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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Dopamine receptors – IUPHAR Review 13</title><author><name sortKey="Beaulieu, Jean Martin" sort="Beaulieu, Jean Martin" uniqKey="Beaulieu J" first="Jean-Martin" last="Beaulieu">Jean-Martin Beaulieu</name><affiliation><nlm:aff id="au1"><institution>Department of Psychiatry and Neuroscience, Faculty of Medicine, Université Laval – IUSMQ</institution><addr-line>Québec, Québec, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Espinoza, Stefano" sort="Espinoza, Stefano" uniqKey="Espinoza S" first="Stefano" last="Espinoza">Stefano Espinoza</name><affiliation><nlm:aff id="au2"><institution>Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia</institution><addr-line>Genova, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gainetdinov, Raul R" sort="Gainetdinov, Raul R" uniqKey="Gainetdinov R" first="Raul R" last="Gainetdinov">Raul R. Gainetdinov</name><affiliation><nlm:aff id="au2"><institution>Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia</institution><addr-line>Genova, Italy</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au3"><institution>Skolkovo Institute of Science and Technologies</institution><addr-line>Skolkovo, Moscow Region, Russia</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au4"><institution>Faculty of Biology, St. Petersburg State University</institution><addr-line>St. Petersburg, Russia</addr-line></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25671228</idno><idno type="pmc">4280963</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280963</idno><idno type="RBID">PMC:4280963</idno><idno type="doi">10.1111/bph.12906</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000B75</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000B75</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Dopamine receptors – IUPHAR Review 13</title><author><name sortKey="Beaulieu, Jean Martin" sort="Beaulieu, Jean Martin" uniqKey="Beaulieu J" first="Jean-Martin" last="Beaulieu">Jean-Martin Beaulieu</name><affiliation><nlm:aff id="au1"><institution>Department of Psychiatry and Neuroscience, Faculty of Medicine, Université Laval – IUSMQ</institution><addr-line>Québec, Québec, Canada</addr-line></nlm:aff></affiliation></author><author><name sortKey="Espinoza, Stefano" sort="Espinoza, Stefano" uniqKey="Espinoza S" first="Stefano" last="Espinoza">Stefano Espinoza</name><affiliation><nlm:aff id="au2"><institution>Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia</institution><addr-line>Genova, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gainetdinov, Raul R" sort="Gainetdinov, Raul R" uniqKey="Gainetdinov R" first="Raul R" last="Gainetdinov">Raul R. Gainetdinov</name><affiliation><nlm:aff id="au2"><institution>Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia</institution><addr-line>Genova, Italy</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au3"><institution>Skolkovo Institute of Science and Technologies</institution><addr-line>Skolkovo, Moscow Region, Russia</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au4"><institution>Faculty of Biology, St. Petersburg State University</institution><addr-line>St. Petersburg, Russia</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">British Journal of Pharmacology</title><idno type="ISSN">0007-1188</idno><idno type="eISSN">1476-5381</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The variety of physiological functions controlled by dopamine in the brain and periphery is mediated by the D<sub>1</sub>, D<sub>2</sub>, D<sub>3</sub>, D<sub>4</sub> and D<sub>5</sub> dopamine GPCRs. Drugs acting on dopamine receptors are significant tools for the management of several neuropsychiatric disorders including schizophrenia, bipolar disorder, depression and Parkinson's disease. Recent investigations of dopamine receptor signalling have shown that dopamine receptors, apart from their canonical action on cAMP-mediated signalling, can regulate a myriad of cellular responses to fine-tune the expression of dopamine-associated behaviours and functions. Such signalling mechanisms may involve alternate G protein coupling or non-G protein mechanisms involving ion channels, receptor tyrosine kinases or proteins such as β-arrestins that are classically involved in GPCR desensitization. Another level of complexity is the growing appreciation of the physiological roles played by dopamine receptor heteromers. Applications of new <italic>in vivo</italic> techniques have significantly furthered the understanding of the physiological functions played by dopamine receptors. Here we provide an update of the current knowledge regarding the complex biology, signalling, physiology and pharmacology of dopamine receptors.