Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer’s disease
Identifieur interne : 000867 ( Pmc/Corpus ); précédent : 000866; suivant : 000868Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer’s disease
Auteurs : Jean-Charles Lambert ; Carla A. Ibrahim-Verbaas ; Denise Harold ; Adam C. Naj ; Rebecca Sims ; Céline Bellenguez ; Gyungah Jun ; Anita L. Destefano ; Joshua C. Bis ; Gary W. Beecham ; Benjamin Grenier-Boley ; Giancarlo Russo ; Tricia A. Thornton-Wells ; Nicola Jones ; Albert V. Smith ; Vincent Chouraki ; Charlene Thomas ; M Arfan Ikram ; Diana Zelenika ; Badri N. Vardarajan ; Yoichiro Kamatani ; Chiao-Feng Lin ; Amy Gerrish ; Helena Schmidt ; Brian Kunkle ; Melanie L. Dunstan ; Agustin Ruiz ; Marie-Thérèse Bihoreau ; Seung-Hoan Choi ; Christiane Reitz ; Florence Pasquier ; Paul Hollingworth ; Alfredo Ramirez ; Olivier Hanon ; Annette L. Fitzpatrick ; Joseph D. Buxbaum ; Dominique Campion ; Paul K. Crane ; Clinton Baldwin ; Tim Becker ; Vilmundur Gudnason ; Carlos Cruchaga ; David Craig ; Najaf Amin ; Claudine Berr ; Oscar L. Lopez ; Philip L. De Jager ; Vincent Deramecourt ; Janet A. Johnston ; Denis Evans ; Simon Lovestone ; Luc Letenneur ; Francisco J. Mor N ; David C. Rubinsztein ; Gudny Eiriksdottir ; Kristel Sleegers ; Alison M. Goate ; Nathalie Fiévet ; Matthew J. Huentelman ; Michael Gill ; Kristelle Brown ; M Ilyas Kamboh ; Lina Keller ; Pascale Barberger-Gateau ; Bernadette Mcguinness ; Eric B. Larson ; Robert Green ; Amanda J. Myers ; Carole Dufouil ; Stephen Todd ; David Wallon ; Seth Love ; Ekaterina Rogaeva ; John Gallacher ; Peter St George-Hyslop ; Jordi Clarimon ; Alberto Lleo ; Anthony Bayer ; Debby W. Tsuang ; Lei Yu ; Magda Tsolaki ; Paola Bossù ; Gianfranco Spalletta ; Petroula Proitsi ; John Collinge ; Sandro Sorbi ; Florentino Sanchez-Garcia ; Nick C. Fox ; John Hardy ; Maria Candida Deniz Naranjo ; Paolo Bosco ; Robert Clarke ; Carol Brayne ; Daniela Galimberti ; Michelangelo Mancuso ; Fiona Matthews ; Susanne Moebus ; Patrizia Mecocci ; Maria Del Zompo ; Wolfgang Maier ; Harald Hampel ; Alberto Pilotto ; Maria Bullido ; Francesco Panza ; Paolo Caffarra ; Benedetta Nacmias ; John R. Gilbert ; Manuel Mayhaus ; Lars Lannfelt ; Hakon Hakonarson ; Sabrina Pichler ; Minerva M. Carrasquillo ; Martin Ingelsson ; Duane Beekly ; Victoria Alvarez ; Fanggeng Zou ; Otto Valladares ; Steven G. Younkin ; Eliecer Coto ; Kara L. Hamilton-Nelson ; Wei Gu ; Cristina Razquin ; Pau Pastor ; Ignacio Mateo ; Michael J. Owen ; Kelley M. Faber ; Palmi V. Jonsson ; Onofre Combarros ; Michael C. O Onovan ; Laura B. Cantwell ; Hilkka Soininen ; Deborah Blacker ; Simon Mead ; Thomas H. Mosley ; David A. Bennett ; Tamara B. Harris ; Laura Fratiglioni ; Clive Holmes ; Renee F A G. De Bruijn ; Peter Passmore ; Thomas J. Montine ; Karolien Bettens ; Jerome I. Rotter ; Alexis Brice ; Kevin Morgan ; Tatiana M. Foroud ; Walter A. Kukull ; Didier Hannequin ; John F. Powell ; Michael A. Nalls ; Karen Ritchie ; Kathryn L. Lunetta ; John S K. Kauwe ; Eric Boerwinkle ; Matthias Riemenschneider ; Mercè Boada ; Mikko Hiltunen ; Eden R. Martin ; Reinhold Schmidt ; Dan Rujescu ; Li-San Wang ; Jean-François Dartigues ; Richard Mayeux ; Christophe Tzourio ; Albert Hofman ; Markus M. Nöthen ; Caroline Graff ; Bruce M. Psaty ; Lesley Jones ; Jonathan L. Haines ; Peter A. Holmans ; Mark Lathrop ; Margaret A. Pericak-Vance ; Lenore J. Launer ; Lindsay A. Farrer ; Cornelia M. Van Duijn ; Christine Van Broeckhoven ; Valentina Moskvina ; Sudha Seshadri ; Julie Williams ; Gerard D. Schellenberg ; Philippe AmouyelSource :
- Nature genetics [ 1061-4036 ] ; 2013.
Abstract
Eleven susceptibility loci for late-onset Alzheimer’s disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this disease remains unexplained. We conducted a large, two-stage meta-analysis of genome-wide association studies (GWAS) in individuals of European ancestry. In stage 1, we used genotyped and imputed data (7,055,881 SNPs) to perform meta-analysis on 4 previously published GWAS data sets consisting of 17,008 Alzheimer’s disease cases and 37,154 controls. In stage 2,11,632 SNPs were genotyped and tested for association in an independent set of 8,572 Alzheimer’s disease cases and 11,312 controls. In addition to the
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DOI: 10.1038/ng.2802
PubMed: 24162737
PubMed Central: 3896259
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PMC:3896259Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer’s disease</title><author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation><nlm:aff id="A1">INSERM, U744, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Université Lille 2, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Institut Pasteur de Lille, Lille, France.</nlm:aff></affiliation></author><author><name sortKey="Ibrahim Verbaas, Carla A" sort="Ibrahim Verbaas, Carla A" uniqKey="Ibrahim Verbaas C" first="Carla A" last="Ibrahim-Verbaas">Carla A. Ibrahim-Verbaas</name><affiliation><nlm:aff id="A4">Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Harold, Denise" sort="Harold, Denise" uniqKey="Harold D" first="Denise" last="Harold">Denise Harold</name><affiliation><nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK.</nlm:aff></affiliation></author><author><name sortKey="Naj, Adam C" sort="Naj, Adam C" uniqKey="Naj A" first="Adam C" last="Naj">Adam C. Naj</name><affiliation><nlm:aff id="A7">Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.</nlm:aff></affiliation></author><author><name sortKey="Sims, Rebecca" sort="Sims, Rebecca" uniqKey="Sims R" first="Rebecca" last="Sims">Rebecca Sims</name><affiliation><nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK.</nlm:aff></affiliation></author><author><name sortKey="Bellenguez, Celine" sort="Bellenguez, Celine" uniqKey="Bellenguez C" first="Céline" last="Bellenguez">Céline Bellenguez</name><affiliation><nlm:aff id="A1">INSERM, U744, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Université Lille 2, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Institut Pasteur de Lille, Lille, France.</nlm:aff></affiliation></author><author><name sortKey="Jun, Gyungah" sort="Jun, Gyungah" uniqKey="Jun G" first="Gyungah" last="Jun">Gyungah Jun</name><affiliation><nlm:aff id="A9">Department of Medicine (Biomedical Genetics), Boston University School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L" last="Destefano">Anita L. Destefano</name><affiliation><nlm:aff id="A11">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C" last="Bis">Joshua C. Bis</name><affiliation><nlm:aff id="A12">Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation></author><author><name sortKey="Beecham, Gary W" sort="Beecham, Gary W" uniqKey="Beecham G" first="Gary W" last="Beecham">Gary W. Beecham</name><affiliation><nlm:aff id="A13">John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, USA.</nlm:aff></affiliation></author><author><name sortKey="Grenier Boley, Benjamin" sort="Grenier Boley, Benjamin" uniqKey="Grenier Boley B" first="Benjamin" last="Grenier-Boley">Benjamin Grenier-Boley</name><affiliation><nlm:aff id="A1">INSERM, U744, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Université Lille 2, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Institut Pasteur de Lille, Lille, France.</nlm:aff></affiliation></author><author><name sortKey="Russo, Giancarlo" sort="Russo, Giancarlo" uniqKey="Russo G" first="Giancarlo" last="Russo">Giancarlo Russo</name><affiliation><nlm:aff id="A15">Functional Genomics Center Zurich, Eidgenössische Technische Hochschule (ETH)/University of Zurich, Zurich, Switzerland.</nlm:aff></affiliation></author><author><name sortKey="Thornton Wells, Tricia A" sort="Thornton Wells, Tricia A" uniqKey="Thornton Wells T" first="Tricia A" last="Thornton-Wells">Tricia A. Thornton-Wells</name><affiliation><nlm:aff id="A16">Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.</nlm:aff></affiliation></author><author><name sortKey="Jones, Nicola" sort="Jones, Nicola" uniqKey="Jones N" first="Nicola" last="Jones">Nicola Jones</name><affiliation><nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK.</nlm:aff></affiliation></author><author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V" last="Smith">Albert V. Smith</name><affiliation><nlm:aff id="A17">Faculty of Medicine, University of Iceland, Reykjavik, Iceland.</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Icelandic Heart Association, Kopavogur, Iceland.</nlm:aff></affiliation></author><author><name sortKey="Chouraki, Vincent" sort="Chouraki, Vincent" uniqKey="Chouraki V" first="Vincent" last="Chouraki">Vincent Chouraki</name><affiliation><nlm:aff id="A1">INSERM, U744, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Université Lille 2, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Institut Pasteur de Lille, Lille, France.</nlm:aff></affiliation></author><author><name sortKey="Thomas, Charlene" sort="Thomas, Charlene" uniqKey="Thomas C" first="Charlene" last="Thomas">Charlene Thomas</name><affiliation><nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK.</nlm:aff></affiliation></author><author><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M Arfan" last="Ikram">M Arfan Ikram</name><affiliation><nlm:aff id="A4">Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A19">Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Netherlands Consortium for Healthy Aging, Leiden, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Zelenika, Diana" sort="Zelenika, Diana" uniqKey="Zelenika D" first="Diana" last="Zelenika">Diana Zelenika</name><affiliation><nlm:aff id="A21">Centre National de Génotypage, Institut Génomique, Commissariat à l’Energie Atomique, Evry, France.</nlm:aff></affiliation></author><author><name sortKey="Vardarajan, Badri N" sort="Vardarajan, Badri N" uniqKey="Vardarajan B" first="Badri N" last="Vardarajan">Badri N. Vardarajan</name><affiliation><nlm:aff id="A9">Department of Medicine (Biomedical Genetics), Boston University School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Kamatani, Yoichiro" sort="Kamatani, Yoichiro" uniqKey="Kamatani Y" first="Yoichiro" last="Kamatani">Yoichiro Kamatani</name><affiliation><nlm:aff id="A22">Fondation Jean Dausset, Centre d’Etude du Polymorphisme Humain (CEPH), Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Lin, Chiao Feng" sort="Lin, Chiao Feng" uniqKey="Lin C" first="Chiao-Feng" last="Lin">Chiao-Feng Lin</name><affiliation><nlm:aff id="A23">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.</nlm:aff></affiliation></author><author><name sortKey="Gerrish, Amy" sort="Gerrish, Amy" uniqKey="Gerrish A" first="Amy" last="Gerrish">Amy Gerrish</name><affiliation><nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK.</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><affiliation><nlm:aff id="A24">Institute for Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.</nlm:aff></affiliation></author><author><name sortKey="Kunkle, Brian" sort="Kunkle, Brian" uniqKey="Kunkle B" first="Brian" last="Kunkle">Brian Kunkle</name><affiliation><nlm:aff id="A13">John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.</nlm:aff></affiliation></author><author><name sortKey="Dunstan, Melanie L" sort="Dunstan, Melanie L" uniqKey="Dunstan M" first="Melanie L" last="Dunstan">Melanie L. Dunstan</name><affiliation><nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK.</nlm:aff></affiliation></author><author><name sortKey="Ruiz, Agustin" sort="Ruiz, Agustin" uniqKey="Ruiz A" first="Agustin" last="Ruiz">Agustin Ruiz</name><affiliation><nlm:aff id="A25">Memory Clinic of Fundació Alzheimer Centre Educacional (ACE). Institut Català de Neurociències Aplicades, Barcelona, Spain.</nlm:aff></affiliation></author><author><name sortKey="Bihoreau, Marie Therese" sort="Bihoreau, Marie Therese" uniqKey="Bihoreau M" first="Marie-Thérèse" last="Bihoreau">Marie-Thérèse Bihoreau</name><affiliation><nlm:aff id="A21">Centre National de Génotypage, Institut Génomique, Commissariat à l’Energie Atomique, Evry, France.</nlm:aff></affiliation></author><author><name sortKey="Choi, Seung Hoan" sort="Choi, Seung Hoan" uniqKey="Choi S" first="Seung-Hoan" last="Choi">Seung-Hoan Choi</name><affiliation><nlm:aff id="A11">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Reitz, Christiane" sort="Reitz, Christiane" uniqKey="Reitz C" first="Christiane" last="Reitz">Christiane Reitz</name><affiliation><nlm:aff id="A26">Taub Institute on Alzheimer’s Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, USA.</nlm:aff></affiliation></author><author><name sortKey="Pasquier, Florence" sort="Pasquier, Florence" uniqKey="Pasquier F" first="Florence" last="Pasquier">Florence Pasquier</name><affiliation><nlm:aff id="A2">Université Lille 2, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A28">Centre National de Reference pour les Malades Alzheimer Jeunes (CNR-MAJ), Centre Hospitalier Régional Universitaire de Lille, Lille, France.</nlm:aff></affiliation></author><author><name sortKey="Hollingworth, Paul" sort="Hollingworth, Paul" uniqKey="Hollingworth P" first="Paul" last="Hollingworth">Paul Hollingworth</name><affiliation><nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK.</nlm:aff></affiliation></author><author><name sortKey="Ramirez, Alfredo" sort="Ramirez, Alfredo" uniqKey="Ramirez A" first="Alfredo" last="Ramirez">Alfredo Ramirez</name><affiliation><nlm:aff id="A29">Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Institute of Human Genetics, University of Bonn, Bonn, Germany.</nlm:aff></affiliation></author><author><name sortKey="Hanon, Olivier" sort="Hanon, Olivier" uniqKey="Hanon O" first="Olivier" last="Hanon">Olivier Hanon</name><affiliation><nlm:aff id="A31">University Paris Descartes, Sorbonne Paris V, Broca Hospital, Geriatrics Department, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Fitzpatrick, Annette L" sort="Fitzpatrick, Annette L" uniqKey="Fitzpatrick A" first="Annette L" last="Fitzpatrick">Annette L. Fitzpatrick</name><affiliation><nlm:aff id="A12">Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A32">Department of Epidemiology, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Department of Global Health, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation></author><author><name sortKey="Buxbaum, Joseph D" sort="Buxbaum, Joseph D" uniqKey="Buxbaum J" first="Joseph D" last="Buxbaum">Joseph D. Buxbaum</name><affiliation><nlm:aff id="A34">Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A35">Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A36">Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, USA.</nlm:aff></affiliation></author><author><name sortKey="Campion, Dominique" sort="Campion, Dominique" uniqKey="Campion D" first="Dominique" last="Campion">Dominique Campion</name><affiliation><nlm:aff id="A37">CNR-MAJ, INSERM, U1079, Rouen University Hospital, Rouen, France.</nlm:aff></affiliation></author><author><name sortKey="Crane, Paul K" sort="Crane, Paul K" uniqKey="Crane P" first="Paul K" last="Crane">Paul K. Crane</name><affiliation><nlm:aff id="A38">Department of Medicine, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation></author><author><name sortKey="Baldwin, Clinton" sort="Baldwin, Clinton" uniqKey="Baldwin C" first="Clinton" last="Baldwin">Clinton Baldwin</name><affiliation><nlm:aff id="A9">Department of Medicine (Biomedical Genetics), Boston University School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Becker, Tim" sort="Becker, Tim" uniqKey="Becker T" first="Tim" last="Becker">Tim Becker</name><affiliation><nlm:aff id="A39">German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany.</nlm:aff></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation><nlm:aff id="A17">Faculty of Medicine, University of Iceland, Reykjavik, Iceland.</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Icelandic Heart Association, Kopavogur, Iceland.</nlm:aff></affiliation></author><author><name sortKey="Cruchaga, Carlos" sort="Cruchaga, Carlos" uniqKey="Cruchaga C" first="Carlos" last="Cruchaga">Carlos Cruchaga</name><affiliation><nlm:aff id="A41">Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A42">Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, USA.</nlm:aff></affiliation></author><author><name sortKey="Craig, David" sort="Craig, David" uniqKey="Craig D" first="David" last="Craig">David Craig</name><affiliation><nlm:aff id="A43">Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University, Belfast, UK.</nlm:aff></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation><nlm:aff id="A5">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Berr, Claudine" sort="Berr, Claudine" uniqKey="Berr C" first="Claudine" last="Berr">Claudine Berr</name><affiliation><nlm:aff id="A44">INSERM, U1061, Faculty of Medicine, Hôpital La Colombière, Montpellier, France.