Articulatory Changes in Vowel Production following STN DBS and Levodopa Intake in Parkinson's Disease
Identifieur interne : 000024 ( Pmc/Curation ); précédent : 000023; suivant : 000025Articulatory Changes in Vowel Production following STN DBS and Levodopa Intake in Parkinson's Disease
Auteurs : Vincent Martel Sauvageau [Canada] ; Johanna-Pascale Roy [Canada] ; Léo Cantin [Canada] ; Michel Prud'Homme [Canada] ; Mélanie Langlois [Canada] ; Joël Macoir [Canada]Source :
- Parkinson's Disease [ 2090-8083 ] ; 2015.
Abstract
Url:
DOI: 10.1155/2015/382320
PubMed: 26558134
PubMed Central: 4617696
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Articulatory Changes in Vowel Production following STN DBS and Levodopa Intake in Parkinson's Disease</title><author><name sortKey="Martel Sauvageau, Vincent" sort="Martel Sauvageau, Vincent" uniqKey="Martel Sauvageau V" first="Vincent" last="Martel Sauvageau">Vincent Martel Sauvageau</name><affiliation wicri:level="1"><nlm:aff id="I1">Centre Interdisciplinaire de Recherche en Réadaptation et en Intégration Sociale, Québec, QC, Canada G1M 2S8</nlm:aff><country>Canada</country><wicri:regionArea>Centre Interdisciplinaire de Recherche en Réadaptation et en Intégration Sociale, Québec, QC</wicri:regionArea></affiliation></author><author><name sortKey="Roy, Johanna Pascale" sort="Roy, Johanna Pascale" uniqKey="Roy J" first="Johanna-Pascale" last="Roy">Johanna-Pascale Roy</name><affiliation wicri:level="1"><nlm:aff id="I2">Centre Interdisciplinaire de Recherche sur les Activités Langagières, Université Laval, Québec, QC, Canada G1V 0A6</nlm:aff><country>Canada</country><wicri:regionArea>Centre Interdisciplinaire de Recherche sur les Activités Langagières, Université Laval, Québec, QC</wicri:regionArea></affiliation></author><author><name sortKey="Cantin, Leo" sort="Cantin, Leo" uniqKey="Cantin L" first="Léo" last="Cantin">Léo Cantin</name><affiliation wicri:level="1"><nlm:aff id="I3">Département des Sciences Neurologiques, CHU de Québec (Hôpital de l'Enfant-Jésus), Québec, QC, Canada G1J 1Z4</nlm:aff><country>Canada</country><wicri:regionArea>Département des Sciences Neurologiques, CHU de Québec (Hôpital de l'Enfant-Jésus), Québec, QC</wicri:regionArea></affiliation></author><author><name sortKey="Prud Homme, Michel" sort="Prud Homme, Michel" uniqKey="Prud Homme M" first="Michel" last="Prud'Homme">Michel Prud'Homme</name><affiliation wicri:level="1"><nlm:aff id="I3">Département des Sciences Neurologiques, CHU de Québec (Hôpital de l'Enfant-Jésus), Québec, QC, Canada G1J 1Z4</nlm:aff><country>Canada</country><wicri:regionArea>Département des Sciences Neurologiques, CHU de Québec (Hôpital de l'Enfant-Jésus), Québec, QC</wicri:regionArea></affiliation></author><author><name sortKey="Langlois, Melanie" sort="Langlois, Melanie" uniqKey="Langlois M" first="Mélanie" last="Langlois">Mélanie Langlois</name><affiliation wicri:level="1"><nlm:aff id="I3">Département des Sciences Neurologiques, CHU de Québec (Hôpital de l'Enfant-Jésus), Québec, QC, Canada G1J 1Z4</nlm:aff><country>Canada</country><wicri:regionArea>Département des Sciences Neurologiques, CHU de Québec (Hôpital de l'Enfant-Jésus), Québec, QC</wicri:regionArea></affiliation></author><author><name sortKey="Macoir, Joel" sort="Macoir, Joel" uniqKey="Macoir J" first="Joël" last="Macoir">Joël Macoir</name><affiliation wicri:level="1"><nlm:aff id="I4">Centre de Recherche, Institut Universitaire en Santé Mentale de Québec, Laboratoire Langage et Cognition, Québec, QC, Canada G1J 2G3</nlm:aff><country>Canada</country><wicri:regionArea>Centre de Recherche, Institut Universitaire en Santé Mentale de Québec, Laboratoire Langage et Cognition, Québec, QC</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26558134</idno><idno type="pmc">4617696</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617696</idno><idno type="RBID">PMC:4617696</idno><idno type="doi">10.1155/2015/382320</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000024</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000024</idno><idno type="wicri:Area/Pmc/Curation">000024</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000024</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Articulatory