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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Role of p53 in Neurodegenerative Diseases</title><author><name sortKey="Chang, J Robert" sort="Chang, J Robert" uniqKey="Chang J" first="J. Robert" last="Chang">J. Robert Chang</name><affiliation><nlm:aff id="aff1">Molecular Studies of Neurodegenerative Diseases Laboratory, Department of Neurology, Temple University School of Medicine, Philadelphia, Pa., USA</nlm:aff></affiliation></author><author><name sortKey="Ghafouri, Mohammad" sort="Ghafouri, Mohammad" uniqKey="Ghafouri M" first="Mohammad" last="Ghafouri">Mohammad Ghafouri</name><affiliation><nlm:aff id="aff2">Conseil Scolaire de District du Centre-Sud-Ouest Ontario, Toronto, Ont., Canada</nlm:aff></affiliation></author><author><name sortKey="Mukerjee, Ruma" sort="Mukerjee, Ruma" uniqKey="Mukerjee R" first="Ruma" last="Mukerjee">Ruma Mukerjee</name><affiliation><nlm:aff id="aff1">Molecular Studies of Neurodegenerative Diseases Laboratory, Department of Neurology, Temple University School of Medicine, Philadelphia, Pa., USA</nlm:aff></affiliation></author><author><name sortKey="Bagashev, Asen" sort="Bagashev, Asen" uniqKey="Bagashev A" first="Asen" last="Bagashev">Asen Bagashev</name><affiliation><nlm:aff id="aff1">Molecular Studies of Neurodegenerative Diseases Laboratory, Department of Neurology, Temple University School of Medicine, Philadelphia, Pa., USA</nlm:aff></affiliation></author><author><name sortKey="Chabrashvili, Tinatin" sort="Chabrashvili, Tinatin" uniqKey="Chabrashvili T" first="Tinatin" last="Chabrashvili">Tinatin Chabrashvili</name><affiliation><nlm:aff id="aff1">Molecular Studies of Neurodegenerative Diseases Laboratory, Department of Neurology, Temple University School of Medicine, Philadelphia, Pa., USA</nlm:aff></affiliation></author><author><name sortKey="Sawaya, Bassel E" sort="Sawaya, Bassel E" uniqKey="Sawaya B" first="Bassel E." last="Sawaya">Bassel E. Sawaya</name><affiliation><nlm:aff id="aff1">Molecular Studies of Neurodegenerative Diseases Laboratory, Department of Neurology, Temple University School of Medicine, Philadelphia, Pa., USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22042001</idno><idno type="pmc">3304514</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304514</idno><idno type="RBID">PMC:3304514</idno><idno type="doi">10.1159/000329999</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000B89</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000B89</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Role of p53 in Neurodegenerative Diseases</title><author><name sortKey="Chang, J Robert" sort="Chang, J Robert" uniqKey="Chang J" first="J. Robert" last="Chang">J. Robert Chang</name><affiliation><nlm:aff id="aff1">Molecular Studies of Neurodegenerative Diseases Laboratory, Department of Neurology, Temple University School of Medicine, Philadelphia, Pa., USA</nlm:aff></affiliation></author><author><name sortKey="Ghafouri, Mohammad" sort="Ghafouri, Mohammad" uniqKey="Ghafouri M" first="Mohammad" last="Ghafouri">Mohammad Ghafouri</name><affiliation><nlm:aff id="aff2">Conseil Scolaire de District du Centre-Sud-Ouest Ontario, Toronto, Ont., Canada</nlm:aff></affiliation></author><author><name sortKey="Mukerjee, Ruma" sort="Mukerjee, Ruma" uniqKey="Mukerjee R" first="Ruma" last="Mukerjee">Ruma Mukerjee</name><affiliation><nlm:aff id="aff1">Molecular Studies of Neurodegenerative Diseases Laboratory, Department of Neurology, Temple University School of Medicine, Philadelphia, Pa., USA</nlm:aff></affiliation></author><author><name sortKey="Bagashev, Asen" sort="Bagashev, Asen" uniqKey="Bagashev A" first="Asen" last="Bagashev">Asen Bagashev</name><affiliation><nlm:aff id="aff1">Molecular Studies of Neurodegenerative Diseases Laboratory, Department of Neurology, Temple University School of Medicine, Philadelphia, Pa., USA</nlm:aff></affiliation></author><author><name sortKey="Chabrashvili, Tinatin" sort="Chabrashvili, Tinatin" uniqKey="Chabrashvili T" first="Tinatin" last="Chabrashvili">Tinatin Chabrashvili</name><affiliation><nlm:aff id="aff1">Molecular Studies of Neurodegenerative Diseases Laboratory, Department of Neurology, Temple University School of Medicine, Philadelphia, Pa., USA</nlm:aff></affiliation></author><author><name sortKey="Sawaya, Bassel E" sort="Sawaya, Bassel E" uniqKey="Sawaya B" first="Bassel E." last="Sawaya">Bassel E. Sawaya</name><affiliation><nlm:aff id="aff1">Molecular Studies of Neurodegenerative Diseases Laboratory, Department of Neurology, Temple University School of Medicine, Philadelphia, Pa., USA</nlm:aff></affiliation></author></analytic><series><title level="j">Neuro-Degenerative Diseases</title><idno type="ISSN">1660-2854</idno><idno type="eISSN">1660-2862</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>p53 plays an important role in many areas of cellular physiology and biology, ranging from cellular development and differentiation to cell cycle arrest and apoptosis. Many of its functions are attributed to its role in assuring proper cellular division. However, since the establishment of its role in cell cycle arrest, damage repair, and apoptosis (thus also establishing its importance in cancer development), numerous reports have demonstrated additional functions of p53 in various cells. In particular, p53 appears to have important functions as it relates to neurodegeneration and synaptic plasticity.