</nlm:aff></affiliation></author><author><name sortKey="Lopez, Oscar L" sort="Lopez, Oscar L" uniqKey="Lopez O" first="Oscar L" last="Lopez">Oscar L. Lopez</name><affiliation><nlm:aff id="A45">Departments of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.</nlm:aff></affiliation></author><author><name sortKey="De Jager, Philip L" sort="De Jager, Philip L" uniqKey="De Jager P" first="Philip L" last="De Jager">Philip L. De Jager</name><affiliation><nlm:aff id="A46">Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A47">Program in Medical and Population Genetics, Broad Institute, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Deramecourt, Vincent" sort="Deramecourt, Vincent" uniqKey="Deramecourt V" first="Vincent" last="Deramecourt">Vincent Deramecourt</name><affiliation><nlm:aff id="A2">Université Lille 2, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A28">Centre National de Reference pour les Malades Alzheimer Jeunes (CNR-MAJ), Centre Hospitalier Régional Universitaire de Lille, Lille, France.</nlm:aff></affiliation></author><author><name sortKey="Johnston, Janet A" sort="Johnston, Janet A" uniqKey="Johnston J" first="Janet A" last="Johnston">Janet A. Johnston</name><affiliation><nlm:aff id="A43">Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University, Belfast, UK.</nlm:aff></affiliation></author><author><name sortKey="Evans, Denis" sort="Evans, Denis" uniqKey="Evans D" first="Denis" last="Evans">Denis Evans</name><affiliation><nlm:aff id="A48">Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA.</nlm:aff></affiliation></author><author><name sortKey="Lovestone, Simon" sort="Lovestone, Simon" uniqKey="Lovestone S" first="Simon" last="Lovestone">Simon Lovestone</name><affiliation><nlm:aff id="A49">Institute of Psychiatry, King’s College London, Denmark Hill, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Letenneur, Luc" sort="Letenneur, Luc" uniqKey="Letenneur L" first="Luc" last="Letenneur">Luc Letenneur</name><affiliation><nlm:aff id="A50">INSERM, U897, Victor Segalen University, Bordeaux, France.</nlm:aff></affiliation></author><author><name sortKey="Mor N, Francisco J" sort="Mor N, Francisco J" uniqKey="Mor N F" first="Francisco J" last="Mor N">Francisco J. Mor N</name><affiliation><nlm:aff id="A51">Departamento de Genómica Estructural, Neocodex, Seville, Spain.</nlm:aff></affiliation></author><author><name sortKey="Rubinsztein, David C" sort="Rubinsztein, David C" uniqKey="Rubinsztein D" first="David C" last="Rubinsztein">David C. Rubinsztein</name><affiliation><nlm:aff id="A52">Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name><affiliation><nlm:aff id="A18">Icelandic Heart Association, Kopavogur, Iceland.</nlm:aff></affiliation></author><author><name sortKey="Sleegers, Kristel" sort="Sleegers, Kristel" uniqKey="Sleegers K" first="Kristel" last="Sleegers">Kristel Sleegers</name><affiliation><nlm:aff id="A53">Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium.</nlm:aff></affiliation><affiliation><nlm:aff id="A54">Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.</nlm:aff></affiliation></author><author><name sortKey="Goate, Alison M" sort="Goate, Alison M" uniqKey="Goate A" first="Alison M" last="Goate">Alison M. Goate</name><affiliation><nlm:aff id="A41">Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A42">Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, USA.</nlm:aff></affiliation></author><author><name sortKey="Fievet, Nathalie" sort="Fievet, Nathalie" uniqKey="Fievet N" first="Nathalie" last="Fiévet">Nathalie Fiévet</name><affiliation><nlm:aff id="A1">INSERM, U744, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Institut Pasteur de Lille, Lille, France.</nlm:aff></affiliation></author><author><name sortKey="Huentelman, Matthew J" sort="Huentelman, Matthew J" uniqKey="Huentelman M" first="Matthew J" last="Huentelman">Matthew J. Huentelman</name><affiliation><nlm:aff id="A55">Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA.</nlm:aff></affiliation></author><author><name sortKey="Gill, Michael" sort="Gill, Michael" uniqKey="Gill M" first="Michael" last="Gill">Michael Gill</name><affiliation><nlm:aff id="A56">Mercer’s Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland.</nlm:aff></affiliation></author><author><name sortKey="Brown, Kristelle" sort="Brown, Kristelle" uniqKey="Brown K" first="Kristelle" last="Brown">Kristelle Brown</name><affiliation><nlm:aff id="A57">Institute of Genetics, Queen’s Medical Centre, University of Nottingham, Nottingham, UK.</nlm:aff></affiliation></author><author><name sortKey="Kamboh, M Ilyas" sort="Kamboh, M Ilyas" uniqKey="Kamboh M" first="M Ilyas" last="Kamboh">M Ilyas Kamboh</name><affiliation><nlm:aff id="A58">Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A59">Alzheimer’s Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.</nlm:aff></affiliation></author><author><name sortKey="Keller, Lina" sort="Keller, Lina" uniqKey="Keller L" first="Lina" last="Keller">Lina Keller</name><affiliation><nlm:aff id="A60">Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Barberger Gateau, Pascale" sort="Barberger Gateau, Pascale" uniqKey="Barberger Gateau P" first="Pascale" last="Barberger-Gateau">Pascale Barberger-Gateau</name><affiliation><nlm:aff id="A50">INSERM, U897, Victor Segalen University, Bordeaux, France.</nlm:aff></affiliation></author><author><name sortKey="Mcguinness, Bernadette" sort="Mcguinness, Bernadette" uniqKey="Mcguinness B" first="Bernadette" last="Mcguinness">Bernadette Mcguinness</name><affiliation><nlm:aff id="A43">Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University, Belfast, UK.</nlm:aff></affiliation></author><author><name sortKey="Larson, Eric B" sort="Larson, Eric B" uniqKey="Larson E" first="Eric B" last="Larson">Eric B. Larson</name><affiliation><nlm:aff id="A38">Department of Medicine, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Group Health Research Institute, Group Health, Seattle, Washington, USA.</nlm:aff></affiliation></author><author><name sortKey="Green, Robert" sort="Green, Robert" uniqKey="Green R" first="Robert" last="Green">Robert Green</name><affiliation><nlm:aff id="A62">Department of Medicine and Partners Center for Personalized Genetic Medicine, Division of Genetics, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Myers, Amanda J" sort="Myers, Amanda J" uniqKey="Myers A" first="Amanda J" last="Myers">Amanda J. Myers</name><affiliation><nlm:aff id="A63">Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida, USA.</nlm:aff></affiliation></author><author><name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name><affiliation><nlm:aff id="A50">INSERM, U897, Victor Segalen University, Bordeaux, France.</nlm:aff></affiliation></author><author><name sortKey="Todd, Stephen" sort="Todd, Stephen" uniqKey="Todd S" first="Stephen" last="Todd">Stephen Todd</name><affiliation><nlm:aff id="A43">Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University, Belfast, UK.</nlm:aff></affiliation></author><author><name sortKey="Wallon, David" sort="Wallon, David" uniqKey="Wallon D" first="David" last="Wallon">David Wallon</name><affiliation><nlm:aff id="A37">CNR-MAJ, INSERM, U1079, Rouen University Hospital, Rouen, France.</nlm:aff></affiliation></author><author><name sortKey="Love, Seth" sort="Love, Seth" uniqKey="Love S" first="Seth" last="Love">Seth Love</name><affiliation><nlm:aff id="A64">University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol, UK.</nlm:aff></affiliation></author><author><name sortKey="Rogaeva, Ekaterina" sort="Rogaeva, Ekaterina" uniqKey="Rogaeva E" first="Ekaterina" last="Rogaeva">Ekaterina Rogaeva</name><affiliation><nlm:aff id="A65">Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada.</nlm:aff></affiliation></author><author><name sortKey="Gallacher, John" sort="Gallacher, John" uniqKey="Gallacher J" first="John" last="Gallacher">John Gallacher</name><affiliation><nlm:aff id="A66">Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, UK.</nlm:aff></affiliation></author><author><name sortKey="St George Hyslop, Peter" sort="St George Hyslop, Peter" uniqKey="St George Hyslop P" first="Peter" last="St George-Hyslop">Peter St George-Hyslop</name><affiliation><nlm:aff id="A52">Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A65">Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada.</nlm:aff></affiliation><affiliation><nlm:aff id="A67">Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Clarimon, Jordi" sort="Clarimon, Jordi" uniqKey="Clarimon J" first="Jordi" last="Clarimon">Jordi Clarimon</name><affiliation><nlm:aff id="A68">Neurology Department. Biomedical Research Institute Sant Pau (IIB Sant Pau). Sant Pau Hospital. Universitat Autònoma de Barcelona, Barcelona, Spain.</nlm:aff></affiliation><affiliation><nlm:aff id="A69">Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain.</nlm:aff></affiliation></author><author><name sortKey="Lleo, Alberto" sort="Lleo, Alberto" uniqKey="Lleo A" first="Alberto" last="Lleo">Alberto Lleo</name><affiliation><nlm:aff id="A68">Neurology Department. Biomedical Research Institute Sant Pau (IIB Sant Pau). Sant Pau Hospital. Universitat Autònoma de Barcelona, Barcelona, Spain.</nlm:aff></affiliation><affiliation><nlm:aff id="A69">Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain.</nlm:aff></affiliation></author><author><name sortKey="Bayer, Anthony" sort="Bayer, Anthony" uniqKey="Bayer A" first="Anthony" last="Bayer">Anthony Bayer</name><affiliation><nlm:aff id="A66">Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, UK.</nlm:aff></affiliation></author><author><name sortKey="Tsuang, Debby W" sort="Tsuang, Debby W" uniqKey="Tsuang D" first="Debby W" last="Tsuang">Debby W. Tsuang</name><affiliation><nlm:aff id="A70">Geriatric Research, Education and Clinical Center (GRECC), Veteran Administration Puget Sound Health Care System (VAPSHCS), Seattle, Washington, USA.</nlm:aff></affiliation></author><author><name sortKey="Yu, Lei" sort="Yu, Lei" uniqKey="Yu L" first="Lei" last="Yu">Lei Yu</name><affiliation><nlm:aff id="A71">Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.</nlm:aff></affiliation></author><author><name sortKey="Tsolaki, Magda" sort="Tsolaki, Magda" uniqKey="Tsolaki M" first="Magda" last="Tsolaki">Magda Tsolaki</name><affiliation><nlm:aff id="A72">Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece.</nlm:aff></affiliation></author><author><name sortKey="Bossu, Paola" sort="Bossu, Paola" uniqKey="Bossu P" first="Paola" last="Bossù">Paola Bossù</name><affiliation><nlm:aff id="A73">Clinical and Behavioral Neurology, Fondazione Santa Lucia, Rome, Italy.</nlm:aff></affiliation></author><author><name sortKey="Spalletta, Gianfranco" sort="Spalletta, Gianfranco" uniqKey="Spalletta G" first="Gianfranco" last="Spalletta">Gianfranco Spalletta</name><affiliation><nlm:aff id="A73">Clinical and Behavioral Neurology, Fondazione Santa Lucia, Rome, Italy.</nlm:aff></affiliation></author><author><name sortKey="Proitsi, Petroula" sort="Proitsi, Petroula" uniqKey="Proitsi P" first="Petroula" last="Proitsi">Petroula Proitsi</name><affiliation><nlm:aff id="A49">Institute of Psychiatry, King’s College London, Denmark Hill, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Collinge, John" sort="Collinge, John" uniqKey="Collinge J" first="John" last="Collinge">John Collinge</name><affiliation><nlm:aff id="A74">MRC Prion Unit, Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Sorbi, Sandro" sort="Sorbi, Sandro" uniqKey="Sorbi S" first="Sandro" last="Sorbi">Sandro Sorbi</name><affiliation><nlm:aff id="A75">NEUROFARBA (Department of Neuroscience, Psychology, Drug Research and Child Health), University of Florence, Florence, Italy.</nlm:aff></affiliation><affiliation><nlm:aff id="A76">Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy.</nlm:aff></affiliation></author><author><name sortKey="Sanchez Garcia, Florentino" sort="Sanchez Garcia, Florentino" uniqKey="Sanchez Garcia F" first="Florentino" last="Sanchez-Garcia">Florentino Sanchez-Garcia</name><affiliation><nlm:aff id="A77">Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain.</nlm:aff></affiliation></author><author><name sortKey="Fox, Nick C" sort="Fox, Nick C" uniqKey="Fox N" first="Nick C" last="Fox">Nick C. Fox</name><affiliation><nlm:aff id="A78">Dementia Research Centre, Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name><affiliation><nlm:aff id="A79">Department of Molecular Neuroscience, Institute of Neurology, London, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A80">Reta Lilla Weston Laboratories, Institute of Neurology, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Deniz Naranjo, Maria Candida" sort="Deniz Naranjo, Maria Candida" uniqKey="Deniz Naranjo M" first="Maria Candida" last="Deniz Naranjo">Maria Candida Deniz Naranjo</name><affiliation><nlm:aff id="A77">Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain.</nlm:aff></affiliation></author><author><name sortKey="Bosco, Paolo" sort="Bosco, Paolo" uniqKey="Bosco P" first="Paolo" last="Bosco">Paolo Bosco</name><affiliation><nlm:aff id="A81">Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Associazione Oasi Maria Santissima Srl, Troina, Italy.</nlm:aff></affiliation></author><author><name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name><affiliation><nlm:aff id="A82">Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of Oxford, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Brayne, Carol" sort="Brayne, Carol" uniqKey="Brayne C" first="Carol" last="Brayne">Carol Brayne</name><affiliation><nlm:aff id="A83">Institute of Public Health, University of Cambridge, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Galimberti, Daniela" sort="Galimberti, Daniela" uniqKey="Galimberti D" first="Daniela" last="Galimberti">Daniela Galimberti</name><affiliation><nlm:aff id="A84">University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy.</nlm:aff></affiliation></author><author><name sortKey="Mancuso, Michelangelo" sort="Mancuso, Michelangelo" uniqKey="Mancuso M" first="Michelangelo" last="Mancuso">Michelangelo Mancuso</name><affiliation><nlm:aff id="A85">Neurological Clinic, University of Pisa, Pisa, Italy.</nlm:aff></affiliation></author><author><name sortKey="Matthews, Fiona" sort="Matthews, Fiona" uniqKey="Matthews F" first="Fiona" last="Matthews">Fiona Matthews</name><affiliation><nlm:aff id="A86">MRC Biostatistics Unit, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Moebus, Susanne" sort="Moebus, Susanne" uniqKey="Moebus S" first="Susanne" last="Moebus">Susanne Moebus</name><affiliation><nlm:aff id="A88">Urban Epidemiology, Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.</nlm:aff></affiliation></author><author><name sortKey="Mecocci, Patrizia" sort="Mecocci, Patrizia" uniqKey="Mecocci P" first="Patrizia" last="Mecocci">Patrizia Mecocci</name><affiliation><nlm:aff id="A89">Section of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy.</nlm:aff></affiliation></author><author><name sortKey="Zompo, Maria Del" sort="Zompo, Maria Del" uniqKey="Zompo M" first="Maria Del" last="Zompo">Maria Del Zompo</name><affiliation><nlm:aff id="A90">Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.</nlm:aff></affiliation></author><author><name sortKey="Maier, Wolfgang" sort="Maier, Wolfgang" uniqKey="Maier W" first="Wolfgang" last="Maier">Wolfgang Maier</name><affiliation><nlm:aff id="A29">Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.</nlm:aff></affiliation><affiliation><nlm:aff id="A39">German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.</nlm:aff></affiliation></author><author><name sortKey="Hampel, Harald" sort="Hampel, Harald" uniqKey="Hampel H" first="Harald" last="Hampel">Harald Hampel</name><affiliation><nlm:aff id="A91">Department of Psychiatry, University of Frankfurt, Frankfurt am Main, Germany.</nlm:aff></affiliation><affiliation><nlm:aff id="A92">Department of Psychiatry, Ludwig Maximilians University, Munich, Germany.</nlm:aff></affiliation></author><author><name sortKey="Pilotto, Alberto" sort="Pilotto, Alberto" uniqKey="Pilotto A" first="Alberto" last="Pilotto">Alberto Pilotto</name><affiliation><nlm:aff id="A93">Gerontology and Geriatrics Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.</nlm:aff></affiliation></author><author><name sortKey="Bullido, Maria" sort="Bullido, Maria" uniqKey="Bullido M" first="Maria" last="Bullido">Maria Bullido</name><affiliation><nlm:aff id="A94">Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas–Universidad Autónoma de Madrid, Madrid, Spain.</nlm:aff></affiliation><affiliation><nlm:aff id="A95">Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.</nlm:aff></affiliation><affiliation><nlm:aff id="A96">Instituto de Investigación Sanitaria Hospital la Paz (IdIPaz), Madrid, Spain.