff" rid="au18">18</xref></contrib><contrib contrib-type="author"><name><surname>Dion</surname><given-names>Patrick A</given-names></name><xref ref-type="aff" rid="au1">1</xref><xref ref-type="aff" rid="au2">2</xref><xref ref-type="aff" rid="au19">19</xref></contrib><contrib contrib-type="author"><name><surname>Montplaisir</surname><given-names>Jacques Y</given-names></name><xref ref-type="aff" rid="au8">8</xref><xref ref-type="aff" rid="au20">20</xref></contrib><contrib contrib-type="author"><name><surname>Giladi</surname><given-names>Nir</given-names></name><xref ref-type="aff" rid="au3">3</xref><xref ref-type="aff" rid="au18">18</xref></contrib><contrib contrib-type="author"><name><surname>Rouleau</surname><given-names>Guy A</given-names></name><xref ref-type="aff" rid="au1">1</xref><xref ref-type="aff" rid="au2">2</xref><xref ref-type="aff" rid="au19">19</xref></contrib><aff id="au1"><label>1</label><institution>Montreal Neurological Institute, McGill University</institution><addr-line>Montréal, Quebec, Canada</addr-line></aff><aff id="au2"><label>2</label><institution>Department of Human Genetics, McGill University</institution><addr-line>Montréal, Quebec, Canada</addr-line></aff><aff id="au3"><label>3</label><institution>Department of Neurology, Tel-Aviv Sourasky Medical Center</institution><addr-line>Tel-Aviv, Israel</addr-line></aff><aff id="au4"><label>4</label><institution>Department of Neurology, Montreal General Hospital</institution><addr-line>Montréal, Quebec, Canada</addr-line></aff><aff id="au5"><label>5</label><institution>Sleep Disorders Unit, Pitié Salpêtrière Hospital, Brain and Spine Institute and Sorbonne Universities, UPMC Paris 6 University</institution><addr-line>Paris, France</addr-line></aff><aff id="au6"><label>6</label><institution>The Genetic Institute, Tel-Aviv Sourasky Medical Center</institution><addr-line>Tel-Aviv, Israel</addr-line></aff><aff id="au7"><label>7</label><institution>Sleep Unit, National Reference Network for Narcolepsy, Department of Neurology, Hôpital-Gui-de Chauliac, CHU Montpellier</institution><addr-line>Montpellier, France</addr-line></aff><aff id="au8"><label>8</label><institution>Centre d’Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal</institution><addr-line>Montréal, Quebec, Canada</addr-line></aff><aff id="au9"><label>9</label><institution>Department of Neurosciences, Université de Montréal</institution><addr-line>Montréal, Canada</addr-line></aff><aff id="au10"><label>10</label><institution>Département de psychologie, Université du Québec à Montréal</institution><addr-line>Montréal, Quebec, Canada</addr-line></aff><aff id="au11"><label>11</label><institution>Sleep Disorders Clinic, Department of Neurology, Innsbruck Medical University</institution><addr-line>Innsbruck, Austria</addr-line></aff><aff id="au12"><label>12</label><institution>Department of Neurology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University</institution><addr-line>New York, New York</addr-line></aff><aff id="au13"><label>13</label><institution>Department of Neurology, Icahn School of Medicine at Mount Sinai</institution><addr-line>New York, New York</addr-line></aff><aff id="au14"><label>14</label><institution>Department of Neurology, Albert Einstein College of Medicine Bronx</institution><addr-line>New York, New York</addr-line></aff><aff id="au15"><label>15</label><institution>Department of Neurology, Beth Israel Medical Center</institution><addr-line>New York, New York</addr-line></aff><aff id="au16"><label>16</label><institution>Columbia Presbyterian Medical Center, Columbia University</institution><addr-line>New York, New York</addr-line></aff><aff id="au17"><label>17</label><institution>Department of clinical neurophysiology and sleep center, University Lille north of France, CHU Lille</institution><addr-line>Lille, France</addr-line></aff><aff id="au18"><label>18</label><institution>The Sackler Faculty of Medicine, Tel-Aviv University</institution><addr-line>Tel-Aviv, Israel</addr-line></aff><aff id="au19"><label>19</label><institution>Department of Neurology and Neurosurgery, McGill University</institution><addr-line>Montréal, Quebec, Canada</addr-line></aff><aff id="au20"><label>20</label><institution>Department of Psychiatry, Université de Montréal</institution><addr-line>Montréal, Quebec, Canada</addr-line></aff></contrib-group><author-notes><corresp id="cor1"><bold>Correspondence</bold> Guy A. Rouleau, Montréal Neurological Institute and Hospital, 3801, University Street, Office 636, Montréal, Québec, Canada H3A 2B4. Tel: +1-514-398-2690; Fax: +1-514-398-8248; E-mail: <email>guy.rouleau@mcgill.ca</email>, Ziv Gan-Or, Department of Human Genetics, Montréal Neurological Institute and Hospital, McGill University, 1033 Pine Avenue, West, Ludmer Pavilion, Room 327, Montreal, Quebec, Canada H3A 1A1. Tel: +1-514-398-6821; Fax: +1-514-398-8248; E-mail: <email>ziv.gan-or@mail.mcgill.ca</email></corresp><fn><p><bold>Funding Information</bold> This work was financially supported by the Canadian Institutes of Health Research (CIHR) and by the Michael J Fox Foundation.</p></fn></author-notes><pub-date pub-type="ppub"><month>9</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>31</day><month>7</month><year>2015</year></pub-date><volume>2</volume><issue>9</issue><fpage>941</fpage><lpage>945</lpage><history><date date-type="received"><day>09</day><month>6</month><year>2015</year></date><date date-type="rev-recd"><day>29</day><month>6</month><year>2015</year></date><date date-type="accepted"><day>30</day><month>6</month><year>2015</year></date></history><permissions><copyright-statement>© 2015 The Authors. <italic>Annals of Clinical and Translational Neurology</italic> published by Wiley Periodicals, Inc on behalf of American Neurological Association.</copyright-statement><copyright-year>2015</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-nd/4.0/"><license-p>This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.</license-p></license></permissions><abstract><p>Rapid eye movement sleep behavior disorder and <italic>GBA</italic> mutations are both associated with Parkinson's disease. The <italic>GBA</italic> gene was sequenced in idiopathic rapid eye movement sleep behavior disorder patients (<italic>n</italic> = 265), and compared to controls (<italic>n</italic> = 2240). Rapid eye movement sleep behavior disorder questionnaire was performed in an independent Parkinson's disease cohort (<italic>n</italic> = 120). <italic>GBA</italic> mutations carriers had an OR of 6.24 (10.2% in patients vs. 1.8% in controls, <italic>P </italic><<italic> </italic>0.0001) for rapid eye movement sleep behavior disorder, and among Parkinson's disease patients, the OR for mutation carriers to have probable rapid eye movement sleep behavior disorder was 3.13 (<italic>P </italic>=<italic> </italic>0.039). These results demonstrate that rapid eye movement sleep behavior disorder is associated with <italic>GBA</italic> mutations, and that combining genetic and prodromal data may assist in identifying individuals susceptible to Parkinson's disease.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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