</p></sec><sec><title>Objective</title><p>In this review, we will address p53 functions as it relates to various neurodegenerative diseases, mainly its implications in the development of HIV-associated neurocognitive disorders.</p></sec><sec><title>Conclusion</title><p>p53 plays a pivotal role in the development of neurodegenerative diseases through its interaction with cellular factors, viral factors, and/or small RNAs that have the ability to promote the development of these diseases. Hence, inhibition of p53 may present an ideal target to restore neuronal functions.</p></sec></div></front></TEI><pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Neurodegener Dis</journal-id><journal-id journal-id-type="publisher-id">NDD</journal-id><journal-title-group><journal-title>Neuro-Degenerative Diseases</journal-title></journal-title-group><issn pub-type="ppub">1660-2854</issn><issn pub-type="epub">1660-2862</issn><publisher><publisher-name>S. Karger AG</publisher-name><publisher-loc>Allschwilerstrasse 10, P.O. Box · Postfach · Case postale, CH–4009, Basel, Switzerland · Schweiz · Suisse, Phone: +41 61 306 11 11, Fax: +41 61 306 12 34, karger@karger.ch</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22042001</article-id><article-id pub-id-type="pmc">3304514</article-id><article-id pub-id-type="doi">10.1159/000329999</article-id><article-id pub-id-type="publisher-id">ndd-0009-0068</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Role of p53 in Neurodegenerative Diseases</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Chang</surname><given-names>J. Robert</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ghafouri</surname><given-names>Mohammad</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mukerjee</surname><given-names>Ruma</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bagashev</surname><given-names>Asen</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chabrashvili</surname><given-names>Tinatin</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sawaya</surname><given-names>Bassel E.</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="corresp" rid="cor1">*</xref></contrib></contrib-group><aff id="aff1"><sup>a</sup>Molecular Studies of Neurodegenerative Diseases Laboratory, Department of Neurology, Temple University School of Medicine, Philadelphia, Pa., USA</aff><aff id="aff2"><sup>b</sup>Conseil Scolaire de District du Centre-Sud-Ouest Ontario, Toronto, Ont., Canada</aff><author-notes><corresp id="cor1">*Bassel E. Sawaya, PhD, Molecular Studies of Neurodegenerative Diseases Laboratory, Department of Neurology, Temple University School of Medicine, 3420 N. Broad Street, Philadelphia, PA 19140 (USA), Tel. +1 215 707 5446, E-Mail <email>sawaya@temple.edu</email></corresp></author-notes><pub-date pub-type="ppub"><month>2</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>28</day><month>10</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>2</month><year>2013</year></pub-date><pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
<volume>9</volume><issue>2</issue><fpage>68</fpage><lpage>80</lpage><history><date date-type="received"><day>10</day><month>3</month><year>2011</year></date><date date-type="accepted"><day>9</day><month>6</month><year>2011</year></date></history><permissions><copyright-statement>Copyright © 2011 by S. Karger AG, Basel</copyright-statement><copyright-year>2011</copyright-year></permissions><abstract><sec><title>Background</title><p>p53 plays an important role in many areas of cellular physiology and biology, ranging from cellular development and differentiation to cell cycle arrest and apoptosis. Many of its functions are attributed to its role in assuring proper cellular division. However, since the establishment of its role in cell cycle arrest, damage repair, and apoptosis (thus also establishing its importance in cancer development), numerous reports have demonstrated additional functions of p53 in various cells. In particular, p53 appears to have important functions as it relates to neurodegeneration and synaptic plasticity.</p></sec><sec><title>Objective</title><p>In this review, we will address p53 functions as it relates to various neurodegenerative diseases, mainly its implications in the development of HIV-associated neurocognitive disorders.</p></sec><sec><title>Conclusion</title><p>p53 plays a pivotal role in the development of neurodegenerative diseases through its interaction with cellular factors, viral factors, and/or small RNAs that have the ability to promote the development of these diseases. Hence, inhibition of p53 may present an ideal target to restore neuronal functions.</p></sec></abstract><kwd-group><title>Key Words</title><kwd>p53</kwd><kwd>Neurodegenerative disease</kwd><kwd>HIV-associated neurocognitive disorders</kwd></kwd-group><counts><fig-count count="2"></fig-count><ref-count count="193"></ref-count><page-count count="13"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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