</nlm:aff></affiliation></author><author><name sortKey="Panza, Francesco" sort="Panza, Francesco" uniqKey="Panza F" first="Francesco" last="Panza">Francesco Panza</name><affiliation><nlm:aff id="A97">Departement of Geriatrics, Center for Aging Brain, University of Bari, Bari, Italy.</nlm:aff></affiliation></author><author><name sortKey="Caffarra, Paolo" sort="Caffarra, Paolo" uniqKey="Caffarra P" first="Paolo" last="Caffarra">Paolo Caffarra</name><affiliation><nlm:aff id="A98">Department of Neuroscience, University of Parma, Parma, Italy.</nlm:aff></affiliation><affiliation><nlm:aff id="A99">Center for Cognitive Disorders, Azienda Unita Sanitaria Local (AUSL), Parma, Italy.</nlm:aff></affiliation></author><author><name sortKey="Nacmias, Benedetta" sort="Nacmias, Benedetta" uniqKey="Nacmias B" first="Benedetta" last="Nacmias">Benedetta Nacmias</name><affiliation><nlm:aff id="A75">NEUROFARBA (Department of Neuroscience, Psychology, Drug Research and Child Health), University of Florence, Florence, Italy.</nlm:aff></affiliation><affiliation><nlm:aff id="A76">Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy.</nlm:aff></affiliation></author><author><name sortKey="Gilbert, John R" sort="Gilbert, John R" uniqKey="Gilbert J" first="John R" last="Gilbert">John R. Gilbert</name><affiliation><nlm:aff id="A13">John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, USA.</nlm:aff></affiliation></author><author><name sortKey="Mayhaus, Manuel" sort="Mayhaus, Manuel" uniqKey="Mayhaus M" first="Manuel" last="Mayhaus">Manuel Mayhaus</name><affiliation><nlm:aff id="A100">Department of Psychiatry, Saarland University Hospital, Homburg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Lannfelt, Lars" sort="Lannfelt, Lars" uniqKey="Lannfelt L" first="Lars" last="Lannfelt">Lars Lannfelt</name><affiliation><nlm:aff id="A101">Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><affiliation><nlm:aff id="A102">Center for Applied Genomics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.</nlm:aff></affiliation></author><author><name sortKey="Pichler, Sabrina" sort="Pichler, Sabrina" uniqKey="Pichler S" first="Sabrina" last="Pichler">Sabrina Pichler</name><affiliation><nlm:aff id="A100">Department of Psychiatry, Saarland University Hospital, Homburg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Carrasquillo, Minerva M" sort="Carrasquillo, Minerva M" uniqKey="Carrasquillo M" first="Minerva M" last="Carrasquillo">Minerva M. Carrasquillo</name><affiliation><nlm:aff id="A103">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.</nlm:aff></affiliation></author><author><name sortKey="Ingelsson, Martin" sort="Ingelsson, Martin" uniqKey="Ingelsson M" first="Martin" last="Ingelsson">Martin Ingelsson</name><affiliation><nlm:aff id="A101">Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Beekly, Duane" sort="Beekly, Duane" uniqKey="Beekly D" first="Duane" last="Beekly">Duane Beekly</name><affiliation><nlm:aff id="A104">National Alzheimer’s Coordinating Center, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation></author><author><name sortKey="Alvarez, Victoria" sort="Alvarez, Victoria" uniqKey="Alvarez V" first="Victoria" last="Alvarez">Victoria Alvarez</name><affiliation><nlm:aff id="A105">Genetica Molecular, Hospital Universitario Central Asturias, Oviedo, Spain.</nlm:aff></affiliation></author><author><name sortKey="Zou, Fanggeng" sort="Zou, Fanggeng" uniqKey="Zou F" first="Fanggeng" last="Zou">Fanggeng Zou</name><affiliation><nlm:aff id="A103">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.</nlm:aff></affiliation></author><author><name sortKey="Valladares, Otto" sort="Valladares, Otto" uniqKey="Valladares O" first="Otto" last="Valladares">Otto Valladares</name><affiliation><nlm:aff id="A23">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.</nlm:aff></affiliation></author><author><name sortKey="Younkin, Steven G" sort="Younkin, Steven G" uniqKey="Younkin S" first="Steven G" last="Younkin">Steven G. Younkin</name><affiliation><nlm:aff id="A103">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.</nlm:aff></affiliation></author><author><name sortKey="Coto, Eliecer" sort="Coto, Eliecer" uniqKey="Coto E" first="Eliecer" last="Coto">Eliecer Coto</name><affiliation><nlm:aff id="A105">Genetica Molecular, Hospital Universitario Central Asturias, Oviedo, Spain.</nlm:aff></affiliation></author><author><name sortKey="Hamilton Nelson, Kara L" sort="Hamilton Nelson, Kara L" uniqKey="Hamilton Nelson K" first="Kara L" last="Hamilton-Nelson">Kara L. Hamilton-Nelson</name><affiliation><nlm:aff id="A13">John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.</nlm:aff></affiliation></author><author><name sortKey="Gu, Wei" sort="Gu, Wei" uniqKey="Gu W" first="Wei" last="Gu">Wei Gu</name><affiliation><nlm:aff id="A100">Department of Psychiatry, Saarland University Hospital, Homburg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Razquin, Cristina" sort="Razquin, Cristina" uniqKey="Razquin C" first="Cristina" last="Razquin">Cristina Razquin</name><affiliation><nlm:aff id="A106">Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain.</nlm:aff></affiliation></author><author><name sortKey="Pastor, Pau" sort="Pastor, Pau" uniqKey="Pastor P" first="Pau" last="Pastor">Pau Pastor</name><affiliation><nlm:aff id="A106">Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain.</nlm:aff></affiliation><affiliation><nlm:aff id="A107">CIBERNED, Instituto de Salud Carlos III, Madrid, Spain.</nlm:aff></affiliation></author><author><name sortKey="Mateo, Ignacio" sort="Mateo, Ignacio" uniqKey="Mateo I" first="Ignacio" last="Mateo">Ignacio Mateo</name><affiliation><nlm:aff id="A108">Neurology Service, Marqués de Valdecilla University Hospital, University of Cantabria and Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Santander, Spain.</nlm:aff></affiliation><affiliation><nlm:aff id="A109">CIBERNED, Marqués de Valdecilla University Hospital, University of Cantabria and IFIMAV, Santander, Spain.</nlm:aff></affiliation></author><author><name sortKey="Owen, Michael J" sort="Owen, Michael J" uniqKey="Owen M" first="Michael J" last="Owen">Michael J. Owen</name><affiliation><nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK.</nlm:aff></affiliation></author><author><name sortKey="Faber, Kelley M" sort="Faber, Kelley M" uniqKey="Faber K" first="Kelley M" last="Faber">Kelley M. Faber</name><affiliation><nlm:aff id="A110">Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA.</nlm:aff></affiliation></author><author><name sortKey="Jonsson, Palmi V" sort="Jonsson, Palmi V" uniqKey="Jonsson P" first="Palmi V" last="Jonsson">Palmi V. Jonsson</name><affiliation><nlm:aff id="A17">Faculty of Medicine, University of Iceland, Reykjavik, Iceland.</nlm:aff></affiliation><affiliation><nlm:aff id="A111">Geriatric Department, Landspitali University Hospital, Reykjavik, Iceland.</nlm:aff></affiliation></author><author><name sortKey="Combarros, Onofre" sort="Combarros, Onofre" uniqKey="Combarros O" first="Onofre" last="Combarros">Onofre Combarros</name><affiliation><nlm:aff id="A108">Neurology Service, Marqués de Valdecilla University Hospital, University of Cantabria and Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Santander, Spain.</nlm:aff></affiliation><affiliation><nlm:aff id="A109">CIBERNED, Marqués de Valdecilla University Hospital, University of Cantabria and IFIMAV, Santander, Spain.</nlm:aff></affiliation></author><author><name sortKey="O Onovan, Michael C" sort="O Onovan, Michael C" uniqKey="O Onovan M" first="Michael C" last="O Onovan">Michael C. O Onovan</name><affiliation><nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK.</nlm:aff></affiliation></author><author><name sortKey="Cantwell, Laura B" sort="Cantwell, Laura B" uniqKey="Cantwell L" first="Laura B" last="Cantwell">Laura B. Cantwell</name><affiliation><nlm:aff id="A23">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.</nlm:aff></affiliation></author><author><name sortKey="Soininen, Hilkka" sort="Soininen, Hilkka" uniqKey="Soininen H" first="Hilkka" last="Soininen">Hilkka Soininen</name><affiliation><nlm:aff id="A112">Institute of Clinical Medicine–Neurology, University of Eastern Finland, Kuopio, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A113">Department of Neurology, Kuopio University Hospital, Kuopio, Finland.</nlm:aff></affiliation></author><author><name sortKey="Blacker, Deborah" sort="Blacker, Deborah" uniqKey="Blacker D" first="Deborah" last="Blacker">Deborah Blacker</name><affiliation><nlm:aff id="A114">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A115">Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Mead, Simon" sort="Mead, Simon" uniqKey="Mead S" first="Simon" last="Mead">Simon Mead</name><affiliation><nlm:aff id="A74">MRC Prion Unit, Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H" last="Mosley">Thomas H. Mosley</name><affiliation><nlm:aff id="A116">Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, Mississippi, USA.</nlm:aff></affiliation></author><author><name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A" last="Bennett">David A. Bennett</name><affiliation><nlm:aff id="A71">Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A117">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, Illinois, USA.</nlm:aff></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B" last="Harris">Tamara B. Harris</name><affiliation><nlm:aff id="A12">Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation></author><author><name sortKey="Fratiglioni, Laura" sort="Fratiglioni, Laura" uniqKey="Fratiglioni L" first="Laura" last="Fratiglioni">Laura Fratiglioni</name><affiliation><nlm:aff id="A60">Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.</nlm:aff></affiliation><affiliation><nlm:aff id="A118">Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Holmes, Clive" sort="Holmes, Clive" uniqKey="Holmes C" first="Clive" last="Holmes">Clive Holmes</name><affiliation><nlm:aff id="A119">Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK.</nlm:aff></affiliation></author><author><name sortKey="De Bruijn, Renee F A G" sort="De Bruijn, Renee F A G" uniqKey="De Bruijn R" first="Renee F A G" last="De Bruijn">Renee F A G. De Bruijn</name><affiliation><nlm:aff id="A4">Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Netherlands Consortium for Healthy Aging, Leiden, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Passmore, Peter" sort="Passmore, Peter" uniqKey="Passmore P" first="Peter" last="Passmore">Peter Passmore</name><affiliation><nlm:aff id="A43">Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University, Belfast, UK.</nlm:aff></affiliation></author><author><name sortKey="Montine, Thomas J" sort="Montine, Thomas J" uniqKey="Montine T" first="Thomas J" last="Montine">Thomas J. Montine</name><affiliation><nlm:aff id="A120">Department of Pathology, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation></author><author><name sortKey="Bettens, Karolien" sort="Bettens, Karolien" uniqKey="Bettens K" first="Karolien" last="Bettens">Karolien Bettens</name><affiliation><nlm:aff id="A53">Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium.</nlm:aff></affiliation><affiliation><nlm:aff id="A54">Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.</nlm:aff></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I" last="Rotter">Jerome I. Rotter</name><affiliation><nlm:aff id="A121">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.</nlm:aff></affiliation></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><affiliation><nlm:aff id="A122">INSERM UMRS 975, CNRS UMR 7225, Université Pierre et Marie Curie, Centre de Recherche de l’Institut du Cerveau et de la Moëlle Epinière (CRICM), Hôpital de la Salpêtrière, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A123">Assistance Publique des Hôpitaux de Paris (AP-HP), Hôpital de la Pitié–Salpêtrière, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Morgan, Kevin" sort="Morgan, Kevin" uniqKey="Morgan K" first="Kevin" last="Morgan">Kevin Morgan</name><affiliation><nlm:aff id="A57">Institute of Genetics, Queen’s Medical Centre, University of Nottingham, Nottingham, UK.</nlm:aff></affiliation></author><author><name sortKey="Foroud, Tatiana M" sort="Foroud, Tatiana M" uniqKey="Foroud T" first="Tatiana M" last="Foroud">Tatiana M. Foroud</name><affiliation><nlm:aff id="A110">Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA.</nlm:aff></affiliation></author><author><name sortKey="Kukull, Walter A" sort="Kukull, Walter A" uniqKey="Kukull W" first="Walter A" last="Kukull">Walter A. Kukull</name><affiliation><nlm:aff id="A32">Department of Epidemiology, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation></author><author><name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name><affiliation><nlm:aff id="A37">CNR-MAJ, INSERM, U1079, Rouen University Hospital, Rouen, France.</nlm:aff></affiliation></author><author><name sortKey="Powell, John F" sort="Powell, John F" uniqKey="Powell J" first="John F" last="Powell">John F. Powell</name><affiliation><nlm:aff id="A49">Institute of Psychiatry, King’s College London, Denmark Hill, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A" last="Nalls">Michael A. Nalls</name><affiliation><nlm:aff id="A124">Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, USA.</nlm:aff></affiliation></author><author><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name><affiliation><nlm:aff id="A44">INSERM, U1061, Faculty of Medicine, Hôpital La Colombière, Montpellier, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A125">Faculty of Medicine, Imperial College, St. Mary’s Hospital, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Lunetta, Kathryn L" sort="Lunetta, Kathryn L" uniqKey="Lunetta K" first="Kathryn L" last="Lunetta">Kathryn L. Lunetta</name><affiliation><nlm:aff id="A11">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Kauwe, John S K" sort="Kauwe, John S K" uniqKey="Kauwe J" first="John S K" last="Kauwe">John S K. Kauwe</name><affiliation><nlm:aff id="A126">Department of Biology, Brigham Young University, Provo, Utah, USA.</nlm:aff></affiliation></author><author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><affiliation><nlm:aff id="A127">Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A128">Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A129">Division of Epidemiology, University of Texas Health Sciences Center at Houston, Houston, Texas, USA.</nlm:aff></affiliation></author><author><name sortKey="Riemenschneider, Matthias" sort="Riemenschneider, Matthias" uniqKey="Riemenschneider M" first="Matthias" last="Riemenschneider">Matthias Riemenschneider</name><affiliation><nlm:aff id="A100">Department of Psychiatry, Saarland University Hospital, Homburg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Boada, Merce" sort="Boada, Merce" uniqKey="Boada M" first="Mercè" last="Boada">Mercè Boada</name><affiliation><nlm:aff id="A25">Memory Clinic of Fundació Alzheimer Centre Educacional (ACE). Institut Català de Neurociències Aplicades, Barcelona, Spain.</nlm:aff></affiliation><affiliation><nlm:aff id="A130">Hospital Universitari Vall d’Hebron–Institut de Recerca, Universitat Autònoma de Barcelona. (VHIR-UAB), Barcelona, Spain.</nlm:aff></affiliation></author><author><name sortKey="Hiltunen, Mikko" sort="Hiltunen, Mikko" uniqKey="Hiltunen M" first="Mikko" last="Hiltunen">Mikko Hiltunen</name><affiliation><nlm:aff id="A112">Institute of Clinical Medicine–Neurology, University of Eastern Finland, Kuopio, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A113">Department of Neurology, Kuopio University Hospital, Kuopio, Finland.</nlm:aff></affiliation></author><author><name sortKey="Martin, Eden R" sort="Martin, Eden R" uniqKey="Martin E" first="Eden R" last="Martin">Eden R. Martin</name><affiliation><nlm:aff id="A13">John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, USA.</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><affiliation><nlm:aff id="A131">Department of Neurology, Medical University of Graz, Graz, Austria.</nlm:aff></affiliation></author><author><name sortKey="Rujescu, Dan" sort="Rujescu, Dan" uniqKey="Rujescu D" first="Dan" last="Rujescu">Dan Rujescu</name><affiliation><nlm:aff id="A132">Department of Psychiatry, University of Halle, Halle, Germany.</nlm:aff></affiliation></author><author><name sortKey="Wang, Li San" sort="Wang, Li San" uniqKey="Wang L" first="Li-San" last="Wang">Li-San Wang</name><affiliation><nlm:aff id="A23">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.</nlm:aff></affiliation></author><author><name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name><affiliation><nlm:aff id="A50">INSERM, U897, Victor Segalen University, Bordeaux, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A133">Centre de Mémoire de Ressources et de Recherche de Bordeaux, Centre Hospitalier Universitaire (CHU) de Bordeaux, Bordeaux, France.