Changes in Vowel Production following STN DBS and Levodopa Intake in Parkinson's Disease</title><author><name sortKey="Martel Sauvageau, Vincent" sort="Martel Sauvageau, Vincent" uniqKey="Martel Sauvageau V" first="Vincent" last="Martel Sauvageau">Vincent Martel Sauvageau</name><affiliation wicri:level="1"><nlm:aff id="I1">Centre Interdisciplinaire de Recherche en Réadaptation et en Intégration Sociale, Québec, QC, Canada G1M 2S8</nlm:aff><country>Canada</country><wicri:regionArea>Centre Interdisciplinaire de Recherche en Réadaptation et en Intégration Sociale, Québec, QC</wicri:regionArea></affiliation></author><author><name sortKey="Roy, Johanna Pascale" sort="Roy, Johanna Pascale" uniqKey="Roy J" first="Johanna-Pascale" last="Roy">Johanna-Pascale Roy</name><affiliation wicri:level="1"><nlm:aff id="I2">Centre Interdisciplinaire de Recherche sur les Activités Langagières, Université Laval, Québec, QC, Canada G1V 0A6</nlm:aff><country>Canada</country><wicri:regionArea>Centre Interdisciplinaire de Recherche sur les Activités Langagières, Université Laval, Québec, QC</wicri:regionArea></affiliation></author><author><name sortKey="Cantin, Leo" sort="Cantin, Leo" uniqKey="Cantin L" first="Léo" last="Cantin">Léo Cantin</name><affiliation wicri:level="1"><nlm:aff id="I3">Département des Sciences Neurologiques, CHU de Québec (Hôpital de l'Enfant-Jésus), Québec, QC, Canada G1J 1Z4</nlm:aff><country>Canada</country><wicri:regionArea>Département des Sciences Neurologiques, CHU de Québec (Hôpital de l'Enfant-Jésus), Québec, QC</wicri:regionArea></affiliation></author><author><name sortKey="Prud Homme, Michel" sort="Prud Homme, Michel" uniqKey="Prud Homme M" first="Michel" last="Prud'Homme">Michel Prud'Homme</name><affiliation wicri:level="1"><nlm:aff id="I3">Département des Sciences Neurologiques, CHU de Québec (Hôpital de l'Enfant-Jésus), Québec, QC, Canada G1J 1Z4</nlm:aff><country>Canada</country><wicri:regionArea>Département des Sciences Neurologiques, CHU de Québec (Hôpital de l'Enfant-Jésus), Québec, QC</wicri:regionArea></affiliation></author><author><name sortKey="Langlois, Melanie" sort="Langlois, Melanie" uniqKey="Langlois M" first="Mélanie" last="Langlois">Mélanie Langlois</name><affiliation wicri:level="1"><nlm:aff id="I3">Département des Sciences Neurologiques, CHU de Québec (Hôpital de l'Enfant-Jésus), Québec, QC, Canada G1J 1Z4</nlm:aff><country>Canada</country><wicri:regionArea>Département des Sciences Neurologiques, CHU de Québec (Hôpital de l'Enfant-Jésus), Québec, QC</wicri:regionArea></affiliation></author><author><name sortKey="Macoir, Joel" sort="Macoir, Joel" uniqKey="Macoir J" first="Joël" last="Macoir">Joël Macoir</name><affiliation wicri:level="1"><nlm:aff id="I4">Centre de Recherche, Institut Universitaire en Santé Mentale de Québec, Laboratoire Langage et Cognition, Québec, QC, Canada G1J 2G3</nlm:aff><country>Canada</country><wicri:regionArea>Centre de Recherche, Institut Universitaire en Santé Mentale de Québec, Laboratoire Langage et Cognition, Québec, QC</wicri:regionArea></affiliation></author></analytic><series><title level="j">Parkinson's Disease</title><idno type="ISSN">2090-8083</idno><idno type="eISSN">2042-0080</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><italic>Purpose</italic>. To investigate the impact of deep brain stimulation of the subthalamic nucleus (STN DBS) and levodopa intake on vowel articulation in dysarthric speakers with Parkinson's disease (PD). <italic>Methods</italic>. Vowel articulation was assessed in seven Quebec French speakers diagnosed with idiopathic PD who underwent STN DBS. Assessments were conducted on- and off-medication, first prior to surgery and then 1 year later. All recordings were made on-stimulation. Vowel articulation was measured using acoustic vowel space and formant centralization ratio. <italic>Results</italic>. Compared to the period before surgery, vowel articulation was reduced after surgery when patients were off-medication, while it was better on-medication. The impact of levodopa intake on vowel articulation changed with