</p></div></front></TEI><pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Br J Pharmacol</journal-id><journal-id journal-id-type="iso-abbrev">Br. J. Pharmacol</journal-id><journal-id journal-id-type="publisher-id">bph</journal-id><journal-title-group><journal-title>British Journal of Pharmacology</journal-title></journal-title-group><issn pub-type="ppub">0007-1188</issn><issn pub-type="epub">1476-5381</issn><publisher><publisher-name>Blackwell Publishing Ltd</publisher-name><publisher-loc>Oxford, UK</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25671228</article-id><article-id pub-id-type="pmc">4280963</article-id><article-id pub-id-type="doi">10.1111/bph.12906</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Dopamine receptors – IUPHAR Review 13</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Beaulieu</surname><given-names>Jean-Martin</given-names></name><xref ref-type="aff" rid="au1">1</xref></contrib><contrib contrib-type="author"><name><surname>Espinoza</surname><given-names>Stefano</given-names></name><xref ref-type="aff" rid="au2">2</xref></contrib><contrib contrib-type="author"><name><surname>Gainetdinov</surname><given-names>Raul R</given-names></name><xref ref-type="aff" rid="au2">2</xref><xref ref-type="aff" rid="au3">3</xref><xref ref-type="aff" rid="au4">4</xref></contrib><aff id="au1"><label>1</label><institution>Department of Psychiatry and Neuroscience, Faculty of Medicine, Université Laval – IUSMQ</institution><addr-line>Québec, Québec, Canada</addr-line></aff><aff id="au2"><label>2</label><institution>Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia</institution><addr-line>Genova, Italy</addr-line></aff><aff id="au3"><label>3</label><institution>Skolkovo Institute of Science and Technologies</institution><addr-line>Skolkovo, Moscow Region, Russia</addr-line></aff><aff id="au4"><label>4</label><institution>Faculty of Biology, St. Petersburg State University</institution><addr-line>St. Petersburg, Russia</addr-line></aff></contrib-group><author-notes><corresp id="cor1">Raul R Gainetdinov, Istituto Italiano di Tecnologia (IIT), Via Morego 30, Genova, 16163, Italy. E-mail: <email>raul.gainetdinov@iit.it</email></corresp><fn><p>This article, written by members of the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC-IUPHAR) subcommittee for the dopamine receptors, confirms the existing nomenclature for these receptors and reviews our current understanding of their structure, pharmacology and functions and their likely physiological roles in health and disease. More information on these receptor families can be found in the Concise Guide to PHARMACOLOGY (<ext-link ext-link-type="uri" xlink:href="http://onlinelibrary.wiley.com/doi/10.1111/bph.12445/abstract">http://onlinelibrary.wiley.com/doi/10.1111/bph.12445/abstract</ext-link>) and for each member of the family in the corresponding database <ext-link ext-link-type="uri" xlink:href="http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=20&familyType=GPCR">http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=20&familyType=GPCR</ext-link>.</p></fn></author-notes><pub-date pub-type="ppub"><month>1</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>24</day><month>11</month><year>2014</year></pub-date><volume>172</volume><issue>1</issue><fpage>1</fpage><lpage>23</lpage><history><date date-type="received"><day>29</day><month>3</month><year>2014</year></date><date date-type="rev-recd"><day>11</day><month>7</month><year>2014</year></date><date date-type="accepted"><day>13</day><month>8</month><year>2014</year></date></history><permissions><copyright-statement>© 2014 The British Pharmacological Society</copyright-statement><copyright-year>2014</copyright-year></permissions><abstract><p>The variety of physiological functions controlled by dopamine in the brain and periphery is mediated by the D<sub>1</sub>, D<sub>2</sub>, D<sub>3</sub>, D<sub>4</sub> and D<sub>5</sub> dopamine GPCRs. Drugs acting on dopamine receptors are significant tools for the management of several neuropsychiatric disorders including schizophrenia, bipolar disorder, depression and Parkinson's disease. Recent investigations of dopamine receptor signalling have shown that dopamine receptors, apart from their canonical action on cAMP-mediated signalling, can regulate a myriad of cellular responses to fine-tune the expression of dopamine-associated behaviours and functions. Such signalling mechanisms may involve alternate G protein coupling or non-G protein mechanisms involving ion channels, receptor tyrosine kinases or proteins such as β-arrestins that are classically involved in GPCR desensitization. Another level of complexity is the growing appreciation of the physiological roles played by dopamine receptor heteromers. Applications of new <italic>in vivo</italic> techniques have significantly furthered the understanding of the physiological functions played by dopamine receptors. Here we provide an update of the current knowledge regarding the complex biology, signalling, physiology and pharmacology of dopamine receptors.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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