</nlm:aff></affiliation></author><author><name sortKey="Mayeux, Richard" sort="Mayeux, Richard" uniqKey="Mayeux R" first="Richard" last="Mayeux">Richard Mayeux</name><affiliation><nlm:aff id="A26">Taub Institute on Alzheimer’s Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, USA.</nlm:aff></affiliation></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><affiliation><nlm:aff id="A134">INSERM, U708, Victor Segalen University, Bordeaux, France.</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="A5">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Netherlands Consortium for Healthy Aging, Leiden, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M" last="Nöthen">Markus M. Nöthen</name><affiliation><nlm:aff id="A135">Institute of Human Genetics, Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.</nlm:aff></affiliation></author><author><name sortKey="Graff, Caroline" sort="Graff, Caroline" uniqKey="Graff C" first="Caroline" last="Graff">Caroline Graff</name><affiliation><nlm:aff id="A117">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, Illinois, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A136">Department of Neurobiology, Karolinska Institutet, Care Sciences and Society, Karolinska Institute–Alzheimer’s Disease Research Center (KIADRC), Stockholm, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M" last="Psaty">Bruce M. Psaty</name><affiliation><nlm:aff id="A12">Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A32">Department of Epidemiology, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Group Health Research Institute, Group Health, Seattle, Washington, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A137">Department of Health Service, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation></author><author><name sortKey="Jones, Lesley" sort="Jones, Lesley" uniqKey="Jones L" first="Lesley" last="Jones">Lesley Jones</name><affiliation><nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK.</nlm:aff></affiliation></author><author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L" last="Haines">Jonathan L. Haines</name><affiliation><nlm:aff id="A16">Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A138">Vanderbilt Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, USA.</nlm:aff></affiliation></author><author><name sortKey="Holmans, Peter A" sort="Holmans, Peter A" uniqKey="Holmans P" first="Peter A" last="Holmans">Peter A. Holmans</name><affiliation><nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK.</nlm:aff></affiliation></author><author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><affiliation><nlm:aff id="A21">Centre National de Génotypage, Institut Génomique, Commissariat à l’Energie Atomique, Evry, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Fondation Jean Dausset, Centre d’Etude du Polymorphisme Humain (CEPH), Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A139">McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada.</nlm:aff></affiliation></author><author><name sortKey="Pericak Vance, Margaret A" sort="Pericak Vance, Margaret A" uniqKey="Pericak Vance M" first="Margaret A" last="Pericak-Vance">Margaret A. Pericak-Vance</name><affiliation><nlm:aff id="A13">John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, USA.</nlm:aff></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name><affiliation><nlm:aff id="A140">Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, USA.</nlm:aff></affiliation></author><author><name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A" last="Farrer">Lindsay A. Farrer</name><affiliation><nlm:aff id="A9">Department of Medicine (Biomedical Genetics), Boston University School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A141">Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A142">Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><affiliation><nlm:aff id="A5">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Netherlands Consortium for Healthy Aging, Leiden, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A143">Center for Medical Systems Biology, Leiden, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name><affiliation><nlm:aff id="A53">Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium.</nlm:aff></affiliation><affiliation><nlm:aff id="A54">Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.</nlm:aff></affiliation></author><author><name sortKey="Moskvina, Valentina" sort="Moskvina, Valentina" uniqKey="Moskvina V" first="Valentina" last="Moskvina">Valentina Moskvina</name><affiliation><nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK.</nlm:aff></affiliation></author><author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><affiliation><nlm:aff id="A142">Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Williams, Julie" sort="Williams, Julie" uniqKey="Williams J" first="Julie" last="Williams">Julie Williams</name><affiliation><nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK.</nlm:aff></affiliation></author><author><name sortKey="Schellenberg, Gerard D" sort="Schellenberg, Gerard D" uniqKey="Schellenberg G" first="Gerard D" last="Schellenberg">Gerard D. Schellenberg</name><affiliation><nlm:aff id="A23">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.</nlm:aff></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation><nlm:aff id="A1">INSERM, U744, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Université Lille 2, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Institut Pasteur de Lille, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A28">Centre National de Reference pour les Malades Alzheimer Jeunes (CNR-MAJ), Centre Hospitalier Régional Universitaire de Lille, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A144">Centre Hospitalier Régional Universitaire de Lille, Lille, France.</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24162737</idno><idno type="pmc">3896259</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896259</idno><idno type="RBID">PMC:3896259</idno><idno type="doi">10.1038/ng.2802</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000867</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000867</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer’s disease</title><author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation><nlm:aff id="A1">INSERM, U744, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Université Lille 2, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Institut Pasteur de Lille, Lille, France.</nlm:aff></affiliation></author><author><name sortKey="Ibrahim Verbaas, Carla A" sort="Ibrahim Verbaas, Carla A" uniqKey="Ibrahim Verbaas C" first="Carla A" last="Ibrahim-Verbaas">Carla A. Ibrahim-Verbaas</name><affiliation><nlm:aff id="A4">Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Harold, Denise" sort="Harold, Denise" uniqKey="Harold D" first="Denise" last="Harold">Denise Harold</name><affiliation><nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK.</nlm:aff></affiliation></author><author><name sortKey="Naj, Adam C" sort="Naj, Adam C" uniqKey="Naj A" first="Adam C" last="Naj">Adam C. Naj</name><affiliation><nlm:aff id="A7">Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.</nlm:aff></affiliation></author><author><name sortKey="Sims, Rebecca" sort="Sims, Rebecca" uniqKey="Sims R" first="Rebecca" last="Sims">Rebecca Sims</name><affiliation><nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK.</nlm:aff></affiliation></author><author><name sortKey="Bellenguez, Celine" sort="Bellenguez, Celine" uniqKey="Bellenguez C" first="Céline" last="Bellenguez">Céline Bellenguez</name><affiliation><nlm:aff id="A1">INSERM, U744, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Université Lille 2, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Institut Pasteur de Lille, Lille, France.</nlm:aff></affiliation></author><author><name sortKey="Jun, Gyungah" sort="Jun, Gyungah" uniqKey="Jun G" first="Gyungah" last="Jun">Gyungah Jun</name><affiliation><nlm:aff id="A9">Department of Medicine (Biomedical Genetics), Boston University School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L" last="Destefano">Anita L. Destefano</name><affiliation><nlm:aff id="A11">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C" last="Bis">Joshua C. Bis</name><affiliation><nlm:aff id="A12">Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation></author><author><name sortKey="Beecham, Gary W" sort="Beecham, Gary W" uniqKey="Beecham G" first="Gary W" last="Beecham">Gary W. Beecham</name><affiliation><nlm:aff id="A13">John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, USA.</nlm:aff></affiliation></author><author><name sortKey="Grenier Boley, Benjamin" sort="Grenier Boley, Benjamin" uniqKey="Grenier Boley B" first="Benjamin" last="Grenier-Boley">Benjamin Grenier-Boley</name><affiliation><nlm:aff id="A1">INSERM, U744, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Université Lille 2, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Institut Pasteur de Lille, Lille, France.</nlm:aff></affiliation></author><author><name sortKey="Russo, Giancarlo" sort="Russo, Giancarlo" uniqKey="Russo G" first="Giancarlo" last="Russo">Giancarlo Russo</name><affiliation><nlm:aff id="A15">Functional Genomics Center Zurich, Eidgenössische Technische Hochschule (ETH)/University of Zurich, Zurich, Switzerland.</nlm:aff></affiliation></author><author><name sortKey="Thornton Wells, Tricia A" sort="Thornton Wells, Tricia A" uniqKey="Thornton Wells T" first="Tricia A" last="Thornton-Wells">Tricia A. Thornton-Wells</name><affiliation><nlm:aff id="A16">Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.</nlm:aff></affiliation></author><author><name sortKey="Jones, Nicola" sort="Jones, Nicola" uniqKey="Jones N" first="Nicola" last="Jones">Nicola Jones</name><affiliation><nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK.</nlm:aff></affiliation></author><author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V" last="Smith">Albert V. Smith</name><affiliation><nlm:aff id="A17">Faculty of Medicine, University of Iceland, Reykjavik, Iceland.</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Icelandic Heart Association, Kopavogur, Iceland.</nlm:aff></affiliation></author><author><name sortKey="Chouraki, Vincent" sort="Chouraki, Vincent" uniqKey="Chouraki V" first="Vincent" last="Chouraki">Vincent Chouraki</name><affiliation><nlm:aff id="A1">INSERM, U744, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Université Lille 2, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Institut Pasteur de Lille, Lille, France.</nlm:aff></affiliation></author><author><name sortKey="Thomas, Charlene" sort="Thomas, Charlene" uniqKey="Thomas C" first="Charlene" last="Thomas">Charlene Thomas</name><affiliation><nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK.</nlm:aff></affiliation></author><author><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M Arfan" last="Ikram">M Arfan Ikram</name><affiliation><nlm:aff id="A4">Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A19">Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Netherlands Consortium for Healthy Aging, Leiden, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Zelenika, Diana" sort="Zelenika, Diana" uniqKey="Zelenika D" first="Diana" last="Zelenika">Diana Zelenika</name><affiliation><nlm:aff id="A21">Centre National de Génotypage, Institut Génomique, Commissariat à l’Energie Atomique, Evry, France.</nlm:aff></affiliation></author><author><name sortKey="Vardarajan, Badri N" sort="Vardarajan, Badri N" uniqKey="Vardarajan B" first="Badri N" last="Vardarajan">Badri N. Vardarajan</name><affiliation><nlm:aff id="A9">Department of Medicine (Biomedical Genetics), Boston University School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Kamatani, Yoichiro" sort="Kamatani, Yoichiro" uniqKey="Kamatani Y" first="Yoichiro" last="Kamatani">Yoichiro Kamatani</name><affiliation><nlm:aff id="A22">Fondation Jean Dausset, Centre d’Etude du Polymorphisme Humain (CEPH), Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Lin, Chiao Feng" sort="Lin, Chiao Feng" uniqKey="Lin C" first="Chiao-Feng" last="Lin">Chiao-Feng Lin</name><affiliation><nlm:aff id="A23">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.</nlm:aff></affiliation></author><author><name sortKey="Gerrish, Amy" sort="Gerrish, Amy" uniqKey="Gerrish A" first="Amy" last="Gerrish">Amy Gerrish</name><affiliation><nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK.</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><affiliation><nlm:aff id="A24">Institute for Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.</nlm:aff></affiliation></author><author><name sortKey="Kunkle, Brian" sort="Kunkle, Brian" uniqKey="Kunkle B" first="Brian" last="Kunkle">Brian Kunkle</name><affiliation><nlm:aff id="A13">John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.</nlm:aff></affiliation></author><author><name sortKey="Dunstan, Melanie L" sort="Dunstan, Melanie L" uniqKey="Dunstan M" first="Melanie L" last="Dunstan">Melanie L. Dunstan</name><affiliation><nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK.</nlm:aff></affiliation></author><author><name sortKey="Ruiz, Agustin" sort="Ruiz, Agustin" uniqKey="Ruiz A" first="Agustin" last="Ruiz">Agustin Ruiz</name><affiliation><nlm:aff id="A25">Memory Clinic of Fundació Alzheimer Centre Educacional (ACE). Institut Català de Neurociències Aplicades, Barcelona, Spain.</nlm:aff></affiliation></author><author><name sortKey="Bihoreau, Marie Therese" sort="Bihoreau, Marie Therese" uniqKey="Bihoreau M" first="Marie-Thérèse" last="Bihoreau">Marie-Thérèse Bihoreau</name><affiliation><nlm:aff id="A21">Centre National de Génotypage, Institut Génomique, Commissariat à l’Energie Atomique, Evry, France.</nlm:aff></affiliation></author><author><name sortKey="Choi, Seung Hoan" sort="Choi, Seung Hoan" uniqKey="Choi S" first="Seung-Hoan" last="Choi">Seung-Hoan Choi</name><affiliation><nlm:aff id="A11">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Reitz, Christiane" sort="Reitz, Christiane" uniqKey="Reitz C" first="Christiane" last="Reitz">Christiane Reitz</name><affiliation><nlm:aff id="A26">Taub Institute on Alzheimer’s Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, USA.</nlm:aff></affiliation></author><author><name sortKey="Pasquier, Florence" sort="Pasquier, Florence" uniqKey="Pasquier F" first="Florence" last="Pasquier">Florence Pasquier</name><affiliation><nlm:aff id="A2">Université Lille 2, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A28">Centre National de Reference pour les Malades Alzheimer Jeunes (CNR-MAJ), Centre Hospitalier Régional Universitaire de Lille, Lille, France.</nlm:aff></affiliation></author><author><name sortKey="Hollingworth, Paul" sort="Hollingworth, Paul" uniqKey="Hollingworth P" first="Paul" last="Hollingworth">Paul Hollingworth</name><affiliation><nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK.</nlm:aff></affiliation></author><author><name sortKey="Ramirez, Alfredo" sort="Ramirez, Alfredo" uniqKey="Ramirez A" first="Alfredo" last="Ramirez">Alfredo Ramirez</name><affiliation><nlm:aff id="A29">Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Institute of Human Genetics, University of Bonn, Bonn, Germany.</nlm:aff></affiliation></author><author><name sortKey="Hanon, Olivier" sort="Hanon, Olivier" uniqKey="Hanon O" first="Olivier" last="Hanon">Olivier Hanon</name><affiliation><nlm:aff id="A31">University Paris Descartes, Sorbonne Paris V, Broca Hospital, Geriatrics Department, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Fitzpatrick, Annette L" sort="Fitzpatrick, Annette L" uniqKey="Fitzpatrick A" first="Annette L" last="Fitzpatrick">Annette L. Fitzpatrick</name><affiliation><nlm:aff id="A12">Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A32">Department of Epidemiology, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Department of Global Health, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation></author><author><name sortKey="Buxbaum, Joseph D" sort="Buxbaum, Joseph D" uniqKey="Buxbaum J" first="Joseph D" last="Buxbaum">Joseph D. Buxbaum</name><affiliation><nlm:aff id="A34">Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A35">Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A36">Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, USA.</nlm:aff></affiliation></author><author><name sortKey="Campion, Dominique" sort="Campion, Dominique" uniqKey="Campion D" first="Dominique" last="Campion">Dominique Campion</name><affiliation><nlm:aff id="A37">CNR-MAJ, INSERM, U1079, Rouen University Hospital, Rouen, France.