STN DBS: before surgery, levodopa impaired articulation, while it no longer had a negative effect after surgery. <italic>Conclusions</italic>. These results indicate that while STN DBS could lead to a direct deterioration in articulation, it may indirectly improve it by reducing the levodopa dose required to manage motor symptoms. These findings suggest that, with respect to speech production, STN DBS and levodopa intake cannot be investigated separately because the two are intrinsically linked. Along with motor symptoms, speech production should be considered when optimizing therapeutic management of patients with PD.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Archibald, N" uniqKey="Archibald N">N. Archibald</name></author><author><name sortKey="Miller, N" uniqKey="Miller N">N. Miller</name></author><author><name sortKey="Rochester, L" uniqKey="Rochester L">L. Rochester</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pahwa, R" uniqKey="Pahwa R">R. Pahwa</name></author><author><name sortKey="Lyons, K E" uniqKey="Lyons K">K. E. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Parkinsons Dis</journal-id><journal-id journal-id-type="iso-abbrev">Parkinsons Dis</journal-id><journal-id journal-id-type="publisher-id">PD</journal-id><journal-title-group><journal-title>Parkinson's Disease</journal-title></journal-title-group><issn pub-type="ppub">2090-8083</issn><issn pub-type="epub">2042-0080</issn><publisher><publisher-name>Hindawi Publishing Corporation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26558134</article-id><article-id pub-id-type="pmc">4617696</article-id><article-id pub-id-type="doi">10.1155/2015/382320</article-id><article-categories><subj-group subj-group-type="heading"><subject>Clinical Study</subject></subj-group></article-categories><title-group><article-title>Articulatory Changes in Vowel Production following STN DBS and Levodopa Intake in Parkinson's Disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Martel Sauvageau</surname><given-names>Vincent</given-names></name><xref ref-type="aff" rid="I1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author"><name><surname>Roy</surname><given-names>Johanna-Pascale</given-names></name><xref ref-type="aff" rid="I2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Cantin</surname><given-names>Léo</given-names></name><xref ref-type="aff" rid="I3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Prud'Homme</surname><given-names>Michel</given-names></name><xref ref-type="aff" rid="I3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Langlois</surname><given-names>Mélanie</given-names></name><xref ref-type="aff" rid="I3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Macoir</surname><given-names>Joël</given-names></name><xref ref-type="aff" rid="I4"><sup>4</sup></xref></contrib></contrib-group><aff id="I1"><sup>1</sup>Centre Interdisciplinaire de Recherche en Réadaptation et en Intégration Sociale, Québec, QC, Canada G1M 2S8</aff><aff id="I2"><sup>2</sup>Centre Interdisciplinaire de Recherche sur les Activités Langagières, Université Laval, Québec, QC, Canada G1V 0A6</aff><aff id="I3"><sup>3</sup>Département des Sciences Neurologiques, CHU de Québec (Hôpital de l'Enfant-Jésus), Québec, QC, Canada G1J 1Z4</aff><aff id="I4"><sup>4</sup>Centre de Recherche, Institut Universitaire en Santé Mentale de Québec, Laboratoire Langage et Cognition, Québec, QC, Canada G1J 2G3</aff><author-notes><corresp id="cor1">*Vincent Martel Sauvageau: <email>vincent.martel-sauvageau@fmed.ulaval.ca</email></corresp><fn fn-type="other"><p>Academic Editor: Huw R. Morris</p></fn></author-notes><pub-date pub-type="ppub"><year>2015</year></pub-date><pub-date pub-type="epub"><day>7</day><month>10</month><year>2015</year></pub-date><volume>2015</volume><elocation-id>382320</elocation-id><history><date date-type="received"><day>7</day><month>7</month><year>2015</year></date><date date-type="rev-recd"><day>24</day><month>8</month><year>2015</year></date><date date-type="accepted"><day>14</day><month>9</month><year>2015</year></date></history><permissions><copyright-statement>Copyright © 2015 Vincent Martel Sauvageau et al.