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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Locus Coeruleus Neuron Density and Parkinsonism in Older Adults without Parkinson’s Disease</title><author><name sortKey="Buchman, Aron S" sort="Buchman, Aron S" uniqKey="Buchman A" first="Aron S." last="Buchman">Aron S. Buchman</name><affiliation><nlm:aff id="A1">Rush Alzheimer’s Disease Center, Rush University Medical Center</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Neurological Sciences, Rush University Medical Center</nlm:aff></affiliation></author><author><name sortKey="Nag, Sukriti" sort="Nag, Sukriti" uniqKey="Nag S" first="Sukriti" last="Nag">Sukriti Nag</name><affiliation><nlm:aff id="A1">Rush Alzheimer’s Disease Center, Rush University Medical Center</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Pathology (Neuropathology), Rush University Medical Center</nlm:aff></affiliation></author><author><name sortKey="Shulman, Joshua M" sort="Shulman, Joshua M" uniqKey="Shulman J" first="Joshua M." last="Shulman">Joshua M. Shulman</name><affiliation><nlm:aff id="A4">Department of Neurology, Brigham and Women’s Hospital, Boston, Massachusetts</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Harvard Medical School, Boston, Massachusetts</nlm:aff></affiliation></author><author><name sortKey="Lim, Andrew S P" sort="Lim, Andrew S P" uniqKey="Lim A" first="Andrew S. P." last="Lim">Andrew S. P. Lim</name><affiliation><nlm:aff id="A6">Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre; University of Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Vanderhorst, Veronique G J M" sort="Vanderhorst, Veronique G J M" uniqKey="Vanderhorst V" first="Veronique G. J. M." last="Vanderhorst">Veronique G. J. M. Vanderhorst</name><affiliation><nlm:aff id="A5">Harvard Medical School, Boston, Massachusetts</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts</nlm:aff></affiliation></author><author><name sortKey="Leurgans, Sue E" sort="Leurgans, Sue E" uniqKey="Leurgans S" first="Sue E." last="Leurgans">Sue E. Leurgans</name><affiliation><nlm:aff id="A1">Rush Alzheimer’s Disease Center, Rush University Medical Center</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Neurological Sciences, Rush University Medical Center</nlm:aff></affiliation></author><author><name sortKey="Schneider, Julie A" sort="Schneider, Julie A" uniqKey="Schneider J" first="Julie A." last="Schneider">Julie A. Schneider</name><affiliation><nlm:aff id="A1">Rush Alzheimer’s Disease Center, Rush University Medical Center</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Neurological Sciences, Rush University Medical Center</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Pathology (Neuropathology), Rush University Medical Center</nlm:aff></affiliation></author><author><name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A." last="Bennett">David A. Bennett</name><affiliation><nlm:aff id="A1">Rush Alzheimer’s Disease Center, Rush University Medical Center</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Neurological Sciences, Rush University Medical Center</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23038629</idno><idno type="pmc">3628555</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628555</idno><idno type="RBID">PMC:3628555</idno><idno type="doi">10.1002/mds.25142</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000830</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000830</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Locus Coeruleus Neuron Density and Parkinsonism in Older Adults without Parkinson’s Disease</title><author><name sortKey="Buchman, Aron S" sort="Buchman, Aron S" uniqKey="Buchman A" first="Aron S." last="Buchman">Aron S. Buchman</name><affiliation><nlm:aff id="A1">Rush Alzheimer’s Disease Center, Rush University Medical Center</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Neurological Sciences, Rush University Medical Center</nlm:aff></affiliation></author><author><name sortKey="Nag, Sukriti" sort="Nag, Sukriti" uniqKey="Nag S" first="Sukriti" last="Nag">Sukriti Nag</name><affiliation><nlm:aff id="A1">Rush Alzheimer’s Disease Center, Rush University Medical Center</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Pathology (Neuropathology), Rush University Medical Center</nlm:aff></affiliation></author><author><name sortKey="Shulman, Joshua M" sort="Shulman, Joshua M" uniqKey="Shulman J" first="Joshua M." last="Shulman">Joshua M. Shulman</name><affiliation><nlm:aff id="A4">Department of Neurology, Brigham and Women’s Hospital, Boston, Massachusetts</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Harvard Medical School, Boston, Massachusetts</nlm:aff></affiliation></author><author><name sortKey="Lim, Andrew