</nlm:aff></affiliation></author><author><name sortKey="Crane, Paul K" sort="Crane, Paul K" uniqKey="Crane P" first="Paul K" last="Crane">Paul K. Crane</name><affiliation><nlm:aff id="A38">Department of Medicine, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation></author><author><name sortKey="Baldwin, Clinton" sort="Baldwin, Clinton" uniqKey="Baldwin C" first="Clinton" last="Baldwin">Clinton Baldwin</name><affiliation><nlm:aff id="A9">Department of Medicine (Biomedical Genetics), Boston University School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Becker, Tim" sort="Becker, Tim" uniqKey="Becker T" first="Tim" last="Becker">Tim Becker</name><affiliation><nlm:aff id="A39">German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany.</nlm:aff></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation><nlm:aff id="A17">Faculty of Medicine, University of Iceland, Reykjavik, Iceland.</nlm:aff></affiliation><affiliation><nlm:aff id="A18">Icelandic Heart Association, Kopavogur, Iceland.</nlm:aff></affiliation></author><author><name sortKey="Cruchaga, Carlos" sort="Cruchaga, Carlos" uniqKey="Cruchaga C" first="Carlos" last="Cruchaga">Carlos Cruchaga</name><affiliation><nlm:aff id="A41">Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A42">Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, USA.</nlm:aff></affiliation></author><author><name sortKey="Craig, David" sort="Craig, David" uniqKey="Craig D" first="David" last="Craig">David Craig</name><affiliation><nlm:aff id="A43">Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University, Belfast, UK.</nlm:aff></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation><nlm:aff id="A5">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Berr, Claudine" sort="Berr, Claudine" uniqKey="Berr C" first="Claudine" last="Berr">Claudine Berr</name><affiliation><nlm:aff id="A44">INSERM, U1061, Faculty of Medicine, Hôpital La Colombière, Montpellier, France.</nlm:aff></affiliation></author><author><name sortKey="Lopez, Oscar L" sort="Lopez, Oscar L" uniqKey="Lopez O" first="Oscar L" last="Lopez">Oscar L. Lopez</name><affiliation><nlm:aff id="A45">Departments of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.</nlm:aff></affiliation></author><author><name sortKey="De Jager, Philip L" sort="De Jager, Philip L" uniqKey="De Jager P" first="Philip L" last="De Jager">Philip L. De Jager</name><affiliation><nlm:aff id="A46">Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A47">Program in Medical and Population Genetics, Broad Institute, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Deramecourt, Vincent" sort="Deramecourt, Vincent" uniqKey="Deramecourt V" first="Vincent" last="Deramecourt">Vincent Deramecourt</name><affiliation><nlm:aff id="A2">Université Lille 2, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A28">Centre National de Reference pour les Malades Alzheimer Jeunes (CNR-MAJ), Centre Hospitalier Régional Universitaire de Lille, Lille, France.</nlm:aff></affiliation></author><author><name sortKey="Johnston, Janet A" sort="Johnston, Janet A" uniqKey="Johnston J" first="Janet A" last="Johnston">Janet A. Johnston</name><affiliation><nlm:aff id="A43">Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University, Belfast, UK.</nlm:aff></affiliation></author><author><name sortKey="Evans, Denis" sort="Evans, Denis" uniqKey="Evans D" first="Denis" last="Evans">Denis Evans</name><affiliation><nlm:aff id="A48">Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA.</nlm:aff></affiliation></author><author><name sortKey="Lovestone, Simon" sort="Lovestone, Simon" uniqKey="Lovestone S" first="Simon" last="Lovestone">Simon Lovestone</name><affiliation><nlm:aff id="A49">Institute of Psychiatry, King’s College London, Denmark Hill, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Letenneur, Luc" sort="Letenneur, Luc" uniqKey="Letenneur L" first="Luc" last="Letenneur">Luc Letenneur</name><affiliation><nlm:aff id="A50">INSERM, U897, Victor Segalen University, Bordeaux, France.</nlm:aff></affiliation></author><author><name sortKey="Mor N, Francisco J" sort="Mor N, Francisco J" uniqKey="Mor N F" first="Francisco J" last="Mor N">Francisco J. Mor N</name><affiliation><nlm:aff id="A51">Departamento de Genómica Estructural, Neocodex, Seville, Spain.</nlm:aff></affiliation></author><author><name sortKey="Rubinsztein, David C" sort="Rubinsztein, David C" uniqKey="Rubinsztein D" first="David C" last="Rubinsztein">David C. Rubinsztein</name><affiliation><nlm:aff id="A52">Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name><affiliation><nlm:aff id="A18">Icelandic Heart Association, Kopavogur, Iceland.</nlm:aff></affiliation></author><author><name sortKey="Sleegers, Kristel" sort="Sleegers, Kristel" uniqKey="Sleegers K" first="Kristel" last="Sleegers">Kristel Sleegers</name><affiliation><nlm:aff id="A53">Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium.</nlm:aff></affiliation><affiliation><nlm:aff id="A54">Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.</nlm:aff></affiliation></author><author><name sortKey="Goate, Alison M" sort="Goate, Alison M" uniqKey="Goate A" first="Alison M" last="Goate">Alison M. Goate</name><affiliation><nlm:aff id="A41">Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A42">Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, USA.</nlm:aff></affiliation></author><author><name sortKey="Fievet, Nathalie" sort="Fievet, Nathalie" uniqKey="Fievet N" first="Nathalie" last="Fiévet">Nathalie Fiévet</name><affiliation><nlm:aff id="A1">INSERM, U744, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Institut Pasteur de Lille, Lille, France.</nlm:aff></affiliation></author><author><name sortKey="Huentelman, Matthew J" sort="Huentelman, Matthew J" uniqKey="Huentelman M" first="Matthew J" last="Huentelman">Matthew J. Huentelman</name><affiliation><nlm:aff id="A55">Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA.</nlm:aff></affiliation></author><author><name sortKey="Gill, Michael" sort="Gill, Michael" uniqKey="Gill M" first="Michael" last="Gill">Michael Gill</name><affiliation><nlm:aff id="A56">Mercer’s Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland.</nlm:aff></affiliation></author><author><name sortKey="Brown, Kristelle" sort="Brown, Kristelle" uniqKey="Brown K" first="Kristelle" last="Brown">Kristelle Brown</name><affiliation><nlm:aff id="A57">Institute of Genetics, Queen’s Medical Centre, University of Nottingham, Nottingham, UK.</nlm:aff></affiliation></author><author><name sortKey="Kamboh, M Ilyas" sort="Kamboh, M Ilyas" uniqKey="Kamboh M" first="M Ilyas" last="Kamboh">M Ilyas Kamboh</name><affiliation><nlm:aff id="A58">Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A59">Alzheimer’s Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.</nlm:aff></affiliation></author><author><name sortKey="Keller, Lina" sort="Keller, Lina" uniqKey="Keller L" first="Lina" last="Keller">Lina Keller</name><affiliation><nlm:aff id="A60">Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Barberger Gateau, Pascale" sort="Barberger Gateau, Pascale" uniqKey="Barberger Gateau P" first="Pascale" last="Barberger-Gateau">Pascale Barberger-Gateau</name><affiliation><nlm:aff id="A50">INSERM, U897, Victor Segalen University, Bordeaux, France.</nlm:aff></affiliation></author><author><name sortKey="Mcguinness, Bernadette" sort="Mcguinness, Bernadette" uniqKey="Mcguinness B" first="Bernadette" last="Mcguinness">Bernadette Mcguinness</name><affiliation><nlm:aff id="A43">Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University, Belfast, UK.</nlm:aff></affiliation></author><author><name sortKey="Larson, Eric B" sort="Larson, Eric B" uniqKey="Larson E" first="Eric B" last="Larson">Eric B. Larson</name><affiliation><nlm:aff id="A38">Department of Medicine, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Group Health Research Institute, Group Health, Seattle, Washington, USA.</nlm:aff></affiliation></author><author><name sortKey="Green, Robert" sort="Green, Robert" uniqKey="Green R" first="Robert" last="Green">Robert Green</name><affiliation><nlm:aff id="A62">Department of Medicine and Partners Center for Personalized Genetic Medicine, Division of Genetics, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Myers, Amanda J" sort="Myers, Amanda J" uniqKey="Myers A" first="Amanda J" last="Myers">Amanda J. Myers</name><affiliation><nlm:aff id="A63">Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida, USA.</nlm:aff></affiliation></author><author><name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name><affiliation><nlm:aff id="A50">INSERM, U897, Victor Segalen University, Bordeaux, France.</nlm:aff></affiliation></author><author><name sortKey="Todd, Stephen" sort="Todd, Stephen" uniqKey="Todd S" first="Stephen" last="Todd">Stephen Todd</name><affiliation><nlm:aff id="A43">Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University, Belfast, UK.</nlm:aff></affiliation></author><author><name sortKey="Wallon, David" sort="Wallon, David" uniqKey="Wallon D" first="David" last="Wallon">David Wallon</name><affiliation><nlm:aff id="A37">CNR-MAJ, INSERM, U1079, Rouen University Hospital, Rouen, France.</nlm:aff></affiliation></author><author><name sortKey="Love, Seth" sort="Love, Seth" uniqKey="Love S" first="Seth" last="Love">Seth Love</name><affiliation><nlm:aff id="A64">University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol, UK.</nlm:aff></affiliation></author><author><name sortKey="Rogaeva, Ekaterina" sort="Rogaeva, Ekaterina" uniqKey="Rogaeva E" first="Ekaterina" last="Rogaeva">Ekaterina Rogaeva</name><affiliation><nlm:aff id="A65">Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada.</nlm:aff></affiliation></author><author><name sortKey="Gallacher, John" sort="Gallacher, John" uniqKey="Gallacher J" first="John" last="Gallacher">John Gallacher</name><affiliation><nlm:aff id="A66">Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, UK.</nlm:aff></affiliation></author><author><name sortKey="St George Hyslop, Peter" sort="St George Hyslop, Peter" uniqKey="St George Hyslop P" first="Peter" last="St George-Hyslop">Peter St George-Hyslop</name><affiliation><nlm:aff id="A52">Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A65">Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada.</nlm:aff></affiliation><affiliation><nlm:aff id="A67">Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Clarimon, Jordi" sort="Clarimon, Jordi" uniqKey="Clarimon J" first="Jordi" last="Clarimon">Jordi Clarimon</name><affiliation><nlm:aff id="A68">Neurology Department. Biomedical Research Institute Sant Pau (IIB Sant Pau). Sant Pau Hospital. Universitat Autònoma de Barcelona, Barcelona, Spain.</nlm:aff></affiliation><affiliation><nlm:aff id="A69">Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain.</nlm:aff></affiliation></author><author><name sortKey="Lleo, Alberto" sort="Lleo, Alberto" uniqKey="Lleo A" first="Alberto" last="Lleo">Alberto Lleo</name><affiliation><nlm:aff id="A68">Neurology Department. Biomedical Research Institute Sant Pau (IIB Sant Pau). Sant Pau Hospital. Universitat Autònoma de Barcelona, Barcelona, Spain.</nlm:aff></affiliation><affiliation><nlm:aff id="A69">Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain.</nlm:aff></affiliation></author><author><name sortKey="Bayer, Anthony" sort="Bayer, Anthony" uniqKey="Bayer A" first="Anthony" last="Bayer">Anthony Bayer</name><affiliation><nlm:aff id="A66">Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, UK.</nlm:aff></affiliation></author><author><name sortKey="Tsuang, Debby W" sort="Tsuang, Debby W" uniqKey="Tsuang D" first="Debby W" last="Tsuang">Debby W. Tsuang</name><affiliation><nlm:aff id="A70">Geriatric Research, Education and Clinical Center (GRECC), Veteran Administration Puget Sound Health Care System (VAPSHCS), Seattle, Washington, USA.</nlm:aff></affiliation></author><author><name sortKey="Yu, Lei" sort="Yu, Lei" uniqKey="Yu L" first="Lei" last="Yu">Lei Yu</name><affiliation><nlm:aff id="A71">Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.</nlm:aff></affiliation></author><author><name sortKey="Tsolaki, Magda" sort="Tsolaki, Magda" uniqKey="Tsolaki M" first="Magda" last="Tsolaki">Magda Tsolaki</name><affiliation><nlm:aff id="A72">Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece.</nlm:aff></affiliation></author><author><name sortKey="Bossu, Paola" sort="Bossu, Paola" uniqKey="Bossu P" first="Paola" last="Bossù">Paola Bossù</name><affiliation><nlm:aff id="A73">Clinical and Behavioral Neurology, Fondazione Santa Lucia, Rome, Italy.</nlm:aff></affiliation></author><author><name sortKey="Spalletta, Gianfranco" sort="Spalletta, Gianfranco" uniqKey="Spalletta G" first="Gianfranco" last="Spalletta">Gianfranco Spalletta</name><affiliation><nlm:aff id="A73">Clinical and Behavioral Neurology, Fondazione Santa Lucia, Rome, Italy.</nlm:aff></affiliation></author><author><name sortKey="Proitsi, Petroula" sort="Proitsi, Petroula" uniqKey="Proitsi P" first="Petroula" last="Proitsi">Petroula Proitsi</name><affiliation><nlm:aff id="A49">Institute of Psychiatry, King’s College London, Denmark Hill, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Collinge, John" sort="Collinge, John" uniqKey="Collinge J" first="John" last="Collinge">John Collinge</name><affiliation><nlm:aff id="A74">MRC Prion Unit, Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Sorbi, Sandro" sort="Sorbi, Sandro" uniqKey="Sorbi S" first="Sandro" last="Sorbi">Sandro Sorbi</name><affiliation><nlm:aff id="A75">NEUROFARBA (Department of Neuroscience, Psychology, Drug Research and Child Health), University of Florence, Florence, Italy.</nlm:aff></affiliation><affiliation><nlm:aff id="A76">Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy.</nlm:aff></affiliation></author><author><name sortKey="Sanchez Garcia, Florentino" sort="Sanchez Garcia, Florentino" uniqKey="Sanchez Garcia F" first="Florentino" last="Sanchez-Garcia">Florentino Sanchez-Garcia</name><affiliation><nlm:aff id="A77">Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain.</nlm:aff></affiliation></author><author><name sortKey="Fox, Nick C" sort="Fox, Nick C" uniqKey="Fox N" first="Nick C" last="Fox">Nick C. Fox</name><affiliation><nlm:aff id="A78">Dementia Research Centre, Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name><affiliation><nlm:aff id="A79">Department of Molecular Neuroscience, Institute of Neurology, London, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A80">Reta Lilla Weston Laboratories, Institute of Neurology, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Deniz Naranjo, Maria Candida" sort="Deniz Naranjo, Maria Candida" uniqKey="Deniz Naranjo M" first="Maria Candida" last="Deniz Naranjo">Maria Candida Deniz Naranjo</name><affiliation><nlm:aff id="A77">Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain.</nlm:aff></affiliation></author><author><name sortKey="Bosco, Paolo" sort="Bosco, Paolo" uniqKey="Bosco P" first="Paolo" last="Bosco">Paolo Bosco</name><affiliation><nlm:aff id="A81">Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Associazione Oasi Maria Santissima Srl, Troina, Italy.</nlm:aff></affiliation></author><author><name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name><affiliation><nlm:aff id="A82">Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of Oxford, Oxford, UK.</nlm:aff></affiliation></author><author><name sortKey="Brayne, Carol" sort="Brayne, Carol" uniqKey="Brayne C" first="Carol" last="Brayne">Carol Brayne</name><affiliation><nlm:aff id="A83">Institute of Public Health, University of Cambridge, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Galimberti, Daniela" sort="Galimberti, Daniela" uniqKey="Galimberti D" first="Daniela" last="Galimberti">Daniela Galimberti</name><affiliation><nlm:aff id="A84">University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy.</nlm:aff></affiliation></author><author><name sortKey="Mancuso, Michelangelo" sort="Mancuso, Michelangelo" uniqKey="Mancuso M" first="Michelangelo" last="Mancuso">Michelangelo Mancuso</name><affiliation><nlm:aff id="A85">Neurological Clinic, University of Pisa, Pisa, Italy.</nlm:aff></affiliation></author><author><name sortKey="Matthews, Fiona" sort="Matthews, Fiona" uniqKey="Matthews F" first="Fiona" last="Matthews">Fiona Matthews</name><affiliation><nlm:aff id="A86">MRC Biostatistics Unit, Cambridge, UK.</nlm:aff></affiliation></author><author><name sortKey="Moebus, Susanne" sort="Moebus, Susanne" uniqKey="Moebus S" first="Susanne" last="Moebus">Susanne Moebus</name><affiliation><nlm:aff id="A88">Urban Epidemiology, Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.</nlm:aff></affiliation></author><author><name sortKey="Mecocci, Patrizia" sort="Mecocci, Patrizia" uniqKey="Mecocci P" first="Patrizia" last="Mecocci">Patrizia Mecocci</name><affiliation><nlm:aff id="A89">Section of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy.