Effects of Levodopa on Regional Cerebral Metabolism and Blood Flow
Identifieur interne : 000841 ( Pmc/Corpus ); précédent : 000840; suivant : 000842Effects of Levodopa on Regional Cerebral Metabolism and Blood Flow
Auteurs : Ji Hyun Ko ; Renata P. Lerner ; David EidelbergSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2014.
Abstract
Levodopa has been at the forefront of antiparkinsonian therapy for a half century. Recent advances in functional brain imaging have contributed substantially to the understanding of the effects of levodopa and other dopaminergic treatment on the activity of abnormal motor and cognitive brain circuits in Parkinson’s disease patients. Progress has also been made in understanding the functional pathology of dyskinesias, a common side effect of levodopa treatment, at both regional and network levels. Here, we review these studies, focusing mainly on the new mechanistic insights provided by metabolic brain imaging and network analysis.
Url:
DOI: 10.1002/mds.26041
PubMed: 25296957
PubMed Central: 4314428
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PMC:4314428Le document en format XML
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<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id><journal-id journal-id-type="pubmed-jr-id">5937</journal-id><journal-id journal-id-type="nlm-ta">Mov Disord</journal-id><journal-id journal-id-type="iso-abbrev">Mov. Disord.</journal-id><journal-title-group><journal-title>Movement disorders : official journal of the Movement Disorder Society</journal-title></journal-title-group><issn pub-type="ppub">0885-3185</issn><issn pub-type="epub">1531-8257</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25296957</article-id><article-id pub-id-type="pmc">4314428</article-id><article-id pub-id-type="doi">10.1002/mds.26041</article-id><article-id pub-id-type="manuscript">NIHMS628503</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Effects of Levodopa on Regional Cerebral Metabolism and Blood Flow</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Ko</surname><given-names>Ji Hyun</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Lerner</surname><given-names>Renata P.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Eidelberg</surname><given-names>David</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib></contrib-group><aff id="A1"><label>1</label>Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY, USA</aff><aff id="A2"><label>2</label>Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, MB, Canada (current address)</aff><author-notes><corresp id="FN1"><label>*</label>Correspondence to: David Eidelberg, MD, Center for Neurosciences, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030., Phone: (516) 562-2498; Fax: (516) 562-1008; <email>david1@nshs.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>17</day><month>9</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>09</day><month>10</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>1</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>1</month><year>2016</year></pub-date><volume>30</volume><issue>1</issue><fpage>54</fpage><lpage>63</lpage><pmc-comment>elocation-id from pubmed: 10.1002/mds.26041</pmc-comment>
<abstract><p id="P1">Levodopa has been at the forefront of antiparkinsonian therapy for a half century. Recent advances in functional brain imaging have contributed substantially to the understanding of the effects of levodopa and other dopaminergic treatment on the activity of abnormal motor and cognitive brain circuits in Parkinson’s disease patients. Progress has also been made in understanding the functional pathology of dyskinesias, a common side effect of levodopa treatment, at both regional and network levels. Here, we review these studies, focusing mainly on the new mechanistic insights provided by metabolic brain imaging and network analysis.</p></abstract><kwd-group><kwd>levodopa</kwd><kwd>metabolism</kwd><kwd>blood flow</kwd><kwd>dopamine</kwd><kwd>positron emission tomography (PET)</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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