Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Striatal ups and downs: Their roles in vulnerability to addictions in humans</title><author><name sortKey="Leyton, Marco" sort="Leyton, Marco" uniqKey="Leyton M" first="Marco" last="Leyton">Marco Leyton</name><affiliation><nlm:aff id="A1">Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, Quebec, H3A 1A1 Canada</nlm:aff></affiliation></author><author><name sortKey="Vezina, Paul" sort="Vezina, Paul" uniqKey="Vezina P" first="Paul" last="Vezina">Paul Vezina</name><affiliation><nlm:aff id="A2">Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, 5841 South Maryland Avenue, MC3077, Chicago, IL 60637, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23333263</idno><idno type="pmc">3743927</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743927</idno><idno type="RBID">PMC:3743927</idno><idno type="doi">10.1016/j.neubiorev.2013.01.018</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000803</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000803</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Striatal ups and downs: Their roles in vulnerability to addictions in humans</title><author><name sortKey="Leyton, Marco" sort="Leyton, Marco" uniqKey="Leyton M" first="Marco" last="Leyton">Marco Leyton</name><affiliation><nlm:aff id="A1">Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, Quebec, H3A 1A1 Canada</nlm:aff></affiliation></author><author><name sortKey="Vezina, Paul" sort="Vezina, Paul" uniqKey="Vezina P" first="Paul" last="Vezina">Paul Vezina</name><affiliation><nlm:aff id="A2">Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, 5841 South Maryland Avenue, MC3077, Chicago, IL 60637, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Neuroscience and biobehavioral reviews</title><idno type="ISSN">0149-7634</idno><idno type="eISSN">1873-7528</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Susceptibility to addictive behaviors has been related to both increases and decreases in striatal function. Both profiles have been reported in humans as well as in animal models. Yet, the mechanisms underlying these opposing effects and the manner in which they relate to the behavioral development and expression of addiction remain unclear. In the present review of human studies, we describe a number of factors that could influence whether striatal hyper- or hypo-function is observed and propose a model that integrates the influence of these opposite responses on the expression of addiction related behaviors. Central to this model is the role played by the presence versus absence of addiction related cues and their ability to regulate responding to abused drugs and other rewards. Striatal function and incentive motivational states are increased in the presence of these cues and decreased in their absence. Alternations between these states might account for the progressive narrowing of interests as addictions develop and point to relevant processes to target in treatment.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7806090</journal-id><journal-id journal-id-type="pubmed-jr-id">6166</journal-id><journal-id journal-id-type="nlm-ta">Neurosci Biobehav Rev</journal-id><journal-id journal-id-type="iso-abbrev">Neurosci Biobehav Rev</journal-id><journal-title-group><journal-title>Neuroscience and biobehavioral reviews</journal-title></journal-title-group><issn pub-type="ppub">0149-7634</issn><issn pub-type="epub">1873-7528</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23333263</article-id><article-id pub-id-type="pmc">3743927</article-id><article-id pub-id-type="doi">10.1016/j.neubiorev.2013.01.018</article-id><article-id pub-id-type="manuscript">NIHMS436830</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Striatal ups and downs: Their roles in vulnerability to addictions in humans</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Leyton</surname><given-names>Marco</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref rid="FN2" ref-type="author-notes">**</xref></contrib><contrib contrib-type="author"><name><surname>Vezina</surname><given-names>Paul</given-names></name><xref ref-type="aff" rid="A2">b</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib></contrib-group><aff id="A1"><label>a</label>Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, Quebec, H3A 1A1 Canada</aff><aff id="A2"><label>b</label>Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, 5841 South Maryland Avenue, MC3077, Chicago, IL 60637, USA</aff><author-notes><corresp id="FN1"><label>*</label>Corresponding author. Tel.: +1 773 702 2890; fax: +1 773 702 0857</corresp><corresp id="FN2"><label>**</label>Co-corresponding author. Tel.: +1 514 398 5804; fax: +1 514 398 4866. <email>marco.leyton@mcgill.ca</email> (M. Leyton), <email>pvezina@yoda.bsd.uchicago.edu</email> (P. Vezina)</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>26</day><month>4</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>16</day><month>1</month><year>2013</year></pub-date><pub-date pub-type="ppub"><month>11</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>11</month><year>2014</year></pub-date><volume>37</volume><issue>0</issue><elocation-id>10.1016/j.neubiorev.2013.01.018</elocation-id><permissions><copyright-statement>© 2013 Elsevier Ltd. All rights reserved.</copyright-statement><copyright-year>2013</copyright-year></permissions><abstract><p id="P1">Susceptibility to addictive behaviors has been related to both increases and decreases in striatal function. Both profiles have been reported in humans as well as in animal models. Yet, the mechanisms underlying these opposing effects and the manner in which they relate to the behavioral development and expression of addiction remain unclear. In the present review of human studies, we describe a number of factors that could influence whether striatal hyper- or hypo-function is observed and propose a model that integrates the influence of these opposite responses on the expression of addiction related behaviors. Central to this model is the role played by the presence versus absence of addiction related cues and their ability to regulate responding to abused drugs and other rewards. Striatal function and incentive motivational states are increased in the presence of these cues and decreased in their absence. Alternations between these states might account for the progressive narrowing of interests as addictions develop and point to relevant processes to target in treatment.</p></abstract><kwd-group><kwd>Basal ganglia</kwd><kwd>Conditioning</kwd><kwd>Dopamine</kwd><kwd>Drug addiction</kwd><kwd>Drug self-administration</kwd><kwd>Functional magnetic resonance imaging</kwd><kwd>Positron emission tomography</kwd><kwd>Sensitization</kwd><kwd>Striatum</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Institute on Drug Abuse : NIDA</funding-source><award-id>R01 DA009397 || DA</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000803 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 000803 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.29. |  |