</nlm:aff></affiliation></author><author><name sortKey="Zompo, Maria Del" sort="Zompo, Maria Del" uniqKey="Zompo M" first="Maria Del" last="Zompo">Maria Del Zompo</name><affiliation><nlm:aff id="A90">Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.</nlm:aff></affiliation></author><author><name sortKey="Maier, Wolfgang" sort="Maier, Wolfgang" uniqKey="Maier W" first="Wolfgang" last="Maier">Wolfgang Maier</name><affiliation><nlm:aff id="A29">Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.</nlm:aff></affiliation><affiliation><nlm:aff id="A39">German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.</nlm:aff></affiliation></author><author><name sortKey="Hampel, Harald" sort="Hampel, Harald" uniqKey="Hampel H" first="Harald" last="Hampel">Harald Hampel</name><affiliation><nlm:aff id="A91">Department of Psychiatry, University of Frankfurt, Frankfurt am Main, Germany.</nlm:aff></affiliation><affiliation><nlm:aff id="A92">Department of Psychiatry, Ludwig Maximilians University, Munich, Germany.</nlm:aff></affiliation></author><author><name sortKey="Pilotto, Alberto" sort="Pilotto, Alberto" uniqKey="Pilotto A" first="Alberto" last="Pilotto">Alberto Pilotto</name><affiliation><nlm:aff id="A93">Gerontology and Geriatrics Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.</nlm:aff></affiliation></author><author><name sortKey="Bullido, Maria" sort="Bullido, Maria" uniqKey="Bullido M" first="Maria" last="Bullido">Maria Bullido</name><affiliation><nlm:aff id="A94">Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas–Universidad Autónoma de Madrid, Madrid, Spain.</nlm:aff></affiliation><affiliation><nlm:aff id="A95">Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.</nlm:aff></affiliation><affiliation><nlm:aff id="A96">Instituto de Investigación Sanitaria Hospital la Paz (IdIPaz), Madrid, Spain.</nlm:aff></affiliation></author><author><name sortKey="Panza, Francesco" sort="Panza, Francesco" uniqKey="Panza F" first="Francesco" last="Panza">Francesco Panza</name><affiliation><nlm:aff id="A97">Departement of Geriatrics, Center for Aging Brain, University of Bari, Bari, Italy.</nlm:aff></affiliation></author><author><name sortKey="Caffarra, Paolo" sort="Caffarra, Paolo" uniqKey="Caffarra P" first="Paolo" last="Caffarra">Paolo Caffarra</name><affiliation><nlm:aff id="A98">Department of Neuroscience, University of Parma, Parma, Italy.</nlm:aff></affiliation><affiliation><nlm:aff id="A99">Center for Cognitive Disorders, Azienda Unita Sanitaria Local (AUSL), Parma, Italy.</nlm:aff></affiliation></author><author><name sortKey="Nacmias, Benedetta" sort="Nacmias, Benedetta" uniqKey="Nacmias B" first="Benedetta" last="Nacmias">Benedetta Nacmias</name><affiliation><nlm:aff id="A75">NEUROFARBA (Department of Neuroscience, Psychology, Drug Research and Child Health), University of Florence, Florence, Italy.</nlm:aff></affiliation><affiliation><nlm:aff id="A76">Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy.</nlm:aff></affiliation></author><author><name sortKey="Gilbert, John R" sort="Gilbert, John R" uniqKey="Gilbert J" first="John R" last="Gilbert">John R. Gilbert</name><affiliation><nlm:aff id="A13">John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, USA.</nlm:aff></affiliation></author><author><name sortKey="Mayhaus, Manuel" sort="Mayhaus, Manuel" uniqKey="Mayhaus M" first="Manuel" last="Mayhaus">Manuel Mayhaus</name><affiliation><nlm:aff id="A100">Department of Psychiatry, Saarland University Hospital, Homburg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Lannfelt, Lars" sort="Lannfelt, Lars" uniqKey="Lannfelt L" first="Lars" last="Lannfelt">Lars Lannfelt</name><affiliation><nlm:aff id="A101">Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><affiliation><nlm:aff id="A102">Center for Applied Genomics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.</nlm:aff></affiliation></author><author><name sortKey="Pichler, Sabrina" sort="Pichler, Sabrina" uniqKey="Pichler S" first="Sabrina" last="Pichler">Sabrina Pichler</name><affiliation><nlm:aff id="A100">Department of Psychiatry, Saarland University Hospital, Homburg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Carrasquillo, Minerva M" sort="Carrasquillo, Minerva M" uniqKey="Carrasquillo M" first="Minerva M" last="Carrasquillo">Minerva M. Carrasquillo</name><affiliation><nlm:aff id="A103">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.</nlm:aff></affiliation></author><author><name sortKey="Ingelsson, Martin" sort="Ingelsson, Martin" uniqKey="Ingelsson M" first="Martin" last="Ingelsson">Martin Ingelsson</name><affiliation><nlm:aff id="A101">Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Beekly, Duane" sort="Beekly, Duane" uniqKey="Beekly D" first="Duane" last="Beekly">Duane Beekly</name><affiliation><nlm:aff id="A104">National Alzheimer’s Coordinating Center, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation></author><author><name sortKey="Alvarez, Victoria" sort="Alvarez, Victoria" uniqKey="Alvarez V" first="Victoria" last="Alvarez">Victoria Alvarez</name><affiliation><nlm:aff id="A105">Genetica Molecular, Hospital Universitario Central Asturias, Oviedo, Spain.</nlm:aff></affiliation></author><author><name sortKey="Zou, Fanggeng" sort="Zou, Fanggeng" uniqKey="Zou F" first="Fanggeng" last="Zou">Fanggeng Zou</name><affiliation><nlm:aff id="A103">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.</nlm:aff></affiliation></author><author><name sortKey="Valladares, Otto" sort="Valladares, Otto" uniqKey="Valladares O" first="Otto" last="Valladares">Otto Valladares</name><affiliation><nlm:aff id="A23">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.</nlm:aff></affiliation></author><author><name sortKey="Younkin, Steven G" sort="Younkin, Steven G" uniqKey="Younkin S" first="Steven G" last="Younkin">Steven G. Younkin</name><affiliation><nlm:aff id="A103">Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.</nlm:aff></affiliation></author><author><name sortKey="Coto, Eliecer" sort="Coto, Eliecer" uniqKey="Coto E" first="Eliecer" last="Coto">Eliecer Coto</name><affiliation><nlm:aff id="A105">Genetica Molecular, Hospital Universitario Central Asturias, Oviedo, Spain.</nlm:aff></affiliation></author><author><name sortKey="Hamilton Nelson, Kara L" sort="Hamilton Nelson, Kara L" uniqKey="Hamilton Nelson K" first="Kara L" last="Hamilton-Nelson">Kara L. Hamilton-Nelson</name><affiliation><nlm:aff id="A13">John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.</nlm:aff></affiliation></author><author><name sortKey="Gu, Wei" sort="Gu, Wei" uniqKey="Gu W" first="Wei" last="Gu">Wei Gu</name><affiliation><nlm:aff id="A100">Department of Psychiatry, Saarland University Hospital, Homburg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Razquin, Cristina" sort="Razquin, Cristina" uniqKey="Razquin C" first="Cristina" last="Razquin">Cristina Razquin</name><affiliation><nlm:aff id="A106">Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain.</nlm:aff></affiliation></author><author><name sortKey="Pastor, Pau" sort="Pastor, Pau" uniqKey="Pastor P" first="Pau" last="Pastor">Pau Pastor</name><affiliation><nlm:aff id="A106">Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain.</nlm:aff></affiliation><affiliation><nlm:aff id="A107">CIBERNED, Instituto de Salud Carlos III, Madrid, Spain.</nlm:aff></affiliation></author><author><name sortKey="Mateo, Ignacio" sort="Mateo, Ignacio" uniqKey="Mateo I" first="Ignacio" last="Mateo">Ignacio Mateo</name><affiliation><nlm:aff id="A108">Neurology Service, Marqués de Valdecilla University Hospital, University of Cantabria and Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Santander, Spain.</nlm:aff></affiliation><affiliation><nlm:aff id="A109">CIBERNED, Marqués de Valdecilla University Hospital, University of Cantabria and IFIMAV, Santander, Spain.</nlm:aff></affiliation></author><author><name sortKey="Owen, Michael J" sort="Owen, Michael J" uniqKey="Owen M" first="Michael J" last="Owen">Michael J. Owen</name><affiliation><nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK.</nlm:aff></affiliation></author><author><name sortKey="Faber, Kelley M" sort="Faber, Kelley M" uniqKey="Faber K" first="Kelley M" last="Faber">Kelley M. Faber</name><affiliation><nlm:aff id="A110">Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA.</nlm:aff></affiliation></author><author><name sortKey="Jonsson, Palmi V" sort="Jonsson, Palmi V" uniqKey="Jonsson P" first="Palmi V" last="Jonsson">Palmi V. Jonsson</name><affiliation><nlm:aff id="A17">Faculty of Medicine, University of Iceland, Reykjavik, Iceland.</nlm:aff></affiliation><affiliation><nlm:aff id="A111">Geriatric Department, Landspitali University Hospital, Reykjavik, Iceland.</nlm:aff></affiliation></author><author><name sortKey="Combarros, Onofre" sort="Combarros, Onofre" uniqKey="Combarros O" first="Onofre" last="Combarros">Onofre Combarros</name><affiliation><nlm:aff id="A108">Neurology Service, Marqués de Valdecilla University Hospital, University of Cantabria and Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Santander, Spain.</nlm:aff></affiliation><affiliation><nlm:aff id="A109">CIBERNED, Marqués de Valdecilla University Hospital, University of Cantabria and IFIMAV, Santander, Spain.</nlm:aff></affiliation></author><author><name sortKey="O Onovan, Michael C" sort="O Onovan, Michael C" uniqKey="O Onovan M" first="Michael C" last="O Onovan">Michael C. O Onovan</name><affiliation><nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK.</nlm:aff></affiliation></author><author><name sortKey="Cantwell, Laura B" sort="Cantwell, Laura B" uniqKey="Cantwell L" first="Laura B" last="Cantwell">Laura B. Cantwell</name><affiliation><nlm:aff id="A23">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.</nlm:aff></affiliation></author><author><name sortKey="Soininen, Hilkka" sort="Soininen, Hilkka" uniqKey="Soininen H" first="Hilkka" last="Soininen">Hilkka Soininen</name><affiliation><nlm:aff id="A112">Institute of Clinical Medicine–Neurology, University of Eastern Finland, Kuopio, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A113">Department of Neurology, Kuopio University Hospital, Kuopio, Finland.</nlm:aff></affiliation></author><author><name sortKey="Blacker, Deborah" sort="Blacker, Deborah" uniqKey="Blacker D" first="Deborah" last="Blacker">Deborah Blacker</name><affiliation><nlm:aff id="A114">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A115">Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Mead, Simon" sort="Mead, Simon" uniqKey="Mead S" first="Simon" last="Mead">Simon Mead</name><affiliation><nlm:aff id="A74">MRC Prion Unit, Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H" last="Mosley">Thomas H. Mosley</name><affiliation><nlm:aff id="A116">Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, Mississippi, USA.</nlm:aff></affiliation></author><author><name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A" last="Bennett">David A. Bennett</name><affiliation><nlm:aff id="A71">Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A117">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, Illinois, USA.</nlm:aff></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B" last="Harris">Tamara B. Harris</name><affiliation><nlm:aff id="A12">Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation></author><author><name sortKey="Fratiglioni, Laura" sort="Fratiglioni, Laura" uniqKey="Fratiglioni L" first="Laura" last="Fratiglioni">Laura Fratiglioni</name><affiliation><nlm:aff id="A60">Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.</nlm:aff></affiliation><affiliation><nlm:aff id="A118">Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Holmes, Clive" sort="Holmes, Clive" uniqKey="Holmes C" first="Clive" last="Holmes">Clive Holmes</name><affiliation><nlm:aff id="A119">Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK.</nlm:aff></affiliation></author><author><name sortKey="De Bruijn, Renee F A G" sort="De Bruijn, Renee F A G" uniqKey="De Bruijn R" first="Renee F A G" last="De Bruijn">Renee F A G. De Bruijn</name><affiliation><nlm:aff id="A4">Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Netherlands Consortium for Healthy Aging, Leiden, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Passmore, Peter" sort="Passmore, Peter" uniqKey="Passmore P" first="Peter" last="Passmore">Peter Passmore</name><affiliation><nlm:aff id="A43">Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University, Belfast, UK.</nlm:aff></affiliation></author><author><name sortKey="Montine, Thomas J" sort="Montine, Thomas J" uniqKey="Montine T" first="Thomas J" last="Montine">Thomas J. Montine</name><affiliation><nlm:aff id="A120">Department of Pathology, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation></author><author><name sortKey="Bettens, Karolien" sort="Bettens, Karolien" uniqKey="Bettens K" first="Karolien" last="Bettens">Karolien Bettens</name><affiliation><nlm:aff id="A53">Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium.</nlm:aff></affiliation><affiliation><nlm:aff id="A54">Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.</nlm:aff></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I" last="Rotter">Jerome I. Rotter</name><affiliation><nlm:aff id="A121">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.</nlm:aff></affiliation></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><affiliation><nlm:aff id="A122">INSERM UMRS 975, CNRS UMR 7225, Université Pierre et Marie Curie, Centre de Recherche de l’Institut du Cerveau et de la Moëlle Epinière (CRICM), Hôpital de la Salpêtrière, Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A123">Assistance Publique des Hôpitaux de Paris (AP-HP), Hôpital de la Pitié–Salpêtrière, Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Morgan, Kevin" sort="Morgan, Kevin" uniqKey="Morgan K" first="Kevin" last="Morgan">Kevin Morgan</name><affiliation><nlm:aff id="A57">Institute of Genetics, Queen’s Medical Centre, University of Nottingham, Nottingham, UK.</nlm:aff></affiliation></author><author><name sortKey="Foroud, Tatiana M" sort="Foroud, Tatiana M" uniqKey="Foroud T" first="Tatiana M" last="Foroud">Tatiana M. Foroud</name><affiliation><nlm:aff id="A110">Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA.</nlm:aff></affiliation></author><author><name sortKey="Kukull, Walter A" sort="Kukull, Walter A" uniqKey="Kukull W" first="Walter A" last="Kukull">Walter A. Kukull</name><affiliation><nlm:aff id="A32">Department of Epidemiology, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation></author><author><name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name><affiliation><nlm:aff id="A37">CNR-MAJ, INSERM, U1079, Rouen University Hospital, Rouen, France.</nlm:aff></affiliation></author><author><name sortKey="Powell, John F" sort="Powell, John F" uniqKey="Powell J" first="John F" last="Powell">John F. Powell</name><affiliation><nlm:aff id="A49">Institute of Psychiatry, King’s College London, Denmark Hill, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A" last="Nalls">Michael A. Nalls</name><affiliation><nlm:aff id="A124">Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, USA.</nlm:aff></affiliation></author><author><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name><affiliation><nlm:aff id="A44">INSERM, U1061, Faculty of Medicine, Hôpital La Colombière, Montpellier, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A125">Faculty of Medicine, Imperial College, St. Mary’s Hospital, London, UK.</nlm:aff></affiliation></author><author><name sortKey="Lunetta, Kathryn L" sort="Lunetta, Kathryn L" uniqKey="Lunetta K" first="Kathryn L" last="Lunetta">Kathryn L. Lunetta</name><affiliation><nlm:aff id="A11">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Kauwe, John S K" sort="Kauwe, John S K" uniqKey="Kauwe J" first="John S K" last="Kauwe">John S K. Kauwe</name><affiliation><nlm:aff id="A126">Department of Biology, Brigham Young University, Provo, Utah, USA.</nlm:aff></affiliation></author><author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><affiliation><nlm:aff id="A127">Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A128">Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A129">Division of Epidemiology, University of Texas Health Sciences Center at Houston, Houston, Texas, USA.</nlm:aff></affiliation></author><author><name sortKey="Riemenschneider, Matthias" sort="Riemenschneider, Matthias" uniqKey="Riemenschneider M" first="Matthias" last="Riemenschneider">Matthias Riemenschneider</name><affiliation><nlm:aff id="A100">Department of Psychiatry, Saarland University Hospital, Homburg, Germany.</nlm:aff></affiliation></author><author><name sortKey="Boada, Merce" sort="Boada, Merce" uniqKey="Boada M" first="Mercè" last="Boada">Mercè Boada</name><affiliation><nlm:aff id="A25">Memory Clinic of Fundació Alzheimer Centre Educacional (ACE). Institut Català de Neurociències Aplicades, Barcelona, Spain.