S P" sort="Lim, Andrew S P" uniqKey="Lim A" first="Andrew S. P." last="Lim">Andrew S. P. Lim</name><affiliation><nlm:aff id="A6">Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre; University of Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Vanderhorst, Veronique G J M" sort="Vanderhorst, Veronique G J M" uniqKey="Vanderhorst V" first="Veronique G. J. M." last="Vanderhorst">Veronique G. J. M. Vanderhorst</name><affiliation><nlm:aff id="A5">Harvard Medical School, Boston, Massachusetts</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts</nlm:aff></affiliation></author><author><name sortKey="Leurgans, Sue E" sort="Leurgans, Sue E" uniqKey="Leurgans S" first="Sue E." last="Leurgans">Sue E. Leurgans</name><affiliation><nlm:aff id="A1">Rush Alzheimer’s Disease Center, Rush University Medical Center</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Neurological Sciences, Rush University Medical Center</nlm:aff></affiliation></author><author><name sortKey="Schneider, Julie A" sort="Schneider, Julie A" uniqKey="Schneider J" first="Julie A." last="Schneider">Julie A. Schneider</name><affiliation><nlm:aff id="A1">Rush Alzheimer’s Disease Center, Rush University Medical Center</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Neurological Sciences, Rush University Medical Center</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Pathology (Neuropathology), Rush University Medical Center</nlm:aff></affiliation></author><author><name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A." last="Bennett">David A. Bennett</name><affiliation><nlm:aff id="A1">Rush Alzheimer’s Disease Center, Rush University Medical Center</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Neurological Sciences, Rush University Medical Center</nlm:aff></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P1">Prior work has showed that nigral neuron density is related to the severity of parkinsonism proximate to death in older persons without a clinical diagnosis of Parkinson’s disease (PD). We tested the hypothesis that neuron density in other brainstem aminergic nuclei is also related to the severity of parkinsonism.</p></sec><sec id="S2"><title>Design</title><p id="P2">We studied brain autopsies from 125 deceased older adults without PD enrolled in the Memory and Aging Project, a clinical-pathologic investigation. Parkinsonism was assessed with a modified version of the Unified Parkinson’s Disease Rating Scale (UPDRS). We measured neuron density in the substantia nigra, ventral tegmental area, locus coeruleus and dorsal raphe; and postmortem indices of Lewy body Alzheimer’s disease and cerebrovascular pathologies.</p></sec><sec id="S3"><title>Results</title><p id="P3">Mean age at death was 88.0 and global parkinsonism was 14.8 (SD=9.50). In a series of regression models which controlled for demographics and neuron density in the substantia nigra, neuron density in the locus coeruleus (Estimate, −0.261, S.E., 0.117, p=0.028) but not in the ventral tegmental area or dorsal raphe was associated with the severity of global parkinsonism proximate to death. These findings were unchanged in models which controlled for post-mortem interval, whole brain weight and other common neuropathologies including Alzheimer’s disease and Lewy body pathology and cerebrovascular vascular pathologies.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">In older adults without a clinical diagnosis of PD, neuron density in locus coeruleus nuclei is associated with the severity of parkinsonism and may contribute to late-life motor impairments.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id><journal-id journal-id-type="pubmed-jr-id">5937</journal-id><journal-id journal-id-type="nlm-ta">Mov Disord</journal-id><journal-id journal-id-type="iso-abbrev">Mov. Disord.</journal-id><journal-title-group><journal-title>Movement disorders : official journal of the Movement Disorder Society</journal-title></journal-title-group><issn pub-type="ppub">0885-3185</issn><issn pub-type="epub">1531-8257</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23038629</article-id><article-id pub-id-type="pmc">3628555</article-id><article-id pub-id-type="doi">10.1002/mds.25142</article-id><article-id pub-id-type="manuscript">NIHMS450817</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Locus Coeruleus Neuron Density and Parkinsonism in Older Adults without Parkinson’s Disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Buchman</surname><given-names>Aron S.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Nag</surname><given-names>Sukriti</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Shulman</surname><given-names>Joshua M.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Lim</surname><given-names>Andrew S.P.