La maladie de Parkinson au Canada (serveur d'exploration)

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<title xml:lang="en">Molecular imaging and neural networks in impulse control disorders in Parkinson’s disease</title>
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<name sortKey="Aracil Bola Os, I" sort="Aracil Bola Os, I" uniqKey="Aracil Bola Os I" first="I." last="Aracil-Bola Os">I. Aracil-Bola Os</name>
<affiliation>
<nlm:aff id="A1">Morton and Gloria Shulman Movement Disorder Unit & Edmond J. Safra Program in Parkinson Disease, Toronto Western Hospital, UHN, University of Toronto, Ontario, Canada</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A2">Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A3">Division of Brain, Imaging and Behaviour – Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Ontario, Canada</nlm:aff>
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<author>
<name sortKey="Strafella, A P" sort="Strafella, A P" uniqKey="Strafella A" first="A. P." last="Strafella">A. P. Strafella</name>
<affiliation>
<nlm:aff id="A1">Morton and Gloria Shulman Movement Disorder Unit & Edmond J. Safra Program in Parkinson Disease, Toronto Western Hospital, UHN, University of Toronto, Ontario, Canada</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A2">Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A3">Division of Brain, Imaging and Behaviour – Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Ontario, Canada</nlm:aff>
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<title xml:lang="en" level="a" type="main">Molecular imaging and neural networks in impulse control disorders in Parkinson’s disease</title>
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<name sortKey="Aracil Bola Os, I" sort="Aracil Bola Os, I" uniqKey="Aracil Bola Os I" first="I." last="Aracil-Bola Os">I. Aracil-Bola Os</name>
<affiliation>
<nlm:aff id="A1">Morton and Gloria Shulman Movement Disorder Unit & Edmond J. Safra Program in Parkinson Disease, Toronto Western Hospital, UHN, University of Toronto, Ontario, Canada</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A2">Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A3">Division of Brain, Imaging and Behaviour – Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Ontario, Canada</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Strafella, A P" sort="Strafella, A P" uniqKey="Strafella A" first="A. P." last="Strafella">A. P. Strafella</name>
<affiliation>
<nlm:aff id="A1">Morton and Gloria Shulman Movement Disorder Unit & Edmond J. Safra Program in Parkinson Disease, Toronto Western Hospital, UHN, University of Toronto, Ontario, Canada</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A2">Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A3">Division of Brain, Imaging and Behaviour – Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Ontario, Canada</nlm:aff>
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<title level="j">Parkinsonism & related disorders</title>
<idno type="ISSN">1353-8020</idno>
<idno type="eISSN">1873-5126</idno>
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<date when="2015">2015</date>
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<p id="P1">Impulse control disorders (ICDs) may arise in Parkinson’s disease (PD) in relation to the use of dopamine agonists (DA). A dysfunction of reward circuits is considered the main underlying mechanism. Neuroimaging has been largely used in this setting to understand the structure of the reward system and its abnormalities brought by exogenous stimulation in PD. Dopaminergic changes, such as increased dopamine release, reduced dopamine transporter activity and other changes, have been shown to be a consistent feature of ICDs in PD. Beyond the striatum, alterations of prefrontal cortical function may also impact an individuals’ propensity for impulsivity. Neuroimaging is advancing our knowledge of the mechanisms involved in the development of these behavioral addictions. An increased understanding of these disorders may lead to the discovery of new therapeutic targets, or the identification of risk factors for the development of these disorders.</p>
</div>
</front>
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<journal-id journal-id-type="nlm-journal-id">9513583</journal-id>
<journal-id journal-id-type="pubmed-jr-id">21522</journal-id>
<journal-id journal-id-type="nlm-ta">Parkinsonism Relat Disord</journal-id>
<journal-id journal-id-type="iso-abbrev">Parkinsonism Relat. Disord.</journal-id>
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<journal-title>Parkinsonism & related disorders</journal-title>
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<issn pub-type="ppub">1353-8020</issn>
<issn pub-type="epub">1873-5126</issn>
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<article-id pub-id-type="pmid">26298389</article-id>
<article-id pub-id-type="pmc">4874782</article-id>
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<article-title>Molecular imaging and neural networks in impulse control disorders in Parkinson’s disease</article-title>
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<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Aracil-Bolaños</surname>
<given-names>I.</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
<xref ref-type="aff" rid="A2">b</xref>
<xref ref-type="aff" rid="A3">c</xref>
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<contrib contrib-type="author">
<name>
<surname>Strafella</surname>
<given-names>A.P.</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
<xref ref-type="aff" rid="A2">b</xref>
<xref ref-type="aff" rid="A3">c</xref>
<xref rid="FN1" ref-type="author-notes">*</xref>
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<aff id="A1">
<label>a</label>
Morton and Gloria Shulman Movement Disorder Unit & Edmond J. Safra Program in Parkinson Disease, Toronto Western Hospital, UHN, University of Toronto, Ontario, Canada</aff>
<aff id="A2">
<label>b</label>
Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada</aff>
<aff id="A3">
<label>c</label>
Division of Brain, Imaging and Behaviour – Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Ontario, Canada</aff>
<author-notes>
<corresp id="FN1">
<label>*</label>
Corresponding author. Toronto Western Hospital and Institute, UHN, CAMH-Research Imaging Centre, University of Toronto, Toronto, Ontario, Canada.
<email>antonio.strafella@uhn.ca</email>
,
<email>antonio.strafella@camh.ca</email>
(A.P. Strafella)</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted">
<day>16</day>
<month>5</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub">
<day>12</day>
<month>8</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="ppub">
<month>1</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="pmc-release">
<day>01</day>
<month>1</month>
<year>2017</year>
</pub-date>
<volume>22</volume>
<issue>Suppl 1</issue>
<fpage>S101</fpage>
<lpage>S105</lpage>
<pmc-comment>elocation-id from pubmed: 10.1016/j.parkreldis.2015.08.003</pmc-comment>
<abstract>
<p id="P1">Impulse control disorders (ICDs) may arise in Parkinson’s disease (PD) in relation to the use of dopamine agonists (DA). A dysfunction of reward circuits is considered the main underlying mechanism. Neuroimaging has been largely used in this setting to understand the structure of the reward system and its abnormalities brought by exogenous stimulation in PD. Dopaminergic changes, such as increased dopamine release, reduced dopamine transporter activity and other changes, have been shown to be a consistent feature of ICDs in PD. Beyond the striatum, alterations of prefrontal cortical function may also impact an individuals’ propensity for impulsivity. Neuroimaging is advancing our knowledge of the mechanisms involved in the development of these behavioral addictions. An increased understanding of these disorders may lead to the discovery of new therapeutic targets, or the identification of risk factors for the development of these disorders.</p>
</abstract>
<kwd-group>
<kwd>Parkinson’s disease</kwd>
<kwd>Impulse control disorders</kwd>
<kwd>Molecular imaging</kwd>
</kwd-group>
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</front>
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