</nlm:aff></affiliation><affiliation><nlm:aff id="A130">Hospital Universitari Vall d’Hebron–Institut de Recerca, Universitat Autònoma de Barcelona. (VHIR-UAB), Barcelona, Spain.</nlm:aff></affiliation></author><author><name sortKey="Hiltunen, Mikko" sort="Hiltunen, Mikko" uniqKey="Hiltunen M" first="Mikko" last="Hiltunen">Mikko Hiltunen</name><affiliation><nlm:aff id="A112">Institute of Clinical Medicine–Neurology, University of Eastern Finland, Kuopio, Finland.</nlm:aff></affiliation><affiliation><nlm:aff id="A113">Department of Neurology, Kuopio University Hospital, Kuopio, Finland.</nlm:aff></affiliation></author><author><name sortKey="Martin, Eden R" sort="Martin, Eden R" uniqKey="Martin E" first="Eden R" last="Martin">Eden R. Martin</name><affiliation><nlm:aff id="A13">John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, USA.</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><affiliation><nlm:aff id="A131">Department of Neurology, Medical University of Graz, Graz, Austria.</nlm:aff></affiliation></author><author><name sortKey="Rujescu, Dan" sort="Rujescu, Dan" uniqKey="Rujescu D" first="Dan" last="Rujescu">Dan Rujescu</name><affiliation><nlm:aff id="A132">Department of Psychiatry, University of Halle, Halle, Germany.</nlm:aff></affiliation></author><author><name sortKey="Wang, Li San" sort="Wang, Li San" uniqKey="Wang L" first="Li-San" last="Wang">Li-San Wang</name><affiliation><nlm:aff id="A23">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.</nlm:aff></affiliation></author><author><name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name><affiliation><nlm:aff id="A50">INSERM, U897, Victor Segalen University, Bordeaux, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A133">Centre de Mémoire de Ressources et de Recherche de Bordeaux, Centre Hospitalier Universitaire (CHU) de Bordeaux, Bordeaux, France.</nlm:aff></affiliation></author><author><name sortKey="Mayeux, Richard" sort="Mayeux, Richard" uniqKey="Mayeux R" first="Richard" last="Mayeux">Richard Mayeux</name><affiliation><nlm:aff id="A26">Taub Institute on Alzheimer’s Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, USA.</nlm:aff></affiliation></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><affiliation><nlm:aff id="A134">INSERM, U708, Victor Segalen University, Bordeaux, France.</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="A5">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Netherlands Consortium for Healthy Aging, Leiden, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M" last="Nöthen">Markus M. Nöthen</name><affiliation><nlm:aff id="A135">Institute of Human Genetics, Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.</nlm:aff></affiliation></author><author><name sortKey="Graff, Caroline" sort="Graff, Caroline" uniqKey="Graff C" first="Caroline" last="Graff">Caroline Graff</name><affiliation><nlm:aff id="A117">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, Illinois, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A136">Department of Neurobiology, Karolinska Institutet, Care Sciences and Society, Karolinska Institute–Alzheimer’s Disease Research Center (KIADRC), Stockholm, Sweden.</nlm:aff></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M" last="Psaty">Bruce M. Psaty</name><affiliation><nlm:aff id="A12">Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A32">Department of Epidemiology, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A61">Group Health Research Institute, Group Health, Seattle, Washington, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A137">Department of Health Service, University of Washington, Seattle, Washington, USA.</nlm:aff></affiliation></author><author><name sortKey="Jones, Lesley" sort="Jones, Lesley" uniqKey="Jones L" first="Lesley" last="Jones">Lesley Jones</name><affiliation><nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK.</nlm:aff></affiliation></author><author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L" last="Haines">Jonathan L. Haines</name><affiliation><nlm:aff id="A16">Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A138">Vanderbilt Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, USA.</nlm:aff></affiliation></author><author><name sortKey="Holmans, Peter A" sort="Holmans, Peter A" uniqKey="Holmans P" first="Peter A" last="Holmans">Peter A. Holmans</name><affiliation><nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK.</nlm:aff></affiliation></author><author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><affiliation><nlm:aff id="A21">Centre National de Génotypage, Institut Génomique, Commissariat à l’Energie Atomique, Evry, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Fondation Jean Dausset, Centre d’Etude du Polymorphisme Humain (CEPH), Paris, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A139">McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada.</nlm:aff></affiliation></author><author><name sortKey="Pericak Vance, Margaret A" sort="Pericak Vance, Margaret A" uniqKey="Pericak Vance M" first="Margaret A" last="Pericak-Vance">Margaret A. Pericak-Vance</name><affiliation><nlm:aff id="A13">John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, USA.</nlm:aff></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name><affiliation><nlm:aff id="A140">Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, USA.</nlm:aff></affiliation></author><author><name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A" last="Farrer">Lindsay A. Farrer</name><affiliation><nlm:aff id="A9">Department of Medicine (Biomedical Genetics), Boston University School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A141">Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A142">Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><affiliation><nlm:aff id="A5">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Netherlands Consortium for Healthy Aging, Leiden, The Netherlands.</nlm:aff></affiliation><affiliation><nlm:aff id="A143">Center for Medical Systems Biology, Leiden, The Netherlands.</nlm:aff></affiliation></author><author><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name><affiliation><nlm:aff id="A53">Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium.</nlm:aff></affiliation><affiliation><nlm:aff id="A54">Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.</nlm:aff></affiliation></author><author><name sortKey="Moskvina, Valentina" sort="Moskvina, Valentina" uniqKey="Moskvina V" first="Valentina" last="Moskvina">Valentina Moskvina</name><affiliation><nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK.</nlm:aff></affiliation></author><author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><affiliation><nlm:aff id="A142">Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.</nlm:aff></affiliation></author><author><name sortKey="Williams, Julie" sort="Williams, Julie" uniqKey="Williams J" first="Julie" last="Williams">Julie Williams</name><affiliation><nlm:aff id="A6">Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK.</nlm:aff></affiliation></author><author><name sortKey="Schellenberg, Gerard D" sort="Schellenberg, Gerard D" uniqKey="Schellenberg G" first="Gerard D" last="Schellenberg">Gerard D. Schellenberg</name><affiliation><nlm:aff id="A23">Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.</nlm:aff></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation><nlm:aff id="A1">INSERM, U744, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Université Lille 2, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Institut Pasteur de Lille, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A28">Centre National de Reference pour les Malades Alzheimer Jeunes (CNR-MAJ), Centre Hospitalier Régional Universitaire de Lille, Lille, France.</nlm:aff></affiliation><affiliation><nlm:aff id="A144">Centre Hospitalier Régional Universitaire de Lille, Lille, France.</nlm:aff></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="ISSN">1061-4036</idno><idno type="eISSN">1546-1718</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P4">Eleven susceptibility loci for late-onset Alzheimer’s disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this disease remains unexplained. We conducted a large, two-stage meta-analysis of genome-wide association studies (GWAS) in individuals of European ancestry. In stage 1, we used genotyped and imputed data (7,055,881 SNPs) to perform meta-analysis on 4 previously published GWAS data sets consisting of 17,008 Alzheimer’s disease cases and 37,154 controls. In stage 2,11,632 SNPs were genotyped and tested for association in an independent set of 8,572 Alzheimer’s disease cases and 11,312 controls. In addition to the <italic>APOE</italic> locus (encoding apolipoprotein E), 19 loci reached genome-wide significance (<italic>P</italic> < 5 × 10<sup>−8</sup>) in the combined stage 1 and stage 2 analysis, of which 11 are newly associated with Alzheimer’s disease.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9216904</journal-id><journal-id journal-id-type="pubmed-jr-id">2419</journal-id><journal-id journal-id-type="nlm-ta">Nat Genet</journal-id><journal-id journal-id-type="iso-abbrev">Nat. Genet.</journal-id><journal-title-group><journal-title>Nature genetics</journal-title></journal-title-group><issn pub-type="ppub">1061-4036</issn><issn pub-type="epub">1546-1718</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24162737</article-id><article-id pub-id-type="pmc">3896259</article-id><article-id pub-id-type="doi">10.1038/ng.2802</article-id><article-id pub-id-type="manuscript">NIHMS540798</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer’s disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Lambert</surname><given-names>Jean-Charles</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref><xref ref-type="author-notes" rid="FN2">145</xref></contrib><contrib contrib-type="author"><name><surname>Ibrahim-Verbaas</surname><given-names>Carla A</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref><xref ref-type="author-notes" rid="FN2">145</xref></contrib><contrib contrib-type="author"><name><surname>Harold</surname><given-names>Denise</given-names></name><xref ref-type="aff" rid="A6">6</xref><xref ref-type="author-notes" rid="FN2">145</xref></contrib><contrib contrib-type="author"><name><surname>Naj</surname><given-names>Adam C</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A8">8</xref><xref ref-type="author-notes" rid="FN2">145</xref></contrib><contrib contrib-type="author"><name><surname>Sims</surname><given-names>Rebecca</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Bellenguez</surname><given-names>Céline</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Jun</surname><given-names>Gyungah</given-names></name><xref ref-type="aff" rid="A9">9</xref><xref ref-type="aff" rid="A10">10</xref><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>DeStefano</surname><given-names>Anita L</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Bis</surname><given-names>Joshua C</given-names></name><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Beecham</surname><given-names>Gary W</given-names></name><xref ref-type="aff" rid="A13">13</xref><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Grenier-Boley</surname><given-names>Benjamin</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" 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contrib-type="author"><name><surname>Brayne</surname><given-names>Carol</given-names></name><xref ref-type="aff" rid="A83">83</xref></contrib><contrib contrib-type="author"><name><surname>Galimberti</surname><given-names>Daniela</given-names></name><xref ref-type="aff" rid="A84">84</xref></contrib><contrib contrib-type="author"><name><surname>Mancuso</surname><given-names>Michelangelo</given-names></name><xref ref-type="aff" rid="A85">85</xref></contrib><contrib contrib-type="author"><name><surname>Matthews</surname><given-names>Fiona</given-names></name><xref ref-type="aff" rid="A86">86</xref></contrib><contrib contrib-type="author"><collab>European Alzheimer’s disease Initiative (EADI)</collab><xref ref-type="author-notes" rid="FN1">87</xref></contrib><contrib contrib-type="author"><collab>Genetic and Environmental Risk in Alzheimer’s Disease (GERAD)</collab><xref ref-type="author-notes" rid="FN1">87</xref></contrib><contrib contrib-type="author"><collab>Alzheimer’s Disease Genetic 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contrib-type="author"><name><surname>Hiltunen</surname><given-names>Mikko</given-names></name><xref ref-type="aff" rid="A112">112</xref><xref ref-type="aff" rid="A113">113</xref></contrib><contrib contrib-type="author"><name><surname>Martin</surname><given-names>Eden R</given-names></name><xref ref-type="aff" rid="A13">13</xref><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Schmidt</surname><given-names>Reinhold</given-names></name><xref ref-type="aff" rid="A131">131</xref></contrib><contrib contrib-type="author"><name><surname>Rujescu</surname><given-names>Dan</given-names></name><xref ref-type="aff" rid="A132">132</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Li-san</given-names></name><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Dartigues</surname><given-names>Jean-François</given-names></name><xref ref-type="aff" rid="A50">50</xref><xref 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rid="A139">139</xref></contrib><contrib contrib-type="author"><name><surname>Pericak-Vance</surname><given-names>Margaret A</given-names></name><xref ref-type="aff" rid="A13">13</xref><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Launer</surname><given-names>Lenore J</given-names></name><xref ref-type="aff" rid="A140">140</xref></contrib><contrib contrib-type="author"><name><surname>Farrer</surname><given-names>Lindsay A</given-names></name><xref ref-type="aff" rid="A9">9</xref><xref ref-type="aff" rid="A10">10</xref><xref ref-type="aff" rid="A11">11</xref><xref ref-type="aff" rid="A141">141</xref><xref ref-type="aff" rid="A142">142</xref></contrib><contrib contrib-type="author"><name><surname>van Duijn</surname><given-names>Cornelia M</given-names></name><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A20">20</xref><xref ref-type="aff" rid="A143">143</xref></contrib><contrib contrib-type="author"><name><surname>Van Broeckhoven</surname><given-names>Christine</given-names></name><xref ref-type="aff" rid="A53">53</xref><xref ref-type="aff" rid="A54">54</xref></contrib><contrib contrib-type="author"><name><surname>Moskvina</surname><given-names>Valentina</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Seshadri</surname><given-names>Sudha</given-names></name><xref ref-type="aff" rid="A142">142</xref><xref ref-type="author-notes" rid="FN2">145</xref><xref ref-type="author-notes" rid="FN3">146</xref></contrib><contrib contrib-type="author"><name><surname>Williams</surname><given-names>Julie</given-names></name><xref ref-type="aff" rid="A6">6</xref><xref ref-type="author-notes" rid="FN2">145</xref><xref ref-type="author-notes" rid="FN3">146</xref></contrib><contrib contrib-type="author"><name><surname>Schellenberg</surname><given-names>Gerard D</given-names></name><xref ref-type="aff" rid="A23">23</xref><xref ref-type="author-notes" rid="FN2">145</xref><xref ref-type="author-notes" rid="FN3">146</xref></contrib><contrib contrib-type="author"><name><surname>Amouyel</surname><given-names>Philippe</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A28">28</xref><xref ref-type="aff" rid="A144">144</xref><xref ref-type="author-notes" rid="FN2">145</xref><xref ref-type="author-notes" rid="FN3">146</xref></contrib></contrib-group><aff id="A1"><label>1</label>INSERM, U744, Lille, France.</aff><aff id="A2"><label>2</label>Université Lille 2, Lille, France.</aff><aff id="A3"><label>3</label>Institut Pasteur de Lille, Lille, France.</aff><aff id="A4"><label>4</label>Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.</aff><aff id="A5"><label>5</label>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.</aff><aff id="A6"><label>6</label>Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK.</aff><aff id="A7"><label>7</label>Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.</aff><aff id="A8"><label>8</label>Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.</aff><aff id="A9"><label>9</label>Department of Medicine (Biomedical Genetics), Boston University School of Public Health, Boston, Massachusetts, USA.</aff><aff id="A10"><label>10</label>Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, USA.</aff><aff id="A11"><label>11</label>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.</aff><aff id="A12"><label>12</label>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.</aff><aff id="A13"><label>13</label>John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.