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>VanderHorst</surname><given-names>Veronique G.J.M.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Leurgans</surname><given-names>Sue E.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Schneider</surname><given-names>Julie A.</given-names></name><degrees>MD, MS</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Bennett</surname><given-names>David A.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib></contrib-group><aff id="A1"><label>1</label>Rush Alzheimer’s Disease Center, Rush University Medical Center</aff><aff id="A2"><label>2</label>Department of Neurological Sciences, Rush University Medical Center</aff><aff id="A3"><label>3</label>Department of Pathology (Neuropathology), Rush University Medical Center</aff><aff id="A4"><label>4</label>Department of Neurology, Brigham and Women’s Hospital, Boston, Massachusetts</aff><aff id="A5"><label>5</label>Harvard Medical School, Boston, Massachusetts</aff><aff id="A6"><label>6</label>Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre; University of Toronto, Canada</aff><aff id="A7"><label>7</label>Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts</aff><author-notes><corresp id="FN1">Contact Information for Corresponding Author: Aron S. Buchman, MD; Rush Alzheimer’s Disease Center; Rush University Medical Center; Armour Academic Facility, Suite #1038; 600 South Paulina Street, Chicago, Illinois 60612; Phone: (312) 942-8974, Fax (312) 563-4604, <email>Aron_S_Buchman@rush.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>6</day><month>3</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>04</day><month>10</month><year>2012</year></pub-date><pub-date pub-type="ppub"><month>11</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>11</month><year>2013</year></pub-date><volume>27</volume><issue>13</issue><fpage>1625</fpage><lpage>1631</lpage><abstract><sec id="S1"><title>Objective</title><p id="P1">Prior work has showed that nigral neuron density is related to the severity of parkinsonism proximate to death in older persons without a clinical diagnosis of Parkinson’s disease (PD). We tested the hypothesis that neuron density in other brainstem aminergic nuclei is also related to the severity of parkinsonism.</p></sec><sec id="S2"><title>Design</title><p id="P2">We studied brain autopsies from 125 deceased older adults without PD enrolled in the Memory and Aging Project, a clinical-pathologic investigation. Parkinsonism was assessed with a modified version of the Unified Parkinson’s Disease Rating Scale (UPDRS). We measured neuron density in the substantia nigra, ventral tegmental area, locus coeruleus and dorsal raphe; and postmortem indices of Lewy body Alzheimer’s disease and cerebrovascular pathologies.</p></sec><sec id="S3"><title>Results</title><p id="P3">Mean age at death was 88.0 and global parkinsonism was 14.8 (SD=9.50). In a series of regression models which controlled for demographics and neuron density in the substantia nigra, neuron density in the locus coeruleus (Estimate, −0.261, S.E., 0.117, p=0.028) but not in the ventral tegmental area or dorsal raphe was associated with the severity of global parkinsonism proximate to death. These findings were unchanged in models which controlled for post-mortem interval, whole brain weight and other common neuropathologies including Alzheimer’s disease and Lewy body pathology and cerebrovascular vascular pathologies.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">In older adults without a clinical diagnosis of PD, neuron density in locus coeruleus nuclei is associated with the severity of parkinsonism and may contribute to late-life motor impairments.</p></sec></abstract><kwd-group><kwd>Parkinson’s disease</kwd><kwd>Parkinsonism</kwd><kwd>Substantia Nigra</kwd><kwd>Locus Coeruleus</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Institute of Neurological Disorders and Stroke : NINDS</funding-source><award-id>R01 NS079623 || NS</award-id></award-group><award-group><funding-source country="United States">National Institute of Neurological Disorders and Stroke : NINDS</funding-source><award-id>R01 NS078009 || NS</award-id></award-group><award-group><funding-source country="United States">National Institute on Aging : NIA</funding-source><award-id>R01 AG024480 || AG</award-id></award-group><award-group><funding-source country="United States">National Institute on Aging : NIA</funding-source><award-id>R01 AG017917 || AG</award-id></award-group><award-group><funding-source country="United States">National Institute on Aging : NIA</funding-source><award-id>K08 AG034290 || AG</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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