</copyright-statement><copyright-year>2015</copyright-year><license license-type="open-access"><license-p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p><italic>Purpose</italic>. To investigate the impact of deep brain stimulation of the subthalamic nucleus (STN DBS) and levodopa intake on vowel articulation in dysarthric speakers with Parkinson's disease (PD). <italic>Methods</italic>. Vowel articulation was assessed in seven Quebec French speakers diagnosed with idiopathic PD who underwent STN DBS. Assessments were conducted on- and off-medication, first prior to surgery and then 1 year later. All recordings were made on-stimulation. Vowel articulation was measured using acoustic vowel space and formant centralization ratio. <italic>Results</italic>. Compared to the period before surgery, vowel articulation was reduced after surgery when patients were off-medication, while it was better on-medication. The impact of levodopa intake on vowel articulation changed with STN DBS: before surgery, levodopa impaired articulation, while it no longer had a negative effect after surgery. <italic>Conclusions</italic>. These results indicate that while STN DBS could lead to a direct deterioration in articulation, it may indirectly improve it by reducing the levodopa dose required to manage motor symptoms. These findings suggest that, with respect to speech production, STN DBS and levodopa intake cannot be investigated separately because the two are intrinsically linked. Along with motor symptoms, speech production should be considered when optimizing therapeutic management of patients with PD.</p></abstract></article-meta></front><floats-group><fig id="fig1" orientation="portrait" position="float"><label>Figure 1</label><caption><p>Formant centralization ratio (higher values = reduced articulation) before (Pre-op) and after (Post-op) STN DBS, off- and on-medication.</p></caption><graphic xlink:href="PD2015-382320.001"></graphic></fig><table-wrap id="tab1" orientation="portrait" position="float"><label>Table 1</label><caption><p>Individual levodopa daily dose before and after surgery and DBS parameters at one-year followup.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="2" colspan="1">Patient</th><th align="center" colspan="2" rowspan="1">L-dopa equivalent (mg)</th><th align="center" colspan="2" rowspan="1">Frequency (Hz)</th><th align="center" colspan="2" rowspan="1">Voltage (V)</th><th align="center" colspan="2" rowspan="1">Pulse width (<italic>µ</italic>s)</th></tr><tr><th align="center" rowspan="1" colspan="1">Pre-op</th><th align="center" rowspan="1" colspan="1">Post-op</th><th align="center" rowspan="1" colspan="1">Left</th><th align="center" rowspan="1" colspan="1">Right</th><th align="center" rowspan="1" colspan="1">Left</th><th align="center" rowspan="1" colspan="1">Right</th><th align="center" rowspan="1" colspan="1">Left</th><th align="center" rowspan="1" colspan="1">Right</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">1</td><td align="center" rowspan="1" colspan="1">1500</td><td align="center" rowspan="1" colspan="1">300</td><td align="center" rowspan="1" colspan="1">130</td><td align="center" rowspan="1" colspan="1">130</td><td align="center" rowspan="1" colspan="1">2.8</td><td align="center" rowspan="1" colspan="1">3.6</td><td align="center" rowspan="1" colspan="1">60</td><td align="center" rowspan="1" colspan="1">60</td></tr><tr><td align="left" rowspan="1" colspan="1">2</td><td align="center" rowspan="1" colspan="1">1688</td><td align="center" rowspan="1" colspan="1">650</td><td align="center" rowspan="1" colspan="1">140</td><td align="center" rowspan="1" colspan="1">140</td><td align="center" rowspan="1" colspan="1">2.5</td><td align="center" rowspan="1" colspan="1">2.5</td><td align="center" rowspan="1" colspan="1">60</td><td align="center" rowspan="1" colspan="1">60</td></tr><tr><td align="left" rowspan="1" colspan="1">3</td><td align="center" rowspan="1" colspan="1">1200</td><td align="center" rowspan="1" colspan="1">750</td><td align="center" rowspan="1" colspan="1">140</td><td align="center" rowspan="1" colspan="1">140</td><td