</aff><aff id="A14"><label>14</label>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, USA.</aff><aff id="A15"><label>15</label>Functional Genomics Center Zurich, Eidgenössische Technische Hochschule (ETH)/University of Zurich, Zurich, Switzerland.</aff><aff id="A16"><label>16</label>Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.</aff><aff id="A17"><label>17</label>Faculty of Medicine, University of Iceland, Reykjavik, Iceland.</aff><aff id="A18"><label>18</label>Icelandic Heart Association, Kopavogur, Iceland.</aff><aff id="A19"><label>19</label>Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.</aff><aff id="A20"><label>20</label>Netherlands Consortium for Healthy Aging, Leiden, The Netherlands.</aff><aff id="A21"><label>21</label>Centre National de Génotypage, Institut Génomique, Commissariat à l’Energie Atomique, Evry, France.</aff><aff id="A22"><label>22</label>Fondation Jean Dausset, Centre d’Etude du Polymorphisme Humain (CEPH), Paris, France.</aff><aff id="A23"><label>23</label>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.</aff><aff id="A24"><label>24</label>Institute for Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.</aff><aff id="A25"><label>25</label>Memory Clinic of Fundació Alzheimer Centre Educacional (ACE). Institut Català de Neurociències Aplicades, Barcelona, Spain.</aff><aff id="A26"><label>26</label>Taub Institute on Alzheimer’s Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA.</aff><aff id="A27"><label>27</label>Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, USA.</aff><aff id="A28"><label>28</label>Centre National de Reference pour les Malades Alzheimer Jeunes (CNR-MAJ), Centre Hospitalier Régional Universitaire de Lille, Lille, France.</aff><aff id="A29"><label>29</label>Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.</aff><aff id="A30"><label>30</label>Institute of Human Genetics, University of Bonn, Bonn, Germany.</aff><aff id="A31"><label>31</label>University Paris Descartes, Sorbonne Paris V, Broca Hospital, Geriatrics Department, Paris, France.</aff><aff id="A32"><label>32</label>Department of Epidemiology, University of Washington, Seattle, Washington, USA.</aff><aff id="A33"><label>33</label>Department of Global Health, University of Washington, Seattle, Washington, USA.</aff><aff id="A34"><label>34</label>Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA.</aff><aff id="A35"><label>35</label>Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA.</aff><aff id="A36"><label>36</label>Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, USA.</aff><aff id="A37"><label>37</label>CNR-MAJ, INSERM, U1079, Rouen University Hospital, Rouen, France.</aff><aff id="A38"><label>38</label>Department of Medicine, University of Washington, Seattle, Washington, USA.</aff><aff id="A39"><label>39</label>German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.</aff><aff id="A40"><label>40</label>Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany.</aff><aff id="A41"><label>41</label>Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.</aff><aff id="A42"><label>42</label>Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, USA.</aff><aff id="A43"><label>43</label>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University, Belfast, UK.</aff><aff id="A44"><label>44</label>INSERM, U1061, Faculty of Medicine, Hôpital La Colombière, Montpellier, France.</aff><aff id="A45"><label>45</label>Departments of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.</aff><aff id="A46"><label>46</label>Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.</aff><aff id="A47"><label>47</label>Program in Medical and Population Genetics, Broad Institute, Boston, Massachusetts, USA.</aff><aff id="A48"><label>48</label>Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA.</aff><aff id="A49"><label>49</label>Institute of Psychiatry, King’s College London, Denmark Hill, London, UK.</aff><aff id="A50"><label>50</label>INSERM, U897, Victor Segalen University, Bordeaux, France.</aff><aff id="A51"><label>51</label>Departamento de Genómica Estructural, Neocodex, Seville, Spain.</aff><aff id="A52"><label>52</label>Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.</aff><aff id="A53"><label>53</label>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium.</aff><aff id="A54"><label>54</label>Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.</aff><aff id="A55"><label>55</label>Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA.</aff><aff id="A56"><label>56</label>Mercer’s Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland.</aff><aff id="A57"><label>57</label>Institute of Genetics, Queen’s Medical Centre, University of Nottingham, Nottingham, UK.</aff><aff id="A58"><label>58</label>Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.</aff><aff id="A59"><label>59</label>Alzheimer’s Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.</aff><aff id="A60"><label>60</label>Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.</aff><aff id="A61"><label>61</label>Group Health Research Institute, Group Health, Seattle, Washington, USA.</aff><aff id="A62"><label>62</label>Department of Medicine and Partners Center for Personalized Genetic Medicine, Division of Genetics, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.</aff><aff id="A63"><label>63</label>Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida, USA.</aff><aff id="A64"><label>64</label>University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol, UK.</aff><aff id="A65"><label>65</label>Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada.</aff><aff id="A66"><label>66</label>Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, UK.</aff><aff id="A67"><label>67</label>Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.</aff><aff id="A68"><label>68</label>Neurology Department. Biomedical Research Institute Sant Pau (IIB Sant Pau). Sant Pau Hospital. Universitat Autònoma de Barcelona, Barcelona, Spain.</aff><aff id="A69"><label>69</label>Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain.</aff><aff id="A70"><label>70</label>Geriatric Research, Education and Clinical Center (GRECC), Veteran Administration Puget Sound Health Care System (VAPSHCS), Seattle, Washington, USA.</aff><aff id="A71"><label>71</label>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.</aff><aff id="A72"><label>72</label>Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece.</aff><aff id="A73"><label>73</label>Clinical and Behavioral Neurology, Fondazione Santa Lucia, Rome, Italy.</aff><aff id="A74"><label>74</label>MRC Prion Unit, Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK.</aff><aff id="A75"><label>75</label>NEUROFARBA (Department of Neuroscience, Psychology, Drug Research and Child Health), University of Florence, Florence, Italy.</aff><aff id="A76"><label>76</label>Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy.</aff><aff id="A77"><label>77</label>Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain.</aff><aff id="A78"><label>78</label>Dementia Research Centre, Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK.</aff><aff id="A79"><label>79</label>Department of Molecular Neuroscience, Institute of Neurology, London, UK.</aff><aff id="A80"><label>80</label>Reta Lilla Weston Laboratories, Institute of Neurology, London, UK.</aff><aff id="A81"><label>81</label>Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Associazione Oasi Maria Santissima Srl, Troina, Italy.</aff><aff id="A82"><label>82</label>Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of Oxford, Oxford, UK.</aff><aff id="A83"><label>83</label>Institute of Public Health, University of Cambridge, Cambridge, UK.</aff><aff id="A84"><label>84</label>University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy.</aff><aff id="A85"><label>85</label>Neurological Clinic, University of Pisa, Pisa, Italy.</aff><aff id="A86"><label>86</label>MRC Biostatistics Unit, Cambridge, UK.</aff><aff id="A88"><label>88</label>Urban Epidemiology, Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.</aff><aff id="A89"><label>89</label>Section of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy.</aff><aff id="A90"><label>90</label>Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.</aff><aff id="A91"><label>91</label>Department of Psychiatry, University of Frankfurt, Frankfurt am Main, Germany.</aff><aff id="A92"><label>92</label>Department of Psychiatry, Ludwig Maximilians University, Munich, Germany.</aff><aff id="A93"><label>93</label>Gerontology and Geriatrics Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.</aff><aff id="A94"><label>94</label>Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas–Universidad Autónoma de Madrid, Madrid, Spain.</aff><aff id="A95"><label>95</label>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.</aff><aff id="A96"><label>96</label>Instituto de Investigación Sanitaria Hospital la Paz (IdIPaz), Madrid, Spain.</aff><aff id="A97"><label>97</label>Departement of Geriatrics, Center for Aging Brain, University of Bari, Bari, Italy.</aff><aff id="A98"><label>98</label>Department of Neuroscience, University of Parma, Parma, Italy.</aff><aff id="A99"><label>99</label>Center for Cognitive Disorders, Azienda Unita Sanitaria Local (AUSL), Parma, Italy.</aff><aff id="A100"><label>100</label>Department of Psychiatry, Saarland University Hospital, Homburg, Germany.</aff><aff id="A101"><label>101</label>Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden.</aff><aff id="A102"><label>102</label>Center for Applied Genomics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.</aff><aff id="A103"><label>103</label>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.</aff><aff id="A104"><label>104</label>National Alzheimer’s Coordinating Center, University of Washington, Seattle, Washington, USA.</aff><aff id="A105"><label>105</label>Genetica Molecular, Hospital Universitario Central Asturias, Oviedo, Spain.</aff><aff id="A106"><label>106</label>Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain.</aff><aff id="A107"><label>107</label>CIBERNED, Instituto de Salud Carlos III, Madrid, Spain.</aff><aff id="A108"><label>108</label>Neurology Service, Marqués de Valdecilla University Hospital, University of Cantabria and Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Santander, Spain.</aff><aff id="A109"><label>109</label>CIBERNED, Marqués de Valdecilla University Hospital, University of Cantabria and IFIMAV, Santander, Spain.</aff><aff id="A110"><label>110</label>Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA.</aff><aff id="A111"><label>111</label>Geriatric Department, Landspitali University Hospital, Reykjavik, Iceland.</aff><aff id="A112"><label>112</label>Institute of Clinical Medicine–Neurology, University of Eastern Finland, Kuopio, Finland.</aff><aff id="A113"><label>113</label>Department of Neurology, Kuopio University Hospital, Kuopio, Finland.</aff><aff id="A114"><label>114</label>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.</aff><aff id="A115"><label>115</label>Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA.</aff><aff id="A116"><label>116</label>Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, Mississippi, USA.</aff><aff id="A117"><label>117</label>Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, Illinois, USA.</aff><aff id="A118"><label>118</label>Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden.</aff><aff id="A119"><label>119</label>Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK.</aff><aff id="A120"><label>120</label>Department of Pathology, University of Washington, Seattle, Washington, USA.</aff><aff id="A121"><label>121</label>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.</aff><aff id="A122"><label>122</label>INSERM UMRS 975, CNRS UMR 7225, Université Pierre et Marie Curie, Centre de Recherche de l’Institut du Cerveau et de la Moëlle Epinière (CRICM), Hôpital de la Salpêtrière, Paris, France.</aff><aff id="A123"><label>123</label>Assistance Publique des Hôpitaux de Paris (AP-HP), Hôpital de la Pitié–Salpêtrière, Paris, France.</aff><aff id="A124"><label>124</label>Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, USA.</aff><aff id="A125"><label>125</label>Faculty of Medicine, Imperial College, St. Mary’s Hospital, London, UK.</aff><aff id="A126"><label>126</label>Department of Biology, Brigham Young University, Provo, Utah, USA.</aff><aff id="A127"><label>127</label>Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA.</aff><aff id="A128"><label>128</label>Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA.</aff><aff id="A129"><label>129</label>Division of Epidemiology, University of Texas Health Sciences Center at Houston, Houston, Texas, USA.</aff><aff id="A130"><label>130</label>Hospital Universitari Vall d’Hebron–Institut de Recerca, Universitat Autònoma de Barcelona. (VHIR-UAB), Barcelona, Spain.</aff><aff id="A131"><label>131</label>Department of Neurology, Medical University of Graz, Graz, Austria.</aff><aff id="A132"><label>132</label>Department of Psychiatry, University of Halle, Halle, Germany.</aff><aff id="A133"><label>133</label>Centre de Mémoire de Ressources et de Recherche de Bordeaux, Centre Hospitalier Universitaire (CHU) de Bordeaux, Bordeaux, France.</aff><aff id="A134"><label>134</label>INSERM, U708, Victor Segalen University, Bordeaux, France.</aff><aff id="A135"><label>135</label>Institute of Human Genetics, Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.</aff><aff id="A136"><label>136</label>Department of Neurobiology, Karolinska Institutet, Care Sciences and Society, Karolinska Institute–Alzheimer’s Disease Research Center (KIADRC), Stockholm, Sweden.</aff><aff id="A137"><label>137</label>Department of Health Service, University of Washington, Seattle, Washington, USA.</aff><aff id="A138"><label>138</label>Vanderbilt Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, USA.</aff><aff id="A139"><label>139</label>McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada.</aff><aff id="A140"><label>140</label>Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, USA.</aff><aff id="A141"><label>141</label>Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.</aff><aff id="A142"><label>142</label>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.</aff><aff id="A143"><label>143</label>Center for Medical Systems Biology, Leiden, The Netherlands.</aff><aff id="A144"><label>144</label>Centre Hospitalier Régional Universitaire de Lille, Lille, France.</aff><author-notes><corresp id="cor1">Correspondence should be addressed to P.A. (<email>philippe.amouyel@pasteur-lille.fr</email>) or J.W. (<email>williamsj@cardiff.ac.uk</email>)</corresp><fn id="FN1"><label>87</label><p id="P1">Full lists of members and affiliations appear in the <xref ref-type="supplementary-material" rid="SD1">Supplementary Note</xref>.</p></fn><fn id="FN2" fn-type="equal"><label>145</label><p id="P2">These authors contributed equally to this work.</p></fn><fn id="FN3"><label>146</label><p id="P3">These authors jointly directed this work.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>23</day><month>12</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>27</day><month>10</month><year>2013</year></pub-date><pub-date pub-type="ppub"><month>12</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>6</month><year>2014</year></pub-date><volume>45</volume><issue>12</issue><fpage>1452</fpage><lpage>1458</lpage><pmc-comment>elocation-id from pubmed: 10.1038/ng.2802</pmc-comment>
<abstract><p id="P4">Eleven susceptibility loci for late-onset Alzheimer’s disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this disease remains unexplained. We conducted a large, two-stage meta-analysis of genome-wide association studies (GWAS) in individuals of European ancestry. In stage 1, we used genotyped and imputed data (7,055,881 SNPs) to perform meta-analysis on 4 previously published GWAS data sets consisting of 17,008 Alzheimer’s disease cases and 37,154 controls. In stage 2,11,632 SNPs were genotyped and tested for association in an independent set of 8,572 Alzheimer’s disease cases and 11,312 controls. In addition to the <italic>APOE</italic> locus (encoding apolipoprotein E), 19 loci reached genome-wide significance (<italic>P</italic> < 5 × 10<sup>−8</sup>) in the combined stage 1 and stage 2 analysis, of which 11 are newly associated with Alzheimer’s disease.</p></abstract><funding-group><award-group><funding-source country="United States">National Institute on Aging : NIA</funding-source><award-id>U01 AG032984 || AG</award-id></award-group><award-group><funding-source country="United States">National Institute on Aging : NIA</funding-source><award-id>R01 AG033193 || AG</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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