align="center" rowspan="1" colspan="1">2.9</td><td align="center" rowspan="1" colspan="1">2.9</td><td align="center" rowspan="1" colspan="1">60</td><td align="center" rowspan="1" colspan="1">60</td></tr><tr><td align="left" rowspan="1" colspan="1">4</td><td align="center" rowspan="1" colspan="1">850</td><td align="center" rowspan="1" colspan="1">600</td><td align="center" rowspan="1" colspan="1">140</td><td align="center" rowspan="1" colspan="1">140</td><td align="center" rowspan="1" colspan="1">2.0</td><td align="center" rowspan="1" colspan="1">3.8</td><td align="center" rowspan="1" colspan="1">60</td><td align="center" rowspan="1" colspan="1">60</td></tr><tr><td align="left" rowspan="1" colspan="1">5</td><td align="center" rowspan="1" colspan="1">1684</td><td align="center" rowspan="1" colspan="1">600</td><td align="center" rowspan="1" colspan="1">140</td><td align="center" rowspan="1" colspan="1">140</td><td align="center" rowspan="1" colspan="1">3.7</td><td align="center" rowspan="1" colspan="1">3.7</td><td align="center" rowspan="1" colspan="1">90</td><td align="center" rowspan="1" colspan="1">60</td></tr><tr><td align="left" rowspan="1" colspan="1">6</td><td align="center" rowspan="1" colspan="1">1094</td><td align="center" rowspan="1" colspan="1">50</td><td align="center" rowspan="1" colspan="1">140</td><td align="center" rowspan="1" colspan="1">140</td><td align="center" rowspan="1" colspan="1">3.0</td><td align="center" rowspan="1" colspan="1">3.0</td><td align="center" rowspan="1" colspan="1">60</td><td align="center" rowspan="1" colspan="1">60</td></tr><tr><td align="left" rowspan="1" colspan="1">7</td><td align="center" rowspan="1" colspan="1">900</td><td align="center" rowspan="1" colspan="1">500</td><td align="center" rowspan="1" colspan="1">130</td><td align="center" rowspan="1" colspan="1">130</td><td align="center" rowspan="1" colspan="1">1.2</td><td align="center" rowspan="1" colspan="1">3.3</td><td align="center" rowspan="1" colspan="1">60</td><td align="center" rowspan="1" colspan="1">60</td></tr></tbody></table></table-wrap><table-wrap id="tab2" orientation="portrait" position="float"><label>Table 2</label><caption><p>Means (standard deviations) for vowel duration (msec.), acoustic vowel space (Hz<sup>2</sup>), and formant centralization ratio before and after STN DBS, off- and on-medication.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1"> </th><th align="center" colspan="2" rowspan="1">Pre-op</th><th align="center" colspan="2" rowspan="1">Post-op</th></tr><tr><th align="left" rowspan="1" colspan="1"> </th><th align="center" rowspan="1" colspan="1">Off-med</th><th align="center" rowspan="1" colspan="1">On-med</th><th align="center" rowspan="1" colspan="1">Off-med</th><th align="center" rowspan="1" colspan="1">On-med</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">Vowel duration (msec.)</td><td align="center" rowspan="1" colspan="1">105.0<break></break>(24.7)</td><td align="center" rowspan="1" colspan="1">103.2<break></break>(31.1)</td><td align="center" rowspan="1" colspan="1">102.6<break></break>(18.7)</td><td align="center" rowspan="1" colspan="1">102.8<break></break>(22.4)</td></tr><tr><td align="center" colspan="5" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1">Acoustic vowel space (Hz<sup>2</sup>)</td><td align="center" rowspan="1" colspan="1">246006<break></break>(48045)</td><td align="center" rowspan="1" colspan="1">222166<break></break>(73934)</td><td align="center" rowspan="1" colspan="1">222430<break></break>(45823)</td><td align="center" rowspan="1" colspan="1">236810<break></break>(69166)</td></tr><tr><td align="center" colspan="5" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1">Formant centralization ratio</td><td align="center" rowspan="1" colspan="1">1.09<break></break>(0.06)</td><td align="center" rowspan="1" colspan="1">1.14<break></break>(0.09)</td><td align="center" rowspan="1" colspan="1">1.12<break></break>(0.06)</td><td align="center" rowspan="1" colspan="1">1.10<break></break>(0.07